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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,742 papers · 148 categories

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123245368490 · Jun 202019922001200920172026
48 results for UK Clinical Practice Research Datalink

Study estimates treatment effect on survival outcomes using targeted maximum likelihood estimation.

problem Estimating treatment effect on time-to-event outcomes in clinical settings.
method Divided into three phases: estimation, feature selection, and targeted maximum likelihood estimation.
result Method performs well in high sample size or event rate conditions.

The study compares machine learning models for depression detection and highlights the importance of feature selection.

problem The choice of features in machine learning models for depression detection is crucial.
method Comparison of seven machine learning models on depression detection tasks.
result Optimal feature selection is essential for accurate and clinically acceptable classification solutions.

New methods improve genetic studies of complex diseases.

problem Improving genetic studies of complex diseases using high-dimensional clinical data.
method Evaluation of unsupervised disentangled representation learning methods (autoencoders, VAE, beta-VAE, FactorVAE) for genetic association studies.
result FactorVAEs and beta-VAEs outperform standard VAEs and non-variational autoencoders in genetic studies of asthma and COPD.

Study improves prediction of UK road accidents' severity using AI.

problem Improving prediction of UK road traffic accident severity.
method Combination of machine learning, econometric, and statistical methods on historical data.
result XGBoost model with RMSE of 0.176 and MAE of 0.087 outperforms naive forecasting.

Study develops a dynamic risk model for COVID-19 mortality using UK Biobank data.

problem Developing tools to monitor high-risk patients during the COVID-19 pandemic.
method Data-driven random forest classification model using baseline characteristics and symptoms.
result Model predicts COVID-19 mortality with excellent performance (AUC: 0.91), identifying novel predictors.

Systematic review of multimodal data challenges and solutions.

problem Challenges in integrating diverse data types for improved diagnostics and personalized care.
method Synthesizing findings from 69 studies on technical obstacles and recent methodological advances.
result Promising solutions like transfer learning, generative models, attention mechanisms, and neural architecture search.

Research quantifies financial exclusion risks in UK, focusing on cash infrastructure and socio-economic factors.

problem Localised financial exclusion in the UK as cash infrastructure declines.
method Developed a composite indicator using various input variables.
result Financial exclusion is more prevalent in deprived communities and affluent areas.

We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical neuroscience studies. However, most registration algorithms are designed for high-resolut…

2018-12-17abs ↗pdf ↗

PKB framework boosts genomic data analysis by integrating pathway knowledge.

problem Boosting discovery power and connecting new findings with biological mechanisms in genomic data.
method Pathway-based Kernel Boosting (PKB) framework integrating clinical and pathway information for prediction of various outcomes.
result PKB substantially outperforms other methods in predicting drug response and cancer survival.

Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…

2019-07-09abs ↗pdf ↗

Accurate volatility modelling is paramount for optimal risk management practices. One stylized feature of financial volatility that impacts the modelling process is long memory explored in this paper for alternative risk measures, observed absolute and squared returns for high frequency intraday UK futures. Volatility …

2011-03-29abs ↗pdf ↗

In this paper, we investigate the capability of the universal Kriging (UK) model for single-objective global optimization applied within an efficient global optimization (EGO) framework. We implemented this combined UK-EGO framework and studied four variants of the UK methods, that is, a UK with a first-order polynomia…

2018-03-23abs ↗pdf ↗

With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…

2017-10-09abs ↗pdf ↗

ROOFS helps researchers select robust biomarker features from complex data.

problem Challenges in feature selection for biomarker discovery and clinical models.
method ROOFS is a Python package that benchmarks multiple feature selection methods on user data.
result ROOFS identifies a filter method as optimal for identifying predictors of lung cancer resistance.

Paper proposes machine learning model for early Alzheimer's diagnosis.

problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.

Framework for imputing missing heart data to simulate brain-heart interactions.

problem Lack of multi-modal patient data representing heart and brain processes.
method Probabilistic framework for joint cardiac data imputation and mechanistic model personalization.
result Accurate imputation of missing cardiac features in incomplete datasets.

Researchers propose a new way to handle missing data in healthcare datasets for better reinforcement learning outcomes.

problem Handling missing data in irregularly sampled clinical datasets for reinforcement learning.
method Alternative representation of patient state that incorporates missingness information.
result Our alternative representation yields consistently better results for optimal control compared to traditional methods.

Crohn's disease, one of two inflammatory bowel diseases (IBD), affects 200,000 people in the UK alone, or roughly one in every 500. We explore the feasibility of deep learning algorithms for identification of terminal ileal Crohn's disease in Magnetic Resonance Enterography images on a small dataset. We show that they …

2019-08-31abs ↗pdf ↗

AdaCare learns health status from biomarkers across multiple time scales.

problem Lack of explicit extraction of historical biomarker variation and adaptability to diverse patient conditions.
method Scale-adaptive feature extraction and recalibration for interpretability.
result AdaCare achieves state-of-the-art prediction accuracy and provides interpretable results.

Two sets of high quality income data are analysed in detail, one set from the UK, one from the USA. It is firstly demonstrated that both a log-normal distribution and a Boltzmann distribution can give very accurate fits to both these data sets. The absence of a power tail in the US data set is then discussed. Taken in …

2004-06-28abs ↗pdf ↗

UK hosts 62.89% of all HYIPs, many registered as 'limited company'.

problem Understanding the prevalence and characteristics of HYIPs in the UK.
method Examined HYIPs' registration in UK, analyzed social media and payment processors, used Cox proportional regression analysis.
result HYIPs with valid UK addresses tend to have longer lifespans.

The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are gr…

2019-04-02abs ↗pdf ↗

Federated ABC-GMM boosts classification performance in imbalanced clinical data.

problem Class imbalance and privacy concerns in federated learning for clinical data.
method Approximate Bayesian computation-based Gaussian Mixture Model (Federated ABC-GMM) for privacy-preserving oversampling.
result Federated ABC-GMM improves F1 score up to nearly ideal performance in imbalanced clinical data.

SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.

problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.

Study develops a new algorithm for assessing clinical trial abstracts.

problem Limited tools for assessing qualitative statements in clinical research.
method Developed a three-class sentiment classification algorithm using BERT model.
result Algorithm achieved 91.3% classification accuracy and 0.92 macro F1-Score.