Bayesian optimization speeds up bioprocess development across scales.
problem Costly and complex bioprocess development across scales and biocatalyst selection.
method Multi-fidelity batch Bayesian optimization framework integrating Gaussian Processes and mixed-variable optimization.
result Reduction in experimental costs and increased yield in bioprocess optimization.
Adjoint SA speeds up bioprocess parameter learning.
problem Challenges in digital twin development for biomanufacturing.
method Adjoint sensitivity analysis on multi-scale enzymatic reaction networks.
result Resilient sensitivities reveal bioprocess regulatory mechanisms.
Paper develops a framework to discover bioprocessing regulatory mechanisms using symbolic and statistical learning.
problem Challenges in modeling complex intracellular regulation, stochastic system behavior, and limited experimental data.
method Symbolic and statistical learning framework based on stochastic differential equations and Bayesian learning.
result Improved sample efficiency and robust model selection compared to state-of-the-art approaches.
Bayesian optimization simplifies bioprocess engineering experiments.
problem Complex biological systems and experimental uncertainty.
method Adapts classical Bayesian optimization for bioprocess engineering.
result Provides accessible introduction to Bayesian optimization for practitioners.
A new method uses ABC-SMC to infer hybrid models in bioprocesses with limited data.
problem Inference of hybrid models in bioprocesses with limited real data and high uncertainties.
method Approximate Bayesian Computation with Sequential Monte Carlo (ABC-SMC) and linear Gaussian dynamic Bayesian network (LG-DBN) for posterior distribution approximation.
result The method accelerates hybrid model inference and supports process monitoring and robust control.
While biomanufacturing plays a significant role in supporting the economy and ensuring public health, it faces critical challenges, including complexity, high variability, lengthy lead time, and very limited process data, especially for personalized new cell and gene biotherapeutics. Driven by these challenges, we prop…
RAPTOR-GEN accelerates digital twin development for biopharmaceuticals.
problem Lack of agility in rapid, on-demand production of biotherapeutics due to bioprocess complexity.
method Bayesian learning framework based on a multi-scale probabilistic knowledge graph (pKG) and stochastic differential equations (SDE).
result RAPTOR-GEN accelerates intelligent digital twin development from sparse and heterogeneous experimental data.
A Human-in-the-Loop Bayesian Optimization framework for constraint-aware bioprocess development.
problem Bioprocess development
method Pareto Front Guided Sampling (PFGS) with Bayesian Optimization (BO)
result Systematic identification of high-performing, feasibility-compliant, and perturbation-resilient operating conditions.
A new RL method handles uncertainty and constraints in real-time optimization.
problem Real-time optimization under process uncertainty and constraints.
method Chance-constrained reinforcement learning to handle probabilistic state constraints.
result Satisfies process constraints with high probability in real-time.
Paper develops efficient Bayesian inference for enzymatic SRNs with LNA metamodel.
problem Bayesian inference for nonlinear SDE-based mechanistic models with partial observations and measurement errors.
method Interpretable Bayesian updating LNA metamodel and efficient posterior sampling.
result Proposed approach demonstrates promising performance in empirical studies.
Optimizes biomanufacturing processes with a new digital twin calibration method.
problem Lack of interpretability and sample efficiency in traditional DoE methods.
method Developed a computational approach to calibrate Bio-SoS digital twin model.
result Guides sample-efficient and interpretable DoEs by quantifying sub-model parameter estimation errors.
Framework for sensitivity analysis in biomanufacturing processes.
problem High complexity and uncertainty in biomanufacturing processes.
method Shapley value estimation for linear and nonlinear pKG models, using quasi-Monte Carlo and antithetic sampling.
result Improved efficiency and accuracy in sensitivity analysis for biomanufacturing processes.