Study uses Thompson Sampling to find optimal drug dosages in clinical trials.
problem Finding the best drug dosage in early-stage clinical trials.
method Adopted Thompson Sampling for dose-finding clinical trials, considering different monotonicity assumptions.
result Thompson Sampling variants outperform existing methods in various dose-finding scenarios.
The paper explores using historical data to improve clinical trial analysis by optimizing covariate weights.
problem Limited covariates in small clinical trials reduce the effectiveness of analysis.
method Leverage historical data to pre-specify covariate weights as a composite covariate.
result A composite covariate improves the cost/benefit ratio and reduces overfitting in small clinical trials.
Enhances clinical trial predictions by quantifying uncertainty.
problem Uncertainty in medical diagnosis and drug discovery predictions.
method Selective classification integrated with Hierarchical Interaction Network (HINT).
result Significant improvement in PR-AUC, F1, ROC-AUC, and overall accuracy.
A novel dose-finding design for cancer clinical trials using level set estimation.
problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.
Generative AI models improve clinical trial data by generating survival outcomes.
problem Generating valid survival outcomes for clinical trials with synthetic data.
method A variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes.
result The method outperforms GAN baselines on fidelity, utility, and privacy metrics.
Shared Keyboard design improves phase I clinical trials by borrowing information across doses.
problem Interim decisions based on current dose data may overlook signals from neighboring doses.
method Bayesian model-assisted design using Beta kernel process with kernel-weighted pseudo-counts.
result Significant improvements in identifying maximum tolerated dose and safety.
Bayesian optimisation outperforms standard ML-II in small samples.
problem Standard ML-II fails in small-sample trials.
method Adopting fully Bayesian optimisation (FBO) as an alternative.
result FBO is more robust and practical than ML-II.
WHOMP optimizes randomized controlled trials by minimizing subgroup bias.
problem Minimizing subgroup bias in randomized controlled trials.
method Wasserstein Homogeneity Partition (WHOMP) method.
result WHOMP optimally minimizes type I and type II errors in trials.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
Syntax designs adaptive trials for subpopulations with potential benefits.
problem Identifying subpopulations with positive treatment effects in diverse patient populations.
method Adaptive patient recruitment and synthetic control estimation.
result Syntax outperforms conventional trial designs in identifying beneficial subpopulations.
MILCCI integrates labels across categories for better understanding of multi-trial data.
problem Understanding how labels encode multi-trial observations and disentangling their effects.
method Sparse per-trial decomposition leveraging label similarities within each category.
result MILCCI identifies interpretable components and integrates label information.
New framework for adaptive clinical trials to address real-world challenges.
problem Real-world challenges in post-regulatory clinical trials.
method RFAN framework integrating regulatory constraints and treatment policy value.
result Empirical evaluation of RFAN's performance.
Machine learning boosts RCT efficiency by controlling type I error and improving statistical power.
problem Improving statistical efficiency in RCTs with complex covariate adjustments.
method Machine learning-assisted adjustment under Rosenbaum's framework for exact tests.
result The proposed method robustly controls type I error and significantly boosts statistical efficiency.
Study adaptive clinical trial methods for identifying patient subpopulations with treatment benefit.
problem Adaptive identification of patient subpopulations with treatment benefit in clinical trials.
method Proposes AdaGGI and AdaGCPI meta-algorithms for subpopulation construction.
result Empirical investigation of AdaGGI and AdaGCPI performance across various simulation scenarios.
This study analyzes VAEs using ID and II, revealing a transition in behaviour and distinct training phases.
problem Understanding the hidden representations and training phases of VAEs.
method Analysis using Intrinsic Dimension (ID) and Information Imbalance (II).
result VAEs exhibit a transition in behaviour and distinct training phases when the bottleneck size exceeds the Intrinsic Dimension of the data.
New method uses latent variables to estimate treatment effects from single-arm trials.
problem Estimating treatment effects from single-arm trials due to lack of external control groups.
method Latent-variable modeling with amortized variational inference for patient matching and direct effect estimation.
result Improved performance in direct treatment effect estimation and effect estimation via patient matching compared to previous methods.
