Generative models create personalized patient health simulations.
problem Creating accurate digital twins for personalized medicine.
method Neural network architecture for conditional generative models of clinical trajectories.
result Same architecture generates accurate twins across 13 indications.
Digital twin reduces costs in various fields.
problem High costs in decision-making processes.
method Use of digital twin model for cost reduction.
result Digital twin acts as a cost reduction method.
Proposes a probabilistic digital twin for dynamical systems using sparse Bayesian learning.
problem Creating and updating accurate digital twins for complex dynamical systems.
method Sparse Bayesian machine learning, two approaches: input-output and output-only.
result Identifies correct perturbation terms and associated parameters in dynamical systems.
Deep RL optimizes sensor placement in digital twins for dynamic data acquisition.
problem Limited applicability of traditional sensor placement techniques for online applications.
method Formulates sensor placement as a Markov decision process and uses deep reinforcement learning.
result Improves predictive accuracy and reliability of digital twins through adaptive sensor repositioning.
Digital twin technology has significant promise, relevance and potential of widespread applicability in various industrial sectors such as aerospace, infrastructure and automotive. However, the adoption of this technology has been slower due to the lack of clarity for specific applications. A discrete damped dynamic sy…
Improved aircraft structure prediction using derivative-enhanced sparse Cholesky GP method.
problem Accurate real-time prediction of aircraft structure performance.
method Combining derivative data with a modified dynamic sparse Cholesky linear system solver.
result Improved prediction accuracy of aircraft structure performance.
Optimizes biomanufacturing processes with a new digital twin calibration method.
problem Lack of interpretability and sample efficiency in traditional DoE methods.
method Developed a computational approach to calibrate Bio-SoS digital twin model.
result Guides sample-efficient and interpretable DoEs by quantifying sub-model parameter estimation errors.
Enhanced multi-fidelity models improve digital twin accuracy and uncertainty quantification.
problem Lack of detailed application-specific data and inaccurate sensor data hinder surrogate model learning for digital twins.
method Proposes a multi-fidelity surrogate model framework integrating PCFE and GP, and deep-HPCFE with auto-regression schemes.
result Demonstrates improved accuracy and uncertainty quantification in digital twin systems.
Novel digital twin for complex systems improves performance.
problem Lack of practical implementation details for stochastic nonlinear MDOF systems.
method Decouples time-scales, uses physics-based model, Bayesian filtering, and machine learning.
result Excellent performance of proposed digital twin framework validated by examples.
A digital twin for multi-scale systems uses physics-based and machine learning models.
problem Lack of application-specific details in digital twin technology.
method Strategically separates into physics-based and data-driven models; uses mixture of experts with Gaussian Process.
result Robust and accurate predictions at future time-steps for multi-scale systems.
Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments. We use an unsupervised machine learning model called a Conditional Restricted Boltzmann Machine (CRBM) to learn the relationships between covariates commonly used to characterize subjects and their disease pr…
Paper introduces a method to learn physics between digital twins using imperfect models.
problem Learning physics from imperfect data and low-fidelity models.
method Bayesian Hierarchical modeling with physics-informed Gaussian processes.
result Models learning between digital twins are less uncertain than independent models but not over-confident.
EHR-MPC optimizes sepsis treatment using digital twins and inference-time control.
problem Optimal sepsis treatment policies are contested and difficult to adapt during inference.
method EHR-MPC decouples learning patient dynamics from treatment optimization, enabling inference-time control over learned digital twins.
result EHR-MPC achieves comparable off-policy performance and improved simulation performance compared to RL baselines.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Automated digital twin discovery from biological data improves drug discovery and personalized medicine.
problem Developing reliable digital twins from noisy, incomplete biological data.
method Symbolic and sparse regression, Bayesian frameworks, deep learning, and large language models.
result Sparse regression generally outperforms symbolic regression, especially with Bayesian frameworks.
Paper introduces probabilistic digital twins for optimal decision making under uncertainty.
problem Optimal sequential decision making under incomplete and uncertain information.
method Formal definition of epistemic uncertainty using measure theory, and solution via deep reinforcement learning.
result Proposes a generic approximate solution for optimal sequential decision making.
Generative model calibrates 3D battery cathode morphologies from 2D images.
problem Calibrate 3D morphologies of all-solid-state battery cathodes from 2D microscopy images.
method Combining GANs with excursion sets of Gaussian random fields.
result Calibrated digital twins enable systematic exploration of morphological scenarios.
Paper presents a deep learning framework for faster, more accurate nuclear reactor power prediction.
problem Inaccurate and inefficient modeling of nuclear reactor transients.
method Hybrid digital twin-focused multi-stage deep learning framework using feed-forward neural networks.
result Achieved remarkable accuracy (96% classification, 2.3% MAPE) with noise-enhanced simulated data.
