In this work, we present a comparison of a shallow and a deep learning architecture for the automated segmentation of white matter lesions in MR images of multiple sclerosis patients. In particular, we train and test both methods on early stage disease patients, to verify their performance in challenging conditions, mo…
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48 results for “Multiple Sclerosis”
Multiple Sclerosis is a degenerative condition of the central nervous system that affects nearly 2.5 million of individuals in terms of their physical, cognitive, psychological and social capabilities. Researchers are currently investigating on the use of patient reported outcome measures for the assessment of impact a…
Model uses smartphone data to assess MS trajectories.
problem Personalized longitudinal MS assessment.
method Imputation, generalized estimation equation, ensemble learning, fine-tuning.
result Promising model for predicting MS over time.
Automated detection of MS lesions improves to 67% with 7T MRI.
problem Accurate detection of small, scarce cortical lesions in MS patients.
method 3D U-Net with brain tissue segmentation, supervised training on 7T MRI.
result 67% lesion detection rate with 42% false positives.
Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments. We use an unsupervised machine learning model called a Conditional Restricted Boltzmann Machine (CRBM) to learn the relationships between covariates commonly used to characterize subjects and their disease pr…
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as registration, individual longitudinal measurements and tissue segmentation for brain v…
Multiple sclerosis (MS) affects the central nervous system with a wide range of symptoms. MS can, for example, cause pain, changes in mood and fatigue, and may impair a person's movement, speech and visual functions. Diagnosis of MS typically involves a combination of complex clinical assessments and tests to rule out …
Enhancing spectral embedding for low-dimensional embeddings in rare disease cohorts
problem Representing clinical concepts and patients in electronic health records
method Spectral-based unsupervised learning with flexible knowledge transfer
result Outperforms competing approaches in challenging scenarios
In machine learning, novelty detection is the task of identifying novel unseen data. During training, only samples from the normal class are available. Test samples are classified as normal or abnormal by assignment of a novelty score. Here we propose novelty detection methods based on training variational autoencoders…
While sample sizes in randomized clinical trials are large enough to estimate the average treatment effect well, they are often insufficient for estimation of treatment-covariate interactions critical to studying data-driven precision medicine. Observational data from real world practice may play an important role in a…
Generative model for SSc disease trajectories using deep learning.
problem Modeling complex disease trajectories in Systemic Sclerosis.
method Semi-supervised deep generative model with latent temporal processes.
result Learned latent processes enable personalized monitoring and prediction.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically predict disease progression to assisted ventilation in ALS patients. However, the clin…
High-dimensional linear classifiers, such as the support vector machine (SVM) and distance weighted discrimination (DWD), are commonly used in biomedical research to distinguish groups of subjects based on a large number of features. However, their use is limited to applications where a single vector of features is mea…
Study predicts when ALS patients will lose speech, swallowing, etc. based on covariates.
problem Predicting when ALS patients will experience significant functional decline.
method Multi-event survival analysis, covariate-based models.
result Covariate-based models outperform Kaplan-Meier estimator in predicting time-to-event outcomes.
Developed a multiway classification method for sparse data.
problem Classification of multiway arrays with sparsity.
method Extended Distance Weighted Discrimination (DWD) to multiway context, accounting for sparsity.
result Improves classification accuracy in multiway structured data.
The paper proposes a deep generative model for complex disease trajectories.
problem Modeling and analyzing complex disease trajectories.
method Deep generative time series approach with semi-supervised latent processes.
result The model can discover novel aspects of diseases and cluster them into new sub-types.
Proposes modifications to model-based forests for HTE estimation in observational data.
problem Estimating heterogeneous treatment effects in observational studies with complex outcomes.
method Orthogonalization strategy from Robinson (1988) applied to model-based forests.
result The orthogonalization strategy reduces confounding effects in simulated studies.
