Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here to identify a subset of individuals who share a common brain signature highly p…
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48 results for “dementia prediction”
Models predict Alzheimer's Dementia from spontaneous speech with high accuracy.
problem Early diagnosis of Alzheimer's Dementia (AD) through spontaneous speech analysis.
method Compared natural language processing techniques including SVM, GBDT, CRFs, and Transformer-based models.
result Top models achieve 0.81-0.82 test set scores for AD vs controls and 4.58 RMSE for Mental Mini State Exam scores.
Paper compares neural networks and classical statistics for dementia prediction, highlighting interpretability of classical methods.
problem Tackles the challenge of interpreting risk factors for dementia prediction.
method Compares neural networks and classical statistics for dementia prediction.
result Classical statistics provide clearer interpretation of risk factors compared to neural networks.
Framework for joint learning of tasks on dementia data with missing values.
problem Lack of multi-task learning, handling time-dependent data, and missing values in dementia forecasting.
method Proposes SSHIBA model using Bayesian variational inference for imputation and combined information from different views.
result SSHIBA model outperforms baselines in predicting diagnosis, ventricle volume, and clinical scores in dementia.
ADReSS Challenge at INTERSPEECH 2020 benchmarks speech recognition for Alzheimer's dementia.
problem Automated recognition of Alzheimer's dementia from spontaneous speech.
method Provides a benchmark speech dataset, defines two tasks (classification and regression), and presents baseline models.
result Demonstrates the feasibility of automated speech recognition for Alzheimer's dementia.
We present a practical health-theme machine learning (ML) application concerning `AI for social good' domain for `Producing Good Outcomes' track. In particular, the solution is concerning the problem of a potential elderly adult dementia onset prediction in aging societies. The paper discusses our attempt and encouragi…
One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but different fashion by the normal aging process. Aging is therefore a confounding …
Paper characterizes early-stage dementia signatures from sensor data.
problem Detecting early-stage dementia from sensor data.
method Developed bespoke behavioural models from longitudinal sensor data.
result Found subtle differences in sleep quality and wandering between dementia patients and controls.
DynForest predicts event probabilities from longitudinal data, handling endogenous predictors.
problem Predicting individual risk using longitudinal patient history.
method Random survival forests with time-fixed features from longitudinal predictors.
result DynForest provides accurate individual event probability predictions.
Our research focuses on analysing human activities according to a known behaviorist scenario, in case of noisy and high dimensional collected data. The data come from the monitoring of patients with dementia diseases by wearable cameras. We define a structural model of video recordings based on a Hidden Markov Model. N…
Improves disease progression prediction using auxiliary surrogate labels and health markers.
problem Challenges in predicting disease progression due to unknown true disease states.
method Integrates hidden Markov model with time-varying discriminative classification model.
result Significant improvement in distinguishing LBD from AD using objective markers.
The emergence of an ageing population is a significant public health concern. This has led to an increase in the number of people living with progressive neurodegenerative disorders like dementia. Consequently, the strain this is places on health and social care services means providing 24-hour monitoring is not sustai…
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream acoustically, syntactically or both. The mostly used tools to perform these analysis…
Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies h…
ICAM: Interpretable Classification via Disentangled Representations and Feature Attribution Mappingcs.LG
ICAM creates interpretable feature attribution maps for brain images.
problem Challenges in predicting class relevance from brain images due to heterogeneity and background variation.
method A VAE-GAN framework for disentangling class relevance from background features.
result FA maps generated by ICAM outperform baseline methods and support phenotype variation exploration.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
Multimodal Inductive Transfer Learning for Detection of Alzheimer's Dementia and its Severityeess.AS
New model detects Alzheimer's and severity from speech, cognitive, and language data.
problem Detecting Alzheimer's disease and its severity from multimodal data.
method Multimodal ensemble system using acoustic, cognitive, and linguistic features.
result State-of-the-art accuracy and robustness in AD detection and MMSE score regression.
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
problem Challenges in observing direct treatment effects in clinical domains.
method Integrates Hidden Markov Model and Multi Task and Multi Graph Convolutional Network for spatiotemporal data.
result Advances predictive causal inference by structurally adapting to spatiotemporal complexities.
AutoElicit uses LLMs to quickly create expert priors for predictive models.
problem Creating accurate priors for predictive models is time-consuming and costly.
method AutoElicit extracts knowledge from LLMs to construct priors for predictive models.
result AutoElicit yields priors that reduce error and save labelling effort.
Hierarchical-CPI improves variable importance measurement for medical data.
problem Limited interpretability of complex medical models.
method Hierarchical-CPI measures conditional variable importance with statistical control, handling correlated data.
result Hierarchical-CPI outperforms existing methods in medical datasets.
Accurate facial expression analysis is an essential step in various clinical applications that involve physical and mental health assessments of older adults (e.g. diagnosis of pain or depression). Although remarkable progress has been achieved toward developing robust facial landmark detection methods, state-of-the-ar…
ANNs extrapolate without training data, leading to uncertain predictions.
problem Uncertainty in ANN predictions for unseen data.
method Quantitative approach based on long-standing methods.
result Quantitative uncertainty assessment for ANN predictions.
