Research
On-device research index

arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,695 papers · 148 categories

Trend · papers per month

187375562749 · Jun 202019922001200920172026
48 results for clinical studies

Study develops a new algorithm for assessing clinical trial abstracts.

problem Limited tools for assessing qualitative statements in clinical research.
method Developed a three-class sentiment classification algorithm using BERT model.
result Algorithm achieved 91.3% classification accuracy and 0.92 macro F1-Score.

With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…

2017-10-09abs ↗pdf ↗

Study improves healthcare time series imputation by considering structured missingness.

problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.

We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical neuroscience studies. However, most registration algorithms are designed for high-resolut…

2018-12-17abs ↗pdf ↗

Novel metrics improve machine learning models for ICU patient care.

problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.

In this chapter, we provide a brief overview of applying machine learning techniques for clinical prediction tasks. We begin with a quick introduction to the concepts of machine learning and outline some of the most common machine learning algorithms. Next, we demonstrate how to apply the algorithms with appropriate to…

2019-09-19abs ↗pdf ↗

The paper explores using historical data to improve clinical trial analysis by optimizing covariate weights.

problem Limited covariates in small clinical trials reduce the effectiveness of analysis.
method Leverage historical data to pre-specify covariate weights as a composite covariate.
result A composite covariate improves the cost/benefit ratio and reduces overfitting in small clinical trials.

Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…

2019-07-09abs ↗pdf ↗

Late fusion of clinical notes and physiological data improves ICU mortality prediction.

problem Improving ICU mortality prediction using multimodal data.
method Late fusion of clinical notes and physiological time series data with a deep learning architecture.
result Late fusion approach provides statistically significant improvement in mortality prediction performance.

FedRD improves risk difference estimation in federated learning for clinical outcomes.

problem Privacy-preserving model co-training in medical research is hindered by server-dependent architectures and focus on relative effect measures.
method FedRD is a server-independent, communication-efficient framework for federated risk difference estimation in distributed survival data.
result FedRD provides valid confidence intervals and hypothesis testing, and is asymptotically equivalent to pooled individual-level analysis.

Study examines biases in clinical word embeddings, revealing performance gaps across groups.

problem Biases in clinical word embeddings leading to performance differences across groups.
method Pretrained BERT models on MIMIC-III, fill-in-the-blank method, fairness evaluation on clinical tasks.
result Classifiers trained from BERT representations exhibit statistically significant differences in performance across groups.

Study improves mortality prediction in hospital patients using comprehensive feature engineering.

problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.

Study adaptive clinical trial methods for identifying patient subpopulations with treatment benefit.

problem Adaptive identification of patient subpopulations with treatment benefit in clinical trials.
method Proposes AdaGGI and AdaGCPI meta-algorithms for subpopulation construction.
result Empirical investigation of AdaGGI and AdaGCPI performance across various simulation scenarios.

Clinical trials in the medical domain are constrained by budgets. The number of patients that can be recruited is therefore limited. When a patient population is heterogeneous, this creates difficulties in learning subgroup specific responses to a particular drug and especially for a variety of dosages. In addition, pa…

2020-01-08abs ↗pdf ↗

Improved language model for French clinical reports achieves state-of-the-art performance in medical NLP tasks.

problem Lack of specialized language models for French clinical reports.
method Adapted a general pre-trained language model (CamemBERT) to French clinical reports using a corpus of 21M reports.
result Pretrained and fine-tuned models improved F1-score by 3 percentage points on APMed task.

CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.

problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).

Clinical notes contain a large amount of clinically valuable information that is ignored in many clinical decision support systems due to the difficulty that comes with mining that information. Recent work has found success leveraging deep learning models for the prediction of clinical outcomes using clinical notes. Ho…

2019-10-30abs ↗pdf ↗

The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are gr…

2019-04-02abs ↗pdf ↗

Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.

problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.

Study examines impact of fairness penalties on clinical risk prediction models.

problem Widespread health disparities in machine learning-guided clinical decision-making.
method Empirical study across multiple databases, outcomes, and sensitive attributes.
result Penalizing fairness violations nearly universally degrades model performance and fairness metrics.

FRESH combines patient-level and aggregate-level data for better clinical decision making.

problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.

Pairwise ranking aligns subjective clinical evaluations with objective indicators.

problem Aligning subjective clinical evaluations with objective indicators for improved diagnosis.
method Pairwise ranking methods to align subjective evaluations with objective indicators.
result The resulting score improves classification accuracy and provides a nuanced severity assessment.

SARD improves deep learning clinical prediction performance.

problem Deep learning models struggle to match linear models in healthcare predictions.
method Reverse Distillation to initialize deep models, combined with contextual and temporal embeddings.
result SARD outperforms state-of-the-art methods on clinical prediction outcomes.

The study compares machine learning models for depression detection and highlights the importance of feature selection.

problem The choice of features in machine learning models for depression detection is crucial.
method Comparison of seven machine learning models on depression detection tasks.
result Optimal feature selection is essential for accurate and clinically acceptable classification solutions.

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one chooses the time of prediction and the prediction horizon. In this paper, we show how…

2018-11-29abs ↗pdf ↗

Improved 3D ECG feature attributions for clinical interpretation.

problem Lack of interpretability in deep learning models for 12-lead ECG analysis.
method Cross-modal mapping of feature attributions from 12-lead ECG models onto CineECG 3D space.
result Mapped feature attributions yield higher Dice scores than standard 12-lead attributions.

Paper proposes machine learning model for early Alzheimer's diagnosis.

problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.

New method stabilizes deep learning models for clinical risk prediction.

problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.

Copula-based fusion improves breast cancer risk stratification.

problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.

AI predicts medical specialty diagnostic choices from EHR records.

problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.