Mathematician summarizes protein geometry and mutation effects.
problem Understanding how proteins mutate and their structure-function relationship.
method Mathematical analysis of protein structures and functions, focusing on hydrogen bonds and secondary structure.
result Protein secondary structure regulates mutation by stabilizing or destabilizing regions.
HIV RNA viral load (VL) is an important outcome variable in studies of HIV infected persons. There exists only a handful of methods which classify patients by viral load patterns. Most methods place limits on the use of viral load measurements, are often specific to a particular study design, and do not account for com…
New method infers viral load from pooled tests.
problem Inefficient viral load inference in pooled testing.
method Message passing algorithm with PCR noise function.
result Accurate viral load inference possible.
Develops a method to analyze SARS-CoV-2 viral load vs. age, finding a significant increase.
problem Determining if SARS-CoV-2 viral load depends on patient age.
method Flexible, non-parametric, hierarchical, Bayesian, causal model.
result Statistically significant increase in viral load with age, but only for one dataset.
The study introduces a high-dimensional tail index model for viral post analysis.
problem Empirical observation of power-law distributions in viral posts.
method High-dimensional tail index regression model, regularized estimator, debiasing for inference.
result Consistency and asymptotic normality of debiased estimator.
Viral zoonoses have emerged as the key drivers of recent pandemics. Human infection by zoonotic viruses are either spillover events -- isolated infections that fail to cause a widespread contagion -- or species jumps, where successful adaptation to the new host leads to a pandemic. Despite expensive bio-surveillance ef…
Machine learning models detect COVID-19 from routine blood tests.
problem Separating COVID-19 from other viral pneumonias using blood tests.
method Employed random forests and support vector machines on blood data.
result SVM-based classifier achieves 84% accuracy in detecting COVID-19.
Develops a risk score to assist ECMO planning for critically ill patients with viral or unspecified pneumonia.
problem Lack of a risk score to guide ECMO planning for critically ill patients.
method Leverages machine learning to develop the PEER score.
result PEER score predicts mortality and decompensation in patients eligible for ECMO.
Viral sequence classification is an important task in pathogen detection, epidemiological surveys and evolutionary studies. Statistical learning methods are widely used to classify and identify viral sequences in samples from environments. These methods face several challenges associated with the nature and properties …
The study examines how model predictions hold up under model extensions.
problem Model predictions may not be robust under model extensions, limiting their applicability.
method The study uses causal ordering to assess robustness of qualitative model predictions and characterizes model extensions that preserve predictions.
result Conditions and techniques are provided to assess robustness of model predictions under model extensions.
Machine learning identifies potential drugs for COVID-19.
problem Finding effective treatments for COVID-19.
method Trained neural network models on virus protein sequences and antiviral drugs.
result Identified potential drug candidates for treating COVID-19.
A new framework maximizes influence spread in social networks by accounting for inter-community diffusion.
problem Real-world social networks have inter-community influence that is often overlooked in community-based IM approaches.
method Community-IM++ uses a heuristic based on community-based diffusion degree and progressive budgeting to model and prioritize cross-community diffusion.
result Community-IM++ achieves near-greedy influence spread at up to 100 times lower runtime than existing methods.
Machine learning model diagnoses COVID-19 from routine blood tests.
problem Difficulty in diagnosing COVID-19 due to inconsistent blood parameter changes.
method Constructed a machine learning model using 5,333 patients with various infections and 160 COVID-19-positive patients.
result Cross-validated AUC of 0.97, sensitivity of 81.9%, specificity of 97.9%.
The paper examines how sampling data affects the performance of submodular maximization.
problem Performance loss due to probability sampling in submodular maximization.
method Examines a simple probability sampling method where each data point is selected with probability at least r.
result The sampling gap is both upper and lower bounded by 1/r for policywise submodular utility functions.
The typical algorithmic problem in viral marketing aims to identify a set of influential users in a social network, who, when convinced to adopt a product, shall influence other users in the network and trigger a large cascade of adoptions. However, the host (the owner of an online social platform) often faces more con…
CogMol designs novel drug-like molecules for SARS-CoV-2 targets.
problem Designing efficient drugs for novel viral proteins.
method End-to-end framework combining VAE, controlled sampling, and predictors.
result Highly selective and affinity molecules for SARS-CoV-2 targets.
