New definition of patient-specific root causes of disease using counterfactuals.
problem Lack of rigorous mathematical formulation for automatic detection of root causes.
method Proposes a counterfactual definition matching clinical intuition and uses Shapley values for causal contribution scores.
result Adapts to disease prevalence, accounts for noisy labels, and admits fast computation.
New model identifies patient-specific disease root causes.
problem Identifying root causes of complex diseases varying between patients.
method Generalized Root Causal Inference (GRCI) algorithm for heteroscedastic noise model.
result GRCI accurately extracts patient-specific root causes.
Identifies patient-specific root causes of disease using structural equation models.
problem Detecting significant variables in complex diseases that differ between patients.
method Defining patient-specific root causes as exogenous errors in a structural equation model, quantifying predictivity using Shapley values, and developing a fast algorithm called Root Causal Inference.
result Significant improvements in accuracy by uncovering root causes with large effect sizes at the individual level but clinically insignificant effect sizes at the group level.
New method identifies root causes in presence of latent confounding.
problem Identifying root causes in the presence of latent variables.
method Extract Errors with Latents (EEL) procedure for inferring root causes.
result Superior accuracy and robustness compared to previous methods.
Identifies root causes of outliers in unknown cyclic graphs.
problem Outliers in unknown cyclic graphs with linear structural equations.
method Identifies a short list of potential root causes based on strong perturbation and structural equations.
result The shortlist includes true root causes and their parents on the cycle.
CROC identifies the earliest-changing stream as the root cause in multi-stream data.
problem Distribution-free root cause analysis in multi-stream data with unknown distributional changes.
method Conformal p-values and finite-sample valid confidence sets.
result CROC efficiently isolates the root cause under minimal assumptions.
Paper simplifies calculating causation probabilities and ranks root causes.
problem Computational challenges in assessing causal relationships.
method Algorithmic simplifications and novel methodological framework for Root Cause Analysis.
result Significantly reduces computational complexity for calculating causation probabilities.
The paper proposes a method to identify root causes of anomalies in time series data.
problem Challenges in identifying the root cause of anomalies in complex software systems.
method Analyzes time series fluctuations to track the propagation of effects through hidden states.
result Identifies causal patterns among observed fluctuations to isolate root causes.
VEGN uses graph neural networks to predict disease-causing mutations from genetic variants.
problem Identifying disease-causing mutations from millions of genetic variants.
method VEGN employs a graph neural network on a heterogeneous graph of genes and variants, learning gene-gene interactions.
result VEGN outperforms existing state-of-the-art models in variant effect prediction.
Paper tackles anomaly detection with missing causal knowledge.
problem Detect anomalies with missing structural knowledge.
method Simple, efficient methods for polytree causal graphs.
result Heuristic identifies root causes based on anomaly scores.
Combining forecasts of 16 ED causes improves accuracy and stability.
problem Forecasting accuracy and stability for ED admissions is poor due to model uncertainty and limited data.
method High-dimensional forecast combinations of 16 cause-specific ED forecasts using extensive covariates.
result Forecast combinations yield forecast accuracies of 3.81%-23.54% across causes, outperforming individual models in 50% of scenarios.
New method combines FMEA and Bayesian Network for root cause analysis in lithium-ion battery production.
problem Complex cause-effect relationships in lithium-ion battery production.
method Combining FMEA with Bayesian Network to detect and resolve inconsistencies.
result Holistic method builds large-scale cross-process Bayesian Failure Network for root cause analysis.
Performance monitoring, anomaly detection, and root-cause analysis in complex cyber-physical systems (CPSs) are often highly intractable due to widely diverse operational modes, disparate data types, and complex fault propagation mechanisms. This paper presents a new data-driven framework for root-cause analysis, based…
Paper adapts causal analysis for time-dependent systems, especially energy management.
problem Challenges in root-cause analysis for systems with lagged time-dependencies, particularly in energy management.
method Adapts causal root-cause analysis method to time-dependent systems, discusses two truncation approaches.
result Extension effectively localizes root-causes in feature and time domain with enough lags.
