Biotech startups are found to be similar to tech startups overall.
problem The uniqueness of biotech startups was previously overemphasized.
method Extensive research from new databases analyzed similarities and differences.
result Biotech startups share similarities in venture capital, exit time, and geography with tech startups.
Biotech IPOs in Q1 2021: advanced degrees, clinical trials, and IP key.
problem Identifying traits of biotech startups that go public.
method Database of biotech IPOs, analysis of leadership, technology, clinical trials, and financing.
result Advanced degrees, clinical trials, and IP are important for biotech startups.
Business cycles affect startup valuations, both directly and indirectly.
problem How do business cycles impact startup valuations?
method Structural Equation Model approach using a dataset of 1,089 venture capital investments.
result Business cycles impact startup valuations both directly and indirectly.
This paper evaluates investment risks in LATAM AI startups using DCF method.
problem Unique challenges and risks faced by LATAM tech startups.
method Total Addressable Market (TAM), Serviceable Available Market (SAM), and Serviceable Obtainable Market (SOM) metrics; Discounted Cash Flow (DCF) method.
result Developed a ranking of emerging powers in Latin America for tech startup investment.
The paper analyzes sectoral diversity in startup ecosystems in Europe and the USA.
problem Investigating sectoral diversity in startup ecosystems.
method Analysis of 20+ startup ecosystems in Europe and the USA using a new visualization tool and numerical simulations.
result Emerging diversity of startup ecosystems can be explained by a preferential attachment model based on sectoral funding.
This study examines the presence of the day-of-the-week effect on daily returns of biotechnology stocks over a 16-year period from January 2002 to December 2015. Using daily returns from the NASDAQ Biotechnology Index (NBI), we find that the stock returns were the lowest on Mondays, and compared to the Mondays the stoc…
Green startups in Italy survive longer than non-green ones.
problem Survival of innovative startups in Italy.
method Comparative analysis of green vs. non-green startups in Italy, 2009-2018.
result Green startups are more than twice as likely to survive than non-green ones.
Study shows startup competition and investor network influence fundraising success at different stages.
problem Misunderstanding of fundraising success factors across startup stages.
method Used Word2Vec for competition measures and Graph Neural Networks for investor network analysis.
result Startup competition is crucial for early-stage fundraising, while growth-stage fundraising is influenced by investor network features.
Enhances VC startup success predictions using graph augmented time series models.
problem Challenges in predicting startup success due to limited financial data and subjective forecasts.
method Integrates inter-company relationships into time series analysis using GraphRAG.
result Significantly outperforms previous models in startup success predictions.
Deep learning helps identify promising startups.
problem Identifying successful startups amidst many.
method Literature review and synthesis of DL-based startup evaluation methods.
result Deep learning shows promise in startup success prediction.
YC Bench forecasts startup success in Y Combinator batches with a short-term metric.
problem Difficult forecasting of startup success due to sparse meaningful outcomes and slow evaluation cycles.
method Developed a live benchmark using publicly available traction signals and web visibility metrics.
result Revealed 6 out of 11 top performers at YC Demo Day with a simple proxy for prior brand recognition.
Predicting startup success using Crunchbase data and deep learning.
problem Predicting startup success in a volatile entrepreneurial ecosystem.
method Novel deep learning model integrating funding metrics, founder features, and industry category.
result Achieved 14 times capital growth and identified high-potential startups.
In this paper we propose a quadratic programming model that can be used for calculating the term structure of electricity prices while explicitly modeling startup costs of power plants. In contrast to other approaches presented in the literature, we incorporate the startup costs in a mathematically rigorous manner with…
We consider the problem of evaluating the quality of startup companies. This can be quite challenging due to the rarity of successful startup companies and the complexity of factors which impact such success. In this work we collect data on tens of thousands of startup companies, their performance, the backgrounds of t…
This paper compares token and equity financing for startups.
problem Understanding differences in return rates between token and equity financing.
method Developed a three-period model to analyze liquidity and return differences.
result Entrepreneurs can achieve higher payoffs by issuing tokens, especially for risk-averse investors with liquidity needs.
The paper shows incorrect mean-variance analysis methods should be avoided.
problem Incorrect ex post mean-variance analysis methods in financial studies.
method Illustrates incorrect methods using 2014 biotech ETF data.
result Ex post mean-variance analysis should not be done as generally practiced.
