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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,657 papers · 148 categories

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4795142189 · Jun 202019922001200920172026
48 results for cell behavior

Proposes CCCVAE for better single-cell clustering with cell-cell communication.

problem Improving single-cell RNA sequencing clustering by incorporating cell-cell communication.
method Integrates cell-cell communication into a variational autoencoder framework.
result Empirical results show CCCVAE outperforms standard VAEs in clustering performance.

GENOT matches cells across data modalities using neural OT solvers.

problem Scalability, privacy, and out-of-sample estimation issues in traditional OT solvers.
method Learn stochastic maps, parameterize OT maps, relax mass conservation, integrate quadratic solvers.
result Demonstrates significant potential for enhancing therapeutic strategies.

Transcriptomics response of SK-N-AS cells to methamidophos (an acetylcholine esterase inhibitor) exposure was measured at 10 time points between 0.5 and 48 h. The data was analyzed using a combination of traditional statistical methods and novel machine learning algorithms for detecting anomalous behavior and infer cau…

2019-08-11abs ↗pdf ↗

New method links covariates to CTMCs using RKHS, improving state transitions modeling.

problem Traditional multistate models rely on linear relationships, limiting flexibility.
method Nonparametric approach using RKHS, with Frequentist and Bayesian versions.
result Effective in identifying nonlinear transition functions and predicting long-term behaviors.

We address the problem of synthetic gene design using Bayesian optimization. The main issue when designing a gene is that the design space is defined in terms of long strings of characters of different lengths, which renders the optimization intractable. We propose a three-step approach to deal with this issue. First, …

2015-05-07abs ↗pdf ↗

Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success sho…

2018-06-29abs ↗pdf ↗

Forest Fire Clustering discovers cell types from single-cell data.

problem Discovering cell types from large-scale single-cell sequencing data.
method Iterative label propagation and parallelized Monte Carlo simulation.
result Forest Fire Clustering outperforms state-of-the-art methods on diverse benchmarks.

Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…

2012-07-13abs ↗pdf ↗

Improved GPLVM model for single-cell RNA-seq data.

problem Lack of effective scalable models for clustering cell types in large-scale single-cell RNA-seq data.
method Introduces amortized stochastic variational Bayesian GPLVM (BGPLVM) tailored for single-cell RNA-seq.
result Matches the performance of scVI on synthetic and real-world datasets and reveals more interpretable latent structures.

The study identifies all possible vector field structures on specific 2D shapes.

problem Optimal discrete gradient vector fields on surfaces with 1-2 critical cells.
method Analysis of discrete vector fields on 2D shapes with minimal critical cells.
result All possible structures of discrete Morse functions on specified shapes.

Combines multi-fidelity and asynchronous batch methods for faster experimental design.

problem Designing optimal experimental setups for battery performance.
method Algorithm combining multi-fidelity and asynchronous batch Bayesian Optimization.
result Algorithm outperforms single-fidelity batch and multi-fidelity sequential methods.

New model identifies cell-specific genes for cancer prognosis.

problem No statistical model to integrate multiscale cancer data.
method Bayesian generalized promotion time cure models (GPTCMs).
result Improves cancer prognosis by identifying cell-specific genes.

MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.

problem Selecting informative genes from large single-cell RNA-seq datasets is challenging and computationally intensive.
method MarkerMap is a generative model that identifies minimal gene sets explaining cell type variability.
result MarkerMap outperforms existing methods in both supervised and unsupervised marker selection.

New metric scores perturbations across populations, not cells, improving model comparison.

problem Single-cell perturbation data overlaps, making per-cell accuracy unreliable.
method Average per-cell probability vectors over all cells of a perturbation to form a population profile and rank candidate perturbations.
result Classifier Discrimination Score (CDS) identifies true perturbation more reliably than pseudobulk-based scores.

The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the precise geometry of an organism and its parts in space. Here, we suggest a set of …

2012-05-05abs ↗pdf ↗

DCENWCNet improves WBC classification with LIME-based explainability.

problem Classifying white blood cells from blood images with high accuracy and interpretability.
method Integrates three CNN architectures with different settings to balance feature learning and performance.
result Achieves highest mean accuracy on the Rabbin-WBC dataset, outperforming state-of-the-art networks.