With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the longitudinal assessment of volume changes in this type of setting. Currently most…
Digital twins improve single-arm trials by providing robust treatment effect estimates.
problem Lack of control arms in single-arm trials limits their gold-standard evidence.
method Outcome-model-based synthetic controls using machine learning models trained on historical data.
result Digital twins offer more robust treatment effect estimates and principled corrections.
We investigate the effect of the proportional hazards assumption on prognostic and predictive models of the survival time of patients suffering from amyotrophic lateral sclerosis (ALS). We theoretically compare the underlying model formulations of several variants of survival forests and implementations thereof, includ…
The biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and difficult to discern. Time-course gene expression data is a rich source of information that can be used to unravel these complex processes, identify biomarkers of drug sensitivity and predict the response to a drug. H…
We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the subgroup-level may be limited. We focus on the case in which subgroup-specific model…
Single-cell RNA sequencing (scRNA-seq) has revolutionized biological discovery, providing an unbiased picture of cellular heterogeneity in tissues. While scRNA-seq has been used extensively to provide insight into both healthy systems and diseases, it has not been used for disease prediction or diagnostics. Graph Atten…
MISTR improves HTE estimation in survival data with heavy censoring and instrumental variables.
problem Estimating HTE in survival data with censoring and unobserved confounders.
method MISTR uses recursively imputed survival trees to handle censoring and instrumental variables.
result MISTR outperforms existing methods under heavy censoring and instrumental variable settings.
In-vivo examination of the physical connectivity of axonal projections through the white matter of the human brain is made possible by diffusion weighted magnetic resonance imaging (dMRI) Analysis of dMRI commonly considers derived scalar metrics such as fractional anisotrophy as proxies for "white matter integrity," a…
Automated Thalamic Nuclei Segmentation Using Multi-Planar Cascaded Convolutional Neural Networkseess.IV
A cascaded multi-planar scheme with a modified residual U-Net architecture was used to segment thalamic nuclei on conventional and white-matter-nulled (WMn) magnetization prepared rapid gradient echo (MPRAGE) data. A single network was optimized to work with images from healthy controls and patients with multiple scler…
Extends Shifts dataset for MS lesion segmentation and marine vessel power estimation.
problem Distributional shift in training and deployment data for ML models.
method Develops new datasets for high-risk industrial applications.
result Demonstrates robustness and uncertainty estimation in new industrial tasks.
The study develops a logic reasoner to verify MS case management specifications.
problem Ensuring correctness and solvability of abstract clinical work products.
method Developed a logic reasoner using UML class and state diagrams, SPIN, and ODM.
result Formal representations of UML diagrams proved consistent for MS case management.
Optimizes treatment duration to maximize quality-adjusted lifetime.
problem Balancing risks and benefits in clinical decision making.
method Proposes a weighted estimating equation to adjust for confounding and informative censoring, and a nonparametric estimator for mean counterfactual quality-adjusted lifetime.
result Shows the optimal time for percutaneous endoscopic gastrostomy insertion in ALS patients.
Bayesian model improves BCI performance for ALS users.
problem Classifying EEG signals for P300 BCIs with low SNR and complex correlations.
method GLASS model with Gaussian Latent channel and Sparse time-varying effects.
result GLASS substantially improves BCI performance in ALS users.
Simultaneous Latent Budget Trees for stratified classification
problem Classification with stratification factors
method Probabilistic machine learning framework
result Interpretation of latent components and conditional split rule
Develops a machine learning model to predict ALS progression and assistive device use.
problem Challenges in predicting clinically meaningful milestones in ALS.
method Integrates longitudinal ALSFRS-R trajectories with survival modeling.
result Generates individualized survival curves and predicts wheelchair-free survival.
