Study develops a new algorithm for assessing clinical trial abstracts.
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With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…
Study improves healthcare time series imputation by considering structured missingness.
We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical neuroscience studies. However, most registration algorithms are designed for high-resolut…
Novel metrics improve machine learning models for ICU patient care.
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonizati…
Deep learning analyzes healthcare provider actions and patient outcomes.
The recent adoption of Electronic Health Records (EHRs) by health care providers has introduced an important source of data that provides detailed and highly specific insights into patient phenotypes over large cohorts. These datasets, in combination with machine learning and statistical approaches, generate new opport…
In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate to…
Skin cancer is one of the most common types of cancer around the world. For this reason, over the past years, different approaches have been proposed to assist detect it. Nonetheless, most of them are based only on dermoscopy images and do not take into account the patient clinical information. In this work, first, we …
The paper explores using historical data to improve clinical trial analysis by optimizing covariate weights.
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
Late fusion of clinical notes and physiological data improves ICU mortality prediction.
FedRD improves risk difference estimation in federated learning for clinical outcomes.
Study examines biases in clinical word embeddings, revealing performance gaps across groups.
Predictive models identify patients at risk of severe COVID-19.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
Owe to the recent advancements in Artificial Intelligence especially deep learning, many data-driven decision support systems have been implemented to facilitate medical doctors in delivering personalized care. We focus on the deep reinforcement learning (DRL) models in this paper. DRL models have demonstrated human-le…
Study adaptive clinical trial methods for identifying patient subpopulations with treatment benefit.
Clinical trials in the medical domain are constrained by budgets. The number of patients that can be recruited is therefore limited. When a patient population is heterogeneous, this creates difficulties in learning subgroup specific responses to a particular drug and especially for a variety of dosages. In addition, pa…
Improved language model for French clinical reports achieves state-of-the-art performance in medical NLP tasks.
The paper predicts diseases using both clinical and genomics data.
We developed an automated deep learning system to detect hip fractures from frontal pelvic x-rays, an important and common radiological task. Our system was trained on a decade of clinical x-rays (~53,000 studies) and can be applied to clinical data, automatically excluding inappropriate and technically unsatisfactory …
Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied quantitatively---could yield important insights into the nature and intrinsic dynamics of seizures. A…
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…
The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are gr…
The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship between kidney tumor morphology and clinical outcomes is difficult due to data scar…
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
Study examines impact of fairness penalties on clinical risk prediction models.
FRESH combines patient-level and aggregate-level data for better clinical decision making.
Pairwise ranking aligns subjective clinical evaluations with objective indicators.
Clinical AI models fail to transfer between sites due to site-specific practices.
SARD improves deep learning clinical prediction performance.
Study re-evaluates MIMIC-III codes, finding many are under-coded.
Study predicts antimicrobial resistance in ICU patients quickly.
System suggests clinical concepts in real-time for faster note creation.
The study compares machine learning models for depression detection and highlights the importance of feature selection.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Improved 3D ECG feature attributions for clinical interpretation.
Paper proposes machine learning model for early Alzheimer's diagnosis.
New method stabilizes deep learning models for clinical risk prediction.
Copula-based fusion improves breast cancer risk stratification.
AI predicts medical specialty diagnostic choices from EHR records.
Over half a million individuals are diagnosed with head and neck cancer each year worldwide. Radiotherapy is an important curative treatment for this disease, but it requires manual time consuming delineation of radio-sensitive organs at risk (OARs). This planning process can delay treatment, while also introducing int…