A ML-based method reconstructs 3D organ doses from 2D radiographs for pediatric abdominal radiotherapy.
problem Reconstructing detailed 3D dose distributions for childhood cancer survivors using limited 2D radiographs.
method Surrogate-free ML approach using 142 abdominal planning CTs, 300 artificial plans, and evolutionary algorithm.
result Accurate 3D dose reconstructions with MAEs ≤ 1.7 Gy for edge organs, validated on independent dataset.
Generative adversarial networks improve radiation therapy planning.
problem Creating optimal radiation therapy plans.
method Using a GAN to predict 3D dose distributions directly.
result Significantly outperforms previous methods in clinical satisfaction and metrics.
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
The development of computed tomography (CT) image reconstruction methods that significantly reduce patient radiation exposure while maintaining high image quality is an important area of research in low-dose CT (LDCT) imaging. We propose a new penalized weighted least squares (PWLS) reconstruction method that exploits …
Study uses Thompson Sampling to find optimal drug dosages in clinical trials.
problem Finding the best drug dosage in early-stage clinical trials.
method Adopted Thompson Sampling for dose-finding clinical trials, considering different monotonicity assumptions.
result Thompson Sampling variants outperform existing methods in various dose-finding scenarios.
GAN normalizes CT scans for consistent radiomic feature values.
problem Variations in dose levels and slice thickness affect radiomic features sensitivity.
method Used a 3D generative adversarial network (GAN) to normalize reduced dose, thick slice images to normal dose, thinner slice images.
result GAN-based approach led to significantly smaller error in radiomic features.
DoSE improves OOD detection by estimating model probability density.
problem Poor specificity of model likelihoods for OOD detection.
method DoSE uses density of states concept to avoid direct model probability comparison.
result DoSE achieves state-of-the-art performance on OOD detection benchmarks.
The distribution of absorbed dose in radionuclide therapy with Lu177 can be approximated by convolving an image of the time-integrated activity distribution with a dose voxel kernel representing different tissue types. This fast but inaccurate approximation is unsuitable for personalised dosimetry because it negle…
Proposes a method for generating prediction intervals in dose-response models using conformal prediction.
problem Uncertainty quantification in continuous treatments for personalized healthcare decisions.
method Causal dose-response problem framed as covariate shift, using weighted conformal prediction with propensity estimation and kernel functions.
result Demonstrates the significance of covariate shift assumptions for robust prediction intervals.
A novel dose-finding design for cancer clinical trials using level set estimation.
problem Finding the maximum tolerated dose (MTD) in phase I cancer clinical trials.
method Proposes a novel dose-finding design based on level set estimation (LSE) to determine the next dose.
result The proposed LSE design achieves higher accuracy in estimating the MTD and lower risk of overdosing compared to existing designs.
Deep learning methods improve Bayesian inversion for efficient 3D imaging.
problem Efficiently solving large-scale inverse problems in medical imaging.
method Two novel deep learning approaches: WGAN with mini-discriminator and neural network loss function.
result Both methods compute posterior mean and standard deviation efficiently, demonstrating promising performance in 3D imaging.
Proposes a new method to measure and avoid harm in machine learning decisions.
problem Measuring and avoiding harm in machine learning algorithms.
method Formal definition of harm and benefit using causal models, counterfactual objective functions.
result Demonstrates that standard machine learning methods can lead to harmful policies under distributional shifts.
Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However, interventions can be expensive and time-consuming. Observational data, where the treat…
Kernel method optimizes personalized dose rules for patients.
problem Finding optimal individualized dose rules for patients.
method Kernel assisted learning method for estimating optimal dose rules.
result The method identifies the optimal individualized dose rule and produces favorable outcomes.
Gaussian surrogates improve Poisson imaging performance at low doses.
problem Improving Poisson imaging performance at low doses.
method Analysis of Poisson and Gaussian surrogate reconstruction objectives under Poisson noise.
result Gaussian surrogates can achieve MSE comparable to Poisson MAP at low doses.
Shared Keyboard design improves phase I clinical trials by borrowing information across doses.
problem Interim decisions based on current dose data may overlook signals from neighboring doses.
method Bayesian model-assisted design using Beta kernel process with kernel-weighted pseudo-counts.
result Significant improvements in identifying maximum tolerated dose and safety.
