We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists. Our algorithm, CheXNet, is a 121-layer convolutional neural network trained on ChestX-ray14, currently the largest publicly available chest X-ray dataset, containing over 100,000 frontal-view X-ray images w…
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Radiologist-level Performance by Using Deep Learning for Segmentation of Breast Cancers on MRI Scanscs.LG
Deep learning network matches radiologists in breast cancer segmentation.
problem Automating radiologist-level cancer segmentation from breast MRI.
method 3D U-Net architecture trained on 382,290 breast scans, compared to 255,500 benign cases.
result Network performance matched radiologists' on 2D segmentation of breast cancers.
We describe a deep learning approach for automated brain hemorrhage detection from computed tomography (CT) scans. Our model emulates the procedure followed by radiologists to analyse a 3D CT scan in real-world. Similar to radiologists, the model sifts through 2D cross-sectional slices while paying close attention to p…
Neural network improves aneurysm classification accuracy in MRI images.
problem Classifying aneurysm status in MRI images with varying radiologist expertise.
method Constructed neural network trained on radiologists' annotations, compared to a control model.
result Proposed model had a higher area under the curve (0.845 vs. 0.793).
With an aging and growing population, the number of women requiring either screening or symptomatic mammograms is increasing. To reduce the number of mammograms that need to be read by a radiologist while keeping the diagnostic accuracy the same or better than current clinical practice, we develop Man and Machine Mammo…
The chest X-ray (CXR) is by far the most commonly performed radiological examination for screening and diagnosis of many cardiac and pulmonary diseases. There is an immense world-wide shortage of physicians capable of providing rapid and accurate interpretation of this study. A radiologist-driven analysis of over two m…
Nodule2vec: a 3D Deep Learning System for Pulmonary Nodule Retrieval Using Semantic Representationcs.IR
System converts 3D lung nodule images into embeddings for retrieval.
problem Retrieving similar 3D lung nodule images for radiologist decision support.
method 3D deep learning, semantic representation, transfer learning, similarity score.
result System can measure similarity between nodule annotations and CBIR results.
Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a syst…
We present a deep convolutional neural network for breast cancer screening exam classification, trained and evaluated on over 200,000 exams (over 1,000,000 images). Our network achieves an AUC of 0.895 in predicting whether there is a cancer in the breast, when tested on the screening population. We attribute the high …
We developed an automated deep learning system to detect hip fractures from frontal pelvic x-rays, an important and common radiological task. Our system was trained on a decade of clinical x-rays (~53,000 studies) and can be applied to clinical data, automatically excluding inappropriate and technically unsatisfactory …
Models extract relevant EHR snippets to aid radiologists in diagnosis.
problem Difficulty in identifying relevant patient record information for diagnosis.
method Distantly supervised transformer-based neural model for extractive summarization.
result Models yield better extractive summaries than unsupervised approaches.
A new COVID-19 CT dataset helps develop AI diagnosis models.
problem Lack of publicly available COVID-19 CT datasets due to privacy issues.
method Built an open-sourced COVID-CT dataset and developed AI diagnosis methods.
result Developed AI diagnosis models achieving high accuracy and performance.
Radiologists typically compare a patient's most recent breast cancer screening exam to their previous ones in making informed diagnoses. To reflect this practice, we propose new neural network models that compare pairs of screening mammograms from the same patient. We train and evaluate our proposed models on over 665,…
High predictive performance and ease of use and interpretability are important requirements for the applicability of a computer-aided diagnosis (CAD) to human reading studies. We propose a CAD system specifically designed to be more comprehensible to the radiologist reviewing screening breast MRI studies. Multiparametr…
Convolutional neural network based systems have largely failed to be adopted in many high-risk application areas, including healthcare, military, security, transportation, finance, and legal, due to their highly uninterpretable "black-box" nature. Towards solving this deficiency, we teach a novel multi-task capsule net…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degener…
A new metric FRD improves comparing medical images.
problem Comparing medical images for distribution or domain differences.
method Developed a new metric FRD using standardized radiomic features.
result FRD outperforms other metrics in various medical imaging applications.