Framework predicts responses in misspecified systems using GPLFM and BNNs.
problem Predicting responses in dynamical systems with model misspecification.
method Integrates GPLFM and BNNs for uncertainty-aware inference and prediction.
result Systematic propagation of uncertainty from diagnosis to prediction.
ISOMORPH creates a digital twin for supply chain logistics, advancing time-series forecasting benchmarks.
problem Lack of public benchmarks for supply chain logistics time-series forecasting.
method Developed a digital twin simulator with interpretable parameters and modular topology, generating datasets and verifying conservation laws.
result Foundation models achieve MASE values exceeding public benchmarks at low-to-moderate horizons, supporting UQ.
Digital twins improve single-arm trials by providing robust treatment effect estimates.
problem Lack of control arms in single-arm trials limits their gold-standard evidence.
method Outcome-model-based synthetic controls using machine learning models trained on historical data.
result Digital twins offer more robust treatment effect estimates and principled corrections.
Generative models improve digital twins for structures with uncertainties.
problem Uncertainty in structural modelling limits deterministic models.
method Two types of generative models: physics-based SFE and data-driven cGANs.
result Data-driven cGANs outperform physics-based models in nonlinear structures.
DeepONets improve surrogate modeling for engineering systems.
problem Accurately modeling complex PDEs for engineering systems.
method DeepONets specialize in approximating mathematical operators for PDEs.
result DeepONets achieve high prediction accuracy and zero-shot capability.
Study uses GPLFM to create Digital Twin for ferry quay health monitoring.
problem Deterioration of ferry quays due to harsh maritime environments and impacts.
method Gaussian Process Latent Force Model (GPLFM) integrating physics-based model and machine learning.
result GPLFM provides accurate acceleration response estimates, even under simplifying assumptions.
Mathematical advances needed for Digital Twins, differing from traditional models.
problem Foundational mathematical advances required for Digital Twins.
method Multi-scale, multi-physics modeling and coupling, different reliability criteria and uncertainty assessments.
result AI/ML methods can perform well in biomedical problems but fail in simple engineering systems.
The paper quantifies and attributes uncertainty in complex system simulations.
problem Uncertainty in complex system simulations due to unknown or approximated subprocesses.
method Developed a framework for quantifying and attributing submodel uncertainty using bootstrapping, Bayesian model averaging, and tree-based methods.
result Individual submodels contribute to overall uncertainty, and their importance can be quantified.
Orchestrating the Twin Transition in GBS: A Socio-Technical Framework
problem MNCs' need to harmonize digital efficiency with environmental stewardship
method Technology Roadmapping (TRM) with ICT-centric innovation ecosystem toolkit
result Central 'operational airlock' for GBS in harmonizing digital and environmental transformation
This research assesses uncertainty quantification and sensitivity analysis for DTs in nuclear fuel performance.
problem Understanding the reliability and performance of advanced nuclear fuels using DTs.
method Introduces ML-based uncertainty quantification and sensitivity analysis methods applied to BISON fuel performance code.
result Demonstrates the effectiveness of DTs in multi-criteria decision-making for nuclear fuel performance.
DeepONet accelerates nuclear DT inference with high accuracy and efficiency.
problem Real-time prediction and model evaluation in nuclear systems.
method Deep Neural Operator (DeepONet) for surrogate modeling.
result DeepONet outperforms traditional ML methods in accuracy and speed.
GANs help create realistic synthetic health data, boosting medical research.
problem Challenges in creating realistic synthetic health data due to private patient data.
method Generative Adversarial Networks (GANs) to learn and produce synthetic health data.
result GANs can produce realistic synthetic health data, overcoming challenges in OHD.
Paper fine-tunes a simulation-driven estimator to reduce out-of-distribution errors.
problem Out-of-distribution errors in simulation-driven parameter estimators.
method Fine-tuning a Two-Stage estimator to improve accuracy for true parameters outside the sampled range.
result The fine-tuning approach reduces out-of-distribution errors and improves accuracy.
This study quantifies uncertainty in comparing treatments using RCTs with before-and-after measures.
problem Uncertainty in comparing treatments using RCTs with before-and-after measures.
method New statistical modeling principle called ETZ enables counterfactual uncertainty quantification (CUQ) in RCTs with Before-and-After Repeated Measures.
result CUQ typically has lower variability than factual uncertainty quantification and can be achieved in RCTs.
Framework corrects model form errors in structural dynamics predictions.
problem Model form errors in parametric models of structural dynamics.
method Gaussian Process Latent Force Model (GPLFM) for non-parametric discrepancy representation, linear Bayesian filtering for state and discrepancy estimation, modal reduction for computational tractability.
result Significant reduction of displacement and rotation prediction errors under unseen excitations.
