With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic pr…
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arXiv research
A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
168,932 papers · 148 categories
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48 results for “Clinical Applications”
A new imputation model for clinical data captures both cross-sectional and temporal correlations.
problem Missing values in multivariable time series clinical data.
method Integrates Gaussian processes with mixture models and individualized mixing weights.
result The proposed model provides more accurate imputation than benchmarks on real-world and synthetic datasets.
Deep learning analyzes healthcare provider actions and patient outcomes.
problem Understanding provider behavior in non-randomized healthcare settings.
method Deep causal behavioral policy learning (DC-BPL) using transformer architecture.
result Optimal provider policies identified for specific patient types.
Survey on DRL for clinical decision support.
problem Improving clinical decision-making through AI.
method Deep reinforcement learning with DNN.
result Survey and comparison of DRL algorithms in clinical applications.
New method detects biomarker-treatment interactions in clinical trials.
problem Detecting interactions between high-dimensional biomarkers and treatments in randomized trials.
method Two-stage penalized regression screening using ridge regression for multivariate screening.
result Ridge regression screening provides greater power than traditional methods in correlated data.
Objective: A clinical decision support tool that automatically interprets EEGs can reduce time to diagnosis and enhance real-time applications such as ICU monitoring. Clinicians have indicated that a sensitivity of 95% with a specificity below 5% was the minimum requirement for clinical acceptance. We propose a highper…
TFM trains Neural SDEs without backpropagation, improving clinical time series modeling.
problem Modeling irregularly sampled time series in medicine.
method Trajectory Flow Matching (TFM) using flow matching for generative modeling.
result TFM improves performance on clinical time series datasets.
Negation detection in Dutch clinical texts: an evaluation of rule-based and machine learning methodscs.CL
Improved negation detection in Dutch clinical texts using machine learning.
problem Extracting negation from clinical text for better model development.
method Comparison of rule-based and machine learning methods (biLSTM, RoBERTa).
result BiLSTM and RoBERTa models outperform rule-based method in F1 score, precision, and recall.
Over half a million individuals are diagnosed with head and neck cancer each year worldwide. Radiotherapy is an important curative treatment for this disease, but it requires manual time consuming delineation of radio-sensitive organs at risk (OARs). This planning process can delay treatment, while also introducing int…
System exposes study population descriptions in clinical guidelines.
problem Challenges in understanding applicability of clinical guidelines.
method Developed an ontology-enabled prototype system using SIO.
result Allows medical practitioners to better understand study populations.
Current clinical practice to monitor patients' health follows either regular or heuristic-based lab test (e.g. blood test) scheduling. Such practice not only gives rise to redundant measurements accruing cost, but may even lead to unnecessary patient discomfort. From the computational perspective, heuristic-based test …
Proposes clustering as a new evaluation method for clinical knowledge embedding.
problem Traditional Link Prediction evaluation protocol loses information and harms model accuracy.
method Proposes Clustering Evaluation Protocol as an alternative.
result Experimental results show the proposed protocol can potentially replace Link Prediction.
Novel framework for uncertainty quantification in metric spaces.
problem Uncertainty quantification in regression models with metric responses.
method Developed algorithms for large datasets, agnostic to predictive models, with asymptotic and non-asymptotic guarantees.
result Asymptotic and non-asymptotic guarantees for special cases, demonstrated in clinical applications.
Improved language model for French clinical reports achieves state-of-the-art performance in medical NLP tasks.
problem Lack of specialized language models for French clinical reports.
method Adapted a general pre-trained language model (CamemBERT) to French clinical reports using a corpus of 21M reports.
result Pretrained and fine-tuned models improved F1-score by 3 percentage points on APMed task.
RAMANMETRIX: a delightful way to analyze Raman spectraphysics.data-an
RAMANMETRIX simplifies Raman spectroscopy data analysis.
problem Complexity of Raman spectroscopy data processing.
method User-friendly software with chemometric analysis workflow.
result Facilitates integration of Raman spectroscopy into clinical routines.
