Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
The paper develops a causal machine learning framework to optimize aid allocation.
problem Optimizing aid allocation to reduce new HIV infections in poor countries.
method The framework uses a balancing autoencoder, counterfactual generator, and inference model to predict heterogeneous treatment effects.
result The framework predicts a reduction of up to 3.3% in new HIV infections, saving 50,000 lives.
Personalized models explain TB treatment outcomes considering patient context.
problem Heterogeneity in TB treatment outcomes due to co-morbidities.
method Multi-task learning approach encoding patient context into personalized models.
result Identifies anemia, age of onset, and HIV as influential for treatment efficacy.
New method combines regional HIV prevention trial data without sharing individual patient info.
problem Regional differences in HIV prevention efficacy, privacy concerns, and data sharing limitations.
method Federated learning approach that combines site-specific estimators via L1-regularization.
result Improved precision in estimating region-specific survival curves.
Due to physiological variation, patients diagnosed with the same condition may exhibit divergent, but related, responses to the same treatments. Hidden Parameter Markov Decision Processes (HiP-MDPs) tackle this transfer-learning problem by embedding these tasks into a low-dimensional space. However, the original formul…
Motivation: HIV is difficult to treat because its virus mutates at a high rate and mutated viruses easily develop resistance to existing drugs. If the relationships between mutations and drug resistances can be determined from historical data, patients can be provided personalized treatment according to their own mutat…
Deep Bayesian models estimate causal effects for dynamic treatment regimes over long follow-up times.
problem Challenges in causal effect estimation for dynamic treatment regimes with long follow-up times.
method Combining outcome regression models with deep Bayesian models for high-dimensional features.
result Stable and accurate dynamic causal effect estimation from observational data, especially with long-term follow-up.
An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this paper, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for su…
We study the problem of off-policy policy evaluation (OPPE) in RL. In contrast to prior work, we consider how to estimate both the individual policy value and average policy value accurately. We draw inspiration from recent work in causal reasoning, and propose a new finite sample generalization error bound for value e…
System predicts HIV patients at risk of dropping out of care.
problem High non-adherence and dropout rates among HIV patients.
method Predictive machine learning model based on resource constraints, stability, and fairness.
result Model performs 3x better than baseline for clinical use and 2.3x better for city-wide use.
In causal inference, a variety of causal effect estimands have been studied, including the sample, uncensored, target, conditional, optimal subpopulation, and optimal weighted average treatment effects. Ad-hoc methods have been developed for each estimand based on inverse probability weighting (IPW) and on outcome regr…
Marginal structural models (MSMs) estimate the causal effect of a time-varying treatment in the presence of time-dependent confounding via weighted regression. The standard approach of using inverse probability of treatment weighting (IPTW) can lead to high-variance estimates due to extreme weights and be sensitive to …
CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
HIV RNA viral load (VL) is an important outcome variable in studies of HIV infected persons. There exists only a handful of methods which classify patients by viral load patterns. Most methods place limits on the use of viral load measurements, are often specific to a particular study design, and do not account for com…
SurvHTE-Bench benchmarks HTE estimation in survival analysis with diverse datasets.
problem Challenges in estimating HTEs from right-censored survival data.
method Modular synthetic datasets, semi-synthetic datasets, and real-world datasets.
result First rigorous comparison of survival HTE methods under diverse conditions.
Proposes a method to avoid excessive exploration in reinforcement learning.
problem Avoiding excessive exploration in reinforcement learning to deploy it in practice.
method Designs a novel algorithm using UCB reinforcement learning policy with adaptive exploration constraints.
result Proves that the approach remains conservative while minimizing regret in tabular settings and validates on real-world tasks.
Model identifies key problems in HIV patients' records.
problem Complex and time-consuming task of identifying patient problems from electronic health records.
method Unsupervised phenotyping approach that jointly learns phenotypes from structured and unstructured data.
result Learned phenotypes and their relatedness are clinically valid and surpass existing methods.
