This monograph introduces deep learning models for predicting time-to-event outcomes.
problem Predicting critical events and their timing from time series data.
method Neural networks and deep learning models for survival analysis.
result Improved accuracy in predicting time-to-event outcomes using deep learning.
Proposes a new model for time-to-event prediction with uncertainty quantification.
problem Lack of uncertainty in time-to-event predictions using recurrent neural networks.
method Deep Kernel Accelerated Failure Time models combining RNN and sparse Gaussian Process.
result Model delivers better uncertainty estimates compared to related methods.
Models for predicting the time of a future event are crucial for risk assessment, across a diverse range of applications. Existing time-to-event (survival) models have focused primarily on preserving pairwise ordering of estimated event times, or relative risk. Model calibration is relatively under explored, despite it…
Bayesian approach clusters survival data for better risk prediction.
problem Identifying subpopulations with distinct risk profiles in survival analysis.
method Bayesian nonparametric approach in a clustered latent space.
result Consistent improvements in predictive performance and interpretability.
Study examines HTE estimation from time-to-event data with competing events.
problem Estimating HTEs from time-to-event data with competing events.
method Outcome modeling approach using plug-in estimators for potential outcomes.
result Competing events introduce new challenges for HTE estimation.
SurvCORN predicts survival curves using conditional ordinal ranking networks.
problem Challenges in survival analysis with censored data.
method SurvCORN: Conditional Ordinal Ranking Neural Network.
result SurvCORN improves accuracy in predicting time-to-event outcomes.
Proposes a deep neural network for predicting clustered time-to-event data.
problem Predicting clustered time-to-event data with subject-specific frailties.
method Deep neural network based gamma frailty model (DNN-FM) trained using negative profiled h-likelihood.
result Enhances prediction performance compared to existing methods.
Harmoniums model multiple time-to-event variables in survival analysis.
problem Survival analysis with multiple, independently censored time-to-event variables and missing observations.
method Energy-based approach with bi-partite structure (harmoniums).
result Harmoniums capture non-linear patterns between time recordings.
A new boosting model handles dependent censoring in time-to-event data.
problem Independent censoring assumption leads to biased predictions in time-to-event analysis.
method Clayton-boost, a boosting approach using Clayton copula.
result Clayton-boost outperforms other methods in handling dependent censoring.
SurvFD and SurvSHAP-IQ provide interpretable survival models by analyzing feature interactions.
problem Non-additivity of hazard and survival functions limits standard additive explanation methods.
method SurvFD decomposes higher-order effects into time-dependent and time-independent components, extending Shapley interactions to time-indexed functions.
result SurvFD and SurvSHAP-IQ offer a new perspective on survival explanations, explicitly characterizing feature interactions.
A new neural network model for predicting event times without distributional assumptions.
problem Predicting event times from censored data with complex assumptions.
method Deep AFT Rank-regression model (DART) using Gehan's rank statistic.
result DART significantly improves performance on various benchmark datasets.
Develops a machine learning model to predict ALS progression and assistive device use.
problem Challenges in predicting clinically meaningful milestones in ALS.
method Integrates longitudinal ALSFRS-R trajectories with survival modeling.
result Generates individualized survival curves and predicts wheelchair-free survival.
VSI model predicts survival distributions efficiently.
problem Predicting time-to-event distributions in clinical applications.
method Variational framework for non-parametric distribution estimation.
result Improved performance over competing solutions.
Proposes isotonic regression for calibrating Deep Cox models' survival probabilities.
problem Poor calibration of Deep Cox models' survival probabilities.
method Isotonic regression for post hoc calibration of Deep Cox models.
result Establishes favorable theoretical guarantees and demonstrates empirical effectiveness.
SurvLatent ODE predicts VTE risk for cancer patients, outperforming current methods.
problem Predicting clinical outcomes from irregularly sampled EHR data with competing events.
method Neural ODE-based Recurrent Neural Networks (ODE-RNN) for flexible survival time estimation.
result SurvLatent ODE outperforms Khorana Risk scores for VTE risk prediction.