Improving Mild Cognitive Impairment Prediction via Reinforcement Learning and Dialogue Simulationcs.LG
Mild cognitive impairment (MCI) is a prodromal phase in the progression from normal aging to dementia, especially Alzheimers disease. Even though there is mild cognitive decline in MCI patients, they have normal overall cognition and thus is challenging to distinguish from normal aging. Using transcribed data obtained …
Develops a new feature theory for robust machine learning.
problem Creating robust machine learning features from training data.
method Stochastic tensor space feature theory with Karhunen-Loeve expansion and hierarchical subspaces.
result Dramatic increases in accuracy for predicting Alzheimer's disease stages.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
Do Pension Benefits Accelerate Cognitive Decline in Late Adulthood? Evidence from Rural Chinaecon.GN
Pension benefits in rural China lead to cognitive decline among the elderly.
problem Cognitive decline in late adulthood among rural Chinese elderly.
method Examined the effects of a new pension scheme on cognitive performance.
result Pension benefits negatively impact cognitive functioning, particularly delayed recall.
We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from …
Traditional voxel-level multiple testing procedures in neuroimaging, mostly -value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, whic…
Develops a regression model for partially observed dynamic tensor data.
problem Characterizing the relationship between dynamic tensor data and external covariates when data is only partially observed.
method Introduces low-rank, sparsity, and fusion structures on the regression coefficient tensor, and uses a loss function projected over observed entries. Developed an efficient non-convex alternating updating algorithm.
result Derived finite-sample error bounds for the estimator.
Recent years have witnessed the emergence and increasing popularity of 3D medical imaging techniques with the development of 3D sensors and technology. However, achieving geometric invariance in the processing of 3D medical images is computationally expensive but nonetheless essential due to the presence of possible er…
The reliability of a deep learning model in clinical out-of-distribution MRI data: a multicohort studyphysics.med-ph
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonizati…
Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker for disease staging. Probabilistic biomarkers naturally support the interpretation…
Recent years have witnessed the emergence of 3D medical imaging techniques with the development of 3D sensors and technology. Due to the presence of noise in image acquisition, registration researchers focused on an alternative way to represent medical images. An alternative way to analyze medical imaging is by underst…
ARMED models improve deep learning interpretability and generalize better on clustered data.
problem Clustered data leads to spurious associations and poor model fitting.
method Adversarial regularization and mixed effects subnetworks.
result ARMED models outperform conventional methods in accuracy and generalization.
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying hi…
Study examines APOE's impact on AD progression using a novel DEBM approach.
problem Understanding APOE's role in AD progression and developing targeted clinical trials.
method Developed a discriminative event-based model (DEBM) and proposed a stratified approach to improve model accuracy.
result Identified APOE carriers' impact on AD progression timeline, aiding clinical trial selection.
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
Fuzzy prediction sets generalize binary predictions to include elements at varying confidence levels.
problem Binary prediction sets are limited; fuzzy prediction sets offer richer guarantees.
method Generalize prediction sets to fuzzy sets, showing they are e-values with merging properties.
result Optimal e-values lead to optimal fuzzy prediction sets, including optimal conformal prediction.
Self-calibrating conformal prediction improves interval efficiency and offers a practical alternative.
problem Improving the reliability and uncertainty quantification of machine learning predictions.
method Combines Venn-Abers calibration and conformal prediction for binary and regression problems.
result Improves interval efficiency through model calibration and offers practical alternatives.
Study uses deep learning to predict asset prices, finds complex target processes lead to meaningless predictions.
problem Complexity of successful price prediction models hinders understanding.
method Deep learning models for high-frequency price prediction, focusing on volatility and directional prediction.
result Inadequately defined target price process renders predictions meaningless.
The paper emphasizes the importance of joint predictions over marginal predictions for decision-making.
problem The need for accurate joint predictions in decision-making problems.
method The paper analyzes combinatorial decision problems, sequential predictions, and multi-armed bandits, introducing an approximate Thompson sampling algorithm and new regret bounds.
result Accurate joint predictions are essential for good performance in decision-making problems.
Behavior modification improves prediction accuracy by nudging user behavior.
problem Improving prediction accuracy using behavior modification techniques.
method Combining prediction and behavior modification with reinforcement learning algorithms.
result Behavior modification can make predictions more certain but may not generalize.
Conformal predictive systems are a recent modification of conformal predictors that output, in regression problems, probability distributions for labels of test observations rather than set predictions. The extra information provided by conformal predictive systems may be useful, e.g., in decision making problems. Conf…
Predictions can shape outcomes, study helps predict these effects.
problem Understanding how predictions influence real-world outcomes.
method Causal identifiability analysis of prediction-covariate-outcome relationships.
result Standard supervised learning can identify transferable relationships from predictions.
Prediction problems often admit competing models that perform almost equally well. This effect challenges key assumptions in machine learning when competing models assign conflicting predictions. In this paper, we define predictive multiplicity as the ability of a prediction problem to admit competing models with confl…
Proposes feature conformal prediction for broader application in semantic feature spaces.
problem Establishing valid prediction intervals in semantic feature spaces.
method Extends conformal prediction to semantic feature spaces using deep representation learning.
result Feature conformal prediction outperforms regular conformal prediction under mild assumptions.
Acute kidney injury (AKI) commonly occurs in hospitalized patients and can lead to serious medical complications. In order to optimally predict AKI before it develops at any time during a hospital stay, we present a novel framework in which AKI is continually predicted automatically from EHR data over the entire hospit…