SRVs improve MSMs for Trp-cage miniprotein, revealing new folding states.
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We study the question of well-posedness of the Cauchy problem for Schrödinger maps from $\rone \times \rtwo$ to the sphere $\stwo$ or to , the hyperbolic space. The idea is to choose an appropriate gauge change so that the derivatives of the map will satisfy a certain nonlinear Schrödinger system of equa…
In the era of deep learning several unsupervised models have been developed to capture the key features in unlabeled handwritten data. Popular among them is the Restricted Boltzmann Machines RBM. However, due to the novelty in handwritten multidialect data, the RBM may fail to generate an efficient representation. In t…
Marginal Structural Models (MSM) are the most popular models for causal inference from time-series observational data. However, they have two main drawbacks: (a) they do not capture subject heterogeneity, and (b) they only consider fixed time intervals and do not scale gracefully with longer intervals. In this work, we…
In this paper, we consider daily financial data of a collection of different stock market indices, exchange rates, and interest rates, and we analyze their multi-scaling properties by estimating a simple specification of the Markov-switching multifractal model (MSM). In order to see how well the estimated models captur…
We propose a multifractal model for short-term interest rates. The model is a version of the Markov-Switching Multifractal (MSM), which incorporates the well-known level effect observed in interest rates. Unlike previously suggested models, the level-MSM model captures the power-law scaling of the structure functions a…
Persistent homology provides a new, efficient molecular descriptor for protein dynamics.
Deeptime simplifies learning dynamical models from time series data.
Markov state models (MSMs) and Master equation models are popular approaches to approximate molecular kinetics, equilibria, metastable states, and reaction coordinates in terms of a state space discretization usually obtained by clustering. Recently, a powerful generalization of MSMs has been introduced, the variationa…
Explicit-duration MSMs model time spent in different regimes.
The modeling of atomistic biomolecular simulations using kinetic models such as Markov state models (MSMs) has had many notable algorithmic advances in recent years. The variational principle has opened the door for a nearly fully automated toolkit for selecting models that predict the long-time kinetics from molecular…
Marginal structural models (MSMs) estimate the causal effect of a time-varying treatment in the presence of time-dependent confounding via weighted regression. The standard approach of using inverse probability of treatment weighting (IPTW) can lead to high-variance estimates due to extreme weights and be sensitive to …
Develops identifiability theory for multi-lag regime-switching models.
Study finds monetary policy uncertainty negatively impacts Bitcoin returns.
In this paper, we use the generalized Hurst exponent approach to study the multi- scaling behavior of different financial time series. We show that this approach is robust and powerful in detecting different types of multiscaling. We observe a puzzling phenomenon where an apparent increase in multifractality is measure…
This paper introduces the Markov-Switching Multifractal Duration (MSMD) model by adapting the MSM stochastic volatility model of Calvet and Fisher (2004) to the duration setting. Although the MSMD process is exponential -mixing as we show in the paper, it is capable of generating highly persistent autocorrelation. W…
Text classification has become indispensable due to the rapid increase of text in digital form. Over the past three decades, efforts have been made to approach this task using various learning algorithms and statistical models based on bag-of-words (BOW) features. Despite its simple implementation, BOW features lack se…
Automatic music transcription (AMT) aims to infer a latent symbolic representation of a piece of music (piano-roll), given a corresponding observed audio recording. Transcribing polyphonic music (when multiple notes are played simultaneously) is a challenging problem, due to highly structured overlapping between harmon…
LSS learns molecular trajectories from MD data.
New model identifies regimes in non-stationary data.
Model-free reinforcement learning agents outperform traditional portfolio management models in asset allocation.
We develop efficient and sharp bounds on policy value under perturbations in MDPs.