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arXiv research

A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.

168,878 papers · 148 categories

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48 results for Clinical Practice Guidelines

Discusses handling intercurrent events in clinical trials with time-to-event outcomes.

problem Handling intercurrent events in clinical trials with time-to-event outcomes.
method Defines estimands and six ICE handling strategies, including new competing-risk strategy.
result Novel methods for handling intercurrent events in clinical trials with time-to-event outcomes.

Current advances in research, development and application of artificial intelligence (AI) systems have yielded a far-reaching discourse on AI ethics. In consequence, a number of ethics guidelines have been released in recent years. These guidelines comprise normative principles and recommendations aimed to harness the …

2019-02-28abs ↗pdf ↗

The paper learns personalized treatment rules from observational data.

problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.

The paper integrates AI and expert knowledge to optimize radiotherapy decisions.

problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.

The study compares machine learning models for depression detection and highlights the importance of feature selection.

problem The choice of features in machine learning models for depression detection is crucial.
method Comparison of seven machine learning models on depression detection tasks.
result Optimal feature selection is essential for accurate and clinically acceptable classification solutions.

This chapter introduces reproducibility in machine learning for medical imaging.

problem Lack of reproducibility in machine learning for medical imaging.
method Distinguishes and defines types of reproducibility, outlines requirements, and discusses utility.
result Discussion on benefits and a plea for a non-dogmatic approach to reproducibility.

Electronic health records (EHR) data provide a cost and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computational cost of analyzing EHR data at daily (or more granular) scale…

2017-05-27abs ↗pdf ↗

SHAP Distance assesses semantic fidelity of synthetic tabular data.

problem Semantic fidelity of synthetic tabular data is not well evaluated.
method SHAP Distance, defined as cosine distance between global SHAP attribution vectors.
result SHAP Distance detects semantic discrepancies overlooked by standard measures.

The paper analyzes SMOTE for imbalanced classification, providing theoretical bounds and guidelines.

problem The challenge of imbalanced classification problems, especially with minority classes.
method Theoretical analysis of SMOTE and related oversampling techniques for minority classes.
result Derives concentration and excess risk bounds for SMOTE and kernel-based classifiers.

The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are gr…

2019-04-02abs ↗pdf ↗

SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.

problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.

Study uses LLMs to create personalized treatment plans for rare gynecological tumors.

problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.

The study examines how experimental design choices affect machine learning model performance.

problem Lack of guidelines on choosing experimental designs and machine learning models.
method 12 experimental designs, 7 families of predictive models, 7 test functions, 8 noise settings.
result Guidelines for practical applications of DOE and ML are provided.

Study improves healthcare time series imputation by considering structured missingness.

problem Structured missingness in clinical data impacts time series imputation models.
method Analysis of different masking strategies on imputation methods using PhysioNet Challenge 2012 dataset.
result Masking choices significantly affect imputation accuracy and clinical prediction.

AI generates a sequence of death causes from hospital records.

problem Accurate death reporting for vital statistics and policy formulation.
method Neural machine translation models to generate causal chains, incorporating medical domain knowledge.
result Achieved 16.04 BLEU score for generating accurate causal chains.

Study finds incorporating fairness in healthcare models doesn't improve performance or net benefit.

problem Addressing health inequities in healthcare through algorithmic fairness.
method Empirical case study using models to estimate atherosclerotic cardiovascular disease risk.
result Incorporating fairness considerations into model training objective does not improve model performance or net benefit.

Robust low-rank matrix estimation is a topic of increasing interest, with promising applications in a variety of fields, from computer vision to data mining and recommender systems. Recent theoretical results establish the ability of such data models to recover the true underlying low-rank matrix when a large portion o…

2011-09-28abs ↗pdf ↗

Study examines biases in clinical word embeddings, revealing performance gaps across groups.

problem Biases in clinical word embeddings leading to performance differences across groups.
method Pretrained BERT models on MIMIC-III, fill-in-the-blank method, fairness evaluation on clinical tasks.
result Classifiers trained from BERT representations exhibit statistically significant differences in performance across groups.

Analysis of flow cytometry data is an essential tool for clinical diagnosis of hematological and immunological conditions. Current clinical workflows rely on a manual process called gating to classify cells into their canonical types. This dependence on human annotation limits the rate, reproducibility, and complexity …

2017-11-21abs ↗pdf ↗

Novel 3D U-Net method for fast, reproducible white matter tract segmentation.

problem Challenges in fast and consistent white matter tract segmentation from diffusion tensor MRI.
method Convolutional neural network (3D U-Net) trained on a large DTI dataset.
result Reproducibility and accuracy of tract-specific diffusion measures.

Federated survival analysis outperforms local and centralized training, with RSF offering the best balance of discrimination, calibration, and robustness.

problem Survival analysis models require large, diverse cohorts but are limited by privacy regulations and lack of centralized data.
method Federated learning (FL) is used to train shared models without exchanging raw data.
result FL consistently outperforms local training and approaches, and occasionally exceeds centralized performance.

Clinical models trained on EHRs degrade in performance over time due to data drift.

problem Model performance degradation over time in clinical settings.
method Accessed year of care for each record in MIMIC, aggregated features into clinical concepts, and tested mitigation strategies.
result State-of-the-art models show significant performance drops when tested on future data compared to historical data.

AACE learns treatment policies from EHRs using annotations to improve accuracy.

problem Learning treatment policies from multimodal EHRs with bias and inefficiency.
method Annotation-assisted coarsened effects (AACE) method.
result AACE outperforms existing methods in predicting treatment benefit from multimodal EHRs.

SARD improves deep learning clinical prediction performance.

problem Deep learning models struggle to match linear models in healthcare predictions.
method Reverse Distillation to initialize deep models, combined with contextual and temporal embeddings.
result SARD outperforms state-of-the-art methods on clinical prediction outcomes.

Machine learning guides clinicians in predictive modeling using big data.

problem Insufficient understanding of machine learning among clinicians hinders its adoption.
method Provides a series of guides on machine learning principles, resampling, model evaluation, and coding.
result Clinicians need methodological rigor and clarity to use machine learning effectively.