A method for logistic regression inference using both internal and external data.
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New method uses unlabeled data to estimate intercept in case-control logistic regression.
Estimates non-parametric logistic model using case-control data and external summary info.
Dimension reduction and variable selection are performed routinely in case-control studies, but the literature on the theoretical aspects of the resulting estimates is scarce. We bring our contribution to this literature by studying estimators obtained via L1 penalized likelihood optimization. We show that the optimize…
CIR method preserves relation for case-control studies.
New method uses geometric mean to avoid non-collapsibility in case-control studies.
The causal assumptions, the study design and the data are the elements required for scientific inference in empirical research. The research is adequately communicated only if all of these elements and their relations are described precisely. Causal models with design describe the study design and the missing data mech…
For classification problems with significant class imbalance, subsampling can reduce computational costs at the price of inflated variance in estimating model parameters. We propose a method for subsampling efficiently for logistic regression by adjusting the class balance locally in feature space via an accept-reject …
A review of contrastive dimension reduction methods for treatment vs control studies.
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
Paper proposes a new method for estimating conditional densities using logistic regressions.
Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o…
regularized logistic regression has now become a workhorse of data mining and bioinformatics: it is widely used for many classification problems, particularly ones with many features. However, regularization typically selects too many features and that so-called false positives are unavoidable. In this pape…
A rigorous ML pipeline for binary classification in biomedical studies, focusing on pancreatic cancer.
Novel approach uses quasi-conformal geometry for OSA classification from cephalometry.
Genome-wide association studies (GWASs) aim to detect genetic risk factors for complex human diseases by identifying disease-associated single-nucleotide polymorphisms (SNPs). The traditional SNP-wise approach along with multiple testing adjustment is over-conservative and lack of power in many GWASs. In this article, …
Study causal inference under specific sampling methods with monotonicity assumptions.
The increasing access to brain signal data using electroencephalography creates new opportunities to study electrophysiological brain activity and perform ambulatory diagnoses of neuronal diseases. This work proposes a pairwise distance learning approach for Schizophrenia classification relying on the spectral properti…
Study improves treatment effect estimation using unlabeled covariates.
We consider a problem of learning a binary classifier only from positive data and unlabeled data (PU learning) and estimating the class-prior in unlabeled data under the case-control scenario. Most of the recent methods of PU learning require an estimate of the class-prior probability in unlabeled data, and it is estim…
Bayesian hyperbolic MDS improves tree-like data representation.
Normative modeling has recently been proposed as an alternative for the case-control approach in modeling heterogeneity within clinical cohorts. Normative modeling is based on single-output Gaussian process regression that provides coherent estimates of uncertainty required by the method but does not consider spatial c…
We develop a real-time anomaly detection algorithm for directed activity on large, sparse networks. We model the propensity for future activity using a dynamic logistic model with interaction terms for sender- and receiver-specific latent factors in addition to sender- and receiver-specific popularity scores; deviation…
Unified theory for semiparametric data fusion with individual-level data.
Algorithm reduces variance in causal effect estimation from multiple datasets.
Causal effect identification considers whether an interventional probability distribution can be uniquely determined without parametric assumptions from measured source distributions and structural knowledge on the generating system. While complete graphical criteria and procedures exist for many identification problem…
Measuring the impact of scientific articles is important for evaluating the research output of individual scientists, academic institutions and journals. While citations are raw data for constructing impact measures, there exist biases and potential issues if factors affecting citation patterns are not properly account…
Proposes spBART for risk prediction using epigenetic signatures and covariates.
OpFlow predicts robust OD flows by learning choice potentials conditioned on spatial exposures.
Bayesian method models binary response and covariates for two groups, estimating causal relationships.
Paper proposes a method for estimating tropical cyclone intensity distribution using deep learning.
Gynaecologists and obstetricians visually interpret cardiotocography (CTG) traces using the International Federation of Gynaecology and Obstetrics (FIGO) guidelines to assess the wellbeing of the foetus during antenatal care. This approach has raised concerns among professionals with regards to inter- and intra-variabi…
gOMP algorithm selects features for various types of data.
Approaches for testing sets of variants, such as a set of rare or common variants within a gene or pathway, for association with complex traits are important. In particular, set tests allow for aggregation of weak signal within a set, can capture interplay among variants, and reduce the burden of multiple hypothesis te…
New optimizer designs respect symmetry, improving deep learning models.
A new method estimates treatment effects across multiple studies considering differences.
Study shows convergence of Fubini-Study currents to equilibrium metrics on Kähler manifolds.
Boosting strategies for merging vs. ensembling studies analyzed.
A critical decision point when training predictors using multiple studies is whether studies should be combined or treated separately. We compare two multi-study prediction approaches in the presence of potential heterogeneity in predictor-outcome relationships across datasets: 1) merging all of the datasets and traini…
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most useful for generating …
Acute respiratory infections have epidemic and pandemic potential and thus are being studied worldwide, albeit in many different contexts and study formats. Predicting infection from symptom data is critical, though using symptom data from varied studies in aggregate is challenging because the data is collected in diff…
This paper reviewed the machine learning-based studies for quantitative positron emission tomography (PET). Specifically, we summarized the recent developments of machine learning-based methods in PET attenuation correction and low-count PET reconstruction by listing and comparing the proposed methods, study designs an…
Ricci flow simulations show unstable Fubini-Study metrics develop singularities.
New method uncovers bias mechanisms in observational studies.
GenAI improves actuarial practices through case studies.
Proves polynomial injectivity of Fubini-Study map for ample line bundles.
Optimal ensemble construction improves prediction accuracy for multi-study tasks, especially in pandemic scenarios.