A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
Deep generative models have been successfully used to learn representations for high-dimensional discrete spaces by representing discrete objects as sequences and employing powerful sequence-based deep models. Unfortunately, these sequence-based models often produce invalid sequences: sequences which do not represent a…
Deep learning techniques have been hugely successful for traditional supervised and unsupervised machine learning problems. In large part, these techniques solve continuous optimization problems. Recently however, discrete generative deep learning models have been successfully used to efficiently search high-dimensiona…
Statistical machine learning models should be evaluated and validated before putting to work. Conventional k-fold Monte Carlo Cross-Validation (MCCV) procedure uses a pseudo-random sequence to partition instances into k subsets, which usually causes subsampling bias, inflates generalization errors and jeopardizes the r…
We present the Latent Sequence Decompositions (LSD) framework. LSD decomposes sequences with variable lengthed output units as a function of both the input sequence and the output sequence. We present a training algorithm which samples valid extensions and an approximate decoding algorithm. We experiment with the Wall …
As high-throughput biological sequencing becomes faster and cheaper, the need to extract useful information from sequencing becomes ever more paramount, often limited by low-throughput experimental characterizations. For proteins, accurate prediction of their functions directly from their primary amino-acid sequences h…
Segmental structure is a common pattern in many types of sequences such as phrases in human languages. In this paper, we present a probabilistic model for sequences via their segmentations. The probability of a segmented sequence is calculated as the product of the probabilities of all its segments, where each segment …
The worldwide surge of multiresistant microbial strains has propelled the search for alternative treatment options. The study of Protein-Protein Interactions (PPIs) has been a cornerstone in the clarification of complex physiological and pathogenic processes, thus being a priority for the identification of vital compon…
Rapid progress in deep learning has spurred its application to bioinformatics problems including protein structure prediction and design. In classic machine learning problems like computer vision, progress has been driven by standardized data sets that facilitate fair assessment of new methods and lower the barrier to …
Study improves predictive performance testing for high-dimensional data using exhaustive nested cross-validation.
problem Reproducibility issues in K-fold cross-validation for high-dimensional data.
method Proposes a novel predictive performance test based on exhaustive nested cross-validation, addressing computational complexity with a closed-form expression.
result Demonstrates the effectiveness of Ridge-based methods in high-dimensional predictive performance testing.
We present the Insertion Transformer, an iterative, partially autoregressive model for sequence generation based on insertion operations. Unlike typical autoregressive models which rely on a fixed, often left-to-right ordering of the output, our approach accommodates arbitrary orderings by allowing for tokens to be ins…
Representation learning of pedestrian trajectories transforms variable-length timestamp-coordinate tuples of a trajectory into a fixed-length vector representation that summarizes spatiotemporal characteristics. It is a crucial technique to connect feature-based data mining with trajectory data. Trajectory representati…
Generative models have long been the dominant approach for speech recognition. The success of these models however relies on the use of sophisticated recipes and complicated machinery that is not easily accessible to non-practitioners. Recent innovations in Deep Learning have given rise to an alternative - discriminati…
Molecule generation is to design new molecules with specific chemical properties and further to optimize the desired chemical properties. Following previous work, we encode molecules into continuous vectors in the latent space and then decode the vectors into molecules under the variational autoencoder (VAE) framework.…
Magnetic resonance imaging (MRI) is being increasingly utilized to assess, diagnose, and plan treatment for a variety of diseases. The ability to visualize tissue in varied contrasts in the form of MR pulse sequences in a single scan provides valuable insights to physicians, as well as enabling automated systems perfor…
Ozsvath and Szabo have established an algebraic relationship, in the form of a spectral sequence, between the reduced Khovanov homology of (the mirror of) a link L in S^3 and the Heegaard Floer homology of its double-branched cover. This relationship has since been recast by the authors as a specific instance of a broa…
Phylogenetic tree reconstruction is traditionally based on multiple sequence alignments (MSAs) and heavily depends on the validity of this information bottleneck. With increasing sequence divergence, the quality of MSAs decays quickly. Alignment-free methods, on the other hand, are based on abstract string comparisons …
Recurrent Neural Networks (RNNs) have been proven to be effective in modeling sequential data and they have been applied to boost a variety of tasks such as document classification, speech recognition and machine translation. Most of existing RNN models have been designed for sequences assumed to be identically and ind…