Proposes a method to create fair ITRs that balance value and fairness.
problem Fairness issues in ITRs that can lead to unfair advantages or disadvantages.
method Optimal transport theory to transform optimal ITRs into fair ITRs.
result Established a theoretical upper bound on value loss for improved trade-off ITRs.
The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space…
Paper proposes a new framework for individualized treatment rules that generalize better across different distributions.
problem Existing individualized treatment rules may not generalize well when training and testing distributions differ.
method Distributionally robust individualized treatment rules (DR-ITR) framework that maximizes worst-case value function across close distributions.
result Calibrated DR-ITR outperforms standard ITR in generalizability.
New method estimates optimal personalized treatment rules from mixed data sources.
problem Combining RCT and observational data for personalized treatment rules.
method Doubly robust estimator for value function, maximizing within pre-specified ITR class.
result Consistent and asymptotically normal optimal value estimator with N−1/3 rate of convergence. Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
LI-ITR combines flexible ML with interpretable approximations for personalized treatment rules.
problem Combining flexibility and interpretability in personalized treatment rules.
method Uses variational autoencoders and a mixture of interpretable experts.
result Accurately recovers true local coefficients and optimal treatment strategies.
Proposes robust ITRs integrating multiple datasets to handle posterior shift.
problem Posterior shift in conditional outcome distributions between source and target populations.
method Distributionally robust approach with closed-form solution and adaptive uncertainty tuning.
result Achieves superior performance compared to existing methods in simulations and real-data applications.
Develops a weighting framework to generalize ITRs from source to target populations.
problem Challenges in generalizing ITRs from a source population to a target population with differing characteristics.
method A robust sample weighting framework using a reproducing kernel Hilbert space to balance covariates and improve ITR learning methods.
result Improves ITR estimation for the target population compared to other weighting methods.
Develops methods for near-optimal personalized treatment recommendations.
problem Assigning optimal treatments to patients based on individual characteristics.
method Outcome weighted learning framework to estimate near-optimal alternative individualized treatment recommendations (A-ITR).
result Consistency of proposed methods and upper bound for risk between optimal and estimated recommendations.
In this work, a classification method for SSVEP-based BCI is proposed. The classification method uses features extracted by traditional SSVEP-based BCI methods and finds optimal discrimination thresholds for each feature to classify the targets. Optimising the thresholds is formalised as a maximisation task of a perfor…
A new method improves efficiency in finding optimal personalized treatment rules.
problem Heteroscedasticity and misspecified treatment-free effect models affect optimal ITR estimation.
method E-Learning framework that accounts for covariate-treatment dependent variance of residuals.
result E-Learning framework improves efficiency of optimal ITR estimation.
The paper develops a method to optimize individualized treatment rules for cost-effectiveness.
problem Developing cost-effective individualized treatment rules for healthcare policy.
method Using conditional random forest and net-monetary-benefit (NMB) to estimate optimal CE-ITR.
result The approach optimizes healthcare resource allocation by maximizing health gains and minimizing costs.
The field of precision medicine aims to tailor treatment based on patient-specific factors in a reproducible way. To this end, estimating an optimal individualized treatment regime (ITR) that recommends treatment decisions based on patient characteristics to maximize the mean of a pre-specified outcome is of particular…
Meta-analysis improves personalized treatment rules across multiple sites.
problem Lack of generalizability in learning individualized treatment rules across different medical sites.
method Developed a method for individual-level meta-analysis of ITRs, borrowing sign-coherency information between sites.
result Jointly learned site-specific ITRs with improved generalizability.
PROWL uses robust reward estimates to improve ITR selection.
problem Reward uncertainty in ITR estimation leads to inflated performance.
method PAC-Bayesian framework with reward uncertainty certificates.
result PROWL achieves better robust treatment regime estimation.
Develops methods for personalized treatment decisions in the presence of unmeasured factors.
problem Personalized treatment decisions in the presence of unmeasured confounding.
method Proximal learning approaches to estimate optimal individualized treatment regimes (ITRs).
result Established identification results for different classes of ITRs, improving decision-making value function.
