Deep Learning can significantly benefit cancer proteomics and genomics. In this study, we attempt to determine a set of critical proteins that are associated with the FLT3-ITD mutation in newly-diagnosed acute myeloid leukemia patients. A Deep Learning network consisting of autoencoders forming a hierarchical model fro…
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48 results for “acute myeloid leukemia”
We explore how Deep Learning (DL) can be utilized to predict prognosis of acute myeloid leukemia (AML). Out of TCGA (The Cancer Genome Atlas) database, 94 AML cases are used in this study. Input data include age, 10 common cytogenetic and 23 most common mutation results; output is the prognosis (diagnosis to death, DTD…
Profile Graphical Modelsstat.ME
Profile graphical models represent multivariate dependence under varying risk factors.
problem Capturing varying conditional independence structures across different levels of a risk factor.
method Introducing a novel class of graphical models (profile graphical models) that represent multivariate dependence under varying risk factors, and developing a Bayesian approach for learning shared sparsity structures.
result Demonstrated enhanced ability to capture subject-specific differences in protein network data from acute myeloid leukemia.
Towards the Latent Transcriptomeq-bio.GN
In this work we propose a method to compute continuous embeddings for kmers from raw RNA-seq data, without the need for alignment to a reference genome. The approach uses an RNN to transform kmers of the RNA-seq reads into a 2 dimensional representation that is used to predict abundance of each kmer. We report that our…
Paper uses optimal transport for low-dimensional representation of leukemia flow cytometry data.
problem Detecting minimal residual disease in leukemia patients using flow cytometry data.
method Optimal transport for dimensionality reduction and visualization of multi-patient flow cytometry datasets.
result OT-based approach provides a more informative two-dimensional representation of leukemia MRD.
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from…
Bayesian model estimates ACT impact on pediatric AML survival.
problem Estimating ACT impact on survival in AML patients with treatment timing issues.
method Generative Bayesian semi-parametric model with Gamma Process priors.
result Posterior inference for ACT efficacy under dynamic rules.
Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying clustering structures. Hence removing noise variables via variable selection is necessary…
Proof of Gromov's theorem on convex polytopes with acute angles.
problem Gromov's conjecture on extremal scalar curvature of convex polytopes.
method Smoothing construction using Dirac operator techniques.
result Detailed proof of Gromov's theorem.
Study on Teichmüller space of acute triangles using explicit calculations.
problem Analogue of Thurston's metric on acute triangles.
method Direct calculation of distance function and Finsler structure.
result Explicit expressions and properties of the metric on acute triangles.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.
Let be the right-angled Coxeter group defined by an abstract triangulation of . We show that is isomorphic to a hyperbolic right-angled reflection group if and only if can be realized as an acute triangulation. The proof relies on the theory of CAT(-1) spaces. A corollary is that an …
Maps between acute triangles with minimal stretch found and studied.
problem Finding the minimal stretch between acute triangles.
method Formula for the smallest Lipschitz constant and analysis of the metric space.
result Metric space of pairs of acute triangles with fixed area is Finsler and geodesics determined.
The paper explores Kähler and anti-Kähler structures on quasi-statistical manifolds.
problem Investigating Kähler and anti-Kähler structures on quasi-statistical manifolds.
method Analyzing conditions for integrability of almost complex structures and defining Kähler and anti-Kähler manifolds.
result Conditions for to be an anti-Kähler manifold are identified.
Improved rigidity of Delaunay triangulated plane.
problem Rigidity of Delaunay triangulated plane under discrete conformality.
method Modifying Wu's proof to weaken the uniformly acute condition to the uniformly Delaunay condition.
result Improved rigidity result for Delaunay triangulated plane.
Bayesian optimization improves classifier selection for acute infection and mortality.
problem Improving accuracy of acute infection and mortality prediction.
method Comparison of hyperparameter optimization methods (grid search, random sampling, Bayesian optimization).
result Bayesian optimization outperforms grid search or random sampling for in-hospital mortality classifiers.
