Deep models improve GWAS by identifying genetic interactions.
problem Missing non-linear interaction effects in GWAS.
method Gradient-based DeepLIFT technique to interpret deep models.
result Known and novel genetic risk factors identified.
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48 results for “Genetic Risk Factors”
Genome-wide association studies (GWAS) have achieved great success in the genetic study of Alzheimer's disease (AD). Collaborative imaging genetics studies across different research institutions show the effectiveness of detecting genetic risk factors. However, the high dimensionality of GWAS data poses significant cha…
One primary task of population health analysis is the identification of risk factors that, for some subpopulation, have a significant association with some health condition. Examples include finding lifestyle factors associated with chronic diseases and finding genetic mutations associated with diseases in precision he…
Genome-wide association studies (GWAS) offer new opportunities to identify genetic risk factors for Alzheimer's disease (AD). Recently, collaborative efforts across different institutions emerged that enhance the power of many existing techniques on individual institution data. However, a major barrier to collaborative…
We analyze large, multi-dimensional, sparse counting data sets, finding unsupervised groups to provide unique insights into genetic data. We create gene and biological pathway groups based on patients' variants to find common risk factors for four common types of cancer (breast, lung, prostate, and colorectal) and auti…
In this work, a novel approach is proposed for joint analysis of high dimensional time-resolved cardiac motion features obtained from segmented cardiac MRI and low dimensional clinical risk factors to improve survival prediction in heart failure. Different methods are evaluated to find the optimal way to insert convent…
Novel method identifies proteomic risk markers for Alzheimer disease.
problem Lack of comprehensive proteomic risk markers for Alzheimer disease diagnosis.
method Deep belief network-based feature selection method using proteomic and clinical data.
result Identified an optimal subset of proteins achieving 90% accuracy in Alzheimer disease diagnosis.
ENN method uses expectile regression for genetic data analysis of complex diseases.
problem Discover additional genetic variants contributing to complex diseases.
method Developed an expectile neural network (ENN) method integrating expectile regression and neural networks.
result ENN method outperforms existing expectile regression in discovering genetic variants predisposing to sub-populations.
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
BayesMR estimates causal effects and directionality from genetic data.
problem Challenges in finding good genetic instruments and estimating causal effects.
method Bayesian Mendelian randomization approach that accounts for pleiotropy and reverse causation.
result BayesMR provides a posterior distribution over causal effects and uncertainty.
GA-MSSR optimizes forex trading rules for higher returns and reduced risk.
problem Noisy market data affects the consistency and profitability of trading algorithms.
method Optimized trading rules derived from technical indicators using a Genetic Algorithm.
result GA-MSSR achieved superior performance with significant positive returns and reduced risk factors.
This study introduces a new GAS blending ensemble model for Bitcoin price prediction.
problem Predicting Bitcoin price fluctuations in the cryptocurrency market.
method Integrates advanced ensemble learning methods, feature selection algorithms, and sentiment analysis.
result The GAS model demonstrates excellent performance in daily Bitcoin trend prediction.
Enhances genetic programming for stock alpha discovery with warm start and structural constraints.
problem Overwhelming search space and computational burden in traditional genetic programming for alpha factor discovery.
method Proposes a new GP framework with warm start and structural constraints to enhance search performance and interpretability.
result Superior out-of-sample prediction results and higher portfolio returns compared to benchmarks.
New methods improve genetic studies of complex diseases.
problem Improving genetic studies of complex diseases using high-dimensional clinical data.
method Evaluation of unsupervised disentangled representation learning methods (autoencoders, VAE, beta-VAE, FactorVAE) for genetic association studies.
result FactorVAEs and beta-VAEs outperform standard VAEs and non-variational autoencoders in genetic studies of asthma and COPD.
Genome-wide association studies (GWA studies or GWAS) investigate the relationships between genetic variants such as single-nucleotide polymorphisms (SNPs) and individual traits. Recently, incorporating biological priors together with machine learning methods in GWA studies has attracted increasing attention. However, …
Gradient boosting enhances existing Mendelian models for genetic disease risk prediction.
problem Improving existing Mendelian models for genetic disease risk prediction.
method Combining gradient boosting with existing Mendelian models.
result Improved model outperforms both original and gradient boosting-only models.