Neyman's framework evaluates personalized treatment rules using experiments.
problem Evaluating the efficacy of individualized treatment rules derived by machine learning.
method Neyman's repeated sampling framework applied to cross-fitted ITRs.
result Ex-post evaluation of ITRs can be more efficient than random assignment.
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
The increasing availability of individual-level data has led to numerous applications of individualized (or personalized) treatment rules (ITRs). Policy makers often wish to empirically evaluate ITRs and compare their relative performance before implementing them in a target population. We propose a new evaluation metr…
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
Proposes a method to estimate personalized treatments from high-dimensional data.
problem Estimating individualized treatment regimes (ITRs) from high-dimensional covariates.
method Directly targets the contrast between potential outcomes, using dimension-reduced outcome-weighted learning.
result Achieves universal consistency, converging to the Bayes risk under mild conditions.
Differentially private method for estimating individualized treatment rules.
problem Estimating individualized treatment rules while preserving privacy.
method Differentially private two-stage empirical risk minimization (DP-2ERM).
result Improved privacy-utility trade-off demonstrated through simulations and applications.
We study the problem of estimating the continuous response over time to interventions using observational time series---a retrospective dataset where the policy by which the data are generated is unknown to the learner. We are motivated by applications where response varies by individuals and therefore, estimating resp…
This paper forecasts renewable energy prospects in South America through cross-border interconnection.
problem Lack of renewable energy integration across South American countries.
method Long-term scenario forecasting methodology applied to raw data from typical countries.
result Promoting cross-border interconnection towards renewables can optimize energy supply, reduce costs, and balance the energy matrix.
We provide additional statistical background for the methodology developed in the clinical analysis of knee osteoarthritis in "A Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight Loss Treatments for Overweight and Obese Adults with Knee Osteoarthritis" (Jiang et al. 2020). Jiang…
Steady-state visual evoked potentials (SSVEP) brain-computer interface (BCI) provides reliable responses leading to high accuracy and information throughput. But achieving high accuracy typically requires a relatively long time window of one second or more. Various methods were proposed to improve sub-second response a…
Bayesian optimization reduces computational effort in aircraft design optimization.
problem High computational cost in industrial aircraft design optimization.
method Constrained Bayesian optimization (Super Efficient Global Optimization with Mixture of Experts)
result Significant computational efficiency improvements over existing Isight optimizers.
Bayesian optimization method tackles combinatorial spaces, scalable for large data.
problem Optimization over combinatorial categorical spaces in natural sciences.
method Combines variational optimization and continuous relaxations for gradient-based optimization.
result Method performs comparably to state-of-the-art methods while scaling well.
New algorithm solves complex stopping problems with robust optimization.
problem Solving complex stochastic optimal stopping problems.
method Simulation-based robust optimization with exact reformulation as a zero-one bilinear program.
result Developed polynomial-time heuristics and algorithms for practical solution.
L2O uses ML to optimize traditional optimization techniques.
problem Real-world optimization problems with shared structures.
method Exploiting shared structures to enhance optimization techniques.
result Better or faster solutions through machine learning integration.
When hyperparameter optimization of a machine learning algorithm is repeated for multiple datasets it is possible to transfer knowledge to an optimization run on a new dataset. We develop a new hyperparameter-free ensemble model for Bayesian optimization that is a generalization of two existing transfer learning extens…
Meta algorithm solves multivariate optimization using univariate optimizers.
problem Multivariate global optimization problems.
method Meta algorithm combining univariate global optimizers.
result Meta algorithm provides robust regret guarantees.
A novel neural network approach for optimization problems.
problem Constrained optimization problems.
method Neural Optimization Machine (NOM) using a specially designed NN architecture and training procedure.
result Solves optimization problems efficiently, especially in high-dimensional spaces.