SDF-Bayes finds safe drug combinations safely, balancing optimism and caution.
problem Finding safe drug combinations in clinical trials with multiple drugs and patient heterogeneity.
method SDF-Bayes uses Bayesian statistics to choose the most likely MTD while ensuring safety constraints.
result SDF-Bayes outperforms existing methods in both accuracy and safety for drug combination trials.
Hypothesis testing is an important problem with applications in target localization, clinical trials etc. Many active hypothesis testing strategies operate in two phases: an exploration phase and a verification phase. In the exploration phase, selection of experiments is such that a moderate level of confidence on the …
Torus graphs analyze multivariate phase coupling among brain signals.
problem Identifying coordinated phase changes across multiple brain regions.
method Torus graphs based on full exponential family with pairwise interactions.
result Torus graphs accurately identify conditional associations in multivariate phase data.
Dictionary Learning has proven to be a powerful tool for many image processing tasks, where atoms are typically defined on small image patches. As a drawback, the dictionary only encodes basic structures. In addition, this approach treats patches of different locations in one single set, which means a loss of informati…
Mild cognitive impairment (MCI) is a prodromal phase in the progression from normal aging to dementia, especially Alzheimers disease. Even though there is mild cognitive decline in MCI patients, they have normal overall cognition and thus is challenging to distinguish from normal aging. Using transcribed data obtained …
Optimizes antenna settings in heterogeneous cellular networks using RL.
problem Complex interactions between cells cause optimization challenges.
method Two-step approach: offline multi-agent mean field RL, online single-agent deep RL.
result Approaches multi-agent RL performance with fewer trials.
An app-based mHealth intervention uses reinforcement learning to send effective reminder notifications.
problem Designing an effective reinforcement learning algorithm for app-based mHealth interventions.
method Developed a reinforcement learning algorithm to send reminder notifications based on participant likelihood of app engagement.
result The algorithm improved app-based mHealth interventions by reducing participant burden and promoting behavior change.
This paper proposes a stochastic model using the concept of Markov chains for the inter-state transitions of the millisecond order quasi-stable phase synchronized patterns or synchrostates, found in multi-channel Electroencephalogram (EEG) signals. First and second order transition probability matrices are estimated fo…
RIF prioritizes predictive biomarkers for precision medicine.
problem Lack of tools to select and prioritize predictive biomarkers.
method Random Interaction Forest (RIF) method.
result RIF outperformed conventional methods in various simulation scenarios and clinical trials.
Randomized Controlled Trials (RCTs) are the gold standard for comparing the effectiveness of a new treatment to the current one (the control). Most RCTs allocate the patients to the treatment group and the control group by uniform randomization. We show that this procedure can be highly sub-optimal (in terms of learnin…
FRESH combines patient-level and aggregate-level data for better clinical decision making.
problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.
The change of two orders of magnitude in the 'new DCF' of NIST's SRE'10, relative to the 'old DCF' evaluation criterion, posed a difficult challenge for participants and evaluator alike. Initially, participants were at a loss as to how to calibrate their systems, while the evaluator underestimated the required number o…
We analyze the sample complexity of the thresholding bandit problem, with and without the assumption that the mean values of the arms are increasing. In each case, we provide a lower bound valid for any risk δ and any δ-correct algorithm; in addition, we propose an algorithm whose sample complexity is of the same o…
Stochastic Gradient Descent phases explained for deep networks.
problem Understanding the different regimes of SGD in deep learning.
method Teacher-student perceptron model, phase diagram analysis.
result SGD phases separated by batch size B∗, scaling with training set size P. The consistency of doubly robust estimators relies on consistent estimation of at least one of two nuisance regression parameters. In moderate to large dimensions, the use of flexible data-adaptive regression estimators may aid in achieving this consistency. However, n1/2-consistency of doubly robust estimators is…
New approach connects quantum phases to VQA trainability, enabling better scaling.
problem Scalability issues in VQAs, especially barren plateaus.
method Analog VQA ansätze composed of quenches of a disordered Ising chain, tuning disorder strength.
result Thermalized and MBL phases reach maximal expressivity at large M, but barren plateaus emerge at smaller M in the thermalized phase. In this paper, we propose exact passive-aggressive (PA) online algorithms for learning to rank. The proposed algorithms can be used even when we have interval labels instead of actual labels for examples. The proposed algorithms solve a convex optimization problem at every trial. We find exact solution to those optimiz…
Machine learning predicts patient recruitment for clinical trials.
problem Improving patient recruitment prediction for clinical trials.
method Machine learning methods applied to historical clinical trial data.
result Reduced prediction error compared to current industry standards.
