Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here to identify a subset of individuals who share a common brain signature highly p…
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48 results for “Clinical Dementia Rating”
One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but different fashion by the normal aging process. Aging is therefore a confounding …
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
ADReSS Challenge at INTERSPEECH 2020 benchmarks speech recognition for Alzheimer's dementia.
problem Automated recognition of Alzheimer's dementia from spontaneous speech.
method Provides a benchmark speech dataset, defines two tasks (classification and regression), and presents baseline models.
result Demonstrates the feasibility of automated speech recognition for Alzheimer's dementia.
Framework for joint learning of tasks on dementia data with missing values.
problem Lack of multi-task learning, handling time-dependent data, and missing values in dementia forecasting.
method Proposes SSHIBA model using Bayesian variational inference for imputation and combined information from different views.
result SSHIBA model outperforms baselines in predicting diagnosis, ventricle volume, and clinical scores in dementia.
The reliability of a deep learning model in clinical out-of-distribution MRI data: a multicohort studyphysics.med-ph
Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on public research cohorts with images acquired with a single scanner or with strict protocol harmonizati…
The emergence of an ageing population is a significant public health concern. This has led to an increase in the number of people living with progressive neurodegenerative disorders like dementia. Consequently, the strain this is places on health and social care services means providing 24-hour monitoring is not sustai…
Accurate facial expression analysis is an essential step in various clinical applications that involve physical and mental health assessments of older adults (e.g. diagnosis of pain or depression). Although remarkable progress has been achieved toward developing robust facial landmark detection methods, state-of-the-ar…
Paper characterizes early-stage dementia signatures from sensor data.
problem Detecting early-stage dementia from sensor data.
method Developed bespoke behavioural models from longitudinal sensor data.
result Found subtle differences in sleep quality and wandering between dementia patients and controls.
Framework combines HMM and MTGCN for spatiotemporal causal inference in clinical data.
problem Challenges in observing direct treatment effects in clinical domains.
method Integrates Hidden Markov Model and Multi Task and Multi Graph Convolutional Network for spatiotemporal data.
result Advances predictive causal inference by structurally adapting to spatiotemporal complexities.
Improving Mild Cognitive Impairment Prediction via Reinforcement Learning and Dialogue Simulationcs.LG
Mild cognitive impairment (MCI) is a prodromal phase in the progression from normal aging to dementia, especially Alzheimers disease. Even though there is mild cognitive decline in MCI patients, they have normal overall cognition and thus is challenging to distinguish from normal aging. Using transcribed data obtained …
DynForest predicts event probabilities from longitudinal data, handling endogenous predictors.
problem Predicting individual risk using longitudinal patient history.
method Random survival forests with time-fixed features from longitudinal predictors.
result DynForest provides accurate individual event probability predictions.
Models predict Alzheimer's Dementia from spontaneous speech with high accuracy.
problem Early diagnosis of Alzheimer's Dementia (AD) through spontaneous speech analysis.
method Compared natural language processing techniques including SVM, GBDT, CRFs, and Transformer-based models.
result Top models achieve 0.81-0.82 test set scores for AD vs controls and 4.58 RMSE for Mental Mini State Exam scores.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
We present a practical health-theme machine learning (ML) application concerning `AI for social good' domain for `Producing Good Outcomes' track. In particular, the solution is concerning the problem of a potential elderly adult dementia onset prediction in aging societies. The paper discusses our attempt and encouragi…
Our research focuses on analysing human activities according to a known behaviorist scenario, in case of noisy and high dimensional collected data. The data come from the monitoring of patients with dementia diseases by wearable cameras. We define a structural model of video recordings based on a Hidden Markov Model. N…
Paper compares neural networks and classical statistics for dementia prediction, highlighting interpretability of classical methods.
problem Tackles the challenge of interpreting risk factors for dementia prediction.
method Compares neural networks and classical statistics for dementia prediction.
result Classical statistics provide clearer interpretation of risk factors compared to neural networks.
Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream acoustically, syntactically or both. The mostly used tools to perform these analysis…
Traditional voxel-level multiple testing procedures in neuroimaging, mostly -value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, whic…
Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies h…
Study examines APOE's impact on AD progression using a novel DEBM approach.
problem Understanding APOE's role in AD progression and developing targeted clinical trials.
method Developed a discriminative event-based model (DEBM) and proposed a stratified approach to improve model accuracy.
result Identified APOE carriers' impact on AD progression timeline, aiding clinical trial selection.
Multimodal Inductive Transfer Learning for Detection of Alzheimer's Dementia and its Severityeess.AS
New model detects Alzheimer's and severity from speech, cognitive, and language data.
problem Detecting Alzheimer's disease and its severity from multimodal data.
method Multimodal ensemble system using acoustic, cognitive, and linguistic features.
result State-of-the-art accuracy and robustness in AD detection and MMSE score regression.
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
Study develops a new algorithm for assessing clinical trial abstracts.
problem Limited tools for assessing qualitative statements in clinical research.
method Developed a three-class sentiment classification algorithm using BERT model.
result Algorithm achieved 91.3% classification accuracy and 0.92 macro F1-Score.