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
Binary classification rules based on covariates typically depend on simple loss functions such as zero-one misclassification. Some cases may require more complex loss functions. For example, individual-level monitoring of HIV-infected individuals on antiretroviral therapy (ART) requires periodic assessment of treatment…
The goal of personalized decision making is to map a unit's characteristics to an action tailored to maximize the expected outcome for that unit. Obtaining high-quality mappings of this type is the goal of the dynamic regime literature. In healthcare settings, optimizing policies with respect to a particular causal pat…
New framework quantifies variable importance across all good models and is stable across data distribution.
problem Conflicting variable importance conclusions from different models trained on the same data.
method Proposes a new variable importance framework that considers all good models and is stable across data distribution.
result Framework accurately estimates true variable importance and recovers rankings for complex setups.
New algorithms improve MPBART for HIV patient data.
problem Improving inference for multinomial outcomes in HIV patient data.
method Introduced two new algorithms for fitting MPBART.
result Better performance in MCMC convergence and predictive accuracy.
Count data, for example the number of observed cases of a disease in a city, often arise in the fields of healthcare analytics and epidemiology. In this paper, we consider performing regression on multivariate data in which our outcome is a count. Specifically, we derive log-likelihood functions for finite mixtures of …
BSFP method reveals latent patterns in multi-omic data for predicting lung function in HIV-associated OLD.
problem Limited understanding of multi-omic molecular phenomena and clinical outcomes in obstructive lung disease.
method Bayesian Simultaneous Factorization and Prediction (BSFP) method for multi-omic data, accommodating imputation and full posterior inference.
result BSFP reveals distinct clusters of patients with OLD and multi-omic patterns related to lung function decline.
It is the main purpose of this paper to introduce a graph-valued stochastic process in order to model the spread of a communicable infectious disease. The major novelty of the SIR model we promote lies in the fact that the social network on which the epidemics is taking place is not specified in advance but evolves thr…
Affinity propagation is an exemplar-based clustering algorithm that finds a set of data-points that best exemplify the data, and associates each datapoint with one exemplar. We extend affinity propagation in a principled way to solve the hierarchical clustering problem, which arises in a variety of domains including bi…
Motivation: Proteins are known to undergo conformational changes in the course of their functions. The changes in conformation are often attributable to a small fraction of residues within the protein. Therefore identification of these variable regions is important for an understanding of protein function. Results: We …
A new graphical model for discrete data without parametric restrictions.
problem Discrete data modeling with restrictions.
method Additive conditional independence and penalized estimation of precision operator.
result Consistency of the estimator in ultrahigh-dimensional settings.
The aim of this paper is to construct a natural Riemann-Lagrange differential geometry on 1-jet spaces, in the sense of nonlinear connections, generalized Cartan connections, d-torsions, d-curvatures, jet electromagnetic fields and jet electromagnetic Yang-Mills energies, starting from some given nonlinear evolution OD…
Bayesian nonparametric method partitions shapes using curves.
problem Capturing complex shapes in multi-dimensional data.
method Proposes a novel spline partitioning approach using curves.
result Demonstrates improved shape modeling compared to existing methods.
A new method combines machine learning with mixed-effects models for better repeated measurement analysis.
problem Inference of linear coefficients in partially linear mixed-effects models with complex interactions and high-dimensional variables.
method Double machine learning approach to estimate nonparametrically nonlinear variables, then use standard linear mixed-effects techniques to estimate the linear coefficient.
result The estimated fixed effects coefficient converges at the parametric rate and is semiparametrically efficient.
SpINNEr uses matrix regression to analyze brain connectivity, improving accuracy over other methods.
problem Analyzing multi-dimensional data like brain imaging arrays using traditional scalar regression methods.
method SpINNEr applies matrix regression with nuclear norm and lasso norms to encourage low rank and sparse solutions.
result SpINNEr outperforms other methods in estimating brain connectivity, especially in well-connected regions.
