System exposes study population descriptions in clinical guidelines.
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Review of machine learning methods for detecting depression from resting EEG.
Deep learning analyzes healthcare provider actions and patient outcomes.
Discusses handling intercurrent events in clinical trials with time-to-event outcomes.
Proposes guidelines for developing medical AI products.
Clinical AI models fail to transfer between sites due to site-specific practices.
Current advances in research, development and application of artificial intelligence (AI) systems have yielded a far-reaching discourse on AI ethics. In consequence, a number of ethics guidelines have been released in recent years. These guidelines comprise normative principles and recommendations aimed to harness the …
The paper learns personalized treatment rules from observational data.
Machine learning improves CAD management outcomes.
In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major depressive disorder (MDD). We are reviewing and discussing findings based on neuroimagi…
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
The study compares machine learning models for depression detection and highlights the importance of feature selection.
This chapter introduces reproducibility in machine learning for medical imaging.
Over half a million individuals are diagnosed with head and neck cancer each year worldwide. Radiotherapy is an important curative treatment for this disease, but it requires manual time consuming delineation of radio-sensitive organs at risk (OARs). This planning process can delay treatment, while also introducing int…
Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale…
SHAP Distance assesses semantic fidelity of synthetic tabular data.
The paper analyzes SMOTE for imbalanced classification, providing theoretical bounds and guidelines.
The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are gr…
Current clinical practice to monitor patients' health follows either regular or heuristic-based lab test (e.g. blood test) scheduling. Such practice not only gives rise to redundant measurements accruing cost, but may even lead to unnecessary patient discomfort. From the computational perspective, heuristic-based test …
Computational analysis on physiological signals would provide immense impact for enabling automated clinical analytics. However, the class imbalance issue where negative or minority class instances are rare in number impairs the robustness of the practical solution. The key idea of our approach is intelligent augmentat…
New framework quantifies and reduces concept-based models' leakage.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
Bayesian optimisation has gained great popularity as a tool for optimising the parameters of machine learning algorithms and models. Somewhat ironically, setting up the hyper-parameters of Bayesian optimisation methods is notoriously hard. While reasonable practical solutions have been advanced, they can often fail to …
The study examines how experimental design choices affect machine learning model performance.
The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription…
Translating machine learning (ML) models effectively to clinical practice requires establishing clinicians' trust. Explainability, or the ability of an ML model to justify its outcomes and assist clinicians in rationalizing the model prediction, has been generally understood to be critical to establishing trust. Howeve…
Objectives: Electronic health records (EHRs) are only a first step in capturing and utilizing health-related data - the challenge is turning that data into useful information. Furthermore, EHRs are increasingly likely to include data relating to patient outcomes, functionality such as clinical decision support, and gen…
Study improves healthcare time series imputation by considering structured missingness.
AI generates a sequence of death causes from hospital records.
Study finds incorporating fairness in healthcare models doesn't improve performance or net benefit.
Robust low-rank matrix estimation is a topic of increasing interest, with promising applications in a variety of fields, from computer vision to data mining and recommender systems. Recent theoretical results establish the ability of such data models to recover the true underlying low-rank matrix when a large portion o…
Study examines biases in clinical word embeddings, revealing performance gaps across groups.
Analysis of flow cytometry data is an essential tool for clinical diagnosis of hematological and immunological conditions. Current clinical workflows rely on a manual process called gating to classify cells into their canonical types. This dependence on human annotation limits the rate, reproducibility, and complexity …
Explainable machine learning (ML) enables human learning from ML, human appeal of automated model decisions, regulatory compliance, and security audits of ML models. Explainable ML (i.e. explainable artificial intelligence or XAI) has been implemented in numerous open source and commercial packages and explainable ML i…
The paper offers guidelines for validating data-driven models.
Compressed sensing in MRI enables high subsampling factors while maintaining diagnostic image quality. This technique enables shortened scan durations and/or improved image resolution. Further, compressed sensing can increase the diagnostic information and value from each scan performed. Overall, compressed sensing has…
Novel 3D U-Net method for fast, reproducible white matter tract segmentation.
SaML guides ML models to avoid survey biases.
We developed an automated deep learning system to detect hip fractures from frontal pelvic x-rays, an important and common radiological task. Our system was trained on a decade of clinical x-rays (~53,000 studies) and can be applied to clinical data, automatically excluding inappropriate and technically unsatisfactory …
Federated survival analysis outperforms local and centralized training, with RSF offering the best balance of discrimination, calibration, and robustness.
Clinical models trained on EHRs degrade in performance over time due to data drift.
AACE learns treatment policies from EHRs using annotations to improve accuracy.
Stability in clinical prediction models is crucial for transferability between studies, yet has received little attention. The problem is paramount in high dimensional data which invites sparse models with feature selection capability. We introduce an effective method to stabilize sparse Cox model of time-to-events usi…
SARD improves deep learning clinical prediction performance.
In this work, we investigate unsupervised representation learning on medical time series, which bears the promise of leveraging copious amounts of existing unlabeled data in order to eventually assist clinical decision making. By evaluating on the prediction of clinically relevant outcomes, we show that in a practical …
Develops ML-DQA for healthcare data quality assurance.
Machine learning guides clinicians in predictive modeling using big data.