Arguably, unsupervised learning plays a crucial role in the majority of algorithms for processing brain imaging. A recently introduced unsupervised approach Deep InfoMax (DIM) is a promising tool for exploring brain structure in a flexible non-linear way. In this paper, we investigate the use of variants of DIM in a se…
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48 results for “Alzheimer's Disease Neuroimaging Initiative”
Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological ima…
Bayesian meta-learning predicts Alzheimer's disease progression.
problem Predicting individual Alzheimer's disease progression from limited data.
method Bayesian meta-learning approach that dynamically predicts disease score distributions.
result Bayesian meta-learner outperforms single-task models and deterministic meta-learners, especially for long-term predictions.
Traditional voxel-level multiple testing procedures in neuroimaging, mostly -value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, whic…
ADCB: An Alzheimer's disease benchmark for evaluating observational estimators of causal effectscs.LG
Proposes a new Alzheimer's disease simulator for causal effect estimation.
problem Lack of suitable benchmarks for evaluating causal effect estimators in real-world healthcare data.
method Developed a simulator of Alzheimer's disease using ADNI dataset, incorporating various parameters to model complexities.
result Compared estimators of average and conditional treatment effects using the new simulator.
Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, …
Deep learning ensemble improves Alzheimer vs. Mild Cognitive Impairment diagnosis.
problem Differentiating Alzheimer Disease from Mild Cognitive Impairment.
method Hybrid deep learning ensemble framework using MRI slices, pretrained models, and stacked ensemble learning.
result State-of-the-art accuracy (99.21%) for Alzheimer vs. Mild Cognitive Impairment classification.
ProJIVE integrates multiple data types to explain joint and individual variation.
problem Integrating multiple types of data on the same subjects.
method Probabilistic EM algorithm for JIVE framework.
result ProJIVE learns biologically meaningful courses of variation and improves accuracy.
Pattern recognition methods using neuroimaging data for the diagnosis of Alzheimer's disease have been the subject of extensive research in recent years. In this paper, we use deep learning methods, and in particular sparse autoencoders and 3D convolutional neural networks, to build an algorithm that can predict the di…
Paper addresses high-dimensional linear regression with missing data, proposing efficient and nearly unbiased estimators.
problem High-dimensional linear regression with blockwise missing covariates and partially observed responses.
method Proposes a computationally efficient estimator and nearly unbiased debiased estimators using blockwise imputation and estimating equations.
result Asymptotically valid confidence intervals and statistical tests constructed based on debiased estimators.
New method handles missing data in multimodal brain imaging.
problem Missing data in multimodal brain imaging.
method Full Information Linked ICA (FI-LICA) algorithm.
result FI-LICA outperforms current practices in classification and prediction.
NEURO-DRAM: a 3D recurrent visual attention model for interpretable neuroimaging classificationcs.LG
Deep learning is attracting significant interest in the neuroimaging community as a means to diagnose psychiatric and neurological disorders from structural magnetic resonance images. However, there is a tendency amongst researchers to adopt architectures optimized for traditional computer vision tasks, rather than des…
The paper generates future brain imaging sequences for Alzheimer's disease detection.
problem Understanding brain aging and neurodegenerative diseases through sequential image data.
method Formulated a min-max problem based on -divergence to learn a time series generator using a deep neural network.
result Generated image sequences converge to the latent truth under specific conditions, enhancing downstream tasks like Alzheimer's disease detection.
A Wide and Deep Neural Network for Survival Analysis from Anatomical Shape and Tabular Clinical Datacs.LG
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused in a single neural network. The network is invariant to shape transformations an…
A test for neural networks identifies genetic associations.
problem Testing complex associations in neural networks.
method Sieve quasi-likelihood ratio test for neural networks with one hidden layer.
result The test statistic has an asymptotic chi-squared distribution.