Compared to in-clinic balance training, in-home training is not as effective. This is, in part, due to the lack of feedback from physical therapists (PTs). Here, we analyze the feasibility of using trunk sway data and machine learning (ML) techniques to automatically evaluate balance, providing accurate assessments out…
Realism in Action: Anomaly-Aware Diagnosis of Brain Tumors from Medical Images Using YOLOv8 and DeiTeess.IV
Framework detects brain tumors robustly from MRI images.
problem Low clinical incidence of brain tumor cases makes diagnosis challenging.
method YOLOv8n for detection, DeiT for classification, PTP metric for evaluation.
result F1-score of 0.92 achieved with reduced computational resources.
New method detects biomarker-treatment interactions in clinical trials.
problem Detecting interactions between high-dimensional biomarkers and treatments in randomized trials.
method Two-stage penalized regression screening using ridge regression for multivariate screening.
result Ridge regression screening provides greater power than traditional methods in correlated data.
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Analysis of flow cytometry data is an essential tool for clinical diagnosis of hematological and immunological conditions. Current clinical workflows rely on a manual process called gating to classify cells into their canonical types. This dependence on human annotation limits the rate, reproducibility, and complexity …
AVRA: Automatic Visual Ratings of Atrophy from MRI images using Recurrent Convolutional Neural Networksphysics.med-ph
Quantifying the degree of atrophy is done clinically by neuroradiologists following established visual rating scales. For these assessments to be reliable the rater requires substantial training and experience, and even then the rating agreement between two radiologists is not perfect. We have developed a model we call…
Pairwise ranking aligns subjective clinical evaluations with objective indicators.
problem Aligning subjective clinical evaluations with objective indicators for improved diagnosis.
method Pairwise ranking methods to align subjective evaluations with objective indicators.
result The resulting score improves classification accuracy and provides a nuanced severity assessment.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
Paper models treatment effects by clustering patients with distinct survival characteristics.
problem Estimating treatment efficacy in clinical settings with censored outcomes.
method Latent variable approach to model heterogeneous treatment effects.
result The latent structure can mediate base survival rates and reveal actionable phenotypes.
ARMED models improve deep learning interpretability and generalize better on clustered data.
problem Clustered data leads to spurious associations and poor model fitting.
method Adversarial regularization and mixed effects subnetworks.
result ARMED models outperform conventional methods in accuracy and generalization.
Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalig…
Objective: To evaluate unsupervised clustering methods for identifying individual-level behavioral-clinical phenotypes that relate personal biomarkers and behavioral traits in type 2 diabetes (T2DM) self-monitoring data. Materials and Methods: We used hierarchical clustering (HC) to identify groups of meals with simila…
ICAM: Interpretable Classification via Disentangled Representations and Feature Attribution Mappingcs.LG
ICAM creates interpretable feature attribution maps for brain images.
problem Challenges in predicting class relevance from brain images due to heterogeneity and background variation.
method A VAE-GAN framework for disentangling class relevance from background features.
result FA maps generated by ICAM outperform baseline methods and support phenotype variation exploration.
Framework improves clinical timeline reconstruction from text and tables.
problem Temporal precision and event timing in clinical narratives and EHRs.
method Retrieval-augmented multimodal alignment framework.
result Consistently improves absolute timestamp accuracy and temporal concordance.
Deep learning predicts heart failure readmission from clinical notes.
problem Predicting and preventing heart failure readmission.
method Convolutional Neural Networks (CNN) trained on clinical notes.
result Deep learning models outperform traditional machine learning methods in readmission prediction.
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying hi…
Bayesian method improves clinical trial efficiency.
problem Increase treatment effect estimates in clinical trials.
method Combines prognostic covariate adjustment with a Bayesian framework.
result Substantial increase in statistical power with controlled type I error.
Biotech IPOs in Q1 2021: advanced degrees, clinical trials, and IP key.
problem Identifying traits of biotech startups that go public.
method Database of biotech IPOs, analysis of leadership, technology, clinical trials, and financing.
result Advanced degrees, clinical trials, and IP are important for biotech startups.
Study improves mortality prediction in hospital patients using comprehensive feature engineering.
problem Accurate prediction of all-cause in-hospital mortality in healthcare.
method Comprehensive feature engineering approach using vital signs, laboratory results, and demographic data.
result Random Forest model achieved highest performance with AUC of 0.94, significantly outperforming other models.
Purpose: Machine learning is broadly used for clinical data analysis. Before training a model, a machine learning algorithm must be selected. Also, the values of one or more model parameters termed hyper-parameters must be set. Selecting algorithms and hyper-parameter values requires advanced machine learning knowledge…
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
problem Personalized treatment optimization in evolving clinical contexts with safety concerns.
method Integrates structured EHR and clinical notes, uses conformal prediction for safe recommendations.
result SAFER outperforms state-of-the-art baselines in recommendation metrics and mortality rates.
Privacy-preserving inference for clinical trials using differential privacy.
problem Balancing knowledge sharing and privacy in healthcare data.
method Differential privacy (DP) applied to log-linear belief updates in distributed settings.
result Differentially private, distributed inference methods outperform existing techniques.
We developed an explainable artificial intelligence (AI) early warning score (xAI-EWS) system for early detection of acute critical illness. While maintaining a high predictive performance, our system explains to the clinician on which relevant electronic health records (EHRs) data the prediction is grounded. Acute cri…
Objective: A clinical decision support tool that automatically interprets EEGs can reduce time to diagnosis and enhance real-time applications such as ICU monitoring. Clinicians have indicated that a sensitivity of 95% with a specificity below 5% was the minimum requirement for clinical acceptance. We propose a highper…