DIMM-SC: A Dirichlet mixture model for clustering droplet-based single cell transcriptomic datastat.ML
Motivation: Single cell transcriptome sequencing (scRNA-Seq) has become a revolutionary tool to study cellular and molecular processes at single cell resolution. Among existing technologies, the recently developed droplet-based platform enables efficient parallel processing of thousands of single cells with direct coun…
Paper proves Pareto efficient insurance for multiple entities.
problem Optimizing insurance for multiple policyholders and insurers.
method Sum-minimization characterization and pairwise implementability analysis.
result Characterization of Pareto efficient insurance arrangements.
Study of multiplicative connections in Lie groupoids.
problem Defining and understanding multiplicative connections in Lie groupoids.
method Definition and study of multiplicative connections satisfying compatibility with the groupoid structure.
result Identification of the obstruction to the existence of a multiplicative connection.
A non-Newtonian approach in differential geometry of curves: multiplicative rectifying curvesmath.DG
Study rectifying curves in 3D multiplicative Euclidean space.
problem Investigate rectifying curves in a non-Newtonian geometry setting.
method Apply multiplicative differential-geometric concepts to rectifying curves.
result Classify multiplicative rectifying curves using spherical curves.
The paper classifies symmetric triads with multiplicities and their applications.
problem Classifying symmetric triads with multiplicities and their applications.
method Developed the theory of symmetric triads with multiplicities, classified abstract triads, and determined corresponding triads for commutative compact triads.
result Classified symmetric triads with multiplicities and their applications.
New method identifies proxies for causal effects on multiple outcomes.
problem Estimating causal effects in scenarios with multiple outcomes and treatments.
method Causal discovery method leveraging multiple outcomes as proxies for each treatment effect.
result Parallel studies of multiple outcomes can assist in causal identification.
We define a concept which we call multiplicity. First, multiplicity of a morphism is defined. Then the multiplicity of an object over another object is defined to be the minimum of the multiplicities of all morphisms from one to another. Based on this multiplicity, we define a pseudo distance on the class of objects. W…
We introduce a multiple conjugation biquandle, and show that it is the universal algebra to define a semi-arc coloring invariant for handlebody-links. A multiple conjugation biquandle is a generalization of a multiple conjugation quandle. We extend the notion of -parallel biquandle operations for any integer , an…
Study finds methods to learn multiple solutions from single task in offline RL.
problem Learning multiple solutions from a single task in offline RL.
method Proposed algorithms for offline RL.
result Empirical results show learning of multiple solutions in offline RL.
Let be a connected symplectic manifold on which a connected Lie group acts properly and in a Hamiltonian fashion with moment map $μ:M \lra \mf g^*$. Our purpose is investigate multiplicity-free actions, giving criteria to decide a multiplicity freenes of the action. As an application we give the complete cl…
MKLpy simplifies Multiple Kernel Learning in Python.
problem Learning optimal kernel functions from data.
method Python-based framework for Multiple Kernel Learning algorithms.
result Maximizes usability and simplifies development of novel solutions.
Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance learning as a typical weakly-supervised learning method is effective for many app…
X-SHAP assesses multiplicative variable contributions in machine learning models.
problem Understanding multiplicative interactions in machine learning models.
method Model-agnostic method that extends SHAP to assess multiplicative contributions.
result X-SHAP proves useful in capturing multiplicative feature importance.
New infinite-dimensional representations with bounded multiplicity found for Lie groups.
problem Finding representations with bounded multiplicity for Lie groups.
method Proving existence of infinite-dimensional irreducible representations with bounded multiplicity property.
result Infinite-dimensional irreducible representations with bounded multiplicity found for non-compact semisimple Lie groups.
Classifies compact multiplicity free quasi-Hamiltonian manifolds.
problem Classifying compact, multiplicity free, quasi-Hamiltonian manifolds.
method Symplectic reductions and Lie group analysis.
result Recover old and find new examples of these structures.
Paper describes how to extend multiple conjugation quandles using maps.
problem Understanding affine extensions of multiple conjugation quandles.
method Introduces augmented MCQ Alexander pairs for affine extensions.
result Affine extensions of multiple conjugation quandles can be described by quadruples of maps.