Enhances patient failure prediction using dynamic survival models.
problem Lack of precise individual level prediction in conventional models.
method Developed counterfactual dynamic survival model (CDSM).
result Inflection point of estimated survival curves predicts patient failure time.
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
problem Challenges in integrating longitudinal tumor measurements, dropout information, and genetic covariates.
method Extended EB-VAE framework to jointly model longitudinal and time-to-event data, incorporating dropout hazard and genetic covariates.
result Hybrid decoder formulation yields consistent treatment-effect parameters and prior predictive performance comparable to neural decoder.
Bayesian VFLMSP improves multimodal survival prediction with privacy.
problem Privacy and reliability in multimodal time-to-event prediction.
method Bayesian Vertical Federated Learning (VFL) with differential privacy.
result Consistent improvements in C-index compared to existing methods.
Exclusive Lasso improves survival prediction in cancer datasets.
problem Enhanced survival prediction in cancer datasets with high-dimensional genomic and clinical data.
method Proposes Exclusive Lasso regularization for feature selection in Cox regression models for grouped variables.
result Demonstrates improved survival prediction performance using Exclusive Lasso compared to standard Cox regression.
gOMP algorithm selects features for various types of data.
problem Feature selection for scalable molecular data.
method Generalized Orthogonal Matching Pursuit algorithm for multiple types of data.
result gOMP performs similarly or better than LASSO on various datasets.
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
SurvITE learns treatment effects from time-to-event data, addressing unique challenges.
problem Inferring heterogeneous treatment effects from time-to-event data.
method Proposes a novel deep learning method for treatment-specific hazard estimation.
result Method outperforms baselines by addressing covariate shifts from various sources.
A new method prices time-to-event cash flows using survival analysis.
problem Pricing insurance investment portfolios with time-to-event cash flows.
method Discrete-time survival analysis framework, hazard rate estimators, asymptotic multivariate normality.
result Pricing model yields estimates closer to actual cash flows than non-random models.
Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records (EHRs) provide an alternative to the longitudinal cohort studies traditio…
auton-survival simplifies survival analysis for healthcare data.
problem Handling censored time-to-event data in healthcare.
method Open-source package for survival regression, adjustment, counterfactual estimation, phenotyping, and treatment effects.
result Demonstrates auton-survival's ability to support complex health and epidemiological questions.
Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called survival analysis, stands as one of the most representative examples of such statisti…
Neural model predicts survival outcomes and reveals feature relationships.
problem Predicting time-to-event outcomes and understanding feature relationships in clinical data.
method Survival and topic modeling combined in a neural network framework.
result Neural survival-supervised topic models achieve competitive accuracy with interpretability.
We present a non-parametric prognostic framework for individualized event prediction based on joint modeling of both longitudinal and time-to-event data. Our approach exploits a multivariate Gaussian convolution process (MGCP) to model the evolution of longitudinal signals and a Cox model to map time-to-event data with…
25% of people who received a liver transplant will go on to develop diabetes within the next 5 years. These thousands of individuals are at 2-fold higher risk of cardiovascular events, graft loss, infections, as well as lower long-term survival. This is partly due to the medication used during and/or after transplant t…
Paper proposes kernelized Stein tests for time-to-event data with censoring.
problem Testing goodness-of-fit for time-to-event data with censoring.
method Combining Stein's method and kernelized discrepancies for non-parametric testing.
result Proposed kernelized Stein discrepancy tests perform better than existing methods.
New survival learners estimate heterogeneous treatment effects from time-to-event data.
problem Estimating HTEs from time-to-event data with censoring outcomes.
method Orthogonal survival learners with theoretical guarantees and custom weighting functions.
result Orthogonal survival learners provide robust and model-agnostic HTE estimation.
ADHAM provides interpretable survival analysis for healthcare.
problem Limited interpretability in deep learning survival models.
method Additive Deep Hazard Analysis Mixtures (ADHAM) with latent subgroup structure.
result ADHAM offers interpretable insights into exposure-outcome associations.
DynForest R package predicts outcomes with time-dependent predictors.
problem Handling time-dependent predictors in random forest models.
method Random forests with time-dependent predictors summarized using flexible linear mixed models.
result DynForest can predict continuous, categorical, and survival outcomes.