The lack of interpretability remains a key barrier to the adoption of deep models in many applications. In this work, we explicitly regularize deep models so human users might step through the process behind their predictions in little time. Specifically, we train deep time-series models so their class-probability pred…
Exact selective inference with randomization for Gaussian regression models.
problem Exact selective inference in Gaussian regression models.
method Introduces a pivot for exact selective inference with randomization, reducing the problem to a bivariate truncated Gaussian distribution.
result Our pivot leads to exact inference and produces narrower confidence intervals than related methods.
This paper proposes a new method for estimating sparse precision matrices in the high dimensional setting. It has been popular to study fast computation and adaptive procedures for this problem. We propose a novel approach, called Sparse Column-wise Inverse Operator, to address these two issues. We analyze an adaptive …
Framework evaluates AI proposals for drug discovery, finds no LLM advantage.
problem No principled framework exists for evaluating AI-guided scientific selection under budget constraints.
method Formally verified metric (BSDS/DQS) penalizes false discoveries and excessive abstention.
result LLMs provide no marginal value over existing classifiers in drug discovery.
GraphITE estimates individual effects of graph-structured treatments.
problem Estimating individual effects of complex treatment structures.
method Graph neural networks and Hilbert-Schmidt Independence Criterion regularization.
result GraphITE outperforms baselines in estimating treatment effects for large numbers of treatments.
M3E2 neural network estimates multiple treatment effects.
problem Estimating effects of multiple treatments simultaneously.
method Multi-task learning neural network model for multiple treatments, continuous and binary.
result M3E2 outperforms baselines in synthetic datasets.
Proposes a new method to estimate continuous treatment policies and match treatments effectively.
problem Current methods struggle with continuous treatment policies and complex matching.
method Formulates treatment effectiveness as a parametrizable model, using deep learning for optimization.
result Significant improvement in treatment effectiveness and matching efficiency.
Framework generates personalized insulin treatment strategies using deep models.
problem Developing optimal personalized treatment strategies for diabetes patients.
method Combines deep generative time series models with decision theory.
result Demonstrated improved personalized insulin treatment strategies for diabetes patients.
Develops deep jump learning for continuous treatment OPE.
problem Estimating mean outcomes under new treatment rules using historical data from different rules.
method Adaptive deep discretization of continuous treatment space using deep learning and multi-scale change point detection.
result Validated method through theoretical results, simulations, and real application to Warfarin Dosing.
Method controls treatment risk in learning beneficial allocations.
problem Learning beneficial treatment allocations with risk control in precision medicine.
method Proposes a certifiable learning method that controls treatment risk with finite samples in the partially identified setting.
result Illustrates method using both simulated and real data.
Optimal adaptive experiment for choosing best treatment with binary outcomes.
problem Choosing the best treatment from binary options in an adaptive experiment.
method Adaptive experiment with two phases: treatment allocation and choice. Neyman allocation method used.
result Neyman allocation is minimax and Bayes optimal, matching lower bounds for regret.
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
Dynamic treatment effects estimated over time using covariate balancing.
problem Estimating treatment effects in panel data with dynamic treatments.
method Dynamic covariate balancing with potential local projections.
result Established inferential guarantees for the proposed method.
CRN model estimates treatment effects over time using adversarial balancing.
problem Estimating treatment effects over time in medical settings.
method Adversarial domain balancing to remove time-varying confounders.
result CRN achieves lower error in estimating counterfactuals and treatment timing.
Heteroskedasticity biases uplift model rankings, leading to inefficient treatment allocation.
problem Bias in uplift model rankings due to heteroskedasticity.
method Theoretical analysis and simulation on real-world data.
result Heteroskedasticity can cause individuals with high treatment effects to be ranked at the bottom, leading to inefficient treatment allocation.