Novel IRL method identifies suboptimal medical decisions in ICU data.
problem Identifying suboptimal medical decisions in clinical settings.
method Incorporates Inverse Reinforcement Learning with a pruning step to identify and remove suboptimal actions.
result Pruning step effectively identifies clinical priorities and values from suboptimal data.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
Pairwise ranking aligns subjective clinical evaluations with objective indicators.
problem Aligning subjective clinical evaluations with objective indicators for improved diagnosis.
method Pairwise ranking methods to align subjective evaluations with objective indicators.
result The resulting score improves classification accuracy and provides a nuanced severity assessment.
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Framework improves health by planning actionable treatment processes.
problem Developing objective treatment processes in clinical settings.
method Surrogate Bayesian model combined with ML for personalized health improvement.
result Computed treatment processes are actionable and consistent with clinical knowledge.
FRESH combines patient-level and aggregate-level data for better clinical decision making.
problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.
Unified framework for human-like decision making in various sequential tasks.
problem Real-life decision-making involves diverse strategies leading to similar outcomes.
method Two-stream reward processing mechanism for flexible and unified models.
result Framework unified MAB, CB, and RL with comparable performance.
Examines fairness in ML for health, highlighting its importance and challenges.
problem Ensuring fairness in ML models for health to prevent health disparities.
method Reviews fairness notions in ML for health, including group, individual, and causal-based approaches.
result Discusses the importance and challenges of fairness in health-focused ML applications.
Machine learning is bringing a paradigm shift to healthcare by changing the process of disease diagnosis and prognosis in clinics and hospitals. This development equips doctors and medical staff with tools to evaluate their hypotheses and hence make more precise decisions. Although most current research in the literatu…
Hybrid Bayesian-conformal framework improves uncertainty quantification in healthcare predictions.
problem Jointly satisfying distribution-free coverage guarantees and risk-adaptive precision in clinical decision-making.
method Integrates Bayesian hierarchical random forests with group-aware conformal calibration, using posterior uncertainties to weight conformity scores.
result Achieves target coverage (94.3% vs 95% target) with adaptive precision, 21% narrower intervals for low-uncertainty cases.
Paper uses ML to classify liver diseases from clinical data.
problem Classifying liver diseases from clinical data.
method Multiple imputation, PCA, data visualizations, binary classifier algorithms (ANN, RF, SVM).
result SVM showed better accuracy (98.23%).
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
problem Uncertainty in biomarker predictions poses risks in clinical deployment.
method Conformal prediction for randomly-timed biomarker trajectories.
result Conformal bands achieve desired coverage and are tighter than baseline.
Optimizes treatment duration to maximize quality-adjusted lifetime.
problem Balancing risks and benefits in clinical decision making.
method Proposes a weighted estimating equation to adjust for confounding and informative censoring, and a nonparametric estimator for mean counterfactual quality-adjusted lifetime.
result Shows the optimal time for percutaneous endoscopic gastrostomy insertion in ALS patients.
System predicts respiratory failure up to 8 hours early.
problem Early detection of respiratory failure in ICU patients.
method Machine learning on ICU patient monitoring data.
result System outperforms traditional clinical decision-making.
Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep Learning models have shown superior performance for robust prediction in computational…
Dynamic treatment regimes are of growing interest across the clinical sciences as these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. A dynamic treatment regime is a sequence of decision rules, with a decision rule per stage of clinical intervention; each de…
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).
The paper studies how noisy labels impact decision-making in machine learning.
problem The impact of noisy labels on decision-making in machine learning.
method Introducing a notion of regret, studying standard approaches, and estimating individual-level mistakes.
result Standard approaches can lead to unforeseen mistakes for individuals, revealing the need for anticipation.
Study benchmarks contextual bandit algorithms for precision oncology using in vitro data.
problem Designing effective protocols for individual treatment assignment in precision oncology.
method Proposed a benchmark dataset of in vitro drug responses to evaluate contextual bandit algorithms.
result Bayesian bandit algorithms performed better than a rule-based baseline in minimizing regret.
The method learns to partition event time space for better prediction.
problem Improving event time prediction in clinical settings with limited data.
method Develops a method to learn cut points for partitioning event time space.
result Improved prediction performance on real-world datasets.
Clinical decision making is challenging because of pathological complexity, as well as large amounts of heterogeneous data generated as part of routine clinical care. In recent years, machine learning tools have been developed to aid this process. Intensive care unit (ICU) admissions represent the most data dense and t…
Review of methods enabling causal predictions under hypothetical interventions.
problem Need for predicting outcomes under hypothetical interventions in decision making.
method Systematic review of methods using causal inference for prediction models.
result Identified 13 methods for causal inference from observational data.
The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship between kidney tumor morphology and clinical outcomes is difficult due to data scar…
Machine learning aids in diagnosing Parkinson's disease with higher accuracy.
problem Subjectivity in traditional PD diagnosis methods and missed early symptoms.
method Machine learning applied to various data modalities for PD and control group classification.
result Machine learning methods show high potential for improving PD diagnosis.
