Deep learning quantifies butterfly phenotypes, validating evolutionary theory.
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We give an explicit handy (and cocycle-free) description of the groupoid of weak maps between two crossed-modules in terms of certain digrams of groups which we we call a {\em butterflies}. We define composition of butterflies and this way find a bicategory that is naturally biequivalent to the 2-category of pointed ho…
Sparse butterfly network replaces dense layers in neural networks, improving expressibility and performance.
Deep networks, especially convolutional neural networks (CNNs), have been successfully applied in various areas of machine learning as well as to challenging problems in other scientific and engineering fields. This paper introduces Butterfly-Net, a low-complexity CNN with structured and sparse cross-channel connection…
In unsupervised domain adaptation (UDA), classifiers for the target domain (TD) are trained with clean labeled data from the source domain (SD) and unlabeled data from TD. However, in the wild, it is difficult to acquire a large amount of perfectly clean labeled data in SD given limited budget. Hence, we consider a new…
ButterflyFlow uses butterfly matrices for efficient invertible layers in normalizing flows.
Characterizes no Butterfly arbitrage in SVI model parameters.
Simplified Butterfly-Net2 improves CNN efficiency in solving PDEs and signal processing tasks.
WideBNet learns inverse scattering from wide-band data efficiently and stably.
Disease phenotyping algorithms process observational clinical data to identify patients with specific diseases. Supervised phenotyping methods require significant quantities of expert-labeled data, while unsupervised methods may learn non-disease phenotypes. To address these limitations, we propose the Semi-Supervised …
Electronic phenotyping is the task of ascertaining whether an individual has a medical condition of interest by analyzing their medical record and is foundational in clinical informatics. Increasingly, electronic phenotyping is performed via supervised learning. We investigate the effectiveness of multitask learning fo…
VBphenoR uses variational Bayes for EHR-based patient phenotyping.
It has been recently shown that sparse, nonnegative tensor factorization of multi-modal electronic health record data is a promising approach to high-throughput computational phenotyping. However, such approaches typically do not leverage available domain knowledge while extracting the phenotypes; hence, some of the su…
The linking genotype to phenotype is the fundamental aim of modern genetics. We focus on study of links between gene expression data and phenotype data through integrative analysis. We propose three approaches. 1) The inherent complexity of phenotypes makes high-throughput phenotype profiling a very difficult and labor…
We show how to integrate a weak morphism of Lie algebra crossed-modules to a weak morphism of Lie 2-groups. To do so we develop a theory of butterflies for 2-term L_infty algebras. In particular, we obtain a new description of the bicategory of 2-term L_infty algebras. We use butterflies to give a functorial constructi…
The widely used genetic pleiotropic analysis of multiple phenotypes are often designed for examining the relationship between common variants and a few phenotypes. They are not suited for both high dimensional phenotypes and high dimensional genotype (next-generation sequencing) data. To overcome these limitations, we …
Bayesian model enhances phenotype discovery in asthma EHRs.
Model identifies key problems in HIV patients' records.
Study on 2-bridge knots, proving equivariant concordance order is infinite.
This paper reviews methods for discovering patient subgroups from EHR data.
Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical condition, and is a crucial part of secondary analysis of healthcare data. We ass…
Tensor factorization models offer an effective approach to convert massive electronic health records into meaningful clinical concepts (phenotypes) for data analysis. These models need a large amount of diverse samples to avoid population bias. An open challenge is how to derive phenotypes jointly across multiple hospi…
Develops methods for GWAS of high dimensional phenotypes using summary statistics.
Unified 3D R-matrices from quantum cluster algebra.
ODBAE detects complex phenotypes in biological data.
Support Vector Regression (SVR) has achieved high performance on forecasting future behavior of random systems. However, the performance of SVR models highly depends upon the appropriate choice of SVR parameters. In this study, a novel BOA-SVR model based on Butterfly Optimization Algorithm (BOA) is presented. The perf…
In this paper we test for the sensitive dependence on initial conditions (the so called "butterfly effect") of energy futures time series (heating oil, natural gas), and thus the determinism of those series. This paper is distinguished from previous studies in the following points: first, we reread existent works in th…
TASTE combines static and temporal data for phenotyping EHRs.
A looming question that must be solved before robotic plant phenotyping capabilities can have significant impact to crop improvement programs is scalability. High Throughput Phenotyping (HTP) uses robotic technologies to analyze crops in order to determine species with favorable traits, however, the current practices r…
Efficient trainable front-end for neural speech enhancement.
We study surfaces of constant positive Gauss curvature in Euclidean 3-space via the harmonicity of the Gauss map. Using the loop group representation, we solve the regular and the singular geometric Cauchy problems for these surfaces, and use these solutions to compute several new examples. We give the criteria on the …
The study classifies points on ruled surfaces in 4-space based on geometric properties.
Characterizes smiles in delta satisfying specific conditions.
SWoTTeD discovers hidden temporal patterns in EHR data.
WEST uses EHRs and expert cases to improve rare disease phenotyping.
OMTL uses ontology to learn from imbalanced EHR data.
We develop a model to cluster time-series data with interval censoring, improving disease phenotyping.
Study develops electronic phenotypes of ICU patient acuity.
Acute Kidney Injury (AKI) is a common clinical syndrome characterized by the rapid loss of kidney excretory function, which aggravates the clinical severity of other diseases in a large number of hospitalized patients. Accurate early prediction of AKI can enable in-time interventions and treatments. However, AKI is hig…
Baseline injury categorization is important to traumatic brain injury (TBI) research and treatment. Current categorization is dominated by symptom-based scores that insufficiently capture injury heterogeneity. In this work, we apply unsupervised clustering to identify novel TBI phenotypes. Our approach uses a generaliz…
Binary PheNorm extends phenotype labeling for EHRs using binary silver labels.
The increased affordability of whole genome sequencing has motivated its use for phenotypic studies. We address the problem of learning interpretable models for discrete phenotypes from whole genomes. We propose a general approach that relies on the Set Covering Machine and a k-mer representation of the genomes. We sho…
Understanding the phenotypic drug response on cancer cell lines plays a vital rule in anti-cancer drug discovery and re-purposing. The Genomics of Drug Sensitivity in Cancer (GDSC) database provides open data for researchers in phenotypic screening to test their models and methods. Previously, most research in these ar…
New method phenotypes sleep apnea patients using time series analysis.
Machine learning predicts plant phenotypes from soil microbiome data.
Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep Learning models have shown superior performance for robust prediction in computational…
Paper studies singularities of timelike minimal surfaces in Minkowski 3-space.
Study developed phenotypes for ICU patients' brain dysfunction states.