FalconBC improves patient-specific cardiovascular modeling by estimating boundary conditions efficiently.
problem Efficiently estimating boundary conditions in patient-specific cardiovascular models, especially in open-loop models and anatomies with lesions.
method A general amortized inference framework based on probabilistic flow that treats clinical targets and anatomies as conditioning variables.
result Demonstrated on two patient-specific models, FalconBC improves efficiency and accuracy in estimating boundary conditions.
New framework predicts arterial blood pressure from MRI data using physics-informed neural networks.
problem Clinical applicability of predictive cardiovascular flow models is hindered by computational cost and tedious pre-processing.
method Physics-informed neural networks constrained by conservation of mass and momentum principles.
result Deep neural networks provide physically consistent predictions for arterial blood pressure without conventional simulators.
Researchers develop methods to reduce simulation costs for cardiovascular modeling.
problem High computational cost of high-fidelity simulations in cardiovascular modeling.
method Use low-fidelity approximations, neural networks, and normalizing flows to construct surrogates.
result Validated methods reduce computational cost while maintaining accuracy.
We consider the problem of modeling cardiovascular responses to physical activity and sleep changes captured by wearable sensors in free living conditions. We use an attentional convolutional neural network to learn parsimonious signatures of individual cardiovascular response from data recorded at the minute level res…
Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndr…
Neural network predicts cardiovascular events from EHRs with high accuracy.
problem Predicting onset of cardiovascular diseases from electronic health records.
method Multi-task gated recurrent units with attention mechanism.
result Model outperforms clinical risk scores in predicting stroke and myocardial infarction.
Study proposes a multimodal model for cardiovascular risk prediction using EHRs.
problem Lack of comprehensive risk prediction from EHRs due to unstructured text.
method Proposes a multimodal BiLSTM model integrating structured and unstructured EHR data.
result Proposed BiLSTM model outperforms other DNN architectures in cardiovascular risk prediction.
SBI improves uncertainty analysis of cardiovascular biomarkers.
problem Mapping waveforms back to plausible physiological parameters.
method Simulation-based inference (SBI) for statistical inference.
result Posterior distributions provide a multi-dimensional representation of uncertainty.
Models for predicting the risk of cardiovascular events based on individual patient characteristics are important tools for managing patient care. Most current and commonly used risk prediction models have been built from carefully selected epidemiological cohorts. However, the homogeneity and limited size of such coho…
We train and validate a semi-supervised, multi-task LSTM on 57,675 person-weeks of data from off-the-shelf wearable heart rate sensors, showing high accuracy at detecting multiple medical conditions, including diabetes (0.8451), high cholesterol (0.7441), high blood pressure (0.8086), and sleep apnea (0.8298). We compa…
Study creates a multimodal learning framework for CVD risk prediction.
problem Predicting cardiovascular disease risk in diverse populations.
method Combines cross modal transformers, graph neural networks, and causal representation learning.
result Model predicts personalized CVD risk with causal invariance across subpopulations.
Neural network predicts falls in elderly people up to 10 minutes in advance.
problem Falls prevention in elderly people, especially in aging societies.
method Gated Recurrent Unit (GRU) based neural networks model using heart rate and mean blood pressure signals.
result Predicted syncope occurrence approximately 10 minutes before manual markers.
Generative ODE model learns unknown variables in medical systems.
problem Estimating unknown variables in complex medical systems.
method Variational autoencoder incorporating known ODE functions.
result Modeling known-unknowns improves system parameter discovery and extrapolation.
Framework for imputing missing heart data to simulate brain-heart interactions.
problem Lack of multi-modal patient data representing heart and brain processes.
method Probabilistic framework for joint cardiac data imputation and mechanistic model personalization.
result Accurate imputation of missing cardiac features in incomplete datasets.
Method generates natural ECGs with 25 interpretable features.
problem Lack of labeled ECGs for supervised learning and automatic diagnostics.
method Variational autoencoder for ECG generation and feature extraction.
result Low Maximum Mean Discrepancy (0.00383) indicates good ECG generation quality.
