In plant and animal breeding studies a distinction is made between the genetic value (additive + epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this paper, we argue that t…
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48 results for “Epistatic Effects”
Locally epistatic genomic relationship matrices for genomic association, prediction and selectionstat.AP
As the amount and complexity of genetic information increases it is necessary that we explore some efficient ways of handling these data. This study takes the "divide and conquer" approach for analyzing high dimensional genomic data. Our aims include reducing the dimensionality of the problem that has to be dealt one a…
Extracting Epistatic Interactions in Type 2 Diabetes Genome-Wide Data Using Stacked Autoencodercs.LG
Deep learning detects genetic interactions in type 2 diabetes.
problem Detecting genetic interactions in complex diseases like type 2 diabetes.
method Stacked Autoencoder for non-linear epistatic interactions.
result Deep learning can uncover missing heritability in complex diseases.
New method interprets neural networks at multiple scales.
problem Interpreting neural networks at various scales and identifying important subsets of inputs.
method Rank Projection Trees framework using any scoring function.
result Successfully identifies biologically important genes and gene sets.
In statistical genetics an important task involves building predictive models for the genotype-phenotype relationships and thus attribute a proportion of the total phenotypic variance to the variation in genotypes. Numerous models have been proposed to incorporate additive genetic effects into models for prediction or …
A computationally simple genome-wide association study (GWAS) algorithm for estimating the main and epistatic effects of markers or single nucleotide polymorphisms (SNPs) is proposed. It is based on the intuitive assumption that changes of alleles corresponding to important SNPs in a pair of individuals lead to large d…
SAERMA combines deep learning and rule mining to identify SNP interactions.
problem Identifying significant SNPs and their interactions in complex diseases.
method Stacked Autoencoder Rule Mining Algorithm (SAERMA) integrating deep learning and association rule mining.
result Achieved high classification accuracy (77% AUC, 77% SE, 68% SP) with 100 units.
We consider the problem of learning a high-dimensional multi-task regression model, under sparsity constraints induced by presence of grouping structures on the input covariates and on the output predictors. This problem is primarily motivated by expression quantitative trait locus (eQTL) mapping, of which the goal is …
New method bypasses assumptions for unbiased estimation of complex system interactions.
problem Inferring pair-wise and higher-order interactions from observational data.
method Cross-disciplinary approach using Targeted Learning for unbiased estimation.
result Universal estimator of all-order symmetric interactions without parametric assumptions.
Study connects Gaussian processes and regularization for sequence-function mappings.
problem Understanding and interpreting sequence-function maps in biology.
method Relates Gaussian process priors, regularization, and gauge fixing in overparameterized weight space.
result Established the relationship between regularized regression and Gaussian processes in function space.
The leverage effect weakly impacts return distributions, especially for small firms.
problem The leverage effect's impact on return distributions is inconsistent and puzzling.
method Analyzed the determinants of return distributions and proposed an indirect method to measure the interaction effect.
result The interaction effect between leverage and mean-reversion is weak and impacts return distributions mainly for small firms.
New method for interpreting non-linear models using forward marginal effects.
problem Interpreting non-linear models' feature effects is challenging.
method Introducing forward marginal effects and partitioning feature space for better interpretation.
result Improved interpretation of non-linear prediction functions.
The Kalinin effectivity is studied and applied to compactifications and Hilbert squares.
problem Understanding Kalinin effectivity in compactifications and its applications.
method Definition, construction methods, and analysis of Kalinin effectivity in various compactifications.
result Wonderful compactifications of hyperplane arrangements and configuration spaces are Kalinin effective.
New method estimates treatment effects in network data, accounting for spillover effects.
problem Treatment effect estimation in networks with spillover effects.
method Augmented inverse probability weighting (AIPW) with cross-fitting and machine learning.
result Semiparametric treatment effect estimator converges at parametric rate and follows Gaussian distribution.
Causalfe estimates treatment effects in panel data with fixed effects.
problem Spurious heterogeneity in treatment effect estimates due to fixed effects in panel data.
method CFFE approach with node-level residualization during tree construction.
result Validates the estimator's performance through simulation studies.
The paper clarifies the distinction between CATE and ITE under ignorability assumptions.
problem Confusion between CATE and ITE hinders personalized effect estimation.
method Clarifies the distinction between CATE and ITE under ignorability assumptions.
result CATE and ITE are not necessarily the same under ignorability assumptions.
GADGET framework decomposes global feature effects using recursive partitioning.
problem Misleading global feature effects when feature interactions are present.
method Generalized additive decomposition of global effects (GADGET) based on recursive partitioning.
result Minimizes interaction-related heterogeneity of local feature effects.
