This monograph introduces deep learning models for predicting time-to-event outcomes.
problem Predicting critical events and their timing from time series data.
method Neural networks and deep learning models for survival analysis.
result Improved accuracy in predicting time-to-event outcomes using deep learning.
Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called survival analysis, stands as one of the most representative examples of such statisti…
A new method prices time-to-event cash flows using survival analysis.
problem Pricing insurance investment portfolios with time-to-event cash flows.
method Discrete-time survival analysis framework, hazard rate estimators, asymptotic multivariate normality.
result Pricing model yields estimates closer to actual cash flows than non-random models.
Harmoniums model multiple time-to-event variables in survival analysis.
problem Survival analysis with multiple, independently censored time-to-event variables and missing observations.
method Energy-based approach with bi-partite structure (harmoniums).
result Harmoniums capture non-linear patterns between time recordings.
Models for predicting the time of a future event are crucial for risk assessment, across a diverse range of applications. Existing time-to-event (survival) models have focused primarily on preserving pairwise ordering of estimated event times, or relative risk. Model calibration is relatively under explored, despite it…
Study examines HTE estimation from time-to-event data with competing events.
problem Estimating HTEs from time-to-event data with competing events.
method Outcome modeling approach using plug-in estimators for potential outcomes.
result Competing events introduce new challenges for HTE estimation.
Proposes a new model for time-to-event prediction with uncertainty quantification.
problem Lack of uncertainty in time-to-event predictions using recurrent neural networks.
method Deep Kernel Accelerated Failure Time models combining RNN and sparse Gaussian Process.
result Model delivers better uncertainty estimates compared to related methods.
Paper compares different models for time-to-event analysis.
problem Comparing models for time-to-event analysis.
method Experimental comparison of semi-parametric, parametric, and machine learning models.
result Models' performance evaluated using concordance index.
The paper proposes a method to identify subgroups with different treatment effects in time-to-event data.
problem Identifying subgroups with differential treatment effects in time-to-event data.
method A mixture model with structured sparsity regularization and novel inference procedure.
result The method effectively recovers sparse phenotypes across real-world clinical studies.
New survival learners estimate heterogeneous treatment effects from time-to-event data.
problem Estimating HTEs from time-to-event data with censoring outcomes.
method Orthogonal survival learners with theoretical guarantees and custom weighting functions.
result Orthogonal survival learners provide robust and model-agnostic HTE estimation.
SurvCORN predicts survival curves using conditional ordinal ranking networks.
problem Challenges in survival analysis with censored data.
method SurvCORN: Conditional Ordinal Ranking Neural Network.
result SurvCORN improves accuracy in predicting time-to-event outcomes.
A new boosting model handles dependent censoring in time-to-event data.
problem Independent censoring assumption leads to biased predictions in time-to-event analysis.
method Clayton-boost, a boosting approach using Clayton copula.
result Clayton-boost outperforms other methods in handling dependent censoring.
Develops a Bayesian method for causal inference with partly censored time-to-event data.
problem Estimating causal effects with unobserved confounders and measurement errors in partly censored time-to-event data.
method Semiparametric Bayesian instrumental variable analysis using a two-stage Dirichlet process mixture model.
result The proposed method outperforms competing methods in simulations and real-world data analysis.
Proposes a deep neural network for predicting clustered time-to-event data.
problem Predicting clustered time-to-event data with subject-specific frailties.
method Deep neural network based gamma frailty model (DNN-FM) trained using negative profiled h-likelihood.
result Enhances prediction performance compared to existing methods.
A new neural network model for predicting event times without distributional assumptions.
problem Predicting event times from censored data with complex assumptions.
method Deep AFT Rank-regression model (DART) using Gehan's rank statistic.
result DART significantly improves performance on various benchmark datasets.
SurvFD and SurvSHAP-IQ provide interpretable survival models by analyzing feature interactions.
problem Non-additivity of hazard and survival functions limits standard additive explanation methods.
method SurvFD decomposes higher-order effects into time-dependent and time-independent components, extending Shapley interactions to time-indexed functions.
result SurvFD and SurvSHAP-IQ offer a new perspective on survival explanations, explicitly characterizing feature interactions.
