A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
CRBM generates digital twins for MS patients, aiding in disease progression analysis.
In this work, we present a comparison of a shallow and a deep learning architecture for the automated segmentation of white matter lesions in MR images of multiple sclerosis patients. In particular, we train and test both methods on early stage disease patients, to verify their performance in challenging conditions, mo…
Multiple Sclerosis is a degenerative condition of the central nervous system that affects nearly 2.5 million of individuals in terms of their physical, cognitive, psychological and social capabilities. Researchers are currently investigating on the use of patient reported outcome measures for the assessment of impact a…
Model uses smartphone data to assess MS trajectories.
Automated detection of MS lesions improves to 67% with 7T MRI.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as registration, individual longitudinal measurements and tissue segmentation for brain v…
Multiple sclerosis (MS) affects the central nervous system with a wide range of symptoms. MS can, for example, cause pain, changes in mood and fatigue, and may impair a person's movement, speech and visual functions. Diagnosis of MS typically involves a combination of complex clinical assessments and tests to rule out …
Enhancing spectral embedding for low-dimensional embeddings in rare disease cohorts
In machine learning, novelty detection is the task of identifying novel unseen data. During training, only samples from the normal class are available. Test samples are classified as normal or abnormal by assignment of a novelty score. Here we propose novelty detection methods based on training variational autoencoders…
While sample sizes in randomized clinical trials are large enough to estimate the average treatment effect well, they are often insufficient for estimation of treatment-covariate interactions critical to studying data-driven precision medicine. Observational data from real world practice may play an important role in a…
Generative model for SSc disease trajectories using deep learning.
Graph Attention Networks predict disease state from single-cell data.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically predict disease progression to assisted ventilation in ALS patients. However, the clin…
High-dimensional linear classifiers, such as the support vector machine (SVM) and distance weighted discrimination (DWD), are commonly used in biomedical research to distinguish groups of subjects based on a large number of features. However, their use is limited to applications where a single vector of features is mea…
Study predicts when ALS patients will lose speech, swallowing, etc. based on covariates.
Developed a multiway classification method for sparse data.
The paper proposes a deep generative model for complex disease trajectories.
Proposes modifications to model-based forests for HTE estimation in observational data.
With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the longitudinal assessment of volume changes in this type of setting. Currently most…
Digital twins improve single-arm trials by providing robust treatment effect estimates.
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model formulations of several variants of survival forests and implementations thereof, includ…
The biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and difficult to discern. Time-course gene expression data is a rich source of information that can be used to unravel these complex processes, identify biomarkers of drug sensitivity and predict the response to a drug. H…
We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the subgroup-level may be limited. We focus on the case in which subgroup-specific model…
MISTR improves HTE estimation in survival data with heavy censoring and instrumental variables.
In-vivo examination of the physical connectivity of axonal projections through the white matter of the human brain is made possible by diffusion weighted magnetic resonance imaging (dMRI) Analysis of dMRI commonly considers derived scalar metrics such as fractional anisotrophy as proxies for "white matter integrity," a…
A cascaded multi-planar scheme with a modified residual U-Net architecture was used to segment thalamic nuclei on conventional and white-matter-nulled (WMn) magnetization prepared rapid gradient echo (MPRAGE) data. A single network was optimized to work with images from healthy controls and patients with multiple scler…
Extends Shifts dataset for MS lesion segmentation and marine vessel power estimation.
The study develops a logic reasoner to verify MS case management specifications.
Optimizes treatment duration to maximize quality-adjusted lifetime.
Bayesian model improves BCI performance for ALS users.
Simultaneous Latent Budget Trees for stratified classification
Develops a machine learning model to predict ALS progression and assistive device use.
Motivation: Single cell transcriptome sequencing (scRNA-Seq) has become a revolutionary tool to study cellular and molecular processes at single cell resolution. Among existing technologies, the recently developed droplet-based platform enables efficient parallel processing of thousands of single cells with direct coun…
Paper proves Pareto efficient insurance for multiple entities.
Study of multiplicative connections in Lie groupoids.
Study rectifying curves in 3D multiplicative Euclidean space.
The paper classifies symmetric triads with multiplicities and their applications.
New method identifies proxies for causal effects on multiple outcomes.
We define a concept which we call multiplicity. First, multiplicity of a morphism is defined. Then the multiplicity of an object over another object is defined to be the minimum of the multiplicities of all morphisms from one to another. Based on this multiplicity, we define a pseudo distance on the class of objects. W…
We introduce a multiple conjugation biquandle, and show that it is the universal algebra to define a semi-arc coloring invariant for handlebody-links. A multiple conjugation biquandle is a generalization of a multiple conjugation quandle. We extend the notion of -parallel biquandle operations for any integer , an…
Study finds methods to learn multiple solutions from single task in offline RL.
Let be a connected symplectic manifold on which a connected Lie group acts properly and in a Hamiltonian fashion with moment map $μ:M \lra \mf g^*$. Our purpose is investigate multiplicity-free actions, giving criteria to decide a multiplicity freenes of the action. As an application we give the complete cl…
MKLpy simplifies Multiple Kernel Learning in Python.
Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance learning as a typical weakly-supervised learning method is effective for many app…
X-SHAP assesses multiplicative variable contributions in machine learning models.
New infinite-dimensional representations with bounded multiplicity found for Lie groups.
Classifies compact multiplicity free quasi-Hamiltonian manifolds.
Paper describes how to extend multiple conjugation quandles using maps.