Method generates anatomically-controllable medical images with segmentation guidance.
problem Challenging to enforce anatomical constraints in generated medical images.
method Segmentation-guided diffusion models with random mask ablation training.
result New state-of-the-art in faithfulness to input anatomical masks.
Extend deep neural networks for multiple anatomical structures in real-time.
problem Lack of comprehensive patient-specific anatomical models for complex surgical planning.
method Class-incremental segmentation framework that extends deep networks with minimal incremental annotation.
result Framework retains previous structure segmentation performance and learns new structures without catastrophic forgetting.
We present a novel approach to automatically segment magnetic resonance (MR) images of the human brain into anatomical regions. Our methodology is based on a deep artificial neural network that assigns each voxel in an MR image of the brain to its corresponding anatomical region. The inputs of the network capture infor…
MosaicMRI expands public datasets for musculoskeletal MRI, revealing cross-anatomical correlations.
problem Limited diversity in public MRI datasets hinders model evaluation across different anatomical settings.
method Developed a large, diverse dataset (MosaicMRI) and conducted experiments on a baseline model (VarNet).
result Models trained on combined anatomies outperform anatomy-specific models in low-sample regimes.
Paper introduces conformal prediction for reliable uncertainty quantification in landmark localization.
problem Systematic underestimation of total predictive uncertainty in landmark localization.
method Conformal prediction framework for multi-output regression, generating flexible prediction regions.
result Methods outperform existing approaches in validity and efficiency across 2D and 3D datasets.
In this work we propose a method for anatomical data augmentation that is based on using slices of computed tomography (CT) examinations that are adjacent to labeled slices as another resource of labeled data for training the network. The extended labeled data is used to train a U-net network for a pixel-wise classific…
Improved 3D ECG feature attributions for clinical interpretation.
problem Lack of interpretability in deep learning models for 12-lead ECG analysis.
method Cross-modal mapping of feature attributions from 12-lead ECG models onto CineECG 3D space.
result Mapped feature attributions yield higher Dice scores than standard 12-lead attributions.
Background: A universal unanswered question in neuroscience and machine learning is whether computers can decode the patterns of the human brain. Multi-Voxels Pattern Analysis (MVPA) is a critical tool for addressing this question. However, there are two challenges in the previous MVPA methods, which include decreasing…
A universal unanswered question in neuroscience and machine learning is whether computers can decode the patterns of the human brain. Multi-Voxels Pattern Analysis (MVPA) is a critical tool for addressing this question. However, there are two challenges in the previous MVPA methods, which include decreasing sparsity an…
Method synthesizes 4D CMR images from XCAT model using GAN and SPADE.
problem Synthesizing realistic 4D CMR images with annotations and adaptable styles.
method Hybrid GAN approach with XCAT anatomical ground truth and SPADE for semantic preservation.
result Synthesized images with modality-specific features learned from real CMR data.
RRN accurately identifies landmarks in CMF bones without segmentation.
problem Accurately identifying landmarks in craniomaxillofacial bones without segmentation.
method End-to-end RRN architecture using dense-block units for landmark imputation.
result RRN achieves <2 mm RMS error in landmarking.
Spatially-aware metrics improve uncertainty evaluation in segmentation.
problem Uncertainty evaluation metrics treat voxels independently, ignoring spatial context.
method Proposed three spatially aware metrics incorporating structural and boundary information.
result Improved alignment with clinically important factors and better discrimination between uncertainty patterns.
Novel deep learning framework for mandible segmentation and landmarking.
problem Challenging problem of mandible segmentation and anatomical landmarking from CBCT scans.
method Three-step approach: deep neural network for segmentation, geodesic space for landmarks, LSTM for closely spaced landmarks.
result Superior efficacy compared to state-of-the-art methods in craniofacial anomalies and diseased states.
VarDeepPCA refines medical image segmentation from small datasets, improving anatomical plausibility and reducing errors.
problem Medical image segmentation fails on out-of-distribution data due to variations in scanners and protocols.
method VarDeepPCA learns valid anatomical geometries using only small in-distribution datasets, providing uncertainty estimates.
result VarDeepPCA restores segmentation maps to OOD data, improving anatomical plausibility and reducing errors.
We propose a method to generate multiple diverse and valid human pose hypotheses in 3D all consistent with the 2D detection of joints in a monocular RGB image. We use a novel generative model uniform (unbiased) in the space of anatomically plausible 3D poses. Our model is compositional (produces a pose by combining par…
Automated labeling of intracranial arteries improves accuracy and efficiency.
problem Challenges in accurately labeling intracranial arteries due to variations and limited datasets.
method Graph Neural Network (GNN) combined with hierarchical refinement for improved accuracy.
result Achieved 97.5% node labeling accuracy on a testing set of 105 scans.