In this work, we investigate unsupervised representation learning on medical time series, which bears the promise of leveraging copious amounts of existing unlabeled data in order to eventually assist clinical decision making. By evaluating on the prediction of clinically relevant outcomes, we show that in a practical …
Decision making from data involves identifying a set of attributes that contribute to effective decision making through computational intelligence. The presence of missing values greatly influences the selection of right set of attributes and this renders degradation in classification accuracies of the classifiers. As …
Batched Neural Bandits reduces policy updates in sequential decision-making.
problem Sequential decision-making with batched policy changes.
method BatchNeuralUCB algorithm combining neural networks and optimism.
result Achieves similar regret as fully sequential version with fewer policy updates.
Clinical decision support systems (CDSS) will play an in-creasing role in improving the quality of medical care for critically ill patients. However, due to limitations in current informatics infrastructure, CDSS do not always have com-plete information on state of supporting physiologic monitor-ing devices, which can …
Owe to the recent advancements in Artificial Intelligence especially deep learning, many data-driven decision support systems have been implemented to facilitate medical doctors in delivering personalized care. We focus on the deep reinforcement learning (DRL) models in this paper. DRL models have demonstrated human-le…
Deep learning, an area of machine learning, is set to revolutionize patient care. But it is not yet part of standard of care, especially when it comes to individual patient care. In fact, it is unclear to what extent data-driven techniques are being used to support clinical decision making (CDS). Heretofore, there has …
Patient journeys are compared to find clusters of similar disease trajectories.
problem Discovering shared health outcomes among patient journeys.
method Comparing longitudinal health data to identify clusters of similar patient trajectories.
result Clusters of patient journeys with similar health outcomes can be identified.
Method predicts ODX scores for breast cancer patients based on clinical data.
problem Predicting ODX scores for breast cancer patients to aid decision-making.
method Distributional random forest approach using 9 clinico-pathological characteristics.
result Correctly predicted 92% of low risk and 40.2% of high risk patients.
In the modern healthcare system, rapidly expanding costs/complexity, the growing myriad of treatment options, and exploding information streams that often do not effectively reach the front lines hinder the ability to choose optimal treatment decisions over time. The goal in this paper is to develop a general purpose (…
Visual system compares and evaluates machine learning models for clinical data predictions.
problem Challenges in comparing and evaluating different machine learning models for medical predictions.
method Developed a visual analytics system to compare and evaluate multiple models' prediction criteria and consistency.
result Demonstrated the effectiveness of the visual analytics system in assisting clinicians and researchers.
PKB framework boosts genomic data analysis by integrating pathway knowledge.
problem Boosting discovery power and connecting new findings with biological mechanisms in genomic data.
method Pathway-based Kernel Boosting (PKB) framework integrating clinical and pathway information for prediction of various outcomes.
result PKB substantially outperforms other methods in predicting drug response and cancer survival.
The paper introduces a new algorithm for fair decision-making in outcome control tasks.
problem Fair and equitable automated decision-making in outcome control tasks.
method Causal analysis and optimization to ensure fairness in decision-making.
result Developed an algorithm for maximizing Y while ensuring causal fairness. Much attention has been devoted recently to the development of machine learning algorithms with the goal of improving treatment policies in healthcare. Reinforcement learning (RL) is a sub-field within machine learning that is concerned with learning how to make sequences of decisions so as to optimize long-term effect…
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.
New algorithms for batch decision-making with high-dimensional user data.
problem Maximizing treatment efficacy in groups of users.
method Teamwork LASSO Bandit algorithm, switching between teamwork and selfish stages.
result Upper bound on expected cumulative regret for the proposed algorithm.
Analyzes COVID-19 data to predict mortality, forecast spread, and optimize resource allocation.
problem Challenges in patient triage, treatment, and care management during the pandemic.
method Integrated four-step approach combining descriptive, predictive, and prescriptive analytics.
result Optimized resource allocation and informed policy decisions.
AI enhances personalized drug development and decision-making in pharma.
problem Traditional drug development lacks personalized treatment plans.
method Application of AI in drug discovery, clinical trials, and post-marketing assessment.
result AI improves personalized medicine, optimizing health outcomes.
Drawing an inspiration from behavioral studies of human decision making, we propose here a more general and flexible parametric framework for reinforcement learning that extends standard Q-learning to a two-stream model for processing positive and negative rewards, and allows to incorporate a wide range of reward-proce…
Estimation of individual treatment effects is commonly used as the basis for contextual decision making in fields such as healthcare, education, and economics. However, it is often sufficient for the decision maker to have estimates of upper and lower bounds on the potential outcomes of decision alternatives to assess …
PNNs improve personalized healthcare policies using mixed integer programming.
problem Learning treatment policies for patients with limited data.
method Prescriptive networks (PNNs) trained with mixed integer programming.
result PNNs outperform existing methods in reducing peak blood pressure.
FIGS improves prediction performance while maintaining interpretability, especially in medical domains.
problem Lack of interpretability in machine learning models, particularly in high-stakes domains like medicine.
method Generalizes CART algorithm to grow multiple trees in summation, combining logical rules with addition.
result FIGS achieves state-of-the-art prediction performance and derives interpretable clinical decision instruments (CDIs).
Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore some variables that are poor in prediction but are critical for decision-making…
Study predicts antimicrobial resistance in ICU patients quickly.
problem Delayed AMR testing in ICU leads to suboptimal treatment.
method Developed predictive models using clinical and microbiological data.
result Machine learning models predict AMR with higher accuracy than naive model.