RAPTOR-GEN accelerates digital twin development for biopharmaceuticals.
problem Lack of agility in rapid, on-demand production of biotherapeutics due to bioprocess complexity.
method Bayesian learning framework based on a multi-scale probabilistic knowledge graph (pKG) and stochastic differential equations (SDE).
result RAPTOR-GEN accelerates intelligent digital twin development from sparse and heterogeneous experimental data.
Emergenet predicts animal influenza strain emergence, outperforming current methods.
problem Limited ability to quantitatively assess animal influenza strain emergence.
method Infer digital twin of sequence evolution using 220,151 HA sequences.
result Emergenet predictions outperform WHO seasonal vaccine recommendations and CDC IRAT scores.
Probabilistic method identifies Purkinje network from ECG data.
problem Challenging task of identifying Purkinje conduction system in heart.
method Bayesian optimization and approximate Bayesian computation for probabilistic identification.
result Generates a population of plausible Purkinje networks fitting ECG within tolerance.
CitySim dataset captures vehicle trajectories for safety research.
problem Lack of fine-grain vehicle trajectories for safety-oriented research.
method Five-step procedure: video stabilization, object filtering, stitching, detection, and error filtering.
result CitySim dataset improves safety evaluations and facilitates digital-twin research.
Develops a machine learning model to predict ALS progression and assistive device use.
problem Challenges in predicting clinically meaningful milestones in ALS.
method Integrates longitudinal ALSFRS-R trajectories with survival modeling.
result Generates individualized survival curves and predicts wheelchair-free survival.
Aims to integrate AI and modelling for patient health forecasting.
problem Personalized, precise treatment plans for patients.
method Graph neural network (GNNs) and generative adversarial network (GANs) for probabilistic simulations.
result Demonstrated integration of molecular data for predicting physiological state evolution.
Paper develops efficient Bayesian inference for enzymatic SRNs with LNA metamodel.
problem Bayesian inference for nonlinear SDE-based mechanistic models with partial observations and measurement errors.
method Interpretable Bayesian updating LNA metamodel and efficient posterior sampling.
result Proposed approach demonstrates promising performance in empirical studies.
Next-gen reservoir computing models dynamical systems from time-series data.
problem Modeling dynamical systems from time-series data.
method Pseudorandom nonlinear projection of time-delay embedded inputs.
result Models remain stable over long rollouts and generalize beyond training data.
Adjoint SA speeds up bioprocess parameter learning.
problem Challenges in digital twin development for biomanufacturing.
method Adjoint sensitivity analysis on multi-scale enzymatic reaction networks.
result Resilient sensitivities reveal bioprocess regulatory mechanisms.
Bayesian PROCOVA uses AI to adjust for covariates in RCTs.
problem Unbiased and precise treatment effect inferences from RCTs.
method Generative AI constructs digital twins for covariate adjustment, using an additive mixture prior.
result Efficiency gains in smaller RCTs compared to frequentist methods.
Study on AI-driven modeling for high burnup accident-tolerant fuels in SMRs.
problem Design and optimization of high burnup accident-tolerant fuels for SMRs.
method Artificial intelligence and multi-scale modeling (neutronics, thermal hydraulics, fuel performance).
result Demonstrated the effectiveness of AI in modeling and optimizing SMR fuels.
We develop DTs for PDE models using KL-NN and TL, analyzing TL's moment equations and one-shot learning for exactness.
problem Creating accurate digital twins for systems governed by PDEs under changing conditions.
method We use KL-NN surrogate models and transfer learning to construct DTs, analyzing the moment equations and proposing one-shot and few-shot learning methods.
result For linear PDEs, one-shot TL is exact; for nonlinear PDEs, some parameters can be transferred with minimal error.
Three physics-constrained regression exercises for image velocimetry and turbulence modeling.
problem Image velocimetry and turbulence modeling challenges.
method Physics-constrained regression exercises implemented as toy problems.
result Python codes provided for all exercises.
A hybrid physics-ML model predicts FO water flux with high accuracy and uncertainty quantification.
problem Challenges in accurately modeling Forward Osmosis water flux due to complex internal mass transfer phenomena.
method Robust Hybrid Physics-ML framework using Gaussian Process Regression (GPR) for uncertainty-aware Jw prediction.
result Achieved a state-of-the-art MAPE of 0.26% and R2 of 0.999 on independent test data.
New methods improve robust decision-making under uncertainty in off-policy evaluation.
problem Statistical uncertainty and causal considerations in off-policy evaluation.
method Marginal Ratio (MR) estimator, Conformal Off-Policy Prediction (COPP), causal bounds.
result Improved robustness and uncertainty quantification in off-policy decision-making.