Natural language processing predicts AKI onset in ICU patients.
problem Early detection of AKI in ICU patients to improve outcomes.
method Clinical notes were processed to generate word and concept embeddings. Five classifiers and a deep learning model were used to predict AKI.
result The best model achieved an AUC of 0.779 for predicting AKI onset.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
Study proposes a self-correcting deep learning model for ICU patient condition prediction.
problem Challenging task of continuously monitoring high-dimensional vital signs and lab measurements in critical care.
method Utilized accumulative ICU data, self-correcting mechanism, and regularization method.
result Outperformed conventional deep learning models in predicting acute kidney injury.
Deep Rule Forests identifies drug-drug and drug-disease interactions causing AKI.
problem Identifying drug-drug and drug-disease interactions leading to AKI.
method Deep Rule Forests (DRF) algorithm discovering rules from multilayer tree models.
result DRF model outperforms other algorithms in prediction accuracy and interpretability.
Improves feature selection in high-dimensional data using LLM-generated weights.
problem Inaccurate LLM-generated weights degrade feature selection performance.
method Integrates LLM-generated weights into prior inclusion probabilities using LLM Sparsity Prior (LSP).
result Improves prediction accuracy and identifies clinically relevant features.
Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing studies consider all patients and therefore restrict to features available in the…
Study identifies three sub-phenotypes of AKI with different severity.
problem Tackles the heterogeneity of AKI to improve targeted interventions.
method Used a memory network-based deep learning approach on EHR data.
result Identified three distinct sub-phenotypes of AKI with varying severity.
This study improves AKI prediction precision using CNN on EHR data.
problem Improving early prediction of AKI in ICU patients.
method Convolutional Neural Network (CNN) on EHR data.
result Best AUROC up to 0.988 on MIMIC-III and 0.936 on eICU data sets.
Acute kidney injury (AKI) is a common and serious complication after a surgery which is associated with morbidity and mortality. The majority of existing perioperative AKI risk score prediction models are limited in their generalizability and do not fully utilize the physiological intraoperative time-series data. Thus,…
A novel continual prediction model outperforms traditional one-time models in predicting AKI.
problem Optimally predicting AKI before it develops during a hospital stay.
method A novel continual prediction model that predicts AKI every time a patient's AKI-relevant variable changes in the EHR.
result The continual prediction model outperformed traditional one-time models, achieving a higher AUC of 0.724 compared to 0.653.
F-GAM improves clinical prediction models for OR outcomes.
problem Limited expressive capability of logistic regression for clinical predictions.
method Factored generalized additive model (F-GAM) that extends GAM with feature interactions.
result F-GAM outperforms other models in AUPRC and AUROC for predicting OR outcomes.
MRI identifies chronic symptoms in mTBI patients.
problem Chronic symptoms in mTBI patients are hard to characterize.
method Multi-parametric MRI and low-dimensional projection.
result MRI metrics correlate with patient symptoms.
To investigate whether training load monitoring data could be used to predict injuries in elite Australian football players, data were collected from elite athletes over 3 seasons at an Australian football club. Loads were quantified using GPS devices, accelerometers and player perceived exertion ratings. Absolute and …
A Convolutional Neural Network was used to predict kidney function in patients with chronic kidney disease from high-resolution digital pathology scans of their kidney biopsies. Kidney biopsies were taken from participants of the NEPTUNE study, a longitudinal cohort study whose goal is to set up infrastructure for obse…
A novel 3D U-Net approach improves kidney tumor segmentation in medical imaging.
problem Challenging manual annotation and great medical impact of kidney tumor segmentation.
method End-to-end cascaded U-Nets with a localization network.
result Achieves Sørensen-Dice coefficients of 0.902 for kidney and 0.408 for tumor segmentation.
Paper develops a model to predict kidney transplant success.
problem Mismatched deceased donor-recipient kidney leads to post-transplant death.
method Data analysis of 584 imported kidneys from 12 transplant centers.
result Predicting model reduces mortality rate due to kidney mismatch.