A new RL framework evaluates dynamic mediation effects over time.
problem Dynamic mediation effects in sequentially assigned treatments.
method Reinforcement Learning framework for decomposition and estimation of causal effects.
result Superior performance demonstrated through numerical studies and real data analysis.
The Zumbach effect is significant under rough Heston but negligible in classical Heston.
problem Identifying the Zumbach effect in stochastic volatility models.
method Explicit computations of the Zumbach effect under rough Heston model.
result The Zumbach effect is negligible in the classical Heston model but significant under rough Heston.
New method predicts drug side effects from combined use.
problem Predicting side effects from drug combinations.
method Multi-relational knowledge graph completion.
result State-of-the-art results on polypharmacy side effect prediction.
A new method purifies interaction effects in models to improve interpretability.
problem Interaction effects can be misinterpreted as separate main effects, complicating model interpretation.
method Proposes pure interaction effects and a Functional ANOVA decomposition algorithm to identify and isolate interaction effects.
result Identifies and separates interaction effects from main effects, showing large disparities in model interpretation.
New memory effect discovered in gravitational wave behavior.
problem Understanding gravitational wave behavior in spacetimes with angular momentum.
method Mathematical analysis of Minkowski spacetime and Kerr black holes.
result Angular momentum memory effect observed at future null infinity.
Effective Yau-Tian-Donaldson conjecture for spherical varieties.
problem Finding effective K-stability criteria for spherical varieties.
method Formulated an effective variant of the Yau-Tian-Donaldson conjecture and reviewed effective K-stability criteria for spherical varieties.
result Effective K-stability criteria can be computed given combinatorial data.
Consistent Causal Inference of Group Effects in Non-Targeted Trials with Finitely Many Effect Levelscs.LG
A new method estimates treatment effects in mixed groups, improving accuracy.
problem Estimating treatment effects in mixed groups with heterogeneous responses.
method PCM (pre-cluster and merge) approach for nonparametric estimation.
result Asymptotic consistency and significant improvement in accuracy over existing methods.
Study estimates heterogeneous principal causal effects with binary treatments and intermediate variables.
problem Estimating subgroup effects within strata defined by potential values of an intermediate variable.
method Proposes a framework for estimating and forming confidence intervals for heterogeneous principal causal effects under principal ignorability assumption. Develops several estimators with varying robustness properties.
result Established large-sample theory and analyzed bias contributions of each approach.
Estimating the average causal effect of intervention in continuous variables using machine learningstat.ML
Study develops method for estimating causal effects in continuous variables.
problem Lack of methods for estimating causal effects in continuous variables.
method Develops a method independent of data generating models for continuous variable interventions.
result Preserves identifiability of data and applies to any generating models.
ICA accurately estimates treatment effects even with confounders.
problem Estimating treatment effects in the presence of confounding variables.
method Uses Independent Component Analysis (ICA) to identify latent sources and estimate mixing coefficients.
result Linear ICA can consistently estimate multiple treatment effects, even with Gaussian confounders, and is more sample-efficient than Orthogonal Machine Learning (OML).
Method improves treatment effect estimation in randomized experiments.
problem Estimating distributional treatment effects in randomized experiments.
method Distributional regression framework with machine learning for variance reduction.
result The proposed method reduces variance of distributional treatment effect estimators.
New method discovers context effects in choice data.
problem Identifying context effects from choice data is challenging.
method Automatic discovery of context effects from observed choices.
result Automatic discovery of context effects from observed choices.
Dropout introduces both explicit and implicit regularization effects.
problem Understanding the full impact of dropout regularization.
method Disentangled explicit and implicit regularization effects through experiments and analytic simplifications.
result Explicit and implicit regularization effects of dropout are distinct and can be characterized analytically.
New test for binary treatment effects using kernel methods.
problem Testing distributional effects of binary treatments.
method Kernel-based doubly-robust test, avoiding permutations.
result Valid type-I error with computational efficiency.
Scalable Krylov Subspace Methods for Generalized Mixed-Effects Models with Crossed Random Effectsstat.ME
New Krylov subspace methods speed up mixed-effects models with crossed random effects.
problem Slow computations for high-dimensional crossed random effects in mixed-effects models.
method Krylov subspace-based methods for generalized mixed-effects models with cross effects.
result Speedups by factors of up to 10,000 in computations for mixed-effects models.
The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases and co-existing conditions. However, a major consequence of polypharmacy is a much higher risk of adverse side effects for the patient. Polypharmacy side effects emerge because of drug-drug interactions, in which activi…
Identifies causal effects in LiNGAM models with latent variables.
problem Identifying causal effects in LiNGAM models with latent confounders.
method Complete graphical characterization and efficient algorithms for certification. RICA adaptation for estimation.
result Efficient algorithms and RICA adaptation for estimating causal effects.