Identifies root causes of outliers using causal DAGs.
problem Detecting and understanding the causes of anomalies in interrelated variables.
method Formal approach using causal directed acyclic graphs (DAGs), outlier scores, and Shapley values.
result Quantifies the extent of outlier scores attributed to ancestors.
The technique of Formal Concept Analysis is applied to a dataset describing the traits of rodents, with the goal of identifying zoonotic disease carriers,or those species carrying infections that can spillover to cause human disease. The concepts identified among these species together provide rules-of-thumb about the …
Method identifies root causes of anomalies in causal processes.
problem Identifying root causes of anomalies in causal processes.
method Noisy functional causal model, Bayesian learning, gradient-based attribution.
result Proposes efficient method to compute anomaly attribution scores.
Paper tackles anomaly detection and RCA in dynamical systems using ICODE Networks.
problem Anomalies in dynamical systems impact performance and reliability.
method Proposes ICODE Networks for anomaly detection, RCA, and type classification.
result Demonstrates the ability to accurately detect anomalies, classify types, and pinpoint origins.
CD-RCA method identifies causal relationships in prediction errors without predefined graphs.
problem Challenges in diagnosing prediction errors due to lack of transparency in black-box models.
method Causal-Discovery-based Root-Cause Analysis (CD-RCA) method that estimates causal relationships without predefined causal graphs.
result CD-RCA outperforms heuristic attribution methods in identifying variable contributions to prediction errors.
Deep neural networks (DNNs) are shown to be promising solutions in many challenging artificial intelligence tasks. However, it is very hard to figure out whether the low precision of a DNN model is an inevitable result, or caused by defects. This paper aims at addressing this challenging problem. We find that the inter…
Machine learning predicts obesity causes using genetic and imaging data.
problem Predicting causes of obesity in children and adults.
method Use ML techniques like decision trees, SVM, RF, GBM, LASSO, BN, and ANN on genetic and imaging data.
result ML models accurately predict obesity causes and chronic diseases.
Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. CD is an autoimmune disorder that is prevalent worldwide and is caused by an increased sensitivity to gluten. Gluten exposure destructs the small intestinal epithelial barrier, res…
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an indivi…
ECGDetect uses deep learning to detect ischemia in heart ECGs.
problem Detecting early signs of acute coronary syndrome in patients.
method Developed a deep learning model using the LTST database.
result Deep neural network achieved 90.31% ROC-AUC, 89.34% sensitivity, 87.81% specificity.
RAID algorithm detects anomalies in real-time IoT systems.
problem Anomaly detection limitations in multivariate dynamic processes.
method Adapts to non-stationary effects and handles data drift.
result Improved detection accuracy and root cause isolation.
Root cause analysis in a large-scale production environment is challenging due to the complexity of services running across global data centers. Due to the distributed nature of a large-scale system, the various hardware, software, and tooling logs are often maintained separately, making it difficult to review the logs…
Root Cause Analysis for Anomalies is challenging because of the trade-off between the accuracy and its explanatory friendliness, required for industrial applications. In this paper we propose a framework for simple and friendly RCA within the Bayesian regime under certain restrictions (that Hessian at the mode is diago…
Unlike traditional programs (such as operating systems or word processors) which have large amounts of code, machine learning tasks use programs with relatively small amounts of code (written in machine learning libraries), but voluminous amounts of data. Just like developers of traditional programs debug errors in the…
Study compares machine learning and process-based models for predicting rice blast disease.
problem Predicting rice blast disease to support rice growers in controlling the disease.
method Compared four models: two process-based (Yoshino and WARM) and two machine learning (M5Rules and RNN).
result Machine learning models outperformed process-based models in predicting rice blast disease.
Deep Rule Forests identifies drug-drug and drug-disease interactions causing AKI.
problem Identifying drug-drug and drug-disease interactions leading to AKI.
method Deep Rule Forests (DRF) algorithm discovering rules from multilayer tree models.
result DRF model outperforms other algorithms in prediction accuracy and interpretability.
With the increasing availability of wearable devices, continuous monitoring of individuals' physiological and behavioral patterns has become significantly more accessible. Access to these continuous patterns about individuals' statuses offers an unprecedented opportunity for studying complex diseases and health conditi…
NetRCA algorithm locates network faults by analyzing derived features and leveraging unlabeled data.
problem Locating the true root cause of network faults is challenging due to complex architectures and limited labeled data.
method NetRCA algorithm extracts derived features, generates new training data, and combines multiple models to enhance performance.
result NetRCA outperforms existing methods in fault cause localization on real-world data.
AI-assisted heart disease diagnosis reduces misdiagnosis and saves lives.
problem Misdiagnosis of heart disease leads to unnecessary deaths.
method Developed an AI application using ML and DNN algorithms on a dataset from the Cleveland Clinic Foundation.
result DNN model achieved a 92% accuracy rate, reducing misdiagnosis.
New method falsifies causal graphs using outlier events.
problem Inferring causal relationships from data is hard.
method Falsify candidate causal graphs based on outlier propagation.
result Statistical tests control false positives and have power guarantees.
New approach identifies and explains errors in machine learning pipelines.
problem Challenges in identifying and explaining errors in complex machine learning pipelines.
method Uses iteration and provenance to automatically infer root causes of failures.
result Significantly improves precision and recall compared to state-of-the-art methods.
Recently we developed a new framework in Hirz et al (2015) to model stochastic mortality using extended CreditRisk+ methodology which is very different from traditional time series methods used for mortality modelling previously. In this framework, deaths are driven by common latent stochastic risk factors which may…
This study evaluates adversarial attacks and defenses for chest X-ray disease classification.
problem Vulnerability of deep neural networks to adversarial examples in chest X-ray disease detection.
method Detailed introduction and evaluation of various attack and defense methods.
result Attack and defense methods perform poorly with excessive iterations and large perturbations.
The paper proposes a new probability distribution for rooted trees.
problem Overfitting in tree selection for statistical models.
method Bayesian approach with a generalized probability distribution for rooted trees.
result Recursive methods to evaluate the probability distribution without approximations.
Paper tackles RCA in complex networks with unknown interdependencies.
problem Difficult RCA in networked systems due to unknown interdependencies.
method Federated learning for feature-partitioned, nonlinear data without modifying client models.
result Established theoretical convergence guarantees and validated on real-world data.
The paper investigates causal relationships in heart failure prediction using machine learning.
problem Understanding the causal relationships between clinical variables and heart failure.
method Proposes a new computational framework for causal structure discovery (CSD) of mixed-type clinical variables for binary disease outcomes.
result Feature importance from nonlinear classifiers strongly correlates with causal strength of variables, but not differentiating cause and effect.
The diagnosis of the Erythemato-squamous disease (ESD) is accepted as a difficult problem in dermatology. ESD is a form of skin disease. It generally causes redness of the skin and also may cause loss of skin. They are generally due to genetic or environmental factors. ESD comprises six classes of skin conditions namel…
We develop a novel algorithm to predict the occurrence of major abdominal surgery within 5 years following Crohn's disease diagnosis using a panel of 29 baseline covariates from the Swedish population registers. We model pseudo-observations based on the Aalen-Johansen estimator of the cause-specific cumulative incidenc…
Heart disease is the leading cause of death, and experts estimate that approximately half of all heart attacks and strokes occur in people who have not been flagged as "at risk." Thus, there is an urgent need to improve the accuracy of heart disease diagnosis. To this end, we investigate the potential of using data ana…
Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker for disease staging. Probabilistic biomarkers naturally support the interpretation…
Deep neural networks improve mean function estimation for functional data.
problem Estimating mean functions of functional data.
method Deep neural networks with ReLU activation, sparsely connected.
result Achieves optimal nonparametric convergence rate in empirical norm.
Study proposes deep learning techniques to diagnose and differentiate Celiac Disease and Environmental Enteropathy from biopsy images.
problem Challenging histopathologic overlap between Celiac Disease and Environmental Enteropathy in biopsy images.
method Color balancing and Random Multimodel Deep Learning (RMDL) architecture to address staining variability.
result Proposed deep learning techniques improve diagnosis accuracy of Celiac Disease and Environmental Enteropathy.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
Diabetes mellitus is a common disease of human body caused by a group of metabolic disorders where the sugar levels over a prolonged period is very high. It affects different organs of the human body which thus harm a large number of the body's system, in particular the blood veins and nerves. Early prediction in such …