For precision medicine and personalized treatment, we need to identify predictive markers of disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans provide information about the disease status. By combining imaging with genome sequencing, we aim at identifying rare genetic markers associa…
Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot easily be identified at early stages. This project investigated machine learning app…
Paper proposes machine learning model for early Alzheimer's diagnosis.
problem Early and accurate diagnosis of Alzheimer's Disease.
method Machine learning models, demographic, biomarker, and cognitive test data.
result 90% accuracy and 87% accuracy in predicting Alzheimer's development.
THS-GAN uses tensorizing and high-order pooling for AD diagnosis.
problem Early diagnosis of Alzheimer's Disease (AD) using MRI images.
method Tensorizing a three-player cooperative game framework with high-order pooling for MRI images.
result THS-GAN achieves superior performance in AD diagnosis compared to existing methods.
Ensemble model predicts AD progression from CN status with high accuracy.
problem Early prediction of clinical progression from cognitively normal to mild cognitive impairment or Alzheimer's disease.
method Ensemble survival analysis combining penalized Cox regression, advanced survival models, and aggregation techniques.
result Ensemble model achieved peak C-index of 0.907 and integrated time-dependent AUC of 0.904, outperforming baseline models.
fcHMRF-LIS controls FDR in neuroimaging data, improving power and scalability.
problem Complex spatial dependencies and high variability in FDR control methods for neuroimaging data.
method fcHMRF-LIS integrates LIS-based testing with fcHMRF to model spatial structures efficiently.
result fcHMRF-LIS achieves accurate FDR control, lower FNR, and higher true positives compared to existing methods.
This paper describes a new neuroimaging analysis toolbox that allows for the modeling of nonlinear effects at the voxel level, overcoming limitations of methods based on linear models like the GLM. We illustrate its features using a relevant example in which distinct nonlinear trajectories of Alzheimer's disease relate…
Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. Despite the many advantages of joint modeling, the standard forms suffer from limitations that arise from a fixed model specification and computational difficulties when applied to …
Imaging-based early diagnosis of Alzheimer Disease (AD) has become an effective approach, especially by using nuclear medicine imaging techniques such as Positron Emission Topography (PET). In various literature it has been found that PET images can be better modeled as signals (e.g. uptake of florbetapir) defined on a…
Robust deep neural networks estimate multi-dimensional functional data robustly.
problem Estimating location function from multi-dimensional functional data robustly.
method Deep neural networks with ReLU activation, robust to outliers and model misspecification.
result Uniform convergence rates for robust deep neural network estimators.
Deep neural networks improve mean function estimation for functional data.
problem Estimating mean functions of functional data.
method Deep neural networks with ReLU activation, sparsely connected.
result Achieves optimal nonparametric convergence rate in empirical norm.
DeepFDR uses deep learning for better FDR control in neuroimaging data.
problem Spatial dependence among voxel-based tests in neuroimaging data.
method DeepFDR leverages unsupervised deep learning-based image segmentation.
result DeepFDR outperforms existing methods in FDR control and computational efficiency.
Study examines APOE's impact on AD progression using a novel DEBM approach.
problem Understanding APOE's role in AD progression and developing targeted clinical trials.
method Developed a discriminative event-based model (DEBM) and proposed a stratified approach to improve model accuracy.
result Identified APOE carriers' impact on AD progression timeline, aiding clinical trial selection.
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for a disease become abnormal based on cross-sectional data. It can…
A new framework detects statistical significance of deep learning in neuroimaging studies.
problem Lack of statistical significance testing in deep learning neuroimaging.
method Non-parametric framework using autoencoders and SVM, with random-effects inference and cross-validation.
result CV and RUB methods offer acceptable false positive rates and statistical power, but low generalization ability.
Paper revisits graph-CNNs using Laplace-Beltrami spectral filters and polynomials.
problem Improving spectral graph convolutional neural networks (graph-CNNs).
method Developed Laplace-Beltrami CNN (LB-CNN) by replacing graph Laplacian with LB operator and approximating spectral filters using Chebyshev, Laguerre, and Hermite polynomials.
result Classification accuracy of LB-CNN is not dependent on the type of polynomials or operators.