Lapse-supported life insurance exacerbates adverse selection risks.
problem Lapse-supported life insurance increases adverse selection costs.
method Modeling 'Term to 100' contracts and analyzing three methods of managing lapse surplus.
result Adverse selection losses can be almost unlimited under certain conditions.
A new model selects low-carbon mutual funds considering ESG criteria, risk, and investor preferences.
problem Aligning financial investments with a low-carbon economy.
method Tri-criterion portfolio selection model using a preference-based multi-objective genetic algorithm (ev-MOGA).
result The model successfully incorporates carbon risk exposure and loss-adverse attitudes into portfolio construction.
Deep Learning of Semi-Competing Risk Data via a New Neural Expectation-Maximization Algorithmstat.ML
New algorithm predicts lung cancer progression and mortality.
problem Predicting semi-competing risk outcomes in lung cancer.
method Neural Expectation-Maximization algorithm for multi-state outcomes.
result Estimates non-parametric baseline hazards and risk functions.
DL/FBF improves GPSR solutions by selecting compact, generalising expressions.
problem Overfitting and structural bloat in symbolic regression with genetic programming.
method Description length (DL) and fractional Bayes factor (FBF) criteria for selecting compact, generalising expressions.
result DL/FBF post-selection improves test performance compared to AIC/BIC baseline.
Practical Portfolio Optimization with Metaheuristics:Pre-assignment Constraint and Margin Tradingq-fin.PM
Metaheuristics optimize portfolios with pre-assignment and margin trading for better risk-adjusted returns.
problem Maximizing returns while minimizing risk in portfolio optimization.
method Incorporates pre-assignment constraints and margin trading strategies using Genetic Algorithms and Particle Swarm Optimization.
result Metaheuristic-based portfolio optimization yields superior risk-adjusted returns compared to traditional methods.
Develops a SAS approach for high-dimensional risk prediction using unlabeled data.
problem Challenges in risk modeling with EHR data due to lack of direct disease outcomes and high dimensionality.
method Surrogate Assisted Semi-supervised Learning (SAS) approach leveraging unlabeled and labeled data.
result Valid inference for predicted risk even when underlying model is dense and mis-specified.
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factor…
Method controls extrapolation in prediction profiles for statistical and machine learning models.
problem Avoiding invalid predictions due to extrapolation in prediction profiles.
method Genetic algorithm optimization over constrained factor regions.
result Optimal factor settings without constraint are often invalid and extrapolated.
Optimizes stock portfolios with profit, risk, and sustainability.
problem Balancing profit, risk, and sustainability in stock portfolio management.
method Developed a novel utility function combining Sharpe ratio and ESG scores; used genetic algorithm for optimization.
result System outperforms traditional reinforcement learning methods and improves on risk and sustainability metrics.
Optimal capital allocation between different assets is an important financial problem, which is generally framed as the portfolio optimization problem. General models include the single-period and multi-period cases. The traditional Mean-Variance model introduced by Harry Markowitz has been the basis of many models use…
Extracting Epistatic Interactions in Type 2 Diabetes Genome-Wide Data Using Stacked Autoencodercs.LG
2 Diabetes is a leading worldwide public health concern, and its increasing prevalence has significant health and economic importance in all nations. The condition is a multifactorial disorder with a complex aetiology. The genetic determinants remain largely elusive, with only a handful of identified candidate genes. G…
We study the performance of various agent strategies in an artificial investment scenario. Agents are equipped with a budget, , and at each time step invest a particular fraction, , of their budget. The return on investment (RoI), , is characterized by a periodic function with different types and leve…
In this paper, we solve portfolio rebalancing problem when security returns are represented by uncertain variables considering transaction costs. The performance of the proposed model is studied using constant-proportion portfolio insurance (CPPI) as rebalancing strategy. Numerical results showed that uncertain paramet…
With the emergence of the Hospital Readmission Reduction Program of the Center for Medicare and Medicaid Services on October 1, 2012, forecasting unplanned patient readmission risk became crucial to the healthcare domain. There are tangible works in the literature emphasizing on developing readmission risk prediction m…
Linear Mixed Models (LMMs) are important tools in statistical genetics. When used for feature selection, they allow to find a sparse set of genetic traits that best predict a continuous phenotype of interest, while simultaneously correcting for various confounding factors such as age, ethnicity and population structure…
Neural networks improve cancer risk prediction from family history data.
problem Improving cancer risk prediction from family history data using machine learning.
method Developed and trained neural network models on large pedigrees to predict hereditary cancers.
result Neural networks can achieve nearly optimal prediction performance and outperform traditional models in misreported data.