Develops a neural surrogate for proton dose calculation using Monte Carlo dropout uncertainty.
problem Computational demand in proton therapy workflows requiring repeated evaluations.
method Integrates Monte Carlo dropout into a neural network surrogate for fast, differentiable dose predictions and uncertainty quantification.
result Shows significant speedups over MC while retaining uncertainty information.
Novel algorithms improve warfarin dose prediction accuracy.
problem Challenges in estimating warfarin dose due to narrow therapeutic index and individual variability.
method Stacked generalization frameworks combining different machine learning algorithms.
result Stacked algorithms outperform the IWPC MLR algorithm, especially in subgroups.
New method estimates optimal dose intervals for personalized treatment.
problem Learning optimal dose intervals from observational data.
method Probability dose interval (PDI) method using DC algorithm.
result Consistent policy with risk converging to best-in-class at root-n rate.
A model predicts which patients can safely use a warfarin dosing algorithm.
problem Determining the optimal initial dose for warfarin patients.
method Support Vector Machines with a polynomial kernel function.
result The model increases dosing accuracy by 15% in RMSE and 17% in MAE.
Proposes estimators for complex dose-response curves using kernel methods.
problem Estimating complex dose-response curves with continuous treatments, mediators, and covariates.
method Kernel ridge regression with sequential kernel embedding technique.
result Simple estimators for mediated and time-varying dose response curves with nonasymptotic uniform rates.
Convolutional LSTM detects emphysema in lung cancer screening images.
problem Learning disease signatures from weakly annotated volumetric medical images.
method 3D volumetric images analyzed as a sequence of 2D images using convolutional LSTM.
result Convolutional LSTM model outperformed other methods in detecting emphysema.
A new cycleGAN architecture reduces memory and parameter requirements for low-dose CT denoising.
problem Efficient unsupervised low-dose CT denoising with minimal memory and parameter usage.
method Single switchable generator using AdaIN layers for efficient training and inference.
result The proposed method outperforms previous cycleGAN approaches with half the parameters.
SEEDA optimizes dose allocation in clinical trials to balance efficacy and safety.
problem Complex relationships between efficacy and toxicity in new drug trials.
method Adaptive clinical trial methodology that maximizes cumulative efficacy while ensuring safety constraints.
result SEEDA outperforms existing methods in finding optimal doses with higher success rates and fewer patients.
New method estimates individual dose-response curves for any number of treatments.
problem Estimating individual dose-response curves for varied exposures.
method Neural network approach for learning counterfactual representations.
result Set a new state-of-the-art in estimating individual dose-response curves.
New framework for managing medical risks using convex responses.
problem Medical risk management and dosing optimization.
method Analyzes convex and concave dose-response functions, defines antifragility.
result Proposes a mathematical framework for integrating nonlinearities in oncology.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
In coronary CT angiography, a series of CT images are taken at different levels of radiation dose during the examination. Although this reduces the total radiation dose, the image quality during the low-dose phases is significantly degraded. To address this problem, here we propose a novel semi-supervised learning tech…
C3T-Budget optimizes drug efficacy in dose-finding trials with budget and safety constraints.
problem Heterogeneous patient populations and budget constraints make dose-finding clinical trials challenging.
method Contextual constrained clinical trial algorithm that maximizes drug efficacy while learning subgroup responses.
result Demonstrates efficient budget usage and balanced learning-treatment trade-off in simulated trials.
This study uses bandit algorithms to predict Warfarin dosages more accurately.
problem Determining the correct initial Warfarin dosage is challenging due to patient variability and adverse effects.
method Developed and evaluated linear bandit algorithms on real data from PharmGKB.
result Proposed algorithms outperformed fixed-dose and clinical algorithms.
BCD-Net improves low-dose CT image reconstruction.
problem Challenges in obtaining accurate low-dose CT images.
method Modified iterative regression CNN, BCD-Net, with faster numerical solvers.
result BCD-Net achieves better image quality and generalization than state-of-the-art methods.
Kernel method estimates long-term effects from short-term data.
problem Estimating long-term effects from short-term data in continuous actions.
method Kernel ridge regression to embed and extrapolate long-term effects.
result Uniform consistency and nonasymptotic error bounds for the estimator.