New method targets vaccines for new variants using Thompson sampling.
problem Deciding how to prioritize vaccines for new variants with delayed feedback.
method Partial likelihood Thompson sampling, updating beliefs with partial likelihood.
result Method effectively prioritizes vaccines based on real-world data.
This article presents a preliminary approach towards characterizing political fake news on Twitter through the analysis of their meta-data. In particular, we focus on more than 1.5M tweets collected on the day of the election of Donald Trump as 45th president of the United States of America. We use the meta-data embedd…
This essay examines how what is considered to be artificial intelligence (AI) has changed over time and come to intersect with the expertise of the author. Initially, AI developed on a separate trajectory, both topically and institutionally, from pattern recognition, neural information processing, decision and control …
Develops a variational method for ultrametric phylogenetic trees.
problem Accurate and efficient approximation of posterior distributions over trees in Bayesian phylogenetics.
method Variational Bayesian approach based on coalescent times of a single-linkage clustering.
result Achieves competitive accuracy with significantly fewer gradient evaluations.
Efficiently models agent dependencies in large social networks.
problem Challenges in incorporating inter-agent dependencies in social reinforcement learning models.
method Clusters users based on payoff and contribution, combines cluster-level policies with personalized agent-level policies, and uses dynamic clustering.
result Our approach learns more accurate policy estimates and converges more quickly than existing methods.
Researchers use clustering to differentiate COVID-19 lung scans.
problem Identifying infected individuals with COVID-19.
method Applied unsupervised clustering techniques using PCA, K-Means++, and RCC.
result KM++ and RCC algorithms improved in clustering COVID-19 lung scans.
Noisy Pooled PCR tests large groups more efficiently.
problem Efficiently test large populations for viral infections.
method Converts group testing to a linear inverse problem with a message passing algorithm.
result Estimates patient illness status with fewer pooled measurements.
How is popularity gained online? Is being successful strictly related to rapidly becoming viral in an online platform or is it possible to acquire popularity in a steady and disciplined fashion? What are other temporal characteristics that can unveil the popularity of online content? To answer these questions, we lever…
In this study, the authors develop a structural model that combines a macro diffusion model with a micro choice model to control for the effect of social influence on the mobile app choices of customers over app stores. Social influence refers to the density of adopters within the proximity of other customers. Using a …
Framework predicts mortality risk in MAFLD subjects.
problem Lack of mortality prediction methods for MAFLD subjects.
method Artificial Intelligence-based framework MAFUS using ML algorithms.
result Support Vector Machines (SVM) is the best model for mortality prediction.
Binary classification rules based on covariates typically depend on simple loss functions such as zero-one misclassification. Some cases may require more complex loss functions. For example, individual-level monitoring of HIV-infected individuals on antiretroviral therapy (ART) requires periodic assessment of treatment…
A typical viral marketing model identifies influential users in a social network to maximize a single product adoption assuming unlimited user attention, campaign budgets, and time. In reality, multiple products need campaigns, users have limited attention, convincing users incurs costs, and advertisers have limited bu…
Paper proposes HGAT for detecting fake news on HIN.
problem Viral spread of fake news causing social harm.
method Hierarchical Graph Attention Network (HGAT) for node representation learning in HIN.
result HGAT outperforms text-based and network-based models.
A dynamic keyword selection model for topic modeling of tweets.
problem Adjusting keywords dynamically to mimic past topics with novelty.
method Generative process selects keywords and documents, trained with variational lower bound and stochastic gradient optimization.
result Keyword-based topic model outperforms a sophisticated baseline model by 67%.
Cascades of information-sharing are a primary mechanism by which content reaches its audience on social media, and an active line of research has studied how such cascades, which form as content is reshared from person to person, develop and subside. In this paper, we perform a large-scale analysis of cascades on Faceb…
In a wide variety of applications, humans interact with a complex environment by means of asynchronous stochastic discrete events in continuous time. Can we design online interventions that will help humans achieve certain goals in such asynchronous setting? In this paper, we address the above problem from the perspect…
New method for fair influence maximization in social networks.
problem Maximizing influence while ensuring fairness across sensitive attributes.
method Co-training an auto-encoder and discriminator to create fair graph embeddings.
result Our method reduces disparity while maintaining competitive influence maximization performance.