Factor risk measuresq-fin.MF
Introduces factor risk measures to assess risk relative to multiple factors.
problem Measuring risk relative to multiple factors.
method Introduces a double-argument mapping as a risk measure to assess risk relative to a vector of factors.
result Characterizes various types of factor risk measures including distortion, quantile, linear, and coherent measures.
Proposes a two-stage method for estimating heterogeneous treatment effects using gradient boosting trees.
problem Estimating heterogeneous treatment effects in randomized clinical trials with high-dimensional predictive markers.
method Two-stage statistical learning procedure using gradient boosting trees (XGBoost) to estimate main effects and HTE.
result Improves efficiency in estimating heterogeneous treatment effects through nonparametric function estimation.
Advances of modern sensing and sequencing technologies generate a deluge of high dimensional space-temporal physiological and next-generation sequencing (NGS) data. Physiological traits are observed either as continuous random functions, or on a dense grid and referred to as function-valued traits. Both physiological a…
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
Genetic programming (GP) is the state-of-the-art in financial automated feature construction task. It employs reverse polish expression to represent features and then conducts the evolution process. However, with the development of deep learning, more powerful feature extraction tools are available. This paper proposes…
In this paper we present an evolutionary optimization approach to solve the risk parity portfolio selection problem. While there exist convex optimization approaches to solve this problem when long-only portfolios are considered, the optimization problem becomes non-trivial in the long-short case. To solve this problem…
Software development effort estimation is considered a fundamental task for software development life cycle as well as for managing project cost, time and quality. Therefore, accurate estimation is a substantial factor in projects success and reducing the risks. In recent years, software effort estimation has received …
Semi-supervised GAN creates synthetic genetic data for disease prediction.
problem Expensive and time-consuming to build large labeled genetic databases.
method Semi-supervised Genetic Generative Adversarial Network (gGAN).
result Model achieved satisfactory results with real genetic data.
BoGA combines evolutionary search with Bayesian optimization for efficient protein design.
problem Designing novel proteins with specific characteristics is challenging due to sequence space complexity.
method BoGA integrates a genetic algorithm with Bayesian optimization to efficiently explore sequence space.
result BoGA accelerates discovery of high-confidence binders for diverse protein design objectives.
Efficiently infers graph edges from genetic similarity data in landscape genetics.
problem Inferring unknown graph edges from genetic similarity data in a heterogeneous landscape.
method Developed an efficient first-order optimization method to solve the inverse landscape genetics problem.
result Our method provides fast and reliable convergence, significantly outperforming existing heuristics.
New risk factors improve stress testing accuracy.
problem Improving stress testing accuracy with new risk factors.
method Adapted PCA and autoencoders for dimension reduction and interpretation.
result Aggregated risk factors enhance stress testing outcomes.
Paper uses machine learning to analyze stock market anomalies, predicting drift direction and portfolio performance.
problem Capturing dynamics of Post-Earnings-Announcement Drift (PEAD) using machine learning.
method Uses Extreme Gradient Boosting (XGBoost) with genetic algorithm optimization to analyze PEAD dynamics.
result Demonstrates how PEAD dynamics are influenced by different factors across sectors and quarters.
Study tests if equity factors explain Bitcoin's risk and returns.
problem Explaining Bitcoin's risk and return with equity factors.
method Applied statistical methods to test Fama-French factors on Bitcoin's excess returns.
result Fama-French factors have explanatory power on Bitcoin's risk and returns.
Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the presence of gene-gene interactions. A non-parametric Bayesian approach in the form o…
This study examines the evolving causal structure of equity risk factors.
problem Redundancy and risk contagion in multi-factor strategies during financial crises.
method Causal structure learning methods applied to US equity market data over 29 years.
result Statistically significant sparsifying trend of causal structure during normal times, but densification during financial stress.
We propose a Bayesian regression method that accounts for multi-way interactions of arbitrary orders among the predictor variables. Our model makes use of a factorization mechanism for representing the regression coefficients of interactions among the predictors, while the interaction selection is guided by a prior dis…