A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
Novel method identifies proteomic risk markers for Alzheimer disease.
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Bayesian meta-learning predicts Alzheimer's disease progression.
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
Proposes a new Alzheimer's disease simulator for causal effect estimation.
We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual chec…
Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible non-linear way. In this paper, we investigate the use of variants of DIM in a se…
HMRNN combines HMMs and neural networks for Alzheimer's disease forecasting.
Paper proposes machine learning model for early Alzheimer's diagnosis.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
The paper generates future brain imaging sequences for Alzheimer's disease detection.
Paper introduces a framework for diagnosing Alzheimer's disease using higher-order topological features from fMRI.
Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies h…
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
StaPLR improves Alzheimer's disease classification by identifying important MRI scan types and measures.
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. Despite the many advantages of joint modeling, the standard forms suffer from limitations that arise from a fixed model specification and computational difficulties when applied to …
Novel approach combines local and global brain changes for AD prediction.
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
Study examines APOE's impact on AD progression using a novel DEBM approach.
Bayesian approach models neurodegenerative diseases without clinical labels.
Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that quantify different aspects of a patient's cognitive state such as learning, memor…
Ensemble model predicts AD progression from CN status with high accuracy.
Improves disease progression prediction using auxiliary surrogate labels and health markers.
Wavelets model complex interactions in spatial transcriptomics.
THS-GAN uses tensorizing and high-order pooling for AD diagnosis.
Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and 3D convolutional neural networks, to build an algorithm that can predict the di…
For precision medicine and personalized treatment, we need to identify predictive markers of disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans provide information about the disease status. By combining imaging with genome sequencing, we aim at identifying rare genetic markers associa…
New method predicts AD progression using MEG brain networks.
SVEHNN explains DNN diagnoses of Alzheimer's disease from neuroanatomy and biomarkers.
Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream acoustically, syntactically or both. The mostly used tools to perform these analysis…
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused in a single neural network. The network is invariant to shape transformations an…
We propose a method to predict the subject-specific longitudinal progression of brain structures extracted from baseline MRI, and evaluate its performance on Alzheimer's disease data. The disease progression is modeled as a trajectory on a group of diffeomorphisms in the context of large deformation diffeomorphic metri…
Method predicts biomarker trajectories with uncertainty bands for Alzheimer's disease.
QC-SPHARM detects Alzheimer's Disease early using hippocampal surface geometry.
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot easily be identified at early stages. This project investigated machine learning app…
Imaging-based early diagnosis of Alzheimer Disease (AD) has become an effective approach, especially by using nuclear medicine imaging techniques such as Positron Emission Topography (PET). In various literature it has been found that PET images can be better modeled as signals (e.g. uptake of florbetapir) defined on a…
Omics-GAN uses GANs to generate synthetic multi-omics data for improved disease prediction.
In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associate…
Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to adopt architectures optimized for traditional computer vision tasks, rather than des…
A novel method predicts shape development using Riemannian shape spaces.
Most machine learning classifiers give predictions for new examples accurately, yet without indicating how trustworthy predictions are. In the medical domain, this hampers their integration in decision support systems, which could be useful in the clinical practice. We use a supervised learning approach that combines E…
ProJIVE integrates multiple data types to explain joint and individual variation.
New model detects Alzheimer's and severity from speech, cognitive, and language data.
Sparse symmetric tensor regression reduces brain connectivity complexity.
Ensemble learning use multiple algorithms to obtain better predictive performance than any single one of its constituent algorithms could. With growing popularity of deep learning, researchers have started to ensemble them for various purposes. Few if any, however, has used the deep learning approach as a means to ense…
Enhances disease progression modeling using LLMs for complex brain connectivity.
In this paper, we introduce the use of a personalized Gaussian Process model (pGP) to predict the key metrics of Alzheimer's Disease progression (MMSE, ADAS-Cog13, CDRSB and CS) based on each patient's previous visits. We start by learning a population-level model using multi-modal data from previously seen patients us…