Electronic Medical Records (EMR) are a rich source of patient information, including measurements reflecting physiologic signs and administered therapies. Identifying which variables are useful in predicting clinical outcomes can be challenging. Advanced algorithms such as deep neural networks were designed to process …
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48 results for “Clinical variables”
New diagnostics detect variability in individual risk estimates from machine learning models in healthcare.
problem Variability in individual risk estimates from machine learning models in healthcare, leading to unreliable treatment decisions.
method Proposed evaluation framework using empirical prediction interval width and empirical decision flip rate diagnostics.
result Randomness in optimization and initialization can lead to substantial individual-level variability in risk estimates, affecting clinical decisions.
A new method uses asymmetric Shapley values to assess gene importance in clinical prediction models.
problem Clinical prediction models struggle with assessing the importance of high-dimensional features like genomics.
method Derive efficient algorithms to compute local and global asymmetric Shapley values for a mixed-dimensional prediction model.
result Asymmetric Shapley values provide a more suitable alternative to quantify feature importance in clinical prediction models.
Causal Explainability of Machine Learning in Heart Failure Prediction from Electronic Health Recordsstat.ML
The paper investigates causal relationships in heart failure prediction using machine learning.
problem Understanding the causal relationships between clinical variables and heart failure.
method Proposes a new computational framework for causal structure discovery (CSD) of mixed-type clinical variables for binary disease outcomes.
result Feature importance from nonlinear classifiers strongly correlates with causal strength of variables, but not differentiating cause and effect.
New method uses probabilistic independence to discover disease signatures from medical records.
problem Insufficiently precise diagnosis of clinical disease leading to treatment failures.
method Unsupervised machine learning using probabilistic independence to disentangle disease patterns.
result Inferred 2000 clinical disease signatures from medical records, improving cancer prediction.
A clinical Meta-Dataset from TCGA for multi-task learning.
problem Clinical decision making requires considering multiple factors; current benchmarks lack consistency and variety.
method Developed a Meta-Dataset with 174 tasks from TCGA, using regression and neural networks.
result Demonstrated the feasibility of predicting multiple clinical variables from gene expression data.
CoI framework models clinical feature interactions, revealing temporal dependencies and enhancing transparency.
problem Capturing latent, time-varying dependencies among clinical features in time-series data.
method Chain-of-Influence (CoI) framework constructs an explicit, time-unfolded graph of feature interactions.
result Achieves state-of-the-art predictive performance (AUROC of 0.960 on CKD progression and 0.950 on ICU mortality).
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Flexible co-data learning improves clinical prediction models.
problem High-dimensional clinical data challenges prediction accuracy.
method Combining domain knowledge and external studies to estimate adaptive multi-group ridge penalties.
result Improves prediction performance and variable selection stability.
Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore some variables that are poor in prediction but are critical for decision-making…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
New framework predicts 5-year glucose values with missing data.
problem Significant missing data in longitudinal glucose studies.
method Reproducing Kernel Hilbert Spaces (RKHS) with missing responses analysis.
result Identifies new factors affecting long-term glucose evolution.
Public benchmark for machine learning models in critical care.
problem Lack of public benchmarks for machine learning in critical care.
method Defined four tasks (mortality prediction, length of stay, phenotyping, decompensation risk) and compared clinical and deep learning models on eICU dataset.
result First public benchmark on multi-centre critical care dataset, comparing clinical models with predictive models.
Study evaluates multi-omics data's role in predicting cancer survival.
problem Determining the usefulness of multi-omics data for predicting disease outcomes.
method 5-fold cross-validation with 12 prediction methods applied to 18 cancer datasets.
result Multi-omics data generally improves prediction performance, but not consistently.
Scalable methods integrate multiview data for clinical outcomes.
problem Jointly associate and predict outcomes from multiple data sources.
method Randomized Fourier bases for nonlinear mappings, view-independent low-dimensional representations.
result Identified molecular signatures for COVID-19 status and severity.
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associate…
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
problem Challenges in observing direct treatment effects in clinical domains.
method Integrates Hidden Markov Model and Multi Task and Multi Graph Convolutional Network for spatiotemporal data.
result Advances predictive causal inference by structurally adapting to spatiotemporal complexities.
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
Proposes a new model for EHR data using time-dependent Gaussian processes.
problem Joint modeling of multiple clinical variables over time.
method Multivariate nonstationary Gaussian processes with time-varying parameters and posterior inference via HMC.
result The proposed model outperforms stationary models and reveals latent correlations predictive of patient risk.
Bayesian model enhances phenotype discovery in asthma EHRs.
problem Lack of interpretability in unsupervised learning phenotyping of EHR data.
method Operationalized a Bayesian latent class framework with clinical knowledge priors.
result Identified an asthma sub-phenotype with elevated eosinophil levels and allergy markers.
Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied quantitatively---could yield important insights into the nature and intrinsic dynamics of seizures. A…
Variable selection in high dimensional space has challenged many contemporary statistical problems from many frontiers of scientific disciplines. Recent technology advance has made it possible to collect a huge amount of covariate information such as microarray, proteomic and SNP data via bioimaging technology while ob…
AdaptiveNet tackles disease progression prediction in rheumatoid arthritis using deep neural networks.
problem Predicting disease progression in rheumatoid arthritis using clinical data.
method AdaptiveNet, a novel recurrent neural network architecture, that handles multiple lists of different events and missing data.
result AdaptiveNet outperforms classical baselines in disease progression prediction.
New method stabilizes deep learning models for clinical risk prediction.
problem Stability issues in deep learning models for clinical risk prediction.
method Bootstrapping-based regularisation framework embedded in deep neural networks.
result Improved prediction stability across multiple datasets.
