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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,742 papers · 148 categories

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3.0%6.0%9.0%12.0% · Nov 201919922001200920172026
48 results for cancer research

Paper proposes scalable method for analyzing multi-omic data.

problem Integrating high-dimensional multi-omic data for cancer subtyping.
method Mixed graphical model approach using Birth-Death MCMC algorithm.
result Our method outperforms LASSO and standard BDMCMC in computational efficiency and model selection accuracy.

Understanding the phenotypic drug response on cancer cell lines plays a vital rule in anti-cancer drug discovery and re-purposing. The Genomics of Drug Sensitivity in Cancer (GDSC) database provides open data for researchers in phenotypic screening to test their models and methods. Previously, most research in these ar…

2018-12-28abs ↗pdf ↗

Paper tackles cancer mutation data challenges by creating useful low-dimensional representations.

problem Challenges in analyzing and using cancer mutation data for classification and clustering.
method Flatsomatic: variational autoencoders (VAEs) to create latent representations of somatic profiles.
result VAE embeddings perform better than PCA for clustering and equally well for classification.

Cancer analysis and prediction is the utmost important research field for well-being of humankind. The Cancer data are analyzed and predicted using machine learning algorithms. Most of the researcher claims the accuracy of the predicted results within 99%. However, we show that machine learning algorithms can easily pr…

2019-03-17abs ↗pdf ↗

Study compares single vs ensemble feature selection for cancer diagnosis.

problem Identifying relevant variables for cancer diagnosis and prognosis.
method Comparison of single feature selection algorithms and ensemble of diverse algorithms.
result Ensemble approach did not improve predictive performance over individual algorithms.

Study identifies biomarkers for lung cancer in female non-smokers.

problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.

Improving cancer treatment decisions requires considering causal effects, not just model accuracy.

problem Cancer outcome prediction models may cause harm when used for treatment decisions.
method Explains the importance of considering causal effects in model validation and provides guidelines.
result Building and validating models that are useful for decision making requires considering causal effects.

There are various algorithms and methodologies used for automated screening of cervical cancer by segmenting and classifying cervical cancer cells into different categories. This study presents a critical review of different research papers published that integrated AI methods in screening cervical cancer via different…

2018-11-02abs ↗pdf ↗

Objectives: Most cancer data sources lack information on metastatic recurrence. Electronic medical records (EMRs) and population-based cancer registries contain complementary information on cancer treatment and outcomes, yet are rarely used synergistically. To enable detection of metastatic breast cancer (MBC), we appl…

2019-01-17abs ↗pdf ↗

Deep learning model explains breast cancer subtypes using logistic regression.

problem Clarifying the mechanisms of breast cancer subtypes for better treatment.
method Developed a PWL model that generates custom-made logistic regression for each patient.
result The PWL model reveals genes relevant to cell cycle-related pathways.

This study predicts ovarian cancer from cysts using TVUS and machine learning.

problem Early detection of ovarian cancer from cysts using TVUS screening.
method Employed Random Forest, KNN, and XGBoost machine learning techniques on PLCO dataset.
result Achieved high accuracy, recall, f1 score, and precision in predicting ovarian cancer.

MINN-SA enhances cancer detection using TCR sequences with better interpretability.

problem Challenges in detecting cancers using TCR sequences due to one-to-many correspondence.
method Multiple Instance Neural Networks based on Sparse Attention (MINN-SA).
result MINN-SA achieves highest AUC scores on 10 cancer types compared to existing MIL approaches.

Deep learning, through the use of neural networks, has demonstrated remarkable ability to automate many routine tasks when presented with sufficient data for training. The neural network architecture (e.g. number of layers, types of layers, connections between layers, etc.) plays a critical role in determining what, if…

2019-09-26abs ↗pdf ↗

Sparse Canonical Correlation Analysis (CCA) has received considerable attention in high-dimensional data analysis to study the relationship between two sets of random variables. However, there has been remarkably little theoretical statistical foundation on sparse CCA in high-dimensional settings despite active methodo…

2013-11-24abs ↗pdf ↗

AI framework uses multi-omics data to personalize cancer treatment suggestions.

problem Leveraging AI for personalized cancer treatment based on complex patient characteristics.
method Modular machine learning framework trained on diverse multi-omics technologies.
result Superior performance in personalized counterfactual treatment suggestions.