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies. These models have differential performance across race and gender groups with inconsistent behavior a…
Cardiovascular diseases are one of the most common causes of death in the world. Prevention, knowledge of previous cases in the family, and early detection is the best strategy to reduce this fact. Different machine learning approaches to automatic diagnostic are being proposed to this task. As in most health problems,…
Mobile electrocardiogram (ECG) recording technologies represent a promising tool to fight the ongoing epidemic of cardiovascular diseases, which are responsible for more deaths globally than any other cause. While the ability to monitor one's heart activity at any time in any place is a crucial advantage of such techno…
BoXHED boosts hazard estimation for dynamic health risk scores.
problem Analyzing time-varying health vitals for disease onset prediction.
method Gradient boosting for nonparametric hazard function estimation with time-dependent covariates.
result Novel interaction effects among risk factors identified in cardiovascular disease onset data.
Generative model learns shape drift for quantifying domain uncertainty in hemodynamics.
problem Quantifying domain uncertainty in medical image segmentation for biomarker estimation.
method Conditional stochastic interpolant framework based on LDDMM registration.
result Generative model can create random perturbations of shapes for biomarker estimation.
New algorithms improve vascular flow simulations in aortic aneurysms.
problem Limited accuracy of MRI in hemodynamics, patient-specific flow boundary conditions, and CFD's computational demands.
method Physics-Informed Neural Networks (PINNs) and Deep Operator Networks (DeepONets) integrated with 3D Navier-Stokes equations.
result Improved computational efficiency and good agreement with CFD simulations.
Study reviews machine learning techniques for stress monitoring.
problem Improving accuracy of stress monitoring devices.
method Reviewed machine learning techniques for various stress indicators.
result Choosing the right classifier depends on multiple factors.
Radiomics identifies subtle cardiac changes in hypertension.
problem Subtle cardiac alterations in hypertension not captured by conventional imaging.
method Combines feature selection and machine learning for identifying structural and tissue changes.
result Radiomics model detects changes beyond conventional imaging.
A clinician desires to use a risk-stratification method that achieves confident risk-stratification - the risk estimates of the different patients reflect the true risks with a high probability. This allows him/her to use these risks to make accurate predictions about prognosis and decisions about screening, treatments…
Deep learning improves CVD risk prediction from health records.
problem Predicting cardiovascular disease risk from administrative health data.
method Combined survival analysis and deep learning models.
result Deep learning models outperform traditional Cox models in accuracy and explained time-to-event occurrence.
A new method for sampling from posterior distributions in Bayesian inverse problems.
problem Sampling from posterior distributions in Bayesian inverse problems is challenging due to intractable terms.
method Proposes a novel approach that decomposes the transitions, allowing a trade-off between complexity of guidance term and prior transitions.
result Validated through experiments on various inverse problems, including challenging cases with latent diffusion models as priors.
Study predicts heart failure patient survival using stacked ensemble ML.
problem Predicting survival of heart failure patients.
method Collect and analyze patient data, apply SMOTE, use K-Means, Fuzzy C-Means clustering, Random Forest, XGBoost, Decision Tree, and propose a stacked ensemble model.
result Supervised ML algorithms outperform unsupervised models, achieving high accuracy and F1 score.
Portable, Wearable and Wireless electrocardiogram (ECG) Systems have the potential to be used as point-of-care for cardiovascular disease diagnostic systems. Such wearable and wireless ECG systems require automatic detection of cardiovascular disease. Even in the primary care, automation of ECG diagnostic systems will …
Random shuffle method boosts HF dataset size 10-21 times.
problem Narrow dataset cardinality in HF clinical studies.
method Random shuffle method to enhance dataset size.
result Enhanced HF dataset size 10-21 times.
We study regularized estimation in high-dimensional longitudinal classification problems, using the lasso and fused lasso regularizers. The constructed coefficient estimates are piecewise constant across the time dimension in the longitudinal problem, with adaptively selected change points (break points). We present an…
Study finds incorporating fairness in healthcare models doesn't improve performance or net benefit.
problem Addressing health inequities in healthcare through algorithmic fairness.
method Empirical case study using models to estimate atherosclerotic cardiovascular disease risk.
result Incorporating fairness considerations into model training objective does not improve model performance or net benefit.
