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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,742 papers · 148 categories

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48 results for CpG Sites

Schwartz's solution to the Björling problem leads to an equivalence class of spatial strips S(t)=(c(t),n(t)) which produce equivalent minimal surfaces. For the particular case when the generating strip S(t) belongs to some plane E and c(t) is symmetric with respect to some straight line in E, the symmetries of the mini…

2010-10-15abs ↗pdf ↗

GIDS reduces high-dimensional response and predictor spaces, improving interpretability and computational efficiency.

problem Challenges in modeling interactions among high-dimensional multimodal data.
method Graph Independence Dual Screening (GIDS) framework that reduces both response and predictor dimensions.
result GIDS reduces feature space to 9,000 CpGs and 2,000 transcripts, revealing coordinated regulatory mechanisms.

Central Pattern Generators (CPGs) are biological neural circuits capable of producing coordinated rhythmic outputs in the absence of rhythmic input. As a result, they are responsible for most rhythmic motion in living organisms. This rhythmic control is broadly applicable to fields such as locomotive robotics and medic…

2019-01-06abs ↗pdf ↗

Novel U-learning method for predicting continuous outcomes from high-dimensional data.

problem Challenges in making valid inferences on predictions from high-dimensional inputs.
method U-learning via combinatory multi-subsampling for ensemble predictions and confidence intervals.
result Valid inferences on predictions from Lasso and neural networks.

iDeepViewLearn combines deep learning and feature selection for multiview learning.

problem Learning nonlinear relationships in data from multiple complementary views.
method Combines deep learning flexibility with statistical feature selection using deep neural networks and graph Laplacian regularization.
result Identifies genes and CpG sites that differentiate between breast cancer survivors and non-survivors.

Estimates users' preference for a site over others using engagement data.

problem Lack of data on users' interactions with other sites makes it hard to estimate preferences for a focal site.
method Uses Hierarchical Bayes Method with two estimation techniques: Markov Chain Monte Carlo and Stochastic Gradient with Langevin Dynamics.
result Good support found for the approach to computing personalized share of engagement.

Paper tackles robust decision-making from multiple sites with shared structure.

problem Learning robust sequential decisions from heterogeneous multi-site datasets.
method Group-Robust MDPs with d-rectangular uncertainty sets, feature-wise worst-case aggregation, and cluster-level pooling.
result Proves suboptimality bound for robust planning policy under robust partial coverage assumption.

Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…

2019-07-09abs ↗pdf ↗

A novel framework synthesizes treatment data across sites using optimal transport.

problem Estimating treatment effects across different sites with varying conditions.
method Distributional causal inference, Optimal Transport for alignment of control group distributions.
result Synthetic treatment group data aligns with true target distribution under general conditions.

Meta-analysis improves personalized treatment rules across multiple sites.

problem Lack of generalizability in learning individualized treatment rules across different medical sites.
method Developed a method for individual-level meta-analysis of ITRs, borrowing sign-coherency information between sites.
result Jointly learned site-specific ITRs with improved generalizability.

Tree-based model averaging improves CATE estimation from diverse sites.

problem Limited sample size and privacy concerns prevent accurate personalized treatment effect estimation.
method Tree-based model averaging approach to estimate CATEs from multiple heterogeneous sites.
result Improved accuracy in estimating conditional average treatment effects (CATEs) across sites.

A rational knot or link can be put into a standard alternating format which has horizontal and vertical twist sites (double helices). The number and type of these twist sites are determined by terms of next-to-highest zz-degree in Kauffman's regular isotopy invariant Λ(a,z)Λ(a,z). In particular, for a knot or link with $c…

2014-10-01abs ↗pdf ↗

The study explores how different Grothendieck topologies and functors between categories preserve locality.

problem Exploring relationships between different Grothendieck topologies and functors.
method Using Grothendieck topologies and functors to relate categories and geometric objects.
result Objects like sheaves, groupoids, and functors are invariant under equivalences of Grothendieck topologies and certain functors.