Develops HCQRF for estimating heterogeneous treatment effects with censored data.
problem Estimating heterogeneous treatment effects on censored responses with high-dimensional variables.
method Hybrid Censored Quantile Regression Forest (HCQRF) combining random forests and censored quantile regression.
result Demonstrates the effectiveness and stability of HCQRF through simulation studies and real-world application.
The paper studies how and when a treatment triggers different effects for individuals.
problem Estimating how treatment effects vary among individuals based on their characteristics.
method Tree-based learning method to find individual-level treatment triggers.
result The proposed method learns treatment triggers better than existing approaches.
New methods estimate interventional effects with multiple mediators using machine learning.
problem Estimating interventional effects with multiple mediators.
method Flexible machine learning techniques for estimation, with weak convergence results for confidence intervals.
result Closed-form confidence intervals and hypothesis tests for interventional mediation effects.
The paper compares methods for estimating individual treatment effects.
problem Estimating the optimal treatment effect for each individual.
method Comparison of machine learning methods for individual treatment effect estimation.
result Combination of Logistic Regression and Difference Score method, as well as Uplift Random Forest method, provides the best prediction accuracy.
Study relaxes identification assumptions for natural direct effects in non-randomized settings.
problem Identifying causal direct effects under unmeasured confounding.
method Developed relaxed conditions for identifying natural direct effects in non-randomized settings.
result Identified natural direct effect under unmeasured confounding conditions.
Study shows how national culture influences investors' tendency to hold or sell stocks.
problem Investors' tendency to hold or sell stocks varies internationally.
method Examined brokerage data from 83 countries, analyzed cultural dimensions and age/gender.
result National culture, specifically long-term orientation and indulgence, influences the disposition effect.
The Sagnac effect is re-examined using Finslerian geometry.
problem Understanding the Sagnac effect in general relativity.
method Reviewing the geometry of the Sagnac effect with a focus on Finslerian metrics.
result An asymmetry in Finslerian metrics affects the Sagnac effect for both future-pointing null and timelike geodesics.
Method estimates treatment effect bounds in sample selection models.
problem Estimating heterogeneous treatment effects in presence of sample selection.
method Debiased/double machine learning approach for non-linear and high-dimensional confounders.
result Substantially tighter effect bounds for younger users.
XTNet estimates complex cross-treatment effects in multi-category, multi-valued settings.
problem Challenges in estimating causal effects for multi-category, multi-valued treatments.
method Dynamic Neural Masking for capturing treatment interactions without restrictive assumptions.
result XTNet consistently outperforms state-of-the-art baselines in multi-category, multi-valued treatment effect estimation.
Statistical Inference for Maximin Effects: Identifying Stable Associations across Multiple Studiesstat.ME
The paper develops methods to identify stable associations across multiple studies.
problem Identifying stable associations across multiple studies with possible distributional shifts.
method Modeling heterogeneous multi-source data with multiple high-dimensional regressions and devising a novel sampling method for valid confidence intervals of maximin effects.
result Significant maximin effects indicate stable associations that can be generalized to target populations.
MOMENT selects and estimates mixed-effects models using moment identities.
problem Selecting and estimating random-effects covariance matrix and fixed-effects coefficients in multiresponse linear mixed-effects models.
method MOMENT is a stage-wise moment-based framework that reduces the random-effects selection problem to a smooth constrained convex optimization problem.
result MOMENT performs competitively and can outperform separate univariate analyses for correlated responses.
NoLimits.jl: Flexible and Composable Nonlinear Mixed-Effects Modeling in Julia
problem Flexible and composable nonlinear mixed-effects modeling
method Macro-based modeling language and unified interface
result Substantially expand the range of nonlinear mixed-effects models
Method estimates heterogeneous causal effects on networks using orthogonal learning.
problem Challenges in estimating causal effects on networks due to treatment effects on both treated and neighbors, and network homophily.
method Two-stage orthogonal learning framework: first stage uses graph neural networks for nuisance components, second stage residualizes and interpretable attention-based model for causal effects.
result Improves heterogeneous effect estimation and supports interpretable analyses.
Novel Fourier-based estimator reveals stochastic leverage effect in high-frequency data.
problem Analyzing the stochastic leverage effect in high-frequency data.
method A novel Fourier-based estimator of the stochastic leverage effect is defined and proven consistent.
result The magnitude of the stochastic leverage effect is detectable at high-frequency.