This work is an endeavor to develop a deep learning methodology for automated anatomical labeling of a given region of interest (ROI) in brain computed tomography (CT) scans. We combine both local and global context to obtain a representation of the ROI. We then use Relation Networks (RNs) to predict the corresponding …
GNNs improve brain activity forecasting in fMRI studies.
problem Understanding neural dynamics in the brain.
method Comparison of GNN architectures for modeling fMRI data.
result GNNs outperform VAR models in robustly scaling to large network studies.
We describe an adversarial learning approach to constrain convolutional neural network training for image registration, replacing heuristic smoothness measures of displacement fields often used in these tasks. Using minimally-invasive prostate cancer intervention as an example application, we demonstrate the feasibilit…
Wide and deep neural network predicts Alzheimer's progression from shape and clinical data.
problem Predicting Alzheimer's disease progression from shape and clinical data.
method Fused anatomical shape and tabular clinical data in a neural network, employing survival analysis loss.
result The model outperforms shape and clinical models individually.
Defines metrics to compare neural network representations.
problem Comparing neural network representations across different architectures and tasks.
method Developed a family of metric spaces and modified existing measures to quantify representational dissimilarity.
result Identified relationships between neural representations and anatomical features.
Deep networks reveal colour opponent cells under retinal constraints.
problem Understanding colour vision in deep neural networks.
method Classifying cells in early layers of anatomically constrained convolutional neural networks.
result Emergence of single and double opponent cells in deep networks.
Gradient-HA aligns fMRI data faster and more accurately.
problem Aligning fMRI data from multiple subjects efficiently and accurately.
method Gradient-HA uses ICA and SGA to solve alignment issues.
result Gradient-HA outperforms other methods in big data fMRI analysis.
VNNs transfer well across datasets for brain age prediction using cortical thickness features.
problem Predicting brain age using anatomical features.
method Transferability of coVariance neural networks (VNNs) in brain age prediction.
result VNNs can assign anatomical interpretability to elevated brain age gap in AD.
Paper proposes a neural network for estimating brain conductivity without segmentation.
problem Accurate head model generation for personalized TMS with realistic conductivity.
method Convolutional neural network estimating conductivity from MRI data.
result Smooth electric field results similar to conventional methods without segmentation.
Early diagnosis, playing an important role in preventing progress and treating the Alzheimer\{'}s disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocamp…
Novel method embeds generative model into Bayesian optimization for HD cardiac model parameter estimation.
problem High-dimensional optimization of patient-specific cardiac model parameters with limited data.
method Embeds a generative variational auto-encoder into the objective function of Bayesian optimization.
result Improves accuracy of parameter estimation with more than 10x gain in efficiency.
Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocampus …
Inter-subject registration of cortical areas is necessary in functional imaging (fMRI) studies for making inferences about equivalent brain function across a population. However, many high-level visual brain areas are defined as peaks of functional contrasts whose cortical position is highly variable. As such, most ali…
AutoML library TPOT optimizes brain age prediction models without prior knowledge.
problem Optimizing machine learning models for brain age prediction.
method TPOT uses genetic programming to find optimal machine learning pipelines.
result TPOT outperformed state-of-the-art models in brain age prediction.
Unified approach for neural networks with multi-compartmental neurons and non-Hebbian plasticity.
problem Limited computational power of existing neural network models for multi-compartmental neurons and non-Hebbian plasticity.
method Unified extension of similarity matching approach to derive neural networks with multi-compartmental neurons and local, non-Hebbian learning rules.
result Unified approach facilitates understanding of multi-compartmental neuronal structures and non-Hebbian plasticity.
RNNs trained on head direction task mimic brain's compass and shifter neurons.
problem Modeling brain's head direction system using neural networks.
method Optimized recurrent neural networks trained on angular velocity integration.
result RNNs naturally emerge with compass and shifter neuron-like properties.
VarDeepPCA: A Sampling-Free Variational DNN Plugin for OOD Segmentation with Uncertainty Estimation
problem Deep neural networks (DNNs) fail to generalize to out-of-distribution (OOD) medical images due to variations in scanners and acquisition protocols.
method VarDeepPCA is a lightweight variational DNN framework that learns a distribution of valid anatomical geometries using small in-distribution datasets.
result VarDeepPCA restores segmentation maps produced by existing methods on OOD data to improve anatomical plausibility and reduce errors.
