New biomarker predicts MRgFUS treatment outcome without contrast agents.
problem Inaccurate assessment of treated tissue viability after MRgFUS.
method Deep learning on noncontrast multiparametric MRI images, voxel-wise registration.
result Predicted follow-up NPV with DICE coefficient 0.71, outperforming current standard.
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Paper presents a machine learning method to predict cancer sub-clones.
problem Predicting the growth of sub-clones in cancer tumors.
method Data-driven machine learning approach to capture sub-clonal characteristics.
result Machine learning can predict which sub-clones are more likely to grow.
TuNet improves glioma segmentation accuracy and efficiency.
problem Accurate and efficient glioma segmentation for early treatment.
method End-to-end cascaded network with hierarchical structure and ResNet-like blocks.
result Improved segmentation accuracy and reduced treatment costs.
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
problem Challenges in integrating longitudinal tumor measurements, dropout information, and genetic covariates.
method Extended EB-VAE framework to jointly model longitudinal and time-to-event data, incorporating dropout hazard and genetic covariates.
result Hybrid decoder formulation yields consistent treatment-effect parameters and prior predictive performance comparable to neural decoder.
Proposes BGNN for tumor heterogeneity prediction using graph neural networks.
problem Tumor classification limitations and heterogeneity assessment challenges.
method Artificial data generation, tumor heterogeneity estimation, and BGNN model development.
result BGNN achieves 89.67% accuracy in predicting tumor heterogeneity. Brain tumor segmentation from Magnetic Resonance Images (MRIs) is an important task to measure tumor responses to treatments. However, automatic segmentation is very challenging. This paper presents an automatic brain tumor segmentation method based on a Normalized Gaussian Bayesian classification and a new 3D Fluid Ve…
Deep learning improves tumor type classification accuracy.
problem Classifying cancer types based on DNA mutations is challenging.
method Deep transfer learning and fine-tuning of gene expression data.
result Significantly improved tumor type classification accuracy (78.3%) using DNA point mutations.
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
Challenge aims to develop automated meningioma MRI segmentation models.
problem Lack of automated, objective tools for meningioma assessment.
method Develop and evaluate models on largest annotated dataset.
result Improved care of patients with meningioma through automated segmentation.
Understanding the dynamics of brain tumor progression is essential for optimal treatment planning. Cast in a mathematical formulation, it is typically viewed as evaluation of a system of partial differential equations, wherein the physiological processes that govern the growth of the tumor are considered. To personaliz…
The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship between kidney tumor morphology and clinical outcomes is difficult due to data scar…
Brain cancer can be very fatal, but chances of survival increase through early detection and treatment. Doctors use Magnetic Resonance Imaging (MRI) to detect and locate tumors in the brain, and very carefully analyze scans to segment brain tumors. Manual segmentation is time consuming and tiring for doctors, and it ca…
The accurate automatic segmentation of gliomas and its intra-tumoral structures is important not only for treatment planning but also for follow-up evaluations. Several methods based on 2D and 3D Deep Neural Networks (DNN) have been developed to segment brain tumors and to classify different categories of tumors from d…
Interventional cancer clinical trials are generally too restrictive, and some patients are often excluded on the basis of comorbidity, past or concomitant treatments, or the fact that they are over a certain age. The efficacy and safety of new treatments for patients with these characteristics are, therefore, not defin…
New gene selection method improves tumor classification accuracy.
problem Efficiently selecting relevant genes from high-dimensional tumor gene expression data.
method Fuzzy-Rough Set Theory for feature dependency analysis.
result The proposed method outperforms state-of-the-art techniques in tumor classification.
Deep Bayesian neural networks improve somatic variant calling accuracy.
problem Improving accuracy in pinpointing somatic variants from next-gen sequencing data.
method Deep Bayesian Recurrent Neural Networks (RNNs) for somatic variant calling.
result Deep Bayesian RNNs provide more reliable confidence intervals for variant calls.
A new method models continuous-time counterfactual outcomes using neural controlled differential equations.
problem Estimating personalized healthcare outcomes over irregularly sampled data.
method Interpreting data as samples from a continuous-time process, modeling latent trajectory using controlled differential equations, and using adversarial training for time-dependent confounding.
result TE-CDE consistently outperforms existing approaches in irregularly sampled scenarios.
Deep neural network improves cancer mutation calls with confidence.
problem Improving accuracy and confidence in somatic variant calls from cancer sequencing.
method Deep Bayesian Recurrent Neural Network (RNN) with flexible priors.
result Enhanced confidence in mutation calls without performance degradation.
Unsupervised method selects genes for tumor subtype discovery.
problem High-dimensional tumor gene expression data with noisy variables and heterogeneity.
method Autoencoders for latent space learning, Multiple Kernel Learning for feature selection, clustering.
result Lower redundancy and better clustering performance compared to benchmarks.
Proposes efficient data acquisition for personalized treatment effects from observational data.
problem Efficiently acquiring outcomes for personalized treatment effects in observational studies.
method Introduces causal, Bayesian acquisition functions to select points with overlapping support.
result Demonstrates improved sample efficiency and accuracy in learning personalized treatment effects.
Study uses image analysis to predict MSI status in tumors.
problem Challenges in distinguishing MSI from its counterpart.
method Interpretable pathological image analysis strategies using Haematoxylin and eosin-stained images.
result Strategies achieve decent performance in MSI prediction.
Q-learning adapted to find near-equivalent treatment strategies.
problem Finding optimal treatment sequences in dynamic treatment regimes.
method Introducing a worst-value tolerance criterion to find sets of near-equivalent policies.
result Constructs families of near-equivalent treatment strategies.
AI framework uses multi-omics data to personalize cancer treatment suggestions.
problem Leveraging AI for personalized cancer treatment based on complex patient characteristics.
method Modular machine learning framework trained on diverse multi-omics technologies.
result Superior performance in personalized counterfactual treatment suggestions.
PDX studies help personalize cancer treatment.
problem Precision medicine in cancer treatment.
method Machine learning methods for estimating optimal ITRs from PDX data.
result Superlearner approach combining multiple ITRs improves personalized treatment recommendations.
The paper uses neural networks to segment brain tumors and predict patient survival.
problem Brain tumor segmentation and survival prediction.
method Fully convolutional neural network with encoder-decoder architecture, radiomic features, and random forest regression.
result 55.4% classification accuracy for predicting survival of patients with gross-total resection.
A novel 3D U-Net approach improves kidney tumor segmentation in medical imaging.
problem Challenging manual annotation and great medical impact of kidney tumor segmentation.
method End-to-end cascaded U-Nets with a localization network.
result Achieves Sørensen-Dice coefficients of 0.902 for kidney and 0.408 for tumor segmentation.
NAS improