In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping chromosomes. A segmentation solution that is fast and automated will enable scaling of co…
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arXiv research
A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
169,051 papers · 148 categories
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48 results for “diagnostic medicine”
Auditor package assesses model performance and detects anomalies.
problem Model failure in real-world data.
method Model-agnostic audit techniques for goodness of fit and performance.
result Flexible and consistent grammar for validating models of any class.
Proposes methods for constructing confidence bands and improving ROC curve estimation in SVM models.
problem Improving ROC curve estimation in SVM models for binary classification problems.
method Develops a method for constructing confidence bands for the SVM ROC curve and provides theoretical justification.
result The risk function of the estimated decision rule is uniformly consistent across the weight parameter.
Representation Learning for Integrating Multi-domain Outcomes to Optimize Individualized Treatmentscs.LG
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
Paper tackles gene mutation prediction for HCC using multi-instance multi-label learning.
problem Gene mutation prediction in hepatocellular carcinoma for personalized treatments.
method Multi-instance multi-label learning with oversampling for data imbalance.
result Proposed approach shows superiority in gene mutation prediction.
The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Cost-efficient feature selection for multi-label classification in medicine.
problem Feature selection in multi-label classification with cost constraints.
method Sequential feature selection maximizing conditional mutual information, followed by cost-free feature selection using shadow features.
result The method effectively reduces prediction costs in medical applications.
Deep learning model performs differently in TB-specific vs non-TB-specific chest X-rays.
problem Limited generalizability of machine learning models for tuberculosis detection.
method Developed a DCNN model using a TB-specific CXR dataset and tested it on a non-TB-specific CXR dataset.
result A deep learning model trained on one population's TB CXR data does not generalize well to another population.
Simplifies decision-making during medical exams with cost-efficient feature acquisition.
problem Guiding physicians during examination acquisition for accurate and efficient diagnosis.
method Dropout at input layer and integrated gradients at test-time for dynamic feature importance.
result More cost- and feature-efficient than prior approaches, achieving higher overall accuracy.
Identifying measurable genetic indicators (or biomarkers) of a specific condition of a biological system is a key element of precision medicine. Indeed it allows to tailor diagnostic, prognostic and treatment choice to individual characteristics of a patient. In machine learning terms, biomarker discovery can be framed…
Deep learning estimates dose voxel kernels from CT data for personalized dosimetry.
problem Accurate estimation of absorbed dose in personalized radionuclide therapy.
method Combining deep learning with CT data to approximate dose voxel kernels from density kernels.
result Deep learning achieved an intersection-over-union score of 0.86 and mean squared error of 1.24×10−4 on real patient data.
Paper tackles medical image diagnosis with unsupervised domain adaptation.
problem Limited labeled samples and label noise in medical images.
method Collaborative Unsupervised Domain Adaptation (UDA) algorithm.
result Empirical results show superiority of the proposed method.
Optimizes personalized medicine prediction by individual tuning.
problem Predicting individual drug responses using genomic information.
method Introduces a new ridge estimator and tuning parameter calibration scheme.
result Optimal in terms of oracle inequalities, fast, and highly effective.
Study identifies subphenotypes of pediatric sepsis to improve ML predictive performance.
problem Enhance machine learning predictive performance in pediatric sepsis.
method Latent profile analysis of clinical data to identify subphenotypes, followed by ML experiments.
result Improved predictive performance of ML models targeting specific subphenotypes of pediatric sepsis.
Applying machine learning in the health care domain has shown promising results in recent years. Interpretable outputs from learning algorithms are desirable for decision making by health care personnel. In this work, we explore the possibility of utilizing causal relationships to refine diagnostic prediction. We focus…
Bandit algorithms optimize treatment decisions for precision medicine.
problem Optimizing treatment decisions for individual patients based on genetic or molecular profiling.
method Contextual bandit algorithms that consider patient characteristics.
result Bandit algorithms are useful for mobile health and digital phenotyping.
Establishes statistical and computational bounds for influence diagnostics.
problem Identifying influential datapoints or subsets in machine learning models.
method Finite-sample statistical bounds and computational complexity for influence functions and approximate maximum influence perturbations.
result Established statistical and computational guarantees for influence diagnostics.
The article explains how to estimate confusion matrices for classifiers using unlabeled data.
problem Estimating sensitivity and specificity of binary medical diagnostic tests without gold standard tests.
method Modifying diagnostic test solutions to estimate confusion matrices for classifiers on unlabeled data.
result The approach can be used to estimate accuracy statistics for supervised or unsupervised binary classifiers on unlabeled data.
Study identifies key brain regions and model architectures for ASD diagnosis.
problem Subjective and time-consuming ASD diagnosis by clinicians.
method Comparative analysis of model architectures and atlas granularities.
result High-performing models use 2-4 hidden layers and 16-64 neurons per layer, and cerebellum is predictive of ASD.
OptiLIME improves LIME explanations by balancing stability and adherence.
problem LIME's instability and lack of reliability in explanations.
method OptiLIME uses a deterministic sampling approach and feature selection to maximize stability while retaining predefined adherence.
result OptiLIME provides more reliable and interpretable explanations.
This paper reviews random forest methods for analyzing longitudinal data in precision medicine.
problem Analyzing longitudinal data for precision medicine.
method Extensions of random forest for longitudinal data analysis.
result Categorization of random forest methods for different data structures and repeated measurements.
New method optimizes individualized decision rules for precision medicine.
problem Heterogeneous patient responses to treatments.
method Proposes a decision-rule based optimized covariates dependent equivalent (CDE) for individualized decision making.
result Numerical experiments show improved performance in estimating optimal IDRs.
AI enhances cancer diagnostics using spectroscopy.
problem Early and accurate cancer diagnosis.
method Combining AI with spectroscopy-based techniques.
result AI improves cancer diagnostics speed and safety.
Paper develops approximation and statistical theory for signature-based path regression.
problem Understanding how fast signatures approximate continuous path functionals.
method Develops \(L^2\) approximation rate for smooth functionals of Itô diffusions and establishes consistency of statistical learning procedures.
result Signature-based methods improve prediction over handcrafted features in various real-data applications.
An Easy to Interpret Diagnostic for Approximate Inference: Symmetric Divergence Over Simulationscs.LG
Paper introduces a diagnostic for approximate inference methods.
problem Estimating errors in probabilistic inference algorithms, especially for approximate methods.
method Repeatedly simulate datasets from the prior and perform inference on each, estimating a symmetric KL-divergence.
result A diagnostic for approximate inference methods can be estimated using symmetric KL-divergence.
This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is so ingrained in medicine that it biases also the representation of clinical pheno…
Machine learning augmented diagnostic testing to identify sources of variability in test performancecs.LG
Machine learning improves diagnostic test accuracy for bovine tuberculosis.
problem Improving diagnostic test sensitivity for bovine tuberculosis.
method Machine learning to assess risk landscapes and predict infection.
result Test sensitivity improved, detecting 240 more infected herds per year.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
A theory for interpreting black-box models in medical diagnostics.
problem Lack of computational formulation for interpreting black-box models in medical diagnostics.
method Defining interpretation as a finite communication between a known model and a black-box model, deriving an algorithm for diagnostic interpretability.
result Demonstrated the feasibility of interpreting black-box models in synthetic supervised classification scenarios.
AI triage and diagnostic system performs similarly to human doctors, with safer triage advice.
problem Improving patient care through more reliable symptom checkers.
method Prospective validation study comparing AI system to human doctors.
result AI system's accuracy in identifying conditions comparable to human doctors, with safer triage advice.
Study compares WTT and DWT for FTIR data feature extraction of medicinal plants.
problem Improving machine learning efficiency with FTIR spectra of medicinal plants.
method Comparison of WTT and DWT for feature extraction, varying preprocessing steps.
result WTT and DWT yield similar results, improving clustering and classification accuracy.
Graph-based approach repairs programs from diagnostic feedback.
problem Learning to repair programs from limited labeled data and compiler error messages.
method Introduces program-feedback graph and graph neural network for reasoning, and self-supervised learning with unlabeled programs.
result DrRepair significantly outperforms prior work, achieving high repair rates.
Paper proposes an integrated M&D approach for large multistream data.
problem Inability to progress in monitoring and diagnostics due to high-dimensionality and volume of multistream data.
method Adaptive Principal Component monitoring (APC) and Principal Component Signal Recovery (PCSR).
result The integrated M&D approach enables early detection and streamlined SPC.