We developed a convolution neural network (CNN) on semi-regular triangulated meshes whose vertices have 6 neighbours. The key blocks of the proposed CNN, including convolution and down-sampling, are directly defined in a vertex domain. By exploiting the ordering property of semi-regular meshes, the convolution is defin…
Transformers improve Alzheimer's disease progression prediction by accounting for irregular biomarker histories.
problem Difficult prediction of medium-horizon Alzheimer's disease progression due to tied clinical scores and irregular biomarker observations.
method Developed a residual gap-aware transformer that combines statistical reference with transformer-based residual learning.
result The proposed model reduces mean error and improves prediction-observation correlation compared to baseline models.
MediEncoder: Nonlinear Representation Learning for High-Dimensional Causal Mediation Analysisstat.ME
MediEncoder learns nonlinear representations for causal mediation analysis.
problem High-dimensional noisy covariates and mediators in biomedical studies.
method Coupled encoder-decoder architecture with cross-factor network.
result Improves estimation accuracy in high-dimensional causal mediation analysis.
Sparse symmetric tensor regression reduces brain connectivity complexity.
problem Complex brain connectivity analysis in neuroimaging.
method Sparse symmetric tensor regression model for functional connectivity.
result Superior performance in Alzheimer's disease detection.
Deep learning models brain deformations based on atrophy and growth data.
problem Simulating brain deformations due to atrophy and growth.
method Differentiable biomechanical model using deep learning.
result Trained model can rapidly simulate new brain deformations with minimal residuals.
Enhanced Survival Treesstat.ME
Enhanced survival trees improve computational efficiency and inference.
problem Censored failure time data and variable selection bias.
method Improved splitting procedure, intersected validation, fused regularization, and bootstrap-based bias correction.
result Valid confidence intervals for median survival times.
Deep learning has shown outstanding performance in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated classification of Alzheimer's disease (AD) has recently gained considerable attention, as r…
Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and to explore relationships between disease and potential biomarkers, feature lear…
With the arrival of the big data era, more and more data are becoming readily available in various real-world applications and those data are usually highly heterogeneous. Taking computational medicine as an example, we have both Electronic Health Records (EHR) and medical images for each patient. For complicated disea…
Genome-wide association studies (GWA studies or GWAS) investigate the relationships between genetic variants such as single-nucleotide polymorphisms (SNPs) and individual traits. Recently, incorporating biological priors together with machine learning methods in GWA studies has attracted increasing attention. However, …
Proposes a deep learning framework for interval-censored survival data.
problem Lack of deep learning methods for interval-censored survival data.
method Partially linear transformation models with DNN approximations for nonlinear effects.
result DNN estimator achieves minimax-optimal convergence and superior performance.
Self-PU combines self-training with PU learning for improved binary classification.
problem Binary classification from unlabeled data and few labeled positives.
method Integrates self-paced training, self-calibrated loss, and self-distillation.
result Significantly improved performance on Alzheimer's Disease classification.
Nowadays, a lot of scientific efforts are concentrated on the diagnosis of Alzheimer's Disease (AD) applying deep learning methods to neuroimaging data. Even for 2017, there were published more than a hundred papers dedicated to AD diagnosis, whereas only a few works considered a problem of mild cognitive impairments (…
Proposes a new method for analyzing multimodal neuroimaging data.
problem Combining interpretability and flexibility in multimodal data analysis.
method Orthogonalized kernel debiased machine learning approach.
result Established consistency and asymptotic normality of the estimated primary parameter.
GIDS reduces high-dimensional response and predictor spaces, improving interpretability and computational efficiency.
problem Challenges in modeling interactions among high-dimensional multimodal data.
method Graph Independence Dual Screening (GIDS) framework that reduces both response and predictor dimensions.
result GIDS reduces feature space to 9,000 CpGs and 2,000 transcripts, revealing coordinated regulatory mechanisms.
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surf…
Develops a new feature theory for robust machine learning.
problem Creating robust machine learning features from training data.
method Stochastic tensor space feature theory with Karhunen-Loeve expansion and hierarchical subspaces.
result Dramatic increases in accuracy for predicting Alzheimer's disease stages.