Kidney function evaluation using dynamic contrast-enhanced MRI (DCE-MRI) images could help in diagnosis and treatment of kidney diseases of children. Automatic segmentation of renal parenchyma is an important step in this process. In this paper, we propose a time and memory efficient fully automated segmentation method…
KiTS19 dataset offers 300 kidney tumor cases with CT data and outcomes.
problem Difficulty in quantifying kidney tumor morphometry due to data scarcity and manual labor.
method Presented KiTS19 dataset with multi-phase CT imaging, segmentation masks, and clinical outcomes.
result Automated segmentation of kidney tumors is now possible with this dataset.
3D U-Net improves kidney and tumor segmentation from CT scans.
problem Manual segmentation by clinicians is laborious and error-prone.
method Multi-scale supervised 3D U-Net with deep supervision and post-processing.
result MSS U-Net achieves high Dice coefficients (0.969 for kidney, 0.805 for tumor) on KiTS19 dataset.
Study tackles workplace injury prediction and prevention.
problem Rare and imbalanced data makes injury risk prediction challenging.
method Ensemble resampling, transfer learning, and variable analysis.
result Improved injury risk prediction and prevention techniques.
Injuries have a great impact on professional soccer, due to their large influence on team performance and the considerable costs of rehabilitation for players. Existing studies in the literature provide just a preliminary understanding of which factors mostly affect injury risk, while an evaluation of the potential of …
The goal of this thesis is to investigate the potential of predictive modelling for football injuries. This work was conducted in close collaboration with Tottenham Hotspurs FC (THFC), the PGA European tour and the participation of Wolverhampton Wanderers (WW). Three investigations were conducted: 1. Predicting the rec…
Machine learning improves kidney transplant outcomes prediction.
problem Improving prediction of kidney transplant success.
method Random forest machine learning model trained on kidney donor risk index data.
result Random forest predicted 2,148 more successful transplants than the risk index.
Unsupervised clustering reveals novel TBI phenotypes.
problem Inadequate categorization of traumatic brain injury (TBI) based on symptoms.
method Applied unsupervised learning with GLRM feature selection.
result Identified four novel TBI phenotypes with distinct feature profiles.
Study uses machine learning and survival analysis to predict CKD progression.
problem Early detection and management of CKD to reduce ESRD risk.
method Combines machine learning and classical statistical models to identify novel CKD progression predictors.
result Deep learning models outperform other methods in predicting CKD progression.
Deep learning predicts ICD codes with high accuracy for patient phenotyping.
problem Variability in ICD code assignment by coders.
method Deep learning model trained on demographics, lab results, and medications.
result Model predictions outperform coder assigned ICD codes in accuracy.
Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.
problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.
Study identifies and estimates treatment effect heterogeneity within principal stratification subpopulations.
problem Causal inference with intermediate outcomes and treatment effect heterogeneity.
method Proposes a novel doubly cross-fit doubly robust machine learner to efficiently learn conditional principal causal effects under principal ignorability.
result Demonstrates informative patterns of treatment effect heterogeneity within the always-survivor subpopulation in an acute lung injury trial.
New fair regression method improves fairness in chronic kidney disease classification.
problem Mitigating societal bias in health care for multiple groups.
method Penalized fair regression framework for multiple groups, with penalties for true positive rate disparity.
result Achieves fairness-accuracy frontier beyond existing methods in simulations and real-world data.
Novel framework detects CKD in diabetic patients using sparse EHR representations.
problem Early detection of CKD in diabetic patients.
method Sparse longitudinal representations of EHR data.
result Proposed model achieves higher predictive performance than baselines.
Proof of Gromov's theorem on convex polytopes with acute angles.
problem Gromov's conjecture on extremal scalar curvature of convex polytopes.
method Smoothing construction using Dirac operator techniques.
result Detailed proof of Gromov's theorem.
Study on Teichmüller space of acute triangles using explicit calculations.
problem Analogue of Thurston's metric on acute triangles.
method Direct calculation of distance function and Finsler structure.
result Explicit expressions and properties of the metric on acute triangles.
AI system predicts acute critical illness from EHRs with explainability.
problem Lack of clinical interpretability in AI predictions for acute critical illness.
method Developed an explainable AI early warning score (xAI-EWS) system.
result System provides clinicians with insights into EHR data explaining predictions.
ECGDetect uses deep learning to detect ischemia in heart ECGs.
problem Detecting early signs of acute coronary syndrome in patients.
method Developed a deep learning model using the LTST database.
result Deep neural network achieved 90.31% ROC-AUC, 89.34% sensitivity, 87.81% specificity.
