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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,786 papers · 148 categories

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4794140187 · May 202619922001200920172026
48 results for cancer risk

Neural networks improve cancer risk prediction from family history data.

problem Improving cancer risk prediction from family history data using machine learning.
method Developed and trained neural network models on large pedigrees to predict hereditary cancers.
result Neural networks can achieve nearly optimal prediction performance and outperform traditional models in misreported data.

Copula-based fusion improves breast cancer risk stratification.

problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.

Proposes a new model to analyze CT scans for lung cancer patients.

problem Analyzing survival risks of lung cancer patients using CT scans.
method Penalized Deep Partially Linear Cox Model (Penalized DPLC) incorporating SCAD penalty and deep neural network.
result The model effectively selects important texture features and estimates nonparametric components.

SurvLatent ODE predicts VTE risk for cancer patients, outperforming current methods.

problem Predicting clinical outcomes from irregularly sampled EHR data with competing events.
method Neural ODE-based Recurrent Neural Networks (ODE-RNN) for flexible survival time estimation.
result SurvLatent ODE outperforms Khorana Risk scores for VTE risk prediction.

We present a novel method for extracting cancer signatures by applying statistical risk models (http://ssrn.com/abstract=2732453) from quantitative finance to cancer genome data. Using 1389 whole genome sequenced samples from 14 cancers, we identify an "overall" mode of somatic mutational noise. We give a prescription …

2016-04-29abs ↗pdf ↗

Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.

problem Improving cancer diagnosis through high-fidelity digital pathology.
method Deep generative model using PathologyGAN to map real images onto a latent space.
result Latent space encodes morphological characteristics and reveals distinct tissue clusters.

Method predicts ODX scores for breast cancer patients based on clinical data.

problem Predicting ODX scores for breast cancer patients to aid decision-making.
method Distributional random forest approach using 9 clinico-pathological characteristics.
result Correctly predicted 92% of low risk and 40.2% of high risk patients.

PersonalizedUS assesses breast cancer risk with local coverage guarantees.

problem Manual BI-RADS scoring leads to unnecessary biopsies and mental health burden.
method Conformal prediction for precise, personalized risk estimates.
result Local coverage guarantees with high sensitivity and specificity.

Improving cancer treatment decisions requires considering causal effects, not just model accuracy.

problem Cancer outcome prediction models may cause harm when used for treatment decisions.
method Explains the importance of considering causal effects in model validation and provides guidelines.
result Building and validating models that are useful for decision making requires considering causal effects.

Study compares LSTM, Transformer, and Mamba for bladder cancer recurrence analysis.

problem Complex time-dependent data in bladder cancer recurrence analysis.
method Evaluation of LSTM, Transformer, and Mamba models using Cox proportional hazards model.
result LSTM-Cox model outperforms Transformer-Cox and Mamba-Cox models in prediction accuracy.

A novel dose-finding design for cancer clinical trials using level set estimation.

problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.

This study predicts ovarian cancer from cysts using TVUS and machine learning.

problem Early detection of ovarian cancer from cysts using TVUS screening.
method Employed Random Forest, KNN, and XGBoost machine learning techniques on PLCO dataset.
result Achieved high accuracy, recall, f1 score, and precision in predicting ovarian cancer.

CAT framework improves AI medical screening fairness and reliability.

problem Imbalanced data, varying performance across cohorts, and patient-level inconsistencies in traditional metrics.
method CAT framework introduces patient-level assessment, entropy-based distribution weighting, and cohort-weighted sensitivity and specificity.
result Enhanced predictive reliability, fairness, and interpretability of AI-driven medical screening models.

New model improves cancer screening prediction accuracy.

problem Modeling disease progression with heterogeneous populations and irregular data.
method Hierarchical Hidden Markov Jump Processes with piece-wise stationary transitions and scalable EM algorithm.
result Model outperforms state-of-the-art models in prediction accuracy and generating Kaplan-Meier estimators.