Study reveals which startup valuation factors are most critical.
problem Understanding the complex factors influencing startup valuations.
method Hierarchical prediction models using decision trees and random forests.
result Identifies which factors most significantly impact startup valuations.
Innovative framework for biotech investments using dynamic asset allocation and diversification.
problem Optimizing investment in growing biotech markets.
method Dynamic asset allocation and class diversification focusing on financial metrics and industry trends.
result Optimized investment framework for versatile application in specialized biotech markets.
Study finds internal view preferred over external view in defining startups.
problem Insufficient understanding of how to start a new business.
method Empirical study with 701 entrepreneurs reflecting on nine resource categories and three business mission elements.
result Tendency to favor internal view over external view, stronger in stable economies.
A new method to value IPOed companies.
problem Valuing companies after IPO.
method Growth Average U1 method.
result Benchmark stocks using linear extrapolation of revenues and profits.
Study predicts startup outcomes like funding, patenting, IPOs using machine learning.
problem Forecasting startup success metrics like funding, patenting, IPOs.
method Developed interpretable machine learning framework, used preprocessing, class imbalance handling, and compared multiple models.
result Achieved high AUROC values for patent, funding, and exit predictions.
Bayesian optimization speeds up bioprocess development across scales.
problem Costly and complex bioprocess development across scales and biocatalyst selection.
method Multi-fidelity batch Bayesian optimization framework integrating Gaussian Processes and mixed-variable optimization.
result Reduction in experimental costs and increased yield in bioprocess optimization.
Designed to compete with fiat currencies, bitcoin proposes it is a crypto-currency alternative. Bitcoin makes a number of false claims, including: solving the double-spending problem is a good thing; bitcoin can be a reserve currency for banking; hoarding equals saving, and that we should believe bitcoin can expand by …
Analyzes how venture investment strategies have evolved over time in different sectors.
problem Understanding changes in venture investment strategies across sectors over time.
method Applied PCA and TCA to analyze a dataset of 52,000 startups and 110,000 funding rounds.
result There has been a shift in venture investment towards lower-tech sectors and a rise in accelerator investments.
New algorithm detects and handles concept drift in data streams.
problem Handling concept drift in data streams for timely predictions.
method Hybrid Forest algorithm combining Hoeffding Trees and fast startup.
result The algorithm outperforms other methods in classification and regression tasks.
TUNet improves protein classification in cell images.
problem Classifying specific proteins in human cells using microscopy images.
method TUNet model incorporating segmentation maps for improved classification.
result TUNet achieves competitive performance in protein classification.
Study uses web search data to analyze tech startups growth.
problem Analyzing growth dynamics of tech startups.
method Utilized Google Trends data for 241 US-based tech startups.
result Web search traffic correlates positively with tech startup growth.
A new auction model for zero-marginal cost products.
problem Determining fair prices for zero-marginal cost products.
method Continuous bidding with self-organized criticality mechanism.
result Avalanches of sales above a critical price.
Study evaluates early-stage cybersecurity firms' performance using Crunchbase data.
problem Assessing performance of early-stage cybersecurity startups.
method Empirical analysis of 19 cybersecurity sectors using Crunchbase data.
result Significant variations in capital raised and post-money valuations across cybersecurity sectors.
We propose a novel information-theoretic approach for Bayesian optimization called Predictive Entropy Search (PES). At each iteration, PES selects the next evaluation point that maximizes the expected information gained with respect to the global maximum. PES codifies this intractable acquisition function in terms of t…
PHBench predicts Series A funding from Product Hunt launch signals with 7.8% accuracy.
problem Predicting startup Series A funding from launch signals on Product Hunt.
method Constructed PHBench from 67,292 Product Hunt posts, linked to funding records, and used a three-component ensemble model.
result Best-performing model achieved F0.5 = 0.097 and AP = 0.037, with a statistically significant advantage over logistic regression.
New method steers protein design towards desired properties.
problem Challenges in designing proteins with specific structures and properties.
method Feynman-Kac framework applied to RFdiffusion models with guiding potentials.
result Significant improvement in predicted interface energetics and binder designability.