The classification procedure of streaming data usually requires various ad hoc methods or particular heuristic models. We explore a novel non-parametric and systematic approach to analysis of heterogeneous sequential data. We demonstrate an application of this method to classification of the delays in responding to the…
Learning the Joint Representation of Heterogeneous Temporal Events for Clinical Endpoint Predictioncs.AI
The availability of a large amount of electronic health records (EHR) provides huge opportunities to improve health care service by mining these data. One important application is clinical endpoint prediction, which aims to predict whether a disease, a symptom or an abnormal lab test will happen in the future according…
Communication-Efficient Federated Risk Difference Estimation for Time-to-Event Clinical Outcomesstat.ML
FedRD improves risk difference estimation in federated learning for clinical outcomes.
problem Privacy-preserving model co-training in medical research is hindered by server-dependent architectures and focus on relative effect measures.
method FedRD is a server-independent, communication-efficient framework for federated risk difference estimation in distributed survival data.
result FedRD provides valid confidence intervals and hypothesis testing, and is asymptotically equivalent to pooled individual-level analysis.
Learning Modular Safe Policies in the Bandit Setting with Application to Adaptive Clinical Trialscs.LG
The stochastic multi-armed bandit problem is a well-known model for studying the exploration-exploitation trade-off. It has significant possible applications in adaptive clinical trials, which allow for dynamic changes in the treatment allocation probabilities of patients. However, most bandit learning algorithms are d…
A new method uses Gaussian Processes for feature-based nonrigid image registration.
problem Estimating dense displacement fields for nonrigid image registration.
method Using Gaussian Processes to estimate both dense displacement field and uncertainty map.
result GP-based interpolation performs similarly to state-of-the-art B-spline interpolation.
Evaluating the clinical similarities between pairwise patients is a fundamental problem in healthcare informatics. A proper patient similarity measure enables various downstream applications, such as cohort study and treatment comparative effectiveness research. One major carrier for conducting patient similarity resea…
Federated learning improves bioinformatics by sharing data legally.
problem Lack of access to diverse data in bioinformatics.
method Combines data from multiple institutions legally.
result Federated learning accelerates clinical discovery and robust exploration.
Extends nonlinear filtering to predictable jump times.
problem Filtering with jumps in both signal and observation, especially when jump times are known.
method Derive Kushner-Stratonovich and Zakai equations for predictable discontinuities.
result Extends classical nonlinear filtering results to a setting with predictable discontinuities.
The past decade has seen an explosion in the amount of digital information stored in electronic health records (EHR). While primarily designed for archiving patient clinical information and administrative healthcare tasks, many researchers have found secondary use of these records for various clinical informatics tasks…
Develops a TL framework for estimating RMST difference in clinical trials.
problem Estimating RMST difference in clinical trials with time-to-event outcomes.
method Targeted learning (TL) framework using pseudo-observations and copy reference (CR) approach for sensitivity analysis.
result Demonstrated the effectiveness of the TL framework using real data.
ABC improves uncertainty quantification in LLMs for clinical diagnostics.
problem Overconfident and poorly calibrated estimates of LLMs in clinical domains.
method Approximate Bayesian Computation (ABC) for likelihood-free inference.
result Improves accuracy by up to 46.9%, reduces Brier scores by 74.4%, and enhances calibration.
The medical research facilitates to acquire a diverse type of data from the same individual for particular cancer. Recent studies show that utilizing such diverse data results in more accurate predictions. The major challenge faced is how to utilize such diverse data sets in an effective way. In this paper, we introduc…
TrialGraph uses graph machine learning to improve clinical trial design and predict side effects.
problem Complexity and cost in clinical trials hinder drug development.
method Curated clinical trial data set converted to graph-structured formats, applied graph machine learning algorithms.
result MetaPath2Vec algorithm performed exceptionally well, improving prediction accuracy.
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
problem Personalized treatment optimization in evolving clinical contexts with safety concerns.
method Integrates structured EHR and clinical notes, uses conformal prediction for safe recommendations.
result SAFER outperforms state-of-the-art baselines in recommendation metrics and mortality rates.
FRESH combines patient-level and aggregate-level data for better clinical decision making.
problem Combining patient-level and aggregate-level data for clinical decision making.
method FRESH method that re-calibrates a patient-level model to match specified aggregate statistics.
result Unified data-efficient model for clinical decision making.
The paper predicts diseases using both clinical and genomics data.
problem Clinical predictions using genomics data are not common.
method Integrated clinical and genomics datasets, machine learning, Principal Component Analysis for feature selection.
result 73% accuracy in predicting 75 disease classes.
Novel IRL method identifies suboptimal medical decisions in ICU data.
problem Identifying suboptimal medical decisions in clinical settings.
method Incorporates Inverse Reinforcement Learning with a pruning step to identify and remove suboptimal actions.
result Pruning step effectively identifies clinical priorities and values from suboptimal data.