VSI model predicts survival distributions efficiently.
problem Predicting time-to-event distributions in clinical applications.
method Variational framework for non-parametric distribution estimation.
result Improved performance over competing solutions.
Paper proposes kernelized Stein tests for time-to-event data with censoring.
problem Testing goodness-of-fit for time-to-event data with censoring.
method Combining Stein's method and kernelized discrepancies for non-parametric testing.
result Proposed kernelized Stein discrepancy tests perform better than existing methods.
Proposes isotonic regression for calibrating Deep Cox models' survival probabilities.
problem Poor calibration of Deep Cox models' survival probabilities.
method Isotonic regression for post hoc calibration of Deep Cox models.
result Establishes favorable theoretical guarantees and demonstrates empirical effectiveness.
Bayesian method estimates LTLL distribution parameters for time-to-event data.
problem Parameter estimation for time-to-event data with left truncation.
method Bayesian inference using Metropolis-Hastings algorithm.
result Bayesian estimation provides more stable and reliable parameter estimates.
Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown) subpopulations with diverse risk profiles or survival distributions. As a result, …
Develops a machine learning model to predict ALS progression and assistive device use.
problem Challenges in predicting clinically meaningful milestones in ALS.
method Integrates longitudinal ALSFRS-R trajectories with survival modeling.
result Generates individualized survival curves and predicts wheelchair-free survival.
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
problem Challenges in integrating longitudinal tumor measurements, dropout information, and genetic covariates.
method Extended EB-VAE framework to jointly model longitudinal and time-to-event data, incorporating dropout hazard and genetic covariates.
result Hybrid decoder formulation yields consistent treatment-effect parameters and prior predictive performance comparable to neural decoder.
Discusses handling intercurrent events in clinical trials with time-to-event outcomes.
problem Handling intercurrent events in clinical trials with time-to-event outcomes.
method Defines estimands and six ICE handling strategies, including new competing-risk strategy.
result Novel methods for handling intercurrent events in clinical trials with time-to-event outcomes.
This study evaluates subgroup analysis methods for time-to-event outcomes in randomized controlled trials.
problem Identifying subgroups of good responders in non-significant randomized controlled trials.
method Evaluation of several subgroup analysis algorithms for time-to-event outcomes using synthetic and semi-synthetic data.
result Provides a new synthetic and semi-synthetic data generation process and an open-source Python package for benchmarking.
SurvITE learns treatment effects from time-to-event data, addressing unique challenges.
problem Inferring heterogeneous treatment effects from time-to-event data.
method Proposes a novel deep learning method for treatment-specific hazard estimation.
result Method outperforms baselines by addressing covariate shifts from various sources.
SurvSet offers a repository of 76 T2E datasets for ML benchmarking.
problem Lack of open-source T2E dataset repositories for ML benchmarking.
method Consistent formatting of datasets for various ML algorithms and statistical methods.
result SurvSet provides a comprehensive resource for T2E analysis.
A new machine learning framework simplifies survival analysis.
problem Survival analysis challenges including censoring, truncation, and multiple events.
method Data augmentation to standard Poisson regression, using various machine learning algorithms.
result General machine learning methods can be applied to time-to-event analysis without specific assumptions.
We present a non-parametric prognostic framework for individualized event prediction based on joint modeling of both longitudinal and time-to-event data. Our approach exploits a multivariate Gaussian convolution process (MGCP) to model the evolution of longitudinal signals and a Cox model to map time-to-event data with…
New methods for time-to-event prediction are proposed by extending the Cox proportional hazards model with neural networks. Building on methodology from nested case-control studies, we propose a loss function that scales well to large data sets, and enables fitting of both proportional and non-proportional extensions o…
SurvLatent ODE predicts VTE risk for cancer patients, outperforming current methods.
problem Predicting clinical outcomes from irregularly sampled EHR data with competing events.
method Neural ODE-based Recurrent Neural Networks (ODE-RNN) for flexible survival time estimation.
result SurvLatent ODE outperforms Khorana Risk scores for VTE risk prediction.