Improved AI lung ultrasound segmentation using expert confidence values.
problem Label uncertainty in lung ultrasound due to subjective interpretation by radiologists.
method Designing a data annotation protocol capturing expert confidence, training AI on binarized labels with confidence thresholds.
result Improved AI segmentation and better clinical outcomes (e.g., S/F oxygenation ratio estimation, patient readmission prediction).
GraphXCOVID uses deep semi-supervised learning to identify COVID-19 from chest X-rays with minimal labels.
problem Identifying COVID-19 on chest X-rays with limited labelled data.
method Graph-based deep semi-supervised framework with pseudo-labeling and attention maps.
result Outperforms current supervised models with a tiny fraction of labelled examples.
New method removes MRI banding without post-processing.
problem MRI banding in reconstructed images.
method Adversarial training to penalize banding structures.
result Superior banding removal compared to baseline.
In this work we propose a method for anatomical data augmentation that is based on using slices of computed tomography (CT) examinations that are adjacent to labeled slices as another resource of labeled data for training the network. The extended labeled data is used to train a U-net network for a pixel-wise classific…
Early detection of breast cancer can increase treatment efficiency. Architectural Distortion (AD) is a very subtle contraction of the breast tissue and may represent the earliest sign of cancer. Since it is very likely to be unnoticed by radiologists, several approaches have been proposed over the years but none using …
CoroNet: A deep neural network for detection and diagnosis of COVID-19 from chest x-ray imageseess.IV
CoroNet detects COVID-19 from chest X-rays with high accuracy.
problem Detecting COVID-19 from chest X-rays using limited testing kits.
method Proposes CoroNet, a deep neural network based on Xception architecture trained on a combined dataset of COVID-19 and pneumonia X-rays.
result CoroNet achieved an overall accuracy of 89.6% and precision/recall rates of 93%/98.2% for 4-class cases (COVID vs Pneumonia bacterial vs pneumonia viral vs normal).
Deep learning models designed for visual classification tasks on natural images have become prevalent in medical image analysis. However, medical images differ from typical natural images in many ways, such as significantly higher resolutions and smaller regions of interest. Moreover, both the global structure and loca…
Lung cancer is one of the death threatening diseases among human beings. Early and accurate detection of lung cancer can increase the survival rate from lung cancer. Computed Tomography (CT) images are commonly used for detecting the lung cancer.Using a data set of thousands of high-resolution lung scans collected from…
Incorporating human domain knowledge for breast tumor diagnosis is challenging, since shape, boundary, curvature, intensity, or other common medical priors vary significantly across patients and cannot be employed. This work proposes a new approach for integrating visual saliency into a deep learning model for breast t…
An assumption-free automatic check of medical images for potentially overseen anomalies would be a valuable assistance for a radiologist. Deep learning and especially Variational Auto-Encoders (VAEs) have shown great potential in the unsupervised learning of data distributions. In principle, this allows for such a chec…
Deep Learning with Permutation-invariant Operator for Multi-instance Histopathology Classificationcs.LG
The computer-aided analysis of medical scans is a longstanding goal in the medical imaging field. Currently, deep learning has became a dominant methodology for supporting pathologists and radiologist. Deep learning algorithms have been successfully applied to digital pathology and radiology, nevertheless, there are st…
Deep learning improves MRI analysis of MSK disorders.
problem Accurate and rapid analysis of musculoskeletal disorders from MRI scans.
method Convolutional neural networks (CNN) for automatic classification of knee abnormalities.
result Multi-view deep learning showed promising performance in classifying MSK abnormalities.
Decision support tools that rely on supervised learning require large amounts of expert annotations. Using past radiological reports obtained from hospital archiving systems has many advantages as training data above manual single-class labels: they are expert annotations available in large quantities, covering a popul…
New method learns to encode predictions within interpretations, improving evaluation.
problem Need for interpretable machine learning, but existing methods are slow or lack fidelity.
method Amortized explanation methods that learn a global selector model optimizing fidelity of interpretations.
result Predictions can be encoded within interpretations, detected by EVAL-X.
Infrastructure monitors AI/ML radiology models across multiple sites.
problem Monitoring and improving AI/ML radiology models across multiple sites.
method Interactive radiology reporting, centralized cloud system, post-marketing surveillance.
result Efficient monitoring and iterative development of AI/ML models without radiologist burden.
AVRA: Automatic Visual Ratings of Atrophy from MRI images using Recurrent Convolutional Neural Networksphysics.med-ph
Quantifying the degree of atrophy is done clinically by neuroradiologists following established visual rating scales. For these assessments to be reliable the rater requires substantial training and experience, and even then the rating agreement between two radiologists is not perfect. We have developed a model we call…
Creating large scale high-quality annotations is a known challenge in medical imaging. In this work, based on the CycleGAN algorithm, we propose leveraging annotations from one modality to be useful in other modalities. More specifically, the proposed algorithm creates highly realistic synthetic CT images (SynCT) from …
Data is one of the essential ingredients to power deep learning research. Small datasets, especially specific to medical institutes, bring challenges to deep learning training stage. This work aims to develop a practical deep multimodal that can classify patients into abnormal and normal categories accurately as well a…
Challenge aims to develop automated meningioma MRI segmentation models.
problem Lack of automated, objective tools for meningioma assessment.
method Develop and evaluate models on largest annotated dataset.
result Improved care of patients with meningioma through automated segmentation.
The paper introduces sanity tests to detect spurious correlations in AI-guided radiology systems.
problem Detecting when AI systems perform well on development data for the wrong reasons.
method Design and implementation of sanity tests to identify spurious correlations.
result Sanity tests can identify spurious correlations in AI-guided radiology systems.
Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas…
Estimating Uncertainty and Interpretability in Deep Learning for Coronavirus (COVID-19) Detectioneess.IV
Bayesian CNN estimates uncertainty in COVID-19 detection.
problem Uncertainty in deep learning predictions for medical diagnosis.
method Drop-weight based Bayesian Convolutional Neural Networks (BCNN).
result Uncertainty correlates with prediction accuracy.
Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational formulation of black-box interpretation, general interpretability research rely hea…
Computer aided diagnostic (CAD) system is crucial for modern med-ical imaging. But almost all CAD systems operate on reconstructed images, which were optimized for radiologists. Computer vision can capture features that is subtle to human observers, so it is desirable to design a CAD system op-erating on the raw data. …
Study uses machine learning to detect early COVID-19 from CT images.
problem Early detection of COVID-19 from CT images.
method Machine learning methods applied to patches of CT images, feature extraction (GLCM, LDP, GLRLM, GLSZM, DWT), SVM classification.
result Best classification accuracy of 99.68% with 10-fold cross-validation and GLSZM feature extraction.
Breast cancer is the most common cancer and is the leading cause of cancer death among women worldwide. Detection of breast cancer, while it is still small and confined to the breast, provides the best chance of effective treatment. Computer Aided Detection (CAD) systems that detect cancer from mammograms will help in …
Purpose: Lung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to analyze the shape and size of a nodule using a global feature extractor, as well as …
Six AI solutions accurately detect growth plate planes in mice bone scans.
problem Manual, time-consuming, and variable bone growth plate detection in micro-CT scans.
method Prepared and annotated a dataset of 3D μCT scans, organized a challenge, and developed six computer vision solutions.
result Achieved mean absolute error of 1.91±0.87 planes from ground truth.
Deep learning methods, and in particular convolutional neural networks (CNNs), have led to an enormous breakthrough in a wide range of computer vision tasks, primarily by using large-scale annotated datasets. However, obtaining such datasets in the medical domain remains a challenge. In this paper, we present methods f…
Using a Generative Adversarial Network for CT Normalization and its Impact on Radiomic Featureseess.IV
GAN normalizes CT scans for consistent radiomic feature values.
problem Variations in dose levels and slice thickness affect radiomic features sensitivity.
method Used a 3D generative adversarial network (GAN) to normalize reduced dose, thick slice images to normal dose, thinner slice images.
result GAN-based approach led to significantly smaller error in radiomic features.
Quantitative CT predicts ILD patterns and prognosis.
problem Diagnosing and predicting prognosis of fibrosing ILD patterns.
method High-resolution CT texture features, TM model for classification and survival analysis.
result TM model outperforms histogram-based model in distinguishing UIP from non-UIP patterns and allows for survival group partitioning.