NESS improves neighbor embedding for smooth cell-state transitions in single-cell data.

problem Challenges in extracting smooth, low-dimensional representations from noisy single-cell data.
method Builds on PCS framework to develop NESS, a stable machine learning approach.
result NESS consistently yields useful biological insights across diverse single-cell datasets.

New model clusters cells and individuals, revealing genetic influences on cell types.

problem Clustering nested data with group-level and observation-level variables.
method Nested Atoms Model (NAM), Bayesian nonparametric approach.
result Identifies clusters of genetically similar individuals with homogeneous cell-type profiles.

For a finite family of 3-dimensional almost contact metric manifolds with closed the structure form ηη is described a construction of an almost contact metric manifold, where the members of the family are building blocks - cells. Obtained manifold share many properties of cells. One of the more important are nullity c…

2012-03-21abs ↗pdf ↗

HSSE framework embeds single-cell RNA-seq data at multiple scales.

problem Capturing heterogeneous local structure in single-cell RNA-seq data.
method Hierarchical sheaf spectral embedding (HSSE) framework.
result HSSE achieves competitive or improved performance in single-cell RNA-seq data representation learning.

Researchers infer gene activity in dividing cells, accounting for protein inheritance and division history.

problem Inferring protein production kinetics in dividing cells due to protein inheritance and division history.
method Adapted conditional normalizing flows to approximate intractable likelihoods from simulated data.
result Glc3 gene is mostly inactive under stress, with brief and transient expression.

SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.

problem Separate clustering and differential expression analysis for scRNA-seq data leads to suboptimal results.
method Develops SimCD, a unified hierarchical gamma-negative binomial model for simultaneous cell clustering and differential expression analysis.
result SimCD outperforms existing methods in discovering cell clusters and capturing dynamic expression changes.

We construct a small regular cellular decomposition of the Fulton MacPherson operad FM2FM_2 that is compatible with the operad composition. The cells are indexed by trees with edges of two colors and vertices labelled by cells of the cacti operad. We compute the generating functions counting the cells, that are algebrai…

2019-06-18abs ↗pdf ↗

sEM uses optimal transport to improve EM algorithm for better convergence and avoiding local optima.

problem Improving the EM algorithm for better convergence and avoiding local optima.
method sEM uses entropic optimal transport to compute responsibilities in the expectation step, leading to better global convergence guarantees and avoiding local optima.
result sEM learns cell labels significantly better than other approaches, improving convergence and avoiding local optima.

CLSB models system dynamics from cross-sectional data with population-level regularization.

problem Challenges in modeling system dynamics from limited cross-sectional samples and heterogeneous individual behaviors.
method Introduces CLSB framework for learning dynamics, regularized for population-level temporal variations.
result Empirically superior in single-cell sequencing data analyses, e.g., simulating cell development and drug response.

The moduli space of Riemann surfaces with at least two punctures can be decomposed into a cell complex by using a particular family of ribbon graphs called Nakamura graphs. We distinguish the moduli space with all punctures labelled from that with a single labelled puncture. In both cases, we describe a cell decomposit…

2015-07-10abs ↗pdf ↗

Neural network predicts electrochemical cell faults with 53% less error.

problem Predicting faults in electrochemical cells to avoid safety hazards and reduce costs.
method Self-supervised encoder-decoder neural network that learns degradation from operating conditions.
result Predicted voltage with 53% less error than parametric models, 64% faster fault prediction.

New system constructs cell-type taxonomy across multiple samples.

problem Challenges in matching clusters from different datasets.
method Combines Optimal Transport with Relaxed Marginal Constraints (OT-RMC) for simultaneous alignment of clusters across multiple samples.
result Highly accurate annotation of cell types and sample-level feature extraction.

SMAI framework tests and integrates single-cell data alignability.

problem Lack of a rigorous statistical test for alignability and distortion during alignment.
method Spectral manifold alignment and inference (SMAI) framework.
result SMAI outperforms existing methods in alignability testing and integration.

We offer the following explanation of the statement of the Kuratowski graph planarity criterion and of 6/7 of the statement of the Robertson-Seymour-Thomas intrinsic linking criterion. Let us call a cell complex 'dichotomial' if to every cell there corresponds a unique cell with the complementary set of vertices. Then …

2011-03-28abs ↗pdf ↗