Diffsurv extends differentiable sorting to handle censored time-to-event data.
problem Handling censored time-to-event data in survival analysis.
method Extending differentiable sorting methods to account for censored samples.
result Diffsurv outperforms established baselines in various risk prediction scenarios.
Paper compares different models for time-to-event analysis.
problem Comparing models for time-to-event analysis.
method Experimental comparison of semi-parametric, parametric, and machine learning models.
result Models' performance evaluated using concordance index.
Super Learner combines dynamic predictions from various models to improve survival estimates.
problem Challenges in obtaining optimal survival estimates for liver failure risk.
method Super Learner framework combining machine learning and statistical procedures.
result Super Learner outperformed individual models in primary biliary cholangitis application.
The paper proposes a method to identify subgroups with different treatment effects in time-to-event data.
problem Identifying subgroups with differential treatment effects in time-to-event data.
method A mixture model with structured sparsity regularization and novel inference procedure.
result The method effectively recovers sparse phenotypes across real-world clinical studies.
Discusses handling intercurrent events in clinical trials with time-to-event outcomes.
problem Handling intercurrent events in clinical trials with time-to-event outcomes.
method Defines estimands and six ICE handling strategies, including new competing-risk strategy.
result Novel methods for handling intercurrent events in clinical trials with time-to-event outcomes.
The development of molecular signatures for the prediction of time-to-event outcomes is a methodologically challenging task in bioinformatics and biostatistics. Although there are numerous approaches for the derivation of marker combinations and their evaluation, the underlying methodology often suffers from the proble…
This study evaluates subgroup analysis methods for time-to-event outcomes in randomized controlled trials.
problem Identifying subgroups of good responders in non-significant randomized controlled trials.
method Evaluation of several subgroup analysis algorithms for time-to-event outcomes using synthetic and semi-synthetic data.
result Provides a new synthetic and semi-synthetic data generation process and an open-source Python package for benchmarking.
Models for predicting the risk of cardiovascular events based on individual patient characteristics are important tools for managing patient care. Most current and commonly used risk prediction models have been built from carefully selected epidemiological cohorts. However, the homogeneity and limited size of such coho…
Study compares Cox model and RSF for predicting patient survival, finding RSF superior in certain scenarios.
problem Comparing predictive accuracy of Cox proportional hazards model and Random Survival Forest for patient-specific survival probabilities.
method Conducted a comprehensive comparison study using simulation scenarios and real-world datasets.
result RSF outperforms Cox model in nonproportional hazards settings and with treatment-covariate interactions.
A new method models individual survival curves using conditional normalizing flows.
problem Precise per-individual predictions in survival analysis.
method Conditional normalizing flows for flexible and individualized survival distributions.
result Efficient estimation of individual survival curves without overfitting.
Random forest (Leo Breiman 2001a) (RF) is a non-parametric statistical method requiring no distributional assumptions on covariate relation to the response. RF is a robust, nonlinear technique that optimizes predictive accuracy by fitting an ensemble of trees to stabilize model estimates. Random survival forests (RSF) …
Improves survival prediction model calibration for better individual decision-making.
problem Survival prediction's marginal and conditional calibration issues.
method Conformal prediction using individual survival probabilities.
result Effective marginal and conditional calibration without compromising discrimination.
We develop a novel algorithm to predict the occurrence of major abdominal surgery within 5 years following Crohn's disease diagnosis using a panel of 29 baseline covariates from the Swedish population registers. We model pseudo-observations based on the Aalen-Johansen estimator of the cause-specific cumulative incidenc…
Develops a Bayesian method for causal inference with partly censored time-to-event data.
problem Estimating causal effects with unobserved confounders and measurement errors in partly censored time-to-event data.
method Semiparametric Bayesian instrumental variable analysis using a two-stage Dirichlet process mixture model.
result The proposed method outperforms competing methods in simulations and real-world data analysis.
Boosting methods for interval-censored data improve predictive accuracy in survival analysis.
problem Handling interval-censored data in survival analysis and time-to-event studies.
method Nonparametric boosting methods using censoring unbiased transformations and functional gradient descent.
result Effective boosting methods for regression and classification with interval-censored data, offering robust performance.