Probabilistic clustering of evolving distances identifies smooth cluster changes.
problem Clustering objects with time-varying pairwise distances.
method Uses Dirichlet process prior to automatically determine clusters at each time point.
result Model outperforms existing methods in synthetic and real-world applications.
New method uses machine learning to estimate drug parameters in brain models.
problem Estimating unknown parameters in complex brain drug models.
method Physics-Informed Neural Networks (PINNs) for inverse problem solving.
result Accurate parameter estimation leads to precise drug concentration profiles.
X-CAL improves survival model calibration without sacrificing predictive power.
problem Improving the calibration of survival models to better match observed data.
method Explicit calibration (X-CAL) turns distributional calibration into a differentiable objective for survival modeling.
result X-CAL improves calibration metrics without significantly reducing predictive performance.
V-Net speeds up brain tumor segmentation in MRI scans.
problem Manual tumor segmentation is time-consuming and inaccurate.
method Applied a volumetric, fully convolutional neural network (V-Net) to MRI scans.
result Achieved a whole tumor dice score of 0.89.
Study improves cancer classification using gene selection and projection methods.
problem Overfitting in high-dimensional microarray datasets for cancer classification.
method FSWOR technique, random projection, Kendall test, ensemble classifiers, LDA projection, Naïve Bayes.
result Achieved a test score of 96%, significantly outperforming existing methods.
New method explains high-dimensional sphere data with latent factors.
problem Understanding intricate dependence structure in high-dimensional sphere data.
method Exploratory factor analysis of the projected normal distribution with a fast alternating expectation profile conditional maximization algorithm.
result Uniformly excellent results on various data types, including tweets, brain imaging, and cancer gene expression.
Deep learning aids in automatic detection and segmentation of brain metastases.
problem Manual detection and segmentation of brain metastases is tedious and time-consuming.
method Deep learning approach using a fully convolutional neural network (CNN).
result Deep learning approach achieves high precision, recall, and Dice scores.
Cellina uses supervised disentanglement to predict cell behavior in tissues.
problem Querying counterfactuals on tissue graphs
method Cellina framework using supervised disentanglement
result Outperforms spatially-informed and non-spatial competitors
New method clusters disease subtypes from model explanations.
problem Discovering disease subtypes in noisy, high-dimensional data.
method Train classifier, extract explanations, cluster in explanation space.
result Cluster analysis on model explanations outperforms classical methods.
Over the past decades, statisticians and machine-learning researchers have developed literally thousands of new tools for the reduction of high-dimensional data in order to identify the variables most responsible for a particular trait. These tools have applications in a plethora of settings, including data analysis in…
Estimates cost savings from early cancer diagnosis.
problem Improving early cancer diagnosis to reduce treatment costs.
method Combining published cancer treatment cost estimates by stage with incidence rates by stage at diagnosis, and extrapolating to other cancer sites.
result Estimates U.S. national annual treatment cost-savings from early cancer diagnosis in the trillions.
Model predicts anti-cancer drug responses using gene and molecular data.
problem Expensive and time-consuming cancer drug discovery and tailoring.
method Uses variational autoencoders and multi-layer perceptrons to encode gene expression and drug data.
result High average R2 of 0.83 and 0.845 in predicting drug responses for breast and pan-cancer cell lines, respectively. Study uses machine learning to predict heart failure in cancer patients.
problem Early detection of cancer patients at risk for cardiotoxicity.
method Examined four machine learning algorithms on 143,199 cancer patients.
result Gradient boosting model achieved best AUC score of 0.9077.
System accurately detects lung cancer from CT images.
problem Early and accurate detection of lung cancer.
method Developed algorithms using a dataset of CT images.
result Accuracy of 72.2% on test dataset.
Method extracts cancer signatures from genome data, reducing noise and variability.
problem Identifying stable cancer signatures from noisy genomic data.
method Applied statistical risk models from finance to cancer genome data, using NMF.
result Extracted signatures have lower variability and improved stability.
Deep learning models improve cancer detection and typing classification from gene expression data.
problem Challenges in establishing specificity for cancer diagnosis using gene expression data.
method Developed deep learning models using mRNA datasets for cancer detection and typing classification.
result Achieved 98% accuracy in cancer detection and 18 out of 32 cancer-typing classifications over 90% accuracy.