Modern biotechnologies often result in high-dimensional data sets with much more variables than observations (n ≪ p). These data sets pose new challenges to statistical analysis: Variable selection becomes one of the most important tasks in this setting. We assess the recently proposed flexible framework for variab…
Smoothed fitness landscape improves protein optimization.
problem Infeasibility of combinatorially large protein sequence space.
method Formulate protein fitness as a graph signal, smooth using Tikunov regularization, and optimize with Gibbs sampling.
result 2.5 fold fitness improvement over training set.
Modeling Bitcoin risk using blockchain graph analysis.
problem Managing cryptocurrency FX risk for startups.
method High-fidelity blockchain graph representation for microstructure modeling.
result Identification of chainlets predicting Bitcoin price and volatility.
BoGA combines evolutionary search with Bayesian optimization for efficient protein design.
problem Designing novel proteins with specific characteristics is challenging due to sequence space complexity.
method BoGA integrates a genetic algorithm with Bayesian optimization to efficiently explore sequence space.
result BoGA accelerates discovery of high-confidence binders for diverse protein design objectives.
Federated learning platform for drug discovery without sharing data.
problem Lack of secure collaboration in drug discovery.
method Industry-scale federated learning platform using cryptographic aggregation.
result Generated new scientific discoveries in drug discovery.
Study examines how social media sentiment impacts biotech stocks.
problem Understanding the impact of social media on biotech stock prices.
method VADER sentiment analysis, ARIMA, and VAR models were used to forecast stock market performance.
result Complex interplay between tweet sentiment and stock market performance was identified.
This study improves valuation of post-revenue biopharmaceutical assets using Pfizer's data.
problem Accurate valuation of post-revenue drug assets in biotech and pharma.
method Historical sales data analysis to forecast future sales and calculate Net Present Value.
result Demonstrates a method for more informed investment decisions in biotech and pharma.
Machine learning identifies potential drugs for COVID-19.
problem Finding effective treatments for COVID-19.
method Trained neural network models on virus protein sequences and antiviral drugs.
result Identified potential drug candidates for treating COVID-19.
Bayesian Neural Networks improve high-dimensional level set estimation.
problem Scalability issue in existing LSE methods for high-dimensional inputs.
method Bayesian Neural Networks with information-based acquisition functions.
result Proposed method achieves better results than state-of-the-art approaches.
This paper compares AI performance in native vs. browser-based implementations.
problem Performance demands in AI applications, especially client-side.
method Comparison study between native code and browser-based (JS, ASM.js, WebAssembly) implementations.
result Current runtime optimizations push browser performance close to native binary.
This paper explores using NFTs for patents, offering a framework and addressing challenges.
problem Lack of research in applying NFT to intellectual property, especially patents.
method Developed a layered conceptual NFT-based patent framework.
result Promotes transparency and liquidity in patent markets.
LEARNA uses deep reinforcement learning to design RNA sequences.
problem Designing RNA molecules to satisfy structural constraints.
method LEARNA employs deep reinforcement learning to train a policy network for RNA design.
result LEARNA achieves new state-of-the-art performance in RNA Design benchmarks.
BioFinBERT analyzes sentiment of biotech press releases and financial text around inflection points.
problem Analyzing sentiment of biotech press releases and financial text around inflection points.
method Finetuning BioBERT on financial datasets to create BioFinBERT for sentiment analysis.
result BioFinBERT accurately analyzes sentiment of biotech press releases and financial text around inflection points.
The paper analyzes game theory in convertible contracts during liquidity events.
problem Optimizing payments in convertible contracts during liquidity events.
method Defined a general model for games, showed non-existence of pure strategy Nash equilibria, developed algorithms for computing equilibria.
result Optimum pure strategy Nash equilibria exist when all contracts are of the same type (SAFE).
The paper categorizes four types of scale-up: smart, dumb, forced, and fumbled.
problem Growing ventures in size and maintaining efficiency.
method Identifying modularity and speed as key factors, categorizing four types of scale-up.
result Modularity and speed are crucial for successful scale-up.
Sparse regression models CMs from oscillatory shear data efficiently.
problem Discovering parsimonious constitutive models from oscillatory shear experiments.
method Sparse regression with tensor basis functions, l1 regularization, and greedy two-stage algorithm.
result Inferred CMs extrapolate well beyond training data and flow conditions.