Copula-based fusion improves breast cancer risk stratification.
problem Combining clinical and genomic risk scores using simple rules fails to capture their joint relationship.
method Used copulas to model the joint relationship between clinical and genomic risk scores.
result Copula-based fusion improves risk stratification, identifying subgroups with the worst prognosis.
Over half a million individuals are diagnosed with head and neck cancer each year worldwide. Radiotherapy is an important curative treatment for this disease, but it requires manual time consuming delineation of radio-sensitive organs at risk (OARs). This planning process can delay treatment, while also introducing int…
ICU mortality scoring systems attempt to predict patient mortality using predictive models with various clinical predictors. Examples of such systems are APACHE, SAPS and MPM. However, most such scoring systems do not actively look for and include interaction terms, despite physicians intuitively taking such interactio…
Exclusive Lasso improves survival prediction in cancer datasets.
problem Enhanced survival prediction in cancer datasets with high-dimensional genomic and clinical data.
method Proposes Exclusive Lasso regularization for feature selection in Cox regression models for grouped variables.
result Demonstrates improved survival prediction performance using Exclusive Lasso compared to standard Cox regression.
Melanoma is the deadliest form of skin cancer. Computer systems can assist in melanoma detection, but are not widespread in clinical practice. In 2016, an open challenge in classification of dermoscopic images of skin lesions was announced. A training set of 900 images with corresponding class labels and semi-automatic…
Challenge hides and seeks privacy in clinical time-series data.
problem De-identifying clinical time-series data while preserving utility and privacy.
method Synthetic data generation to preserve temporal dynamics and limit re-identification risk.
result A novel competition tracks synthetic data generation and patient re-identification.
Proposes a novel imputation network for clinical time series data.
problem Missing value imputation in clinical time series data with sparsity, irregularity, and high-dimensionality.
method Variational-recurrent imputation network that considers correlated features, temporal dynamics, and uncertainty.
result The proposed method outperformed state-of-the-art methods on real-world EHR datasets.
The study uncovers invariant features in healthcare models that traditional methods overlook.
problem Discovering overlooked invariant features in healthcare models.
method Empirical learning of transformations minimizing Wasserstein distance and adding similarity regularization.
result LSTM models and BioBERT reveal invariant features not previously recognized.
Model learns to select relevant clinical variables for disease subtype prediction from small data.
problem Few-shot disease subtype prediction from small genomic data.
method Meta learning Prototypical Network with feature selection and sample reweighting.
result Superior performance in predicting disease subtypes and identifying genes.
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
Study proposes a multimodal model for cardiovascular risk prediction using EHRs.
problem Lack of comprehensive risk prediction from EHRs due to unstructured text.
method Proposes a multimodal BiLSTM model integrating structured and unstructured EHR data.
result Proposed BiLSTM model outperforms other DNN architectures in cardiovascular risk prediction.
Machine learning (ML) techniques such as (deep) artificial neural networks (DNN) are solving very successfully a plethora of tasks and provide new predictive models for complex physical, chemical, biological and social systems. However, in most cases this comes with the disadvantage of acting as a black box, rarely pro…
Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk pre…
Deep learning classifies keratoconus patients with high accuracy.
problem Accurately identifying keratoconus patients for early intervention.
method Unsupervised and semi-supervised machine learning models using corneal topography and clinical data.
result Unsupervised method with 29 variables shows better classification accuracy.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
HBR improves normative modeling of neuroimaging data across multiple sites.
problem Dealing with nuisance variation in neuroimaging data across different sites.
method Hierarchical Bayesian regression (HBR) for multi-site normative modeling.
result HBR provides more accurate normative ranges compared to existing methods.
Paper proposes a method to estimate intra-observer variability in echocardiography quality assessment.
problem Intra-observer variability in echocardiography quality assessment impacts deep neural network reliability.
method Modeling intra-observer variability as aleatoric uncertainty in a regression problem.
result The proposed method reduces error from 0.11 to 0.09, improving test accuracy by 5.7%.
Generative AI models improve clinical trial data by generating survival outcomes.
problem Generating valid survival outcomes for clinical trials with synthetic data.
method A variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes.
result The method outperforms GAN baselines on fidelity, utility, and privacy metrics.
Develops a new model for generating counterfactuals using incomplete data.
problem Lack of complete labels and data in medical image analysis.
method Semi-supervised deep causal generative model that infers missing values using causal inference.
result Generates realistic counterfactuals even with incomplete labels.
Neural Processes Mixed-Effect Models for Deep Normative Modeling of Clinical Neuroimaging Datastat.ML
Normative modeling has recently been introduced as a promising approach for modeling variation of neuroimaging measures across individuals in order to derive biomarkers of psychiatric disorders. Current implementations rely on Gaussian process regression, which provides coherent estimates of uncertainty needed for the …
Improved AI lung ultrasound segmentation using expert confidence values.
problem Label uncertainty in lung ultrasound due to subjective interpretation by radiologists.
method Designing a data annotation protocol capturing expert confidence, training AI on binarized labels with confidence thresholds.
result Improved AI segmentation and better clinical outcomes (e.g., S/F oxygenation ratio estimation, patient readmission prediction).
Monotonicity helps in safely optimizing unknown functions.
problem Sequentially maximizing an unknown function with safety constraints.
method Gaussian process with monotonicity assumption, inspired by GP-UCB and SafeOpt.
result The proposed M-SafeUCB algorithm achieves theoretical guarantees and safety.
A large fraction of the electronic health records consists of clinical measurements collected over time, such as blood tests, which provide important information about the health status of a patient. These sequences of clinical measurements are naturally represented as time series, characterized by multiple variables a…
The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to community-wide data curation efforts. However, due to inherent variabilities in …