Study uses Apple ML to accurately detect and classify lung cancer.
problem Accurate diagnosis and sub-classification of non-small cell lung cancer.
method Evaluation of Apple Create ML module on histopathological images.
result 100% detection and successful subclassification of non-small cell lung cancer.
Study predicts 10-year survival rates for breast cancer patients.
problem Predicting long-term survival of breast cancer patients.
method Machine learning approaches to assess survival rates.
result Improved accuracy in predicting 10-year survival.
New *K-means method finds cancer signatures without NMF.
problem Identifying cancer signatures from genome data.
method Applying *K-means clustering to 1,389 cancer samples.
result 3 cancers lack cluster-like structures, 2 have high correlations.
Cancer patients admitted to ICU had improved survival over 10 years.
problem To assess changes in survival of cancer patients admitted to ICU over 10 years.
method Retrospective analysis of MIMIC-III database, adjusted for confounders using logistic regression.
result Cancer patients had significantly lower 28-day and 1-year mortality rates over 10 years.
Paper identifies key CpG methylation sites for breast cancer.
problem Early detection and treatment of breast cancer.
method Used machine learning on TCGA dataset to classify cancer vs. non-cancer samples.
result Reduced model with 25 key CpG sites achieves over 94% accuracy.
Noise-filtering improves cancer drug sensitivity prediction.
problem Improving accuracy of cancer drug sensitivity predictions.
method Integrates numerical linear algebra and information retrieval techniques to filter out noisy cancer cell lines.
result Our approach yields the highest AUC on clinical trial data.
Data mining techniques predict breast cancer types with high accuracy.
problem Early detection of breast cancer to reduce mortality rates.
method Twelve classification algorithms applied to the Breast Cancer Wisconsin dataset.
result High accuracy in predicting malignant and benign breast cancer.
Study examines perceptions and attitudes about breast cancer on Twitter.
problem Understanding public perceptions and attitudes towards breast cancer on social media.
method Identified and collected tweets, used topic modeling and sentiment analysis.
result Identified themes and quantified users' perceptions and emotions about breast cancer.
Machine learning clusters mutations in cancer exomes, improving diagnostic speed and cost.
problem Extracting stable mutation structures from cancer exome data for early diagnostics.
method Statistically deterministic machine learning algorithm *K-means applied to exome samples.
result Majority of cancer types exhibit stable mutation clustering, while NMF methods are unstable.
Deep learning predicts breast cancer with high accuracy from patient data.
problem Early detection of breast cancer from patient data.
method Feature selection and k-fold Monte Carlo cross-validation using deep learning.
result Deep learning model effectively distinguishes between cancer and healthy patients.
Machine learning accurately diagnoses cancer from whole genome sequencing data.
problem Accurate cancer diagnosis at all stages.
method Novel MLAC (Machine Learning Against Cancer) method using next-gen RNA sequencing.
result Perfect precision, sensitivity, and specificity achieved for most tumor types.
Neural networks improve cancer risk prediction from family history data.
problem Improving cancer risk prediction from family history data using machine learning.
method Developed and trained neural network models on large pedigrees to predict hereditary cancers.
result Neural networks can achieve nearly optimal prediction performance and outperform traditional models in misreported data.
Machine learning detects metastatic breast cancer cases from linked EMR and cancer registry data.
problem Lack of metastatic recurrence data in cancer registries and EMRs.
method Semi-supervised machine learning on linked EMR and CCR data.
result Model achieved high accuracy in detecting metastatic breast cancer cases.
L-Perceptron improves breast cancer diagnosis and survival prediction.
problem Improving early prognosis and survival prediction rates for breast cancer.
method Proposes a novel type of perceptron (L-Perceptron) for better accuracy and sensitivity.
result Achieves 97.42% and 98.73% accuracy and sensitivity in Wisconsin Breast Cancer dataset.
System automates identification of cancer drug repurposing from PubMed.
problem Manual extraction of cancer drug repurposing evidence from scientific publications is infeasible.
method NLP pipeline including querying, filtering, entity extraction, classification, and study type classification.
result Automated system extracts cancer drug repurposing evidence from PubMed abstracts.
Deep neural networks improve cancer nuclei classification and survival analysis.
problem Accurate cell nuclei classification for cancer diagnosis and survival analysis.
method Implementation and evaluation of deep neural network models and ensembles for nuclei classification in RCC and PCa.
result Convolutional neural network system based on residual learning significantly improves cell nuclei classification.