In this paper, the development of a probabilistic network for the diagnosis of acute cardiopulmonary diseases is presented. This paper is a draft version of the article published after peer review in 2018 (https://doi.org/10.1002/bimj.201600206). A panel of expert physicians collaborated to specify the qualitative part…
Computable Phenotypes to Characterize Changing Patient Brain Dysfunction in the Intensive Care Unitq-bio.QM
Study developed phenotypes for ICU patients' brain dysfunction states.
problem Underdiagnosis of acute brain dysfunction in ICU patients.
method Created algorithms to quantify and cluster brain dysfunction states.
result Developed three phenotypes of ICU patients' brain dysfunction states.
Background: Fluctuating hearing loss is characteristic of Meniere's Disease (MD) during acute episodes. However, no reliable audiometric hallmarks are available for counselling the hearing recovery possibility. Aims/Objectives: To find parameters for predicting MD hearing outcomes. Material and Methods: We applied mach…
Flow cytometry is often used to characterize the malignant cells in leukemia and lymphoma patients, traced to the level of the individual cell. Typically, flow cytometric data analysis is performed through a series of 2-dimensional projections onto the axes of the data set. Through the years, clinicians have determined…
The paper classifies Poincaré complexes as topological manifolds.
problem Classifying Poincaré complexes as topological manifolds.
method Using spherical fibrations and CW-complexes, the paper proves stability and homotopy equivalence.
result A sufficient condition for Poincaré complexes to be homotopy types of topological manifolds.
It has been shown that the Alvarez-Gaum-Witten miraculous anomaly cancellation formula in type IIB superstring theory and its various generalizations can be derived from modularity of certain characteristic forms. In this paper, we show that the Green-Schwarz formula and the Schwarz-Witten formula i…
Large vessel occlusion (LVO) plays an important role in the diagnosis of acute ischemic stroke. Identifying LVO of patients in the early stage on admission would significantly lower the probabilities of suffering from severe effects due to stroke or even save their lives. In this paper, we utilized both structural and …
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
Plane triangulations remain rigid under discrete conformal changes.
problem Rigidity of acute triangulations under discrete conformal changes.
method Maximum principles, discrete Liouville theorem, extremal lengths, Euclidean to hyperbolic discrete conformality.
result Uniformly acute triangulations are rigid under Luo's discrete conformal change.
In critical care, intensivists are required to continuously monitor high dimensional vital signs and lab measurements to detect and diagnose acute patient conditions. This has always been a challenging task. In this study, we propose a novel self-correcting deep learning prediction approach to address this challenge. W…
We construct discrete and faithful representations into the isometry group of a hyperbolic space of the fundamental groups of acute negatively curved even-sided polygons of finite groups.
The paper examines properties of self-affine Sierpiński sponges using metric invariants.
problem Investigating properties of self-affine Sierpiński sponges using metric invariants.
method Examined through maximal power law property and perfectly disconnectedness.
result Characterized self-affine Sierpiński sponges by their metric properties.
Timely prediction of clinically critical events in Intensive Care Unit (ICU) is important for improving care and survival rate. Most of the existing approaches are based on the application of various classification methods on explicitly extracted statistical features from vital signals. In this work, we propose to elim…
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
J.J.L. Velzquez in 1994 used the degree theory to show that there is a perturbation of Simons' cone, starting from which the mean curvature flow develops a type singularity at the origin. He also showed that under a proper time-dependent rescaling of the solution around the origin, the rescaled…
Exact computation of posterior distribution of mixture weights in hierarchical Bayesian modelsstat.ME
This paper computes exact posterior distributions of mixture weights in hierarchical Bayesian models.
problem Uncertainty in class membership or data-generating processes in heterogeneous data.
method Exact marginalization of mixture weights using dynamic programming and FFT for two components, and joint dynamic program for K >= 3 components.
result Exact posterior distributions of mixture weights are finite mixtures of Beta distributions, providing credible intervals and per-observation local false-discovery rates.
The study finds minimal hypersurfaces in wedge-shaped manifolds with boundary.
problem Finding minimal hypersurfaces in wedge-shaped manifolds with boundary.
method Developed a min-max theory for locally wedge-shaped manifolds with boundary.
result Proved existence of smooth free boundary minimal hypersurfaces in wedge-shaped manifolds.
