A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
TFM trains Neural SDEs without backpropagation, improving clinical time series modeling.
Clinical forecasting based on electronic medical records (EMR) can uncover the temporal correlations between patients' conditions and outcomes from sequences of longitudinal clinical measurements. In this work, we propose an intervention-augmented deep state space generative model to capture the interactions among clin…
Framework improves clinical timeline reconstruction from text and tables.
Medical researchers are coming to appreciate that many diseases are in fact complex, heterogeneous syndromes composed of subpopulations that express different variants of a related complication. Time series data extracted from individual electronic health records (EHR) offer an exciting new way to study subtle differen…
Ability to quantify and predict progression of a disease is fundamental for selecting an appropriate treatment. Many clinical metrics cannot be acquired frequently either because of their cost (e.g. MRI, gait analysis) or because they are inconvenient or harmful to a patient (e.g. biopsy, x-ray). In such scenarios, in …
Novel metrics improve machine learning models for ICU patient care.
Novel framework predicts brain biomarker trajectories with superior performance.
We introduce a probabilistic generative model for disentangling spatio-temporal disease trajectories from series of high-dimensional brain images. The model is based on spatio-temporal matrix factorization, where inference on the sources is constrained by anatomically plausible statistical priors. To model realistic tr…
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associate…
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Generative models create personalized patient health simulations.
Study develops electronic phenotypes of ICU patient acuity.
New method predicts Alzheimer's risk with individual uncertainty estimates.
Novel IRL method identifies suboptimal medical decisions in ICU data.
Generative model for SSc disease trajectories using deep learning.
Patient journeys are compared to find clusters of similar disease trajectories.
The paper proposes a deep generative model for complex disease trajectories.
Disease progression models are instrumental in predicting individual-level health trajectories and understanding disease dynamics. Existing models are capable of providing either accurate predictions of patients prognoses or clinically interpretable representations of disease pathophysiology, but not both. In this pape…
Modeling continuous-time physiological processes that manifest a patient's evolving clinical states is a key step in approaching many problems in healthcare. In this paper, we develop the Hidden Absorbing Semi-Markov Model (HASMM): a versatile probabilistic model that is capable of capturing the modern electronic healt…
Unified framework for human-like decision making in various sequential tasks.
Standard models assign disease progression to discrete categories or stages based on well-characterized clinical markers. However, such a system is potentially at odds with our understanding of the underlying biology, which in highly complex systems may support a (near-)continuous evolution of disease from inception to…
More than two thirds of mental health problems have their onset during childhood or adolescence. Identifying children at risk for mental illness later in life and predicting the type of illness is not easy. We set out to develop a platform to define subtypes of childhood social-emotional development using longitudinal,…
Proposes a method to improve treatment policies in data-scarce clinical settings.
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
Predicts clinical events using a landmark approach with machine learning for large biomarker histories.
The paper proposes a new method for clustering survival data using smoothed log-hazard trajectories.
EHR-MPC optimizes sepsis treatment using digital twins and inference-time control.
Patient subtyping based on temporal observations can lead to significantly nuanced subtyping that acknowledges the dynamic characteristics of diseases. Existing methods for subtyping trajectories treat the evolution of clinical observations as a homogeneous process or employ data available at regular intervals. In real…
Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is not always a single readily available biomarker to quantify disease severity. Eve…
In many forecasting applications, it is valuable to predict not only the value of a signal at a certain time point in the future, but also the values leading up to that point. This is especially true in clinical applications, where the future state of the patient can be less important than the patient's overall traject…
Deep learning models can infer individual trajectories from sparse data.
Early recognition of risky trajectories during an Intensive Care Unit (ICU) stay is one of the key steps towards improving patient survival. Learning trajectories from physiological signals continuously measured during an ICU stay requires learning time-series features that are robust and discriminative across diverse …
Estimates causal effects from patient trajectories using DeepACE model.
Patients initially diagnosed with early mild cognitive impairment (eMCI) are known to be a clinically heterogeneous group with very subtle patterns of brain atrophy. To examine the boarders between normal controls (NC) and eMCI, Magnetic Resonance Imaging (MRI) was extensively used as a non-invasive imaging modality to…
Proposes SSC for estimating counterfactual survival trajectories from observational data.
Accurate prediction of disease trajectories is critical for early identification and timely treatment of patients at risk. Conventional methods in survival analysis are often constrained by strong parametric assumptions and limited in their ability to learn from high-dimensional data, while existing neural network mode…
C-kNN-LSH identifies similar patient histories for causal inference in longitudinal data.
Dynamic topic model improves mental health note analysis for children.
Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that quantify different aspects of a patient's cognitive state such as learning, memor…
Deep learning for integrating diverse clinical measurements.
ES-VAE models skeletal pose trajectories by removing nuisance factors.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
Develops a machine learning model to predict ALS progression and assistive device use.
Aims to integrate AI and modelling for patient health forecasting.
Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from Electronic Medical Records (EMR) of about 12000 patients who were admitted to the…
Proposes a new method for dynamic treatment regimes that improves sample efficiency and stability.