Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction of MCI individuals will progress to dementia, even when screened using biomarkers. We propose here to identify a subset of individuals who share a common brain signature highly p…
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ADReSS Challenge at INTERSPEECH 2020 benchmarks speech recognition for Alzheimer's dementia.
problem Automated recognition of Alzheimer's dementia from spontaneous speech.
method Provides a benchmark speech dataset, defines two tasks (classification and regression), and presents baseline models.
result Demonstrates the feasibility of automated speech recognition for Alzheimer's dementia.
Models predict Alzheimer's Dementia from spontaneous speech with high accuracy.
problem Early diagnosis of Alzheimer's Dementia (AD) through spontaneous speech analysis.
method Compared natural language processing techniques including SVM, GBDT, CRFs, and Transformer-based models.
result Top models achieve 0.81-0.82 test set scores for AD vs controls and 4.58 RMSE for Mental Mini State Exam scores.
Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this dementia is crucial although it is a challenging task. Recently, many studies h…
Introduction: Alzheimer's disease is a type of dementia in which early diagnosis plays a major rule in the quality of treatment. Among new works in the diagnosis of Alzheimer's disease, there are many of them analyzing the voice stream acoustically, syntactically or both. The mostly used tools to perform these analysis…
Multimodal Inductive Transfer Learning for Detection of Alzheimer's Dementia and its Severityeess.AS
New model detects Alzheimer's and severity from speech, cognitive, and language data.
problem Detecting Alzheimer's disease and its severity from multimodal data.
method Multimodal ensemble system using acoustic, cognitive, and linguistic features.
result State-of-the-art accuracy and robustness in AD detection and MMSE score regression.
Framework for joint learning of tasks on dementia data with missing values.
problem Lack of multi-task learning, handling time-dependent data, and missing values in dementia forecasting.
method Proposes SSHIBA model using Bayesian variational inference for imputation and combined information from different views.
result SSHIBA model outperforms baselines in predicting diagnosis, ventricle volume, and clinical scores in dementia.
Paper characterizes early-stage dementia signatures from sensor data.
problem Detecting early-stage dementia from sensor data.
method Developed bespoke behavioural models from longitudinal sensor data.
result Found subtle differences in sleep quality and wandering between dementia patients and controls.
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
Paper compares neural networks and classical statistics for dementia prediction, highlighting interpretability of classical methods.
problem Tackles the challenge of interpreting risk factors for dementia prediction.
method Compares neural networks and classical statistics for dementia prediction.
result Classical statistics provide clearer interpretation of risk factors compared to neural networks.
Improves disease progression prediction using auxiliary surrogate labels and health markers.
problem Challenges in predicting disease progression due to unknown true disease states.
method Integrates hidden Markov model with time-varying discriminative classification model.
result Significant improvement in distinguishing LBD from AD using objective markers.
Traditional voxel-level multiple testing procedures in neuroimaging, mostly -value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, whic…
Study examines APOE's impact on AD progression using a novel DEBM approach.
problem Understanding APOE's role in AD progression and developing targeted clinical trials.
method Developed a discriminative event-based model (DEBM) and proposed a stratified approach to improve model accuracy.
result Identified APOE carriers' impact on AD progression timeline, aiding clinical trial selection.
Develops a new feature theory for robust machine learning.
problem Creating robust machine learning features from training data.
method Stochastic tensor space feature theory with Karhunen-Loeve expansion and hierarchical subspaces.
result Dramatic increases in accuracy for predicting Alzheimer's disease stages.
AI predicts dementia onset from emotional face evaluations.
problem Early detection of dementia in aging societies.
method Behavioral responses analysis and AI regression.
result Encouraging AI-based prediction results for MoCA scores.
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
Improving Mild Cognitive Impairment Prediction via Reinforcement Learning and Dialogue Simulationcs.LG
Mild cognitive impairment (MCI) is a prodromal phase in the progression from normal aging to dementia, especially Alzheimers disease. Even though there is mild cognitive decline in MCI patients, they have normal overall cognition and thus is challenging to distinguish from normal aging. Using transcribed data obtained …
One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but different fashion by the normal aging process. Aging is therefore a confounding …
Our research focuses on analysing human activities according to a known behaviorist scenario, in case of noisy and high dimensional collected data. The data come from the monitoring of patients with dementia diseases by wearable cameras. We define a structural model of video recordings based on a Hidden Markov Model. N…
The emergence of an ageing population is a significant public health concern. This has led to an increase in the number of people living with progressive neurodegenerative disorders like dementia. Consequently, the strain this is places on health and social care services means providing 24-hour monitoring is not sustai…
Alzheimer's disease is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. In this respect, we regard probabilistic classification as a method of designing a probabilistic biomarker for disease staging. Probabilistic biomarkers naturally support the interpretation…
Novel method identifies proteomic risk markers for Alzheimer disease.
problem Lack of comprehensive proteomic risk markers for Alzheimer disease diagnosis.
method Deep belief network-based feature selection method using proteomic and clinical data.
result Identified an optimal subset of proteins achieving 90% accuracy in Alzheimer disease diagnosis.