PathologyGAN learns deep representations of cancer tissue images.
problem Limited high-quality labels for cancer tissue images.
method Developed a GAN framework for unsupervised learning of cancer tissue phenotypes.
result Generated high-quality images with interpretable latent space.
Study identifies biomarkers for lung cancer in female non-smokers.
problem Identifying prognostic biomarkers for stage III NSCLC in non-smoking females.
method Gene expression profiling and XGBoost machine learning algorithm.
result Top biomarkers validated in literature, with AUC score of 0.835.
Deep autoencoder predicts cancer types from DNA methylation patterns.
problem Differentiating cancer types based on DNA methylation states.
method Deep learning system with CpG island state classification and statistical methods.
result Overall Sensitivity of 88.24%, Specificity of 83.33%, Accuracy of 84.75%.
Deep CNN model improves breast cancer screening exam classification.
problem Improving accuracy in breast cancer screening exam classification.
method Localization-based deep CNN trained on 200,000 exams.
result AUC of 0.919 in predicting malignancy, reducing error rate by 23%.
Modeling correlated mutations in cancer for personalized treatment.
problem Identifying mutations for personalized cancer therapy in heterogeneous profiles.
method Proposed correlated zero-inflated negative binomial process with mixed beta-Bernoulli and variational inference.
result Identified biologically relevant correlations between somatic mutations.
Network Elastic Net identifies smoking-specific gene expression for lung cancer prognosis.
problem Identifying smoking-specific gene expression biomarkers in lung cancer prognosis.
method Introduces Network Elastic Net, a method that clusters and regresses on graphs based on smoking behavior.
result Shows efficacy of clusters in identifying cancer stages using gene expression and smoking behavior.
The study improves colorectal cancer survivability prediction by considering ethnicity.
problem Improving colorectal cancer survivability prediction using machine learning.
method Machine learning techniques applied to SEER cancer incidence database, comparing different ethnicities.
result Models perform better on single-ethnicity populations and provide different feature importance rankings.
Automates deep learning model development for cancer data.
problem Manual design of high-performing deep learning models for cancer data is time-consuming and requires expertise.
method Reinforcement-learning-based neural architecture search with custom building blocks.
result Automated discovery of deep neural network architectures with similar or higher accuracy.
Tree model predicts breast cancer in older women.
problem Breast cancer prediction in older women with DCIS grades.
method Tree augmented naive Bayesian network trained on clinical data.
result Biopsy threshold recommendation of >2% for older women.
BIDIFAC+ factorizes linked matrices for cancer studies.
problem Integrating multiple omics platforms across various cancer types.
method Flexible approach to simultaneous factorization and decomposition of linked matrices using BIDIFAC+.
result Identifies shared and specific modes of variability across multiple omics platforms and cancer types.
Deep learning improves prostate cancer diagnosis using MRI.
problem Improving accuracy in prostate cancer diagnosis.
method Developed XmasNet, a deep learning architecture based on convolutional neural networks, trained on 3D multiparametric MRI data.
result XmasNet outperformed traditional machine learning models and achieved the second highest AUC (0.84) in the PROSTATEx challenge.
Paper proposes scalable method for analyzing multi-omic data.
problem Integrating high-dimensional multi-omic data for cancer subtyping.
method Mixed graphical model approach using Birth-Death MCMC algorithm.
result Our method outperforms LASSO and standard BDMCMC in computational efficiency and model selection accuracy.
Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.
problem Improving cancer diagnosis through high-fidelity digital pathology.
method Deep generative model using PathologyGAN to map real images onto a latent space.
result Latent space encodes morphological characteristics and reveals distinct tissue clusters.
Machine learning can predict cancer with 100% accuracy on a dataset.
problem Accuracy of cancer predictions using machine learning.
method Extensive experiments on the Wisconsin Diagnostic Breast Cancer dataset.
result Machine learning algorithms can be easily misled to achieve 100% accuracy.
Model predicts drug response in tumors using genomic profiles.
problem Challenges in translating genomic insights to tumor-specific drug response predictions.
method Deep neural network (DNN) model trained on mutation and expression profiles of cancer cell lines.
result Achieved mean squared error of 1.96 for predicting IC50 values of 265 drugs.
Deep neural networks infer multiple cancer properties from transcriptome data.
problem Limited use of biomarkers in molecular cancer pathology due to computational challenges.
method Multi-task and transfer learning architecture encoding whole transcriptome into a latent vector.
result Significantly better at predicting tissue-of-origin, disease state, and cancer type.