PT-WGAN reduces PET image noise without losing details.
problem Low-dose PET images suffer from noise and artifacts.
method Parameter-transferred Wasserstein GAN for denoising.
result PT-WGAN outperforms state-of-the-art methods in denoising.
Bayesian model for cancer drug studies maps dose-response curves.
problem Mapping dose-response curves in cancer drug studies.
method Bayesian Tensor Filtering (BTF) with low-dimensional embeddings and structured shrinkage priors.
result BTF outperforms state-of-the-art methods in cancer drug studies.
ContiVAE estimates individual dose-response curves from unobserved confounders using observational data.
problem Estimating causal effects of continuous treatments considering unobserved confounders.
method Variational auto-encoder with a Tilted Gaussian prior distribution modeling hidden confounders as latent variables.
result ContiVAE outperforms existing methods by up to 62% in predicting individual dose-response curves.
Extracts airways from 3D CT data using graph refinement methods.
problem Extracting airway trees from volumetric CT data.
method Two methods: mean-field approximation and graph neural networks.
result Both methods improve airway detection accuracy.
Model based iterative reconstruction (MBIR) algorithms for low-dose X-ray CT are computationally expensive. To address this problem, we recently proposed a deep convolutional neural network (CNN) for low-dose X-ray CT and won the second place in 2016 AAPM Low-Dose CT Grand Challenge. However, some of the texture were n…
Kernel methods identify treatment effects with unobserved confounding using negative controls.
problem Learning causal relationships with unmeasured confounding.
method Kernel ridge regression algorithms for nonparametric treatment effects.
result Uniform consistency and finite sample rates of convergence proved.
New kernel methods estimate complex causal relationships.
problem Estimating nonparametric causal functions like dose-response curves.
method Kernel ridge regression with decomposition property.
result Uniform consistency with finite sample rates proved.
Paper develops methods to estimate derivative of dose-response curve for continuous treatments.
problem Estimating the derivative of the dose-response curve for continuous treatments.
method Doubly robust (DR) inference method using kernel smoothing, bias-corrected IPW and DR estimators.
result Proposes novel bias-corrected IPW and DR estimators for continuous treatments.
A new model improves CT image quality from low-dose scans.
problem Improving CT image quality from low-dose scans.
method Multi-layer Residual Sparsifying Transform (MRST) learning model for low-dose CT reconstruction.
result The MRST model outperforms conventional methods in maintaining subtle details.
Deep learning identifies functional primitives in stroke rehabilitation.
problem Measuring the necessary dose of rehabilitation training for stroke recovery.
method Automatic identification of functional primitives using IMUs and deep learning.
result Convolutional neural network achieved 70% accuracy in primitive classification.
This work combines deep learning and sparse coding for CT image reconstruction.
problem Improving image quality in low-dose CT scans.
method Sparse signal representation using learned dictionaries, inspired by variational autoencoders and deep learning techniques.
result Regularization with learned dictionaries achieves competitive performance in CT reconstruction.
CASCADE improves uncertainty communication in Parkinson's disease medication management.
problem Uncertainty in clinical decision-making for Parkinson's disease patients.
method CASCADE uses a novel conformal prediction framework to adaptively scale prediction intervals based on classification uncertainty.
result CASCADE produces more efficient and robust prediction intervals for Parkinson's disease patients.
Quadratic autoencoder improves low-dose CT image denoising.
problem Low-dose CT image denoising.
method Quadratic autoencoder architecture applied to CT denoising.
result Quadratic autoencoder achieves superior denoising performance and efficiency.
Image denoising techniques are essential to reducing noise levels and enhancing diagnosis reliability in low-dose computed tomography (CT). Machine learning based denoising methods have shown great potential in removing the complex and spatial-variant noises in CT images. However, some residue artifacts would appear in…
3D point cloud attacks examine how neural networks can be fooled.
problem Understanding how 3D neural networks can be exploited by attackers.
method Examined two categories of attacks: distributional and shape attacks.
result Some shape attacks can fool 3D point cloud classification models even after preprocessing.
Method bounds continuous-valued treatment effects when confounding variables are hidden.
problem Inferring causal effects of continuous treatments when hidden confounders are present.
method Novel methodology to bound average and conditional average continuous-valued treatment effects.
result Method gives tighter coverage of true dose-response curve than existing methods.