Deep learning improves survival analysis for complex data types.
problem Limited application of DL in survival analysis for complex data.
method Comprehensive review of DL methods for time-to-event analysis.
result Methods often ignore complex settings like multiple risks and censoring.
auton-survival simplifies survival analysis for healthcare data.
problem Handling censored time-to-event data in healthcare.
method Open-source package for survival regression, adjustment, counterfactual estimation, phenotyping, and treatment effects.
result Demonstrates auton-survival's ability to support complex health and epidemiological questions.
The Cox proportional hazards model is ubiquitous in the analysis of time-to-event data. However, when the data dimension p is comparable to the sample size N, maximum likelihood estimates for its regression parameters are known to be biased or break down entirely due to overfitting. This prompted the introduction of …
Bayesian VFLMSP improves multimodal survival prediction with privacy.
problem Privacy and reliability in multimodal time-to-event prediction.
method Bayesian Vertical Federated Learning (VFL) with differential privacy.
result Consistent improvements in C-index compared to existing methods.
Proposes efficient estimators for weighted cumulative treatment effects in observational studies.
problem Inconsistent and inefficient estimators due to model misspecification and lack of overlap.
method Double/debiased machine learning for weighted cumulative causal effects.
result Proposed estimators are consistent, asymptotically linear, and reach semiparametric efficiency bounds.
Enhances patient failure prediction using dynamic survival models.
problem Lack of precise individual level prediction in conventional models.
method Developed counterfactual dynamic survival model (CDSM).
result Inflection point of estimated survival curves predicts patient failure time.
MOB-dS uses permutation to correct for dependency in discrete survival data.
problem Identifying subgroups in discrete event time data with potential spurious results.
method Model-based recursive partitioning (MOB) with modified data matrix and permutation test.
result MOB-dS controls type I error rate better than standard MOB for discrete survival data.
Exclusive Lasso improves survival prediction in cancer datasets.
problem Enhanced survival prediction in cancer datasets with high-dimensional genomic and clinical data.
method Proposes Exclusive Lasso regularization for feature selection in Cox regression models for grouped variables.
result Demonstrates improved survival prediction performance using Exclusive Lasso compared to standard Cox regression.
Neural model predicts survival outcomes and reveals feature relationships.
problem Predicting time-to-event outcomes and understanding feature relationships in clinical data.
method Survival and topic modeling combined in a neural network framework.
result Neural survival-supervised topic models achieve competitive accuracy with interpretability.
gOMP algorithm selects features for various types of data.
problem Feature selection for scalable molecular data.
method Generalized Orthogonal Matching Pursuit algorithm for multiple types of data.
result gOMP performs similarly or better than LASSO on various datasets.
The paper benchmarks OS with RCTs, accounting for right-censoring.
problem Benchmarking observational studies with experimental data under censoring.
method Two cases: independent and dependent censoring. Censoring-doubly-robust signal for CATE.
result Effectiveness of censoring-aware tests verified via experiments and real data.
Survival analysis has been developed and applied in the number of areas including manufacturing, finance, economics and healthcare. In healthcare domain, usually clinical data are high-dimensional, sparse and complex and sometimes there exists few amount of time-to-event (labeled) instances. Therefore building an accur…
A new method models individual survival curves using conditional normalizing flows.
problem Precise per-individual predictions in survival analysis.
method Conditional normalizing flows for flexible and individualized survival distributions.
result Efficient estimation of individual survival curves without overfitting.
Enhances survival analysis by separating population behavior from individual dynamics.
problem Improving the training and inference of survival analysis models for sparsely occurring events.
method Decouples survival analysis into an aggregated baseline hazard and independent survival scores.
result Achieves competitive performance and robust results without fine-tuning.
25% of people who received a liver transplant will go on to develop diabetes within the next 5 years. These thousands of individuals are at 2-fold higher risk of cardiovascular events, graft loss, infections, as well as lower long-term survival. This is partly due to the medication used during and/or after transplant t…
Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records (EHRs) provide an alternative to the longitudinal cohort studies traditio…
In epidemiology, identifying the effect of exposure variables in relation to a time-to-event outcome is a classical research area of practical importance. Incorporating propensity score in the Cox regression model, as a measure to control for confounding, has certain advantages when outcome is rare. However, in situati…