Deep neural networks predict B-cell epitopes for SARS-CoV and SARS-CoV-2.
problem Accurate prediction of B-cell epitopes for vaccine design.
method Deep neural network model with regularization techniques and key features analysis.
result Overall accuracy of 82% in predicting COVID-19 cases.
Study uses machine learning to detect early COVID-19 from CT images.
problem Early detection of COVID-19 from CT images.
method Machine learning methods applied to patches of CT images, feature extraction (GLCM, LDP, GLRLM, GLSZM, DWT), SVM classification.
result Best classification accuracy of 99.68% with 10-fold cross-validation and GLSZM feature extraction.
Detection of protein-protein interactions (PPIs) plays a vital role in molecular biology. Particularly, infections are caused by the interactions of host and pathogen proteins. It is important to identify host-pathogen interactions (HPIs) to discover new drugs to counter infectious diseases. Conventional wet lab PPI pr…
New Hawkes processes model spatiotemporal events with triggering and clustering.
problem Modeling self-excitatory behavior in spatiotemporal data.
method Developed a new class of spatiotemporal Hawkes processes with efficient inference method.
result Efficiently modeled and inferred spatiotemporal events with triggering and clustering.
Generative Distribution Embeddings learn multiscale representations of distributions.
problem Learning representations of entire distributions for multiscale reasoning.
method Introducing GDE framework that lifts autoencoders to the space of distributions, using conditional generative models and distributional invariance.
result GDEs learn predictive sufficient statistics embedded in Wasserstein space, recovering distances and trajectories for Gaussian and Gaussian mixture distributions.
Deep learning ensembles improve COVID-19 detection from chest X-rays.
problem Detecting COVID-19 from chest X-rays using machine learning.
method Custom CNN and ImageNet models, transfer learning, iterative pruning, ensemble learning.
result 99.01% accuracy in detecting COVID-19 from chest X-rays.
Deep learning models learn chaotic system dynamics from real and simulated data.
problem Training deep learning models for chaotic systems requires big data.
method Jointly train deep neural networks on real and simulated data, enforcing physical laws.
result Proposes knowledge-based deep learning (KDL) for accurate forecasting of chaotic systems.
Framework uses machine learning to distinguish major COVID-19 variants.
problem Discriminate and visualize associations between major COVID-19 variants based on genome sequences.
method Unsupervised machine learning methods, including k-mer analysis, PCA, t-SNE, UMAP, and agglomerative hierarchical clustering.
result Framework effectively distinguishes between major variants and identifies emerging variants.
Study reveals widespread manipulation of meme coins, leading to significant economic losses.
problem Widespread manipulation of meme coins leading to economic losses.
method Cross-chain analysis of 34,988 tokens across Ethereum, BNB Smart Chain, Solana, and Base.
result 82.8% of high-return tokens show evidence of artificial growth strategies.
Estimates support in distributions with sampling artifacts and errors.
problem Support estimation in the presence of sampling artifacts and errors.
method Regularized weighted Chebyshev approximations with Touchard polynomials, discretized semi-infinte programming.
result Significant improvements over noiseless support estimation methods.
Network metrics form a fundamental part of the network analysis toolbox. Used to quantitatively measure different aspects of the network, these metrics can give insights into the underlying network structure and function. In this work, we connect network metrics to modern probabilistic machine learning. We focus on the…
The problem to accurately and parsimoniously characterize random series of events (RSEs) present in the Web, such as e-mail conversations or Twitter hashtags, is not trivial. Reports found in the literature reveal two apparent conflicting visions of how RSEs should be modeled. From one side, the Poissonian processes, o…
Bayesian deep learning ensemble improves pneumonia diagnosis accuracy.
problem Manual, time-consuming pneumonia diagnosis with high inter-observer variability.
method Multi-level ensemble classification system using Bayesian Deep Learning.
result Accuracy of 98.06% in differentiating four pathologies.
Network medicine predicts repurposable drugs for COVID-19.
problem Identifying effective drugs for SARS-CoV-2 infections quickly.
method Artificial intelligence, network diffusion, and network proximity algorithms.
result A multimodal approach combining predictions from multiple algorithms outperforms individual methods.
Algorithm estimates clock in network cascades to improve performance.
problem Temporal distortion in cascade observation leads to performance degradation.
method Formulated clock estimation problem, developed FastClock algorithm.
result FastClock algorithm outperforms state-of-the-art in terms of accuracy and speed.