New algorithms ensure reproducibility and optimal convergence in convex optimization.
problem Trade-off between reproducibility and convergence rate in convex optimization.
method Regularization-based algorithms for smooth convex minimization and minimax optimization.
result Achieves optimal reproducibility and near-optimal gradient complexity for various oracle settings.
New algorithm selects robust martingale for optimal stopping problems.
problem Optimal stopping problems in stochastic processes.
method Randomized dual martingale minimization algorithm.
result Efficiently selects Doob martingale as close as possible.
Numerical optimization is an important tool in the field of computational physics in general and in nano-optics in specific. It has attracted attention with the increase in complexity of structures that can be realized with nowadays nano-fabrication technologies for which a rational design is no longer feasible. Also, …
This paper shows how to combine optimal tests into log-optimal processes.
problem How to combine optimal sequential tests into log-optimal processes.
method Using a new class of WAIT e-processes, the paper aggregates asymptotically optimal sequential tests into asymptotically log-optimal processes.
result It is possible to aggregate asymptotically optimal sequential tests into asymptotically log-optimal e-processes.
Learning optimal feedback control laws capable of executing optimal trajectories is essential for many robotic applications. Such policies can be learned using reinforcement learning or planned using optimal control. While reinforcement learning is sample inefficient, optimal control only plans an optimal trajectory fr…
Paper studies optimal control for a specific geometric problem.
problem Optimal control problem associated with the Paneitz obstacle problem.
method Existence and regularity results for optimal controls.
result Existence of optimal controls and their properties.
New algorithm AG-OG optimizes separable convex-concave problems efficiently.
problem Efficiently solving separable convex-concave minimax optimization problems.
method Leverages Nesterov acceleration and optimistic gradient on component and coupling parts of the problem.
result Achieves optimal convergence rate for various settings including bilinearly coupled problems.
Adapts Bayesian optimization for mixed constraints in aircraft design.
problem Optimizing expensive black box functions with mixed constraints.
method Super efficient global optimization with upper trust bound for constraints, Gaussian process uncertainty, refinement procedure.
result Superior performance on aircraft design problem compared to state-of-the-art solvers.
Adam optimizer converges to zeros of a new vector field, not just gradient zeros.
problem Prove convergence rates for Adam optimizer in simple quadratic optimization problems.
method Introduced Adam vector field to analyze Adam optimizer's convergence.
result Established optimal convergence rates for Adam optimizer.
Optimal crypto asset routing with CFMMs, including fixed costs.
problem Optimizing order execution on a network of CFMMs with fixed costs.
method Convex optimization for no fixed costs, mixed-integer convex for fixed costs, heuristics for approximate solutions.
result Approximate solutions to optimal routing and arbitrage certification problems.
BOSH optimizes functions with stochastic evaluations more efficiently and precisely.
problem Optimizing functions with noisy evaluations can lead to suboptimal solutions.
method BOSH uses a hierarchical Gaussian process to generate a growing pool of realizations.
result BOSH provides more efficient and higher-precision optimization than standard BO.
VeLO learns versatile optimizers from deep learning tasks.
problem Training deep learning models with hand-designed optimizers.
method Meta-training a neural network optimizer on a wide variety of optimization tasks.
result The learned optimizer automatically adapts to different optimization tasks without hyperparameter tuning.
New learned optimizers outperform baselines by incorporating known and novel mechanisms.
problem Understanding how learned optimizers outperform traditional ones.
method Careful analysis and visualization of learned optimizers trained on various tasks.
result Learned optimizers incorporate known techniques like momentum and gradient clipping, as well as new forms of learning rate adaptation.
PAGE optimizes nonconvex problems with optimal convergence rates.
problem Nonconvex optimization problems.
method PAGE algorithm for achieving optimal convergence rates.
result PAGE achieves optimal convergence rates for nonconvex optimization.
A new method learns DAGs from data using permutation optimization.
problem Discovering latent DAGs from observational data.
method Optimizes over the Permutahedron to learn topological orderings and edges.
result Our method optimizes exact DAGs, is modular, and performs well on real-world data.