Proposes a new framework for evaluating diagnostic models with multiple co-primary endpoints.
problem Overoptimistic assessments of predictive performance in automated medical testing devices.
method Multiple testing framework for diagnostic accuracy studies with co-primary endpoints, using a parametric simultaneous test procedure and Bayesian approach to determine optimal number of models.
result Our approach leads to a better final diagnostic model and increased statistical power.
The paper analyzes convergence in SGD with momentum and proposes a diagnostic test.
problem Detecting convergence in stochastic gradient descent with momentum.
method Analyzes the transient and stationary phases of SGD with momentum, constructs a statistical diagnostic test.
result The proposed diagnostic test effectively detects convergence in the stationary phase of SGD with momentum.
Counting and classifying blood cells is an important diagnostic tool in medicine. Support Vector Machines are increasingly popular and efficient and could replace artificial neural network systems. Here a method to classify blood cells is proposed using SVM. A set of statistics on images are implemented in C++. The MPE…
Paper proposes a coupling-based diagnostic for SGD stepsize optimization.
problem Optimizing stepsize for SGD convergence.
method Coupling-based convergence diagnostic for monitoring stationarity.
result Proposed stepsize scheme achieves superior performance across convex and non-convex problems.
There is tremendous interest in precision medicine as a means to improve patient outcomes by tailoring treatment to individual characteristics. An individualized treatment rule formalizes precision medicine as a map from patient information to a recommended treatment. A treatment rule is defined to be optimal if it max…
Trustworthy Predictive Distributions for Tail Events with Semiparametric Diagnostic Transport Mapsstat.ML
Paper improves predictive distributions for rare events using a simple framework.
problem Local miscalibration of predictive distributions for rare events.
method Semiparametric diagnostic transport maps to correct tail probabilities.
result Semiparametric maps improve predictions for severe weather hazards.
TADDAA improves accuracy diagnostics for variational approximations.
problem Challenges in evaluating the accuracy of variational approximations.
method Uses many short parallel MCMC chains to obtain lower bounds on the error of each posterior functional of interest.
result Validates the practical utility and computational efficiency of TADDAA on various models.
Proposes a diagnostic method to evaluate factor models using cap-axis integrals.
problem Improving factor model evaluation in low-dimensional spaces.
method Lifts pricing errors into a bridge-alpha curve along the market-capitalization rank axis.
result The cap-axis norm is distinct from Sharpe gain and size exposure.
Proposes a diagnostic method to evaluate factor models using cap-axis integrals.
problem Improving factor model evaluation for low-dimensional models.
method Lifts pricing errors into a bridge-alpha curve along the market-capitalization rank axis.
result The cap-axis norm is distinct from Sharpe gain and size exposure.
The receiver operating characteristic (ROC) curve is a very useful tool for analyzing the diagnostic/classification power of instruments/classification schemes as long as a binary-scale gold standard is available. When the gold standard is continuous and there is no confirmative threshold, ROC curve becomes less useful…
Deep ROC analysis improves model selection and interpretation in medical and AI applications.
problem Inadequate performance measures for binary classifiers.
method Deep ROC analysis, translating AUC and partial AUC into balanced average accuracy and post-test measures.
result Deep ROC analysis provides balanced average accuracy, average sensitivity, and average specificity.
Language models fail to process hallucinated responses, and this study diagnoses the failure.
problem Language models fail to process hallucinated responses, leading to over-concentration or diffuse attention.
method The study uses forced scoring of benchmark-labeled responses to compute attention shapes and analyze the symmetric component of the degree-normalized attention operator.
result The study proves that every transpose-invariant spectral diagnostic of the attention operator is orientation-blind and bounds the sensitivity of any Lipschitz diagnostic by the asymmetry coefficient \(G\).
Expands statistical background for knee osteoarthritis treatment models.
problem Developing optimal exercise and weight loss treatments for knee osteoarthritis.
method Precision medicine models and jackknife cross-validation method.
result Jackknife estimator provides consistent value function estimation.
AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered structure of biomedical data together interact to present a joint challenge in the hi…
Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researc…