New federated method preserves privacy and estimates treatment effects.

problem Privacy-preserving causal inference for multi-site studies.
method Multiply robust nuisance function estimation, transfer learning.
result Efficient and optimal treatment effect estimation under different scenarios.

A site-specific Gordian distance between two spatial embeddings of an abstract graph is the minimal number of crossing changes from one to another where each crossing change is performed between two previously specified abstract edges of the graph. It is infinite in some cases. We determine the site-specific Gordian di…

2017-03-28abs ↗pdf ↗

Owners of a web-site are often interested in analysis of groups of users of their site. Information on these groups can help optimizing the structure and contents of the site. In this paper we use an approach based on formal concepts for constructing taxonomies of user groups. For decreasing the huge amount of concepts…

2009-05-09abs ↗pdf ↗

FONT clusters patients across health systems with privacy and efficiency.

problem Challenges in multi-site cluster analysis due to data-sharing restrictions.
method Federated One-shot Ensemble Clustering (FONT) algorithm that requires only a single round of communication and exchanges only fitted model parameters and class labels.
result FONT improves consistency of patient clusters across sites compared to locally fitted clusters.

Many researches demonstrated that the DNA methylation, which occurs in the context of a CpG, has strong correlation with diseases, including cancer. There is a strong interest in analyzing the DNA methylation data to find how to distinguish different subtypes of the tumor. However, the conventional statistical methods …

2018-08-02abs ↗pdf ↗

PLOT uses optimal transport to find neural site handles for causal abstraction.

problem Finding the relevant neural site for causal analysis is computationally challenging.
method PLOT employs optimal transport to localize causal variables from neural network outputs.
result PLOT efficiently finds intervention handles for causal abstraction in neural networks.

HBR improves normative modeling of neuroimaging data across multiple sites.

problem Dealing with nuisance variation in neuroimaging data across different sites.
method Hierarchical Bayesian regression (HBR) for multi-site normative modeling.
result HBR provides more accurate normative ranges compared to existing methods.

A cased-based reasoning method predicts rare events on strategic sites using satellite imagery.

problem Manual prediction of rare events on strategic sites is impractical due to large datasets.
method Case-based reasoning approach incorporating expert knowledge for irregular time series and small datasets.
result The method significantly outperforms random selection on challenging applications.

Physics-informed GANs model subsurface flow at the Hanford Site.

problem Uncertainty quantification for subsurface flow modeling at the Hanford Site.
method Physics-informed GANs, hierarchical domain parallelism, multiple GPUs, efficient communication.
result Highly scalable physics-informed GANs model subsurface flow on Summit supercomputer.

Collecting the large datasets needed to train deep neural networks can be very difficult, particularly for the many applications for which sharing and pooling data is complicated by practical, ethical, or legal concerns. However, it may be the case that derivative datasets or predictive models developed within individu…

2018-05-28abs ↗pdf ↗

We associate to any integrable Poisson manifold a stack, i.e. a category fibered in groupoids over a site. The site in question has objects Dirac manifolds and morphisms pairs consisting of a smooth map and a closed 2-form. We show that two Poisson manifolds are symplectically Morita equivalent if and only if their ass…

2017-03-10abs ↗pdf ↗

Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well. However, understanding of the roles of nega…

2011-04-07abs ↗pdf ↗

This thesis is divided into four chapters. The first chapter discusses the relationship between stacks on a site and groupoids internal to the site. It includes a rigorous proof of the folklore result that there is an equivalence between the bicategory of internal groupoids and the bicategory of geometric stacks. The s…

2018-06-05abs ↗pdf ↗

GOPSA optimizes EEG data for cross-site age prediction, improving performance on multiple metrics.

problem Predictive shifts in EEG data from different sites and participants.
method Geodesic Optimization for Predictive Shift Adaptation (GOPSA) on the SPD manifold.
result Significantly higher performance on age prediction metrics compared to state-of-the-art methods.

Learning from the crowd has become increasingly popular in the Web and social media. There is a wide variety of crowdlearning sites in which, on the one hand, users learn from the knowledge that other users contribute to the site, and, on the other hand, knowledge is reviewed and curated by the same users using assessm…

2016-12-14abs ↗pdf ↗