Paper identifies key CpG methylation sites for breast cancer.
arXiv research
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Schwartz's solution to the Björling problem leads to an equivalence class of spatial strips S(t)=(c(t),n(t)) which produce equivalent minimal surfaces. For the particular case when the generating strip S(t) belongs to some plane E and c(t) is symmetric with respect to some straight line in E, the symmetries of the mini…
GIDS reduces high-dimensional response and predictor spaces, improving interpretability and computational efficiency.
Central Pattern Generators (CPGs) are biological neural circuits capable of producing coordinated rhythmic outputs in the absence of rhythmic input. As a result, they are responsible for most rhythmic motion in living organisms. This rhythmic control is broadly applicable to fields such as locomotive robotics and medic…
Novel U-learning method for predicting continuous outcomes from high-dimensional data.
DNA Methylation has been the most extensively studied epigenetic mark. Usually a change in the genotype, DNA sequence, leads to a change in the phenotype, observable characteristics of the individual. But DNA methylation, which happens in the context of CpG (cytosine and guanine bases linked by phosphate backbone) dinu…
iDeepViewLearn combines deep learning and feature selection for multiview learning.
A Deep Autoencoder based content retrieval algorithm is proposed for prediction and differentiation of cancer types based on the presence of epigenetic patterns of DNA methylation identified in genetic regions known as CpG islands. The developed deep learning system uses a CpG island state classification sub-system to …
Estimates users' preference for a site over others using engagement data.
Site-specific recombination is an enzymatic process where two sites of precise sequence and orientation along a circle come together, are cleaved, and the ends are recombined. Site-specific recombination on a knotted substrate produces another knot or a two-component link depending on the relative orientation of the si…
Paper tackles robust decision-making from multiple sites with shared structure.
Clinical AI models fail to transfer between sites due to site-specific practices.
Treatment recommendations within Clinical Practice Guidelines (CPGs) are largely based on findings from clinical trials and case studies, referred to here as research studies, that are often based on highly selective clinical populations, referred to here as study cohorts. When medical practitioners apply CPG recommend…
A novel machine learning optimization process coined Restrictive Federated Model Selection (RFMS) is proposed under the scenario, for example, when data from healthcare units can not leave the site it is situated on and it is forbidden to carry out training algorithms on remote data sites due to either technical or pri…
A novel framework synthesizes treatment data across sites using optimal transport.
Meta-analysis improves personalized treatment rules across multiple sites.
Tree-based model averaging improves CATE estimation from diverse sites.
A rational knot or link can be put into a standard alternating format which has horizontal and vertical twist sites (double helices). The number and type of these twist sites are determined by terms of next-to-highest -degree in Kauffman's regular isotopy invariant . In particular, for a knot or link with $c…
The study explores how different Grothendieck topologies and functors between categories preserve locality.
Paper tackles online facility location with user requests and provides a quasi-linear time algorithm.
New federated method preserves privacy and estimates treatment effects.
Method improves robustness and generalizability of CATE estimation.
A site-specific Gordian distance between two spatial embeddings of an abstract graph is the minimal number of crossing changes from one to another where each crossing change is performed between two previously specified abstract edges of the graph. It is infinite in some cases. We determine the site-specific Gordian di…
Owners of a web-site are often interested in analysis of groups of users of their site. Information on these groups can help optimizing the structure and contents of the site. In this paper we use an approach based on formal concepts for constructing taxonomies of user groups. For decreasing the huge amount of concepts…
Paper proves model structures equal for smooth manifolds and Cartesian spaces.
Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products and they can act as substrates for further rounds of site-specific recombination. They are also one of the simplest families of knots and …
FONT clusters patients across health systems with privacy and efficiency.
Connectivity studies using resting-state functional magnetic resonance imaging are increasingly pooling data acquired at multiple sites. While this may allow investigators to speed up recruitment or increase sample size, multisite studies also potentially introduce systematic biases in connectivity measures across site…
RNA-binding proteins (RBPs) play crucial roles in many biological processes, e.g. gene regulation. Computational identification of RBP binding sites on RNAs are urgently needed. In particular, RBPs bind to RNAs by recognizing sequence motifs. Thus, fast locating those motifs on RNA sequences is crucial and time-efficie…
Many researches demonstrated that the DNA methylation, which occurs in the context of a CpG, has strong correlation with diseases, including cancer. There is a strong interest in analyzing the DNA methylation data to find how to distinguish different subtypes of the tumor. However, the conventional statistical methods …
Desingularizes singular spaces using sheaves and groupoids.
PLOT uses optimal transport to find neural site handles for causal abstraction.
HBR improves normative modeling of neuroimaging data across multiple sites.
Paper proposes federated offline RL for personalized medicine.
A cased-based reasoning method predicts rare events on strategic sites using satellite imagery.
Physics-informed GANs model subsurface flow at the Hanford Site.
Masked LARk prevents cross-site tracking while training models.
Collecting the large datasets needed to train deep neural networks can be very difficult, particularly for the many applications for which sharing and pooling data is complicated by practical, ethical, or legal concerns. However, it may be the case that derivative datasets or predictive models developed within individu…
We associate to any integrable Poisson manifold a stack, i.e. a category fibered in groupoids over a site. The site in question has objects Dirac manifolds and morphisms pairs consisting of a smooth map and a closed 2-form. We show that two Poisson manifolds are symplectically Morita equivalent if and only if their ass…
Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well. However, understanding of the roles of nega…
Many studies in biomedical and health sciences involve small sample sizes due to logistic or financial constraints. Often, identifying weak (but scientifically interesting) associations between a set of predictors and a response necessitates pooling datasets from multiple diverse labs or groups. While there is a rich l…
In this study, the wind data series from five locations in Aegean Sea islands, the most active `hotspots' in terms of refugee influx during the Oct/2015 - Jan/2016 period, are investigated. The analysis of the three-per-site data series includes standard statistical analysis and parametric distributions, auto-correlati…
This thesis is divided into four chapters. The first chapter discusses the relationship between stacks on a site and groupoids internal to the site. It includes a rigorous proof of the folklore result that there is an equivalence between the bicategory of internal groupoids and the bicategory of geometric stacks. The s…
GOPSA optimizes EEG data for cross-site age prediction, improving performance on multiple metrics.
Algorithm detects surgical site infections from hospital data.
Learning from the crowd has become increasingly popular in the Web and social media. There is a wide variety of crowdlearning sites in which, on the one hand, users learn from the knowledge that other users contribute to the site, and, on the other hand, knowledge is reviewed and curated by the same users using assessm…
A theory of dg schemes is developed so that it becomes a homotopy site, and the corresponding infinity category of stacks is equivalent to the infinity category of stacks, as constructed by Toen and Vezzosi, on the site of dg algebras whose cohomologies have finitely many generators in each degree. Stacks represented b…
We develop a topological model of site-specific recombination that applies to substrates which are the connected sum of two torus links of the form . Then we use our model to prove that all knots and links that can be produced by site-specific recombination on such substrates are contained in one of two…