Cellina uses supervised disentanglement to predict cell behavior in tissues.
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Proposes CCCVAE for better single-cell clustering with cell-cell communication.
GENOT matches cells across data modalities using neural OT solvers.
Transcriptomics response of SK-N-AS cells to methamidophos (an acetylcholine esterase inhibitor) exposure was measured at 10 time points between 0.5 and 48 h. The data was analyzed using a combination of traditional statistical methods and novel machine learning algorithms for detecting anomalous behavior and infer cau…
A new image completion method inspired by brain cells.
Cell nuclei detection is a challenging research topic because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success shown by deep learning method…
New method links covariates to CTMCs using RKHS, improving state transitions modeling.
Kernel testing compares cell states in single-cell data.
We address the problem of synthetic gene design using Bayesian optimization. The main issue when designing a gene is that the design space is defined in terms of long strings of characters of different lengths, which renders the optimization intractable. We propose a three-step approach to deal with this issue. First, …
Detection of cell nuclei in microscopic images is a challenging research topic, because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic of enduring interest with promising recent success sho…
Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer vision and machine learning methods, analysis of multi-label samples (region containi…
Forest Fire Clustering discovers cell types from single-cell data.
Matching cells over time has long been the most difficult step in cell tracking. In this paper, we approach this problem by recasting it as a classification problem. We construct a feature set for each cell, and compute a feature difference vector between a cell in the current frame and a cell in a previous frame. Then…
Improved GPLVM model for single-cell RNA-seq data.
The study identifies all possible vector field structures on specific 2D shapes.
Combines multi-fidelity and asynchronous batch methods for faster experimental design.
New model identifies cell-specific genes for cancer prognosis.
MarkerMap selects key genes for cell type analysis in single-cell RNA-seq.
Proposes CXNs for neural network computations on cell complexes.
In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become the central component to identify and characterize novel cell types and gene exp…
New metric scores perturbations across populations, not cells, improving model comparison.
Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profil…
The process of morphogenesis, which can be defined as an evolution of the form of an organism, is one of the most intriguing mysteries in the life sciences. It is clear, that gene expression patterns cannot explain the development of the precise geometry of an organism and its parts in space. Here, we suggest a set of …
DCENWCNet improves WBC classification with LIME-based explainability.
Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. During the development of epilepsy, granule cell integration is profoundly…
NESS improves neighbor embedding for smooth cell-state transitions in single-cell data.
New model clusters cells and individuals, revealing genetic influences on cell types.
Cell-based NAS search spaces are redundant and lack novelty.
For a finite family of 3-dimensional almost contact metric manifolds with closed the structure form is described a construction of an almost contact metric manifold, where the members of the family are building blocks - cells. Obtained manifold share many properties of cells. One of the more important are nullity c…
HSSE framework embeds single-cell RNA-seq data at multiple scales.
Researchers infer gene activity in dividing cells, accounting for protein inheritance and division history.
SimCD simultaneously clusters cells and identifies differential gene expression in scRNA-seq data.
Understanding cell identity is an important task in many biomedical areas. Expression patterns of specific marker genes have been used to characterize some limited cell types, but exclusive markers are not available for many cell types. A second approach is to use machine learning to discriminate cell types based on th…
Two simple homotopy equivalent 2-complexes K2 and L2 are related by an algebraic criterion of their corresponding presentations as stated in [HoMeSier]. Frank Quinn set it into a topological context (see [Qu1]) and call these 2-complexes related by an s-move. Using elementary 3-expansions, K2 extends to 3-cells in K3 r…
We construct a small regular cellular decomposition of the Fulton MacPherson operad that is compatible with the operad composition. The cells are indexed by trees with edges of two colors and vertices labelled by cells of the cacti operad. We compute the generating functions counting the cells, that are algebrai…
sEM uses optimal transport to improve EM algorithm for better convergence and avoiding local optima.
Study homology of periodic cell complexes using quotient spaces and spectral sequences.
CLSB models system dynamics from cross-sectional data with population-level regularization.
Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the demand for and development of label-free methodologies to classify cells is strong…
The moduli space of Riemann surfaces with at least two punctures can be decomposed into a cell complex by using a particular family of ribbon graphs called Nakamura graphs. We distinguish the moduli space with all punctures labelled from that with a single labelled puncture. In both cases, we describe a cell decomposit…
Neural network predicts electrochemical cell faults with 53% less error.
New system constructs cell-type taxonomy across multiple samples.
Generalising a seminal result of Epstein and Penner for cusped hyperbolic manifolds, Cooper and Long showed that each decorated strictly convex projective cusped manifold has a canonical cell decomposition. Penner used the former result to describe a natural cell decomposition of decorated Teichmüller space of puncture…
SMAI framework tests and integrates single-cell data alignability.
We offer the following explanation of the statement of the Kuratowski graph planarity criterion and of 6/7 of the statement of the Robertson-Seymour-Thomas intrinsic linking criterion. Let us call a cell complex 'dichotomial' if to every cell there corresponds a unique cell with the complementary set of vertices. Then …
Minimal example found for two finite CW-complexes sharing a common covering.
We present a conditional generative model to learn variation in cell and nuclear morphology and the location of subcellular structures from microscopy images. Our model generalizes to a wide range of subcellular localization and allows for a probabilistic interpretation of cell and nuclear morphology and structure loca…
Multi-StyleGAN simulates live cell microscopy imagery.