Probabilistic atlases provide essential spatial contextual information for image interpretation, Bayesian modeling, and algorithmic processing. Such atlases are typically constructed by grouping subjects with similar demographic information. Importantly, use of the same scanner minimizes inter-group variability. Howeve…
MKCapsnet improves schizophrenia identification using multi-kernels and dropout.
problem Identifying schizophrenia using existing methods requires two steps and large amounts of data.
method Developed a multi-kernel capsule network (MKCapsnet) inspired by brain anatomy.
result Outperformed state-of-the-art methods in schizophrenia identification.
There is a growing interest in joint multi-subject fMRI analysis. The challenge of such analysis comes from inherent anatomical and functional variability across subjects. One approach to resolving this is a shared response factor model. This assumes a shared and time synchronized stimulus across subjects. Such a model…
This research uses Siamese networks to identify partial mouse brain images from the Allen atlas.
problem Identifying precise mouse brain microscopy images from the Allen atlas.
method Siamese Networks with contrastive learning to find corresponding atlas plates for partial images.
result Siamese CNNs achieved 25% TOP-1 and 100% TOP-5 accuracy in identifying brain slices from the Allen atlas.
A new metric FRD improves comparing medical images.
problem Comparing medical images for distribution or domain differences.
method Developed a new metric FRD using standardized radiomic features.
result FRD outperforms other metrics in various medical imaging applications.
Neuroscience is undergoing faster changes than ever before. Over 100 years our field qualitatively described and invasively manipulated single or few organisms to gain anatomical, physiological, and pharmacological insights. In the last 10 years neuroscience spawned quantitative big-sample datasets on microanatomy, syn…
AI system helps clinicians assess liver metastases quickly and with explanations.
problem Manual assessment of metastases is time-consuming and subjective.
method Interactive AI system with model interpretability.
result AI-assisted assessment improves efficiency and provides explanations.
A novel method predicts shape development using Riemannian shape spaces.
problem Predicting future shape development from a single observation.
method Proposes a novel prediction method that encodes shapes in a Riemannian shape space and learns hierarchical statistical models.
result Outperforms deep learning-supported variants and state-of-the-art methods in predicting shape development.
Bayesian U-Net exploits epistemic uncertainty for anomaly detection in retinal OCT images.
problem Anomaly detection in retinal OCT images using weak labels of healthy anatomy.
method Bayesian U-Net trained on weak labels of healthy anatomy, using Monte Carlo dropout for uncertainty estimation, and post-processing to transfer uncertainty to anomaly segmentations.
result Achieved a Dice index of 0.789 in an independent test set of AMD cases.
Modeling disease progression in brain images using monotonic Gaussian Processes.
problem Disentangling spatio-temporal disease trajectories from brain imaging data.
method Spatio-temporal matrix factorization with anatomically plausible priors, monotonic Gaussian Processes, and sparse codes.
result Monotonic Gaussian Processes model realistic disease trajectories in brain imaging data.
A new method models uncertainty in medical image segmentation.
problem Inherent ambiguity in anatomical structure and pathology segmentation.
method Hierarchical probabilistic model with variational autoencoder.
result Generates more realistic and diverse segmentation samples.
Novel approach uses quasi-conformal geometry for OSA classification from cephalometry.
problem Classifying obstructive sleep apnea (OSA) based on craniofacial profiles.
method Quasi-conformal geometry for local deformation analysis of 15 landmark points in lateral cephalograms.
result Proposed model achieves 92.5% testing accuracy.
New generalized Lie algebroids solve optimal control problems.
problem Optimal control problems not solvable by Lie algebroids.
method Proved generalized Lie algebroids as distinguished examples, disproved a theorem, and provided a new framework.
result Generalized Lie algebroids solve problems Lie algebroids cannot.
Improves MRI-based brain surface reconstruction with minimal deformation energy loss.
problem Ensuring optimal deformation energy and consistency in learning-based cortical surface reconstruction.
method Design and implementation of a Minimal Energy Deformation (MED) loss in the V2C-Flow model.
result Significant improvements in training consistency and reproducibility without sacrificing reconstruction accuracy and topological correctness.
Generative adversarial networks reconstruct MRI images without full data.
problem Lack of fully-sampled ground truth data for supervised MRI reconstruction.
method Generative adversarial networks for unsupervised MRI reconstruction.
result Reconstructed images show more anatomical structure than conventional methods.