We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from …
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
problem Differentiating Alzheimer Disease from Mild Cognitive Impairment.
method Hybrid deep learning ensemble framework using MRI slices, pretrained models, and stacked ensemble learning.
result State-of-the-art accuracy (99.21%) for Alzheimer vs. Mild Cognitive Impairment classification.
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes, as inputs. However, regional aggregates are a crude summary of the underlying hi…
ADCB: An Alzheimer's disease benchmark for evaluating observational estimators of causal effectscs.LG
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual chec…
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible non-linear way. In this paper, we investigate the use of variants of DIM in a se…
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
On the design of convolutional neural networks for automatic detection of Alzheimer's diseaseeess.IV
Improved CNNs detect Alzheimer's with 14% accuracy boost.
problem Early detection of Alzheimer's Disease using MRI scans.
method Optimized 3D CNNs with instance normalization, spatial downsampling, model widening, and age information.
result 14% increase in test accuracy distinguishing AD, MCI, and controls.
Sparse GFA identifies disease factors in FTD subgroups.
problem Heterogeneity in neurological disorders hinders understanding and treatment.
method Sparse Group Factor Analysis (GFA) with regularised horseshoe priors.
result Identified latent disease factors differentially expressed in FTD subgroups.
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
SVEHNN explains DNN diagnoses of Alzheimer's disease from neuroanatomy and biomarkers.
problem Interpreting deep neural networks for medical diagnosis, especially in the clinic.
method Shapley Value Explanation of Heterogeneous Neural Networks (SVEHNN) for local explanations.
result SVEHNN provides interpretable explanations for DNN diagnoses with reduced runtime.
StaPLR improves Alzheimer's disease classification by identifying important MRI scan types and measures.
problem Classifying Alzheimer's disease using multi-source MRI data.
method Stacked penalized logistic regression (StaPLR) with hierarchical multi-view structure and new view importance measure.
result StaPLR identifies the most important MRI scan types and measures for Alzheimer's disease classification.
HMRNN combines HMMs and neural networks for Alzheimer's disease forecasting.
problem Improving disease progression modeling with hidden states not fully known.
method Developed HMRNN combining HMMs and recurrent neural networks.
result HMRNN improves disease forecasting and offers novel clinical interpretation.
Paper introduces a framework for diagnosing Alzheimer's disease using higher-order topological features from fMRI.
problem Diagnosing Alzheimer's disease using brain network topology.
method Persistent homology to extract higher-order features (cycles, cavities) from fMRI data.
result Framework significantly outperforms existing methods in AD classification.
DynForest predicts event probabilities from longitudinal data, handling endogenous predictors.
problem Predicting individual risk using longitudinal patient history.
method Random survival forests with time-fixed features from longitudinal predictors.
result DynForest provides accurate individual event probability predictions.
The paper generates future brain imaging sequences for Alzheimer's disease detection.
problem Understanding brain aging and neurodegenerative diseases through sequential image data.
method Formulated a min-max problem based on -divergence to learn a time series generator using a deep neural network.
result Generated image sequences converge to the latent truth under specific conditions, enhancing downstream tasks like Alzheimer's disease detection.
THS-GAN uses tensorizing and high-order pooling for AD diagnosis.
problem Early diagnosis of Alzheimer's Disease (AD) using MRI images.
method Tensorizing a three-player cooperative game framework with high-order pooling for MRI images.
result THS-GAN achieves superior performance in AD diagnosis compared to existing methods.
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising 18-month trajectories of 44 clinical variables from 1908 patients with Mild Cognitive…
Novel approach combines local and global brain changes for AD prediction.
problem Detecting Alzheimer's disease through local and global brain changes.
method Patch-based 3D-CNNs combined with global topological features for multi-scale brain tissue connectivity.
result Average precision score of 0.95 for classifying cognitively normal subjects and AD patients (prevalence ~55%).
Ensemble model predicts AD progression from CN status with high accuracy.
problem Early prediction of clinical progression from cognitively normal to mild cognitive impairment or Alzheimer's disease.
method Ensemble survival analysis combining penalized Cox regression, advanced survival models, and aggregation techniques.
result Ensemble model achieved peak C-index of 0.907 and integrated time-dependent AUC of 0.904, outperforming baseline models.
Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that quantify different aspects of a patient's cognitive state such as learning, memor…
ICAM: Interpretable Classification via Disentangled Representations and Feature Attribution Mappingcs.LG
ICAM creates interpretable feature attribution maps for brain images.
problem Challenges in predicting class relevance from brain images due to heterogeneity and background variation.
method A VAE-GAN framework for disentangling class relevance from background features.
result FA maps generated by ICAM outperform baseline methods and support phenotype variation exploration.
A Wide and Deep Neural Network for Survival Analysis from Anatomical Shape and Tabular Clinical Datacs.LG
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused in a single neural network. The network is invariant to shape transformations an…
Ensemble learning use multiple algorithms to obtain better predictive performance than any single one of its constituent algorithms could. With growing popularity of deep learning, researchers have started to ensemble them for various purposes. Few if any, however, has used the deep learning approach as a means to ense…