An accurate model of patient-specific kidney graft survival distributions can help to improve shared-decision making in the treatment and care of patients. In this paper, we propose a deep learning method that directly models the survival function instead of estimating the hazard function to predict survival times for …
This study uses reinforcement learning to mitigate imminent collisions by controlling car speed and direction.
problem Mitigating imminent collisions on roads.
method Constructed a model using camera images to predict obstacle dynamics. Trained reinforcement learning policies to control braking and steering.
result Both reinforcement learning policies outperform a baseline policy, with the injury model-based policy showing the highest performance.
Let C(L) be the right-angled Coxeter group defined by an abstract triangulation L of S2. We show that C(L) is isomorphic to a hyperbolic right-angled reflection group if and only if L can be realized as an acute triangulation. The proof relies on the theory of CAT(-1) spaces. A corollary is that an …
Study identifies key MRI features for predicting cognitive performance after mTBI.
problem Identify relevant diffusion MRI metrics for cognitive functions in mTBI patients.
method Proposes a novel feature selection method combining best-first search with genetic algorithm crossover.
result Achieves significantly more accurate predictions than other feature selection algorithms.
Bayesian method for estimating functional graphical models from neuroimaging data.
problem Estimating dependence structures from functional data in neuroscience.
method Fully Bayesian regularization scheme, including direct Bayesian analog of functional graphical lasso and graphical horseshoe.
result Insight into brain compensation after traumatic brain injury.
The study predicts acute hypotensive episodes using unsupervised learning and hashing.
problem Early detection of acute hypotensive episodes in ICU.
method Unsupervised representation learning and stratified locality sensitive hashing applied to multivariate time-series data.
result The method accurately predicts upcoming acute hypotensive episodes.
Maps between acute triangles with minimal stretch found and studied.
problem Finding the minimal stretch between acute triangles.
method Formula for the smallest Lipschitz constant and analysis of the metric space.
result Metric space of pairs of acute triangles with fixed area is Finsler and geodesics determined.
The paper explores Kähler and anti-Kähler structures on quasi-statistical manifolds.
problem Investigating Kähler and anti-Kähler structures on quasi-statistical manifolds.
method Analyzing conditions for integrability of almost complex structures and defining Kähler and anti-Kähler manifolds.
result Conditions for (Nˊ,h,abla,L) to be an anti-Kähler manifold are identified. Improved rigidity of Delaunay triangulated plane.
problem Rigidity of Delaunay triangulated plane under discrete conformality.
method Modifying Wu's proof to weaken the uniformly acute condition to the uniformly Delaunay condition.
result Improved rigidity result for Delaunay triangulated plane.
Bayesian optimization improves classifier selection for acute infection and mortality.
problem Improving accuracy of acute infection and mortality prediction.
method Comparison of hyperparameter optimization methods (grid search, random sampling, Bayesian optimization).
result Bayesian optimization outperforms grid search or random sampling for in-hospital mortality classifiers.
A new method quantifies uncertainty in brain injury simulations.
problem High computational cost and high-dimensional inputs/outputs limit traditional UQ methods for biofidelic head models.
method Two-stage, data-driven manifold learning framework using Gaussian kernel-density estimation, diffusion maps, and Grassmannian diffusion maps.
result Surrogate models reduce computational cost while providing highly accurate approximations of the computational model.
In this paper, the development of a probabilistic network for the diagnosis of acute cardiopulmonary diseases is presented. This paper is a draft version of the article published after peer review in 2018 (https://doi.org/10.1002/bimj.201600206). A panel of expert physicians collaborated to specify the qualitative part…
Study developed phenotypes for ICU patients' brain dysfunction states.
problem Underdiagnosis of acute brain dysfunction in ICU patients.
method Created algorithms to quantify and cluster brain dysfunction states.
result Developed three phenotypes of ICU patients' brain dysfunction states.
We study the behavior of a Time-Aware Long Short-Term Memory Autoencoder, a state-of-the-art method, in the context of learning latent representations from irregularly sampled patient data. We identify a key issue in the way such recurrent neural network models are being currently used and show that the solution of the…