Proposes a multi-resolution model for prostate cancer classification using mpMRI.

problem Improving voxel-wise classification of prostate cancer using multi-parametric MRI data.
method Multi-resolution Super Learner framework combining local base learners at multiple resolutions and spatial Gaussian kernel smoothing.
result Enhanced voxel-wise classification of prostate cancer status and clinical significance.

TransST improves spatial transcriptomics data analysis by identifying cell clusters and biomarkers.

problem Low resolution and insufficient sequencing depth in spatial transcriptomics data.
method Transfer learning framework to adaptively leverage external cell-labeled information.
result TransST successfully identifies five biologically meaningful cell clusters and separates adipose tissues from connective issues.

The potential benefits of applying machine learning methods to -omics data are becoming increasingly apparent, especially in clinical settings. However, the unique characteristics of these data are not always well suited to machine learning techniques. These data are often generated across different technologies in dif…

2018-11-26abs ↗pdf ↗

Data integration methods that analyze multiple sources of data simultaneously can often provide more holistic insights than can separate inquiries of each data source. Motivated by the advantages of data integration in the era of "big data", we investigate feature selection for high-dimensional multi-view data with mix…

2019-03-27abs ↗pdf ↗

Many researches demonstrated that the DNA methylation, which occurs in the context of a CpG, has strong correlation with diseases, including cancer. There is a strong interest in analyzing the DNA methylation data to find how to distinguish different subtypes of the tumor. However, the conventional statistical methods …

2018-08-02abs ↗pdf ↗

A rigorous ML pipeline for binary classification in biomedical studies, focusing on pancreatic cancer.

problem Handling bias in ML models for complex biomedical data.
method Customizable ML analysis pipeline with 9 algorithms, hyperparameter optimization, and thorough evaluation.
result Comparison of ML algorithms to ExSTraCS, highlighting interpretability and bias handling.

New framework distinguishes lung cancer subtypes using MALDI mass spectrometry.

problem Distinguishing between adenocarcinoma and squamous cell carcinoma subtypes in lung cancer.
method Supervised topological data analysis on MALDI mass spectrometry imaging data.
result The proposed framework successfully classifies lung cancer subtypes with competitive results.

Model predicts anti-cancer drug responses using gene and molecular data.

problem Expensive and time-consuming cancer drug discovery and tailoring.
method Uses variational autoencoders and multi-layer perceptrons to encode gene expression and drug data.
result High average R2R^{2} of 0.83 and 0.845 in predicting drug responses for breast and pan-cancer cell lines, respectively.

PKB framework boosts genomic data analysis by integrating pathway knowledge.

problem Boosting discovery power and connecting new findings with biological mechanisms in genomic data.
method Pathway-based Kernel Boosting (PKB) framework integrating clinical and pathway information for prediction of various outcomes.
result PKB substantially outperforms other methods in predicting drug response and cancer survival.

We estimate treatment cost-savings from early cancer diagnosis. For breast, lung, prostate and colorectal cancers and melanoma, which account for more than 50% of new incidences projected in 2017, we combine published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis. We extrapolate to…

2017-08-30abs ↗pdf ↗

We present a novel method for extracting cancer signatures by applying statistical risk models (http://ssrn.com/abstract=2732453) from quantitative finance to cancer genome data. Using 1389 whole genome sequenced samples from 14 cancers, we identify an "overall" mode of somatic mutational noise. We give a prescription …

2016-04-29abs ↗pdf ↗

Machine learning accurately diagnoses cancer from whole genome sequencing data.

problem Accurate cancer diagnosis at all stages.
method Novel MLAC (Machine Learning Against Cancer) method using next-gen RNA sequencing.
result Perfect precision, sensitivity, and specificity achieved for most tumor types.

Neural networks improve cancer risk prediction from family history data.

problem Improving cancer risk prediction from family history data using machine learning.
method Developed and trained neural network models on large pedigrees to predict hereditary cancers.
result Neural networks can achieve nearly optimal prediction performance and outperform traditional models in misreported data.

Bayesian Cox model identifies biomarkers from multi-omics data.

problem Produce interpretable survival prognosis from multi-omics data.
method Penalized semiparametric Bayesian Cox model with graph-structured selection priors.
result Model identifies new biomarkers and improves survival prediction.

Two new feature selection methods improve breast cancer diagnosis accuracy.

problem Improving breast cancer diagnosis accuracy and reducing dataset dimensions.
method Imperialist Competitive Algorithm (ICA) and Bat Algorithm (BA) integrated with ML algorithms.
result BA-based feature selection method outperforms other methods with 99.12% accuracy.