In this paper we propose network methodology to infer prognostic cancer biomarkers based on the epigenetic pattern DNA methylation. Epigenetic processes such as DNA methylation reflect environmental risk factors, and are increasingly recognised for their fundamental role in diseases such as cancer. DNA methylation is a…

2015-06-17abs ↗pdf ↗

Bayesian framework improves survival prediction accuracy and uncertainty quantification.

problem Inaccurate uncertainty estimates in survival models.
method Bayesian framework combining variational inference, neural multi-task logistic regression, and sparsity-inducing prior.
result Better quantification of survival uncertainty and more accurate predictions.

Paper develops a method to predict cancer patient survival using molecular profiles.

problem Accurately predicting cancer patient survival with complex survival-molecular profile relationships.
method Kernel Cox partially linear regression with a novel regularized garrotized kernel machine (RegGKM) method.
result The proposed method outperforms other methods in predicting survival accuracy.

Over 150,000 new people in the United States are diagnosed with colorectal cancer each year. Nearly a third die from it (American Cancer Society). The only approved noninvasive diagnosis tools currently involve fecal blood count tests (FOBTs) or stool DNA tests. Fecal blood count tests take only five minutes and are av…

2017-08-13abs ↗pdf ↗

Model predicts anti-cancer drug responses using gene and molecular data.

problem Expensive and time-consuming cancer drug discovery and tailoring.
method Uses variational autoencoders and multi-layer perceptrons to encode gene expression and drug data.
result High average R2R^{2} of 0.83 and 0.845 in predicting drug responses for breast and pan-cancer cell lines, respectively.

PDBAL targets experiments for probabilistic models to maximize insights.

problem Designing experiments to yield valuable insights efficiently.
method Combines user-specified risk function with probabilistic model to adaptively choose designs.
result PDBAL consistently outperforms standard approaches in simulations and real-world drug screen data.

We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis. We extrapolate to…

2017-08-30abs ↗pdf ↗

Gradient boosting enhances existing Mendelian models for genetic disease risk prediction.

problem Improving existing Mendelian models for genetic disease risk prediction.
method Combining gradient boosting with existing Mendelian models.
result Improved model outperforms both original and gradient boosting-only models.

Machine learning accurately diagnoses cancer from whole genome sequencing data.

problem Accurate cancer diagnosis at all stages.
method Novel MLAC (Machine Learning Against Cancer) method using next-gen RNA sequencing.
result Perfect precision, sensitivity, and specificity achieved for most tumor types.

Deep learning models are vulnerable to adversarial attacks, leading to critical errors.

problem Vulnerability of deep learning models to adversarial attacks in critical applications.
method Implemented various defenses (adversarial training, dimensionality reduction, prediction similarity) against adversarial attacks.
result Models became more robust against adversarial attacks without significant loss in accuracy.

We present *K-means clustering algorithm and source code by expanding statistical clustering methods applied in https://ssrn.com/abstract=2802753 to quantitative finance. *K-means is statistically deterministic without specifying initial centers, etc. We apply *K-means to extracting cancer signatures from genome data w…

2017-03-02abs ↗pdf ↗

Non-synonymous single nucleotide polymorphisms (nsSNPs) are single nucleotide substitution occurring in the coding region of a gene and leads to a change in amino-acid sequence of protein. The studies have shown these variations may be associated with disease. Thus, investigating the effects of nsSNPs on protein functi…

2018-05-06abs ↗pdf ↗

Accurately predicting drug responses to cancer is an important problem hindering oncologists' efforts to find the most effective drugs to treat cancer, which is a core goal in precision medicine. The scientific community has focused on improving this prediction based on genomic, epigenomic, and proteomic datasets measu…

2016-12-02abs ↗pdf ↗

System automates identification of cancer drug repurposing from PubMed.

problem Manual extraction of cancer drug repurposing evidence from scientific publications is infeasible.
method NLP pipeline including querying, filtering, entity extraction, classification, and study type classification.
result Automated system extracts cancer drug repurposing evidence from PubMed abstracts.

Study identifies biomarkers for lung cancer in female non-smokers.

problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.