Cluster analysis aims at separating patients into phenotypically heterogenous groups and defining therapeutically homogeneous patient subclasses. It is an important approach in data-driven disease classification and subtyping. Acute coronary syndrome (ACS) is a syndrome due to sudden decrease of coronary artery blood f…
This project was motivated by a dialysis study in northern Taiwan. Dialysis patients, after shunt implantation, may experience two types ("acute" or "non-acute") of shunt thrombosis, both of which may recur. We formulate the problem under the framework of recurrent events data in the presence of competing risks. In par…
Logistic regression (LR) is widely used in clinical prediction because it is simple to deploy and easy to interpret. Nevertheless, being a linear model, LR has limited expressive capability and often has unsatisfactory performance. Generalized additive models (GAMs) extend the linear model with transformations of input…
Acute kidney injury (AKI) in critically ill patients is associated with significant morbidity and mortality. Development of novel methods to identify patients with AKI earlier will allow for testing of novel strategies to prevent or reduce the complications of AKI. We developed data-driven prediction models to estimate…
Heart disease remains the leading cause of death in the United States. Compared with risk assessment guidelines that require manual calculation of scores, machine learning-based prediction for disease outcomes such as mortality can be utilized to save time and improve prediction accuracy. This study built and evaluated…
Predicting the risk of mortality for patients with acute myocardial infarction (AMI) using electronic health records (EHRs) data can help identify risky patients who might need more tailored care. In our previous work, we built computational models to predict one-year mortality of patients admitted to an intensive care…
Liouville theorem for minimal graphs on manifolds with specific properties.
problem Characterizing positive minimal graphic functions on specific Riemannian manifolds.
method Using volume doubling property and uniform Neumann-Poincaré inequality.
result Positive minimal graphic functions on the manifold are constants.
Patients who suffer an acute coronary syndrome are at elevated risk for adverse cardiovascular events such as myocardial infarction and cardiovascular death. Accurate assessment of this risk is crucial to their course of care. We focus on estimating a patient's risk of cardiovascular death after an acute coronary syndr…
Study reviews machine learning techniques for stress monitoring.
problem Improving accuracy of stress monitoring devices.
method Reviewed machine learning techniques for various stress indicators.
result Choosing the right classifier depends on multiple factors.
Deep Rule Forests identifies drug-drug and drug-disease interactions causing AKI.
problem Identifying drug-drug and drug-disease interactions leading to AKI.
method Deep Rule Forests (DRF) algorithm discovering rules from multilayer tree models.
result DRF model outperforms other algorithms in prediction accuracy and interpretability.
Due to the advantage of achieving a better performance under weak regularization, elastic net has attracted wide attention in statistics, machine learning, bioinformatics, and other fields. In particular, a variation of the elastic net, adaptive elastic net (AEN), integrates the adaptive grouping effect. In this paper,…
An analysis of multivariate measures of skewness and kurtosis of skew-elliptical distributionsmath.ST
The paper analyzes skewness and kurtosis measures for skew-elliptical distributions.
problem Examining skewness and kurtosis measures for skew-elliptical distributions.
method Deriving exact expressions for skewness and kurtosis measures for skew-elliptical distributions, constructing test statistics, and comparing measures through simulations and real data analysis.
result Exact expressions and test statistics for skewness and kurtosis measures for various skew-elliptical distributions.
Improves feature selection in high-dimensional data using LLM-generated weights.
problem Inaccurate LLM-generated weights degrade feature selection performance.
method Integrates LLM-generated weights into prior inclusion probabilities using LLM Sparsity Prior (LSP).
result Improves prediction accuracy and identifies clinically relevant features.
We study Wick-rotations of left-invariant metrics on Lie groups, using results from real GIT (\cite{1}, \cite{2}, \cite{3}). An invariant for Wick-rotation of Lie groups is given, and we describe when a pseudo-Riemannian Lie group can be Wick-rotated to a Riemannian Lie group. We also prove a general version (for gener…
Gradient estimates for special harmonic functions on manifolds.
problem Estimating gradients of -harmonic functions on Riemannian manifolds.
method Using Moser iteration method, volume comparison theorem, and Sobolev embedding theorem.
result Explicit global gradient estimates for positive entire -harmonic functions.