DWTS uses observational data to improve clinical trial efficiency.
problem Lack of definitive conclusions from randomized clinical trials due to insufficient patient cohorts and confounding biases.
method DWTS combines observational data with randomized clinical trials using Doubly Debiased LASSO (DDL) to identify reliable covariates.
result DWTS reduces cumulative regret in clinical trials compared to standard methods.
Improved model predicts ICU readmission and mortality with interpretable results.
problem Lack of clinically interpretable predictions from deep learning models on clinical notes.
method Augmented a convolutional model with an attention mechanism for clinical note prediction.
result Attention mechanism improves prediction performance while providing interpretable results.
Examines fairness in ML for health, highlighting its importance and challenges.
problem Ensuring fairness in ML models for health to prevent health disparities.
method Reviews fairness notions in ML for health, including group, individual, and causal-based approaches.
result Discusses the importance and challenges of fairness in health-focused ML applications.
HBR improves normative modeling of neuroimaging data across multiple sites.
problem Dealing with nuisance variation in neuroimaging data across different sites.
method Hierarchical Bayesian regression (HBR) for multi-site normative modeling.
result HBR provides more accurate normative ranges compared to existing methods.
Paper tackles robust batched bandits for heavy-tailed rewards.
problem Clinical trials and other applications with heavy-tailed rewards.
method Proposes robust batched bandit algorithms for heavy-tailed rewards in finite-arm and Lipschitz-continuous settings.
result Heavier-tailed rewards require fewer batches for near-optimal regret in the instance-independent regime and Lipschitz setting.
Proposes a new Q-learning method for survival outcomes in clinical trials.
problem Incomplete follow-up data and nonlinear covariate effects in clinical trials.
method Combines Buckley-James boosting with flexible base learners for estimating optimal treatment regimes.
result Improves treatment decision accuracy and stability in longitudinal clinical trials.
Clinical AI models fail to transfer between sites due to site-specific practices.
problem Clinical AI models perform poorly at new sites.
method Identify and isolate site-specific clinical practices affecting data distribution.
result A potential solution to improve model transferability.
Dynamic CBDT improves treatment effect estimation in clinical data.
problem Estimating heterogeneous treatment effects in observational data with high accuracy and interpretability.
method Dynamic Regularized Causal Boosted Decision Trees (CBDT) integrating variance regularization and calibration.
result Significantly improved estimation accuracy and reliable coverage of true treatment effects.
System suggests clinical concepts in real-time for faster note creation.
problem Efficiently creating structured clinical notes with minimal keystrokes.
method Contextual autocompletion using shallow neural networks.
result Reduces keystrokes by 67% in real hospital environments.
New method improves compatibility of risk stratification models without sacrificing accuracy.
problem Compatibility issues arise when updating clinical machine learning models.
method Proposes rank-based compatibility measure and new loss function.
result Increased compatibility of models by 0.019 with no loss in discriminative performance.
We study the problem of privacy-preserving machine learning (PPML) for ensemble methods, focusing our effort on random forests. In collaborative analysis, PPML attempts to solve the conflict between the need for data sharing and privacy. This is especially important in privacy sensitive applications such as learning pr…
The study explores statistical methods to interpret radiological models and identify key features.
problem Interpreting complex radiological models for clinical use.
method Exploration of statistical techniques to assess relationships between radiomic features.
result Identification of key relationships and features for improved interpretability.
We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical neuroscience studies. However, most registration algorithms are designed for high-resolut…
Machine learning aids in clinical prediction tasks.
problem Improving accuracy in clinical predictions.
method Introduction to machine learning concepts and algorithms, followed by practical application to clinical datasets.
result Demonstrated the application of machine learning models to clinical prediction problems.
Aiming for Relevancecs.LG
Novel metrics improve machine learning models for ICU patient care.
problem Predicting vital sign trajectories for early detection of adverse events.
method Developed novel performance metrics aligned with clinical contexts, validated on simulated and real datasets, and optimized neural networks using these metrics.
result Neural networks trained with these metrics excel in predicting clinically significant events.
AI predicts medical specialty diagnostic choices from EHR records.
problem Predicting timely medical specialty diagnostic workups for patients.
method Ensemble of feed-forward neural networks trained on EHR data.
result Significantly higher accuracy compared to traditional checklists.