We find optimal learning rate schedules for a random feature model.
problem Choosing optimal learning rates for deep learning models.
method We analyze a powerlaw random feature model trained with SGD, considering optimal schedules as numerical and analytical problems.
result We discover two regimes: easy and hard phases, with different optimal learning rate schedules.
Study shows how anisotropic data affects learning dynamics in phase retrieval.
problem Understanding learning dynamics in phase retrieval with anisotropic Gaussian inputs.
method Developed a tractable reduction to reveal a three-phase trajectory and derived scaling laws.
result Found that anisotropy leads to a three-phase trajectory: fast escape, slow convergence, and spectral-tail learning.
We identify the leading order term of the asymptotic expansion of the Witten-Reshetikhin-Turaev invariants for finite order mapping tori with classical invariants for all simple and simply-connected compact Lie groups. The square root of the Reidemeister torsion is used as a density on the moduli space of flat connecti…
Doctor2Vec learns doctor representations from EHRs for better clinical trial recruitment.
problem Identifying the right doctors for clinical trials based on EHR data and trial descriptions.
method Dynamic Memory Network with attention mechanism to learn doctor and trial representations.
result Improved performance by up to 8.7% in PR-AUC on real-world trials and EHR data.
Combines trial and observational data to improve policy evaluation.
problem External validity of randomized trial results in target populations.
method Uses covariate data to model trial sampling and certifies policy evaluations.
result Valid trial-based policy evaluations under model miscalibration.
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
The paper compares methods for estimating heterogeneous treatment effects using multiple randomized trials.
problem Estimating heterogeneous treatment effects reliably and precisely with a single dataset is challenging.
method Non-parametric approaches for estimating heterogeneous treatment effects using data from multiple trials.
result Methods that directly allow for heterogeneity of the treatment effect across trials perform better than those that do not.
C3T-Budget optimizes drug efficacy in dose-finding trials with budget and safety constraints.
problem Heterogeneous patient populations and budget constraints make dose-finding clinical trials challenging.
method Contextual constrained clinical trial algorithm that maximizes drug efficacy while learning subgroup responses.
result Demonstrates efficient budget usage and balanced learning-treatment trade-off in simulated trials.
New study shows non-adaptive trials can be outperformed by adaptive designs in treatment selection.
problem Determining the best allocation of resources in clinical trials.
method Analysis of batched arm elimination designs and comparison with completely randomized trials.
result Simple adaptive designs universally and strictly dominate non-adaptive completely randomized trials for at least three treatment arms.
New method detects biomarker-treatment interactions in clinical trials.
problem Detecting interactions between high-dimensional biomarkers and treatments in randomized trials.
method Two-stage penalized regression screening using ridge regression for multivariate screening.
result Ridge regression screening provides greater power than traditional methods in correlated data.
The personalization of treatment via bio-markers and other risk categories has drawn increasing interest among clinical scientists. Personalized treatment strategies can be learned using data from clinical trials, but such trials are very costly to run. This paper explores the use of active learning techniques to desig…
Estimates vaccine effectiveness and immune correlates in TND studies with missing data.
problem Confounding and missing data in TND studies of vaccine effectiveness and immune correlates.
method Targeted maximum likelihood estimation using a semiparametric logistic regression model.
result Valid causal inference of vaccine effectiveness and immune correlates in TND studies with missing exposure data.
QR-learner estimates individual treatment effects using external data.
problem Limited power to detect individual treatment effects in randomized trials.
method Model-agnostic learner that estimates conditional average treatment effects (CATE) using external data.
result QR-learner reduces mean squared error and can recover true CATE.
Bayesian BIC for multi-trial data improves VAR model order selection.
problem Optimal VAR model order selection for multi-trial event-based data.
method Derive and apply Bayesian Information Criterion (BIC) for multi-trial ensemble data.
result Multi-trial BIC successfully recovers real model order and estimates small model order.