ECGDetect uses deep learning to detect ischemia in heart ECGs.
problem Detecting early signs of acute coronary syndrome in patients.
method Developed a deep learning model using the LTST database.
result Deep neural network achieved 90.31% ROC-AUC, 89.34% sensitivity, 87.81% specificity.
G-Net uses deep learning for complex counterfactual outcome prediction.
problem Estimating counterfactual outcomes under dynamic treatment strategies.
method G-Net is a sequential deep learning framework for G-computation.
result G-Net can handle complex temporal data and provide accurate treatment effects.
CardiacGen generates realistic ECG signals for training deep learning models.
problem Creating realistic synthetic ECG signals for training deep learning models.
method Hierarchical deep generative model with multi-objective loss functions.
result Synthetic ECG signals from CardiacGen can be used for data augmentation and improve classifier performance.
The morphological structure of left ventricle segmented from cardiac magnetic resonance images can be used to calculate key clinical parameters, and it is of great significance to the accurate and efficient diagnosis of cardiovascular diseases. Compared with traditional methods, the segmentation algorithms based on ful…
The CHAMPION study clusters multi-dimensional accelerometer data to understand health links.
problem Clustering multi-dimensional data from pediatric longitudinal studies.
method Developed a finite mixture of multidimensional arrays model for clustering 4-dimensional accelerometer data.
result Demonstrated the feasibility and utility of clustering higher order data.
Acceleration of machine learning research in healthcare is challenged by lack of large annotated and balanced datasets. Furthermore, dealing with measurement inaccuracies and exploiting unsupervised data are considered to be central to improving existing solutions. In particular, a primary objective in predictive model…
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
The paper introduces Precision Disease Networks (PDN) for predicting medical outcomes.
problem Predicting medical outcomes for patients with diseases.
method Building patient-specific disease networks, clustering, and data visualization.
result PDN improves prediction of patient outcomes compared to standard statistical analysis.
Electrocardiogram (ECG) can be reliably used as a measure to monitor the functionality of the cardiovascular system. Recently, there has been a great attention towards accurate categorization of heartbeats. While there are many commonalities between different ECG conditions, the focus of most studies has been classifyi…
New test identifies specific biological parameters for personalized CVD detection.
problem Ineffectual pathology tests fail to consider platelet activation and inter-individual variability.
method Stochastic platelet deposition model and approximate Bayesian computation with discriminative summary statistics.
result Inferred parameters help identify specific biological parameters for personalized CVD detection.
A new method classifies heart sounds using i-vectors and machine learning.
problem Heart sound classification for disease diagnostics.
method Extract i-vectors from MFCC features, apply PCA and VAE for dimensionality reduction, then use GMMs and SVM for classification.
result The method improves heart sound classification by 16% on the Physionet dataset.
The paper proposes a method to identify subgroups with different treatment effects in time-to-event data.
problem Identifying subgroups with differential treatment effects in time-to-event data.
method A mixture model with structured sparsity regularization and novel inference procedure.
result The method effectively recovers sparse phenotypes across real-world clinical studies.
The retinal vascular condition is a reliable biomarker of several ophthalmologic and cardiovascular diseases, so automatic vessel segmentation may be crucial to diagnose and monitor them. In this paper, we propose a novel method that combines the multiscale analysis provided by the Stationary Wavelet Transform with a m…
Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records (EHRs) provide an alternative to the longitudinal cohort studies traditio…
DWTS uses observational data to improve clinical trial efficiency.
problem Lack of definitive conclusions from randomized clinical trials due to insufficient patient cohorts and confounding biases.
method DWTS combines observational data with randomized clinical trials using Doubly Debiased LASSO (DDL) to identify reliable covariates.
result DWTS reduces cumulative regret in clinical trials compared to standard methods.
Study improves CAD diagnosis accuracy by selecting significant features.
problem Improving accuracy of CAD diagnosis through feature selection.
method Integrated machine learning approach using random trees (RTs), C5.0, SVM, and CHAID.
result Random trees model outperforms other models in CAD diagnosis.
Models predict patients at risk of uncontrolled hypertension.
problem Identifying patients at risk of uncontrolled hypertension.
method Developed machine learning models (logistic regression and recurrent neural networks) using EHR data.
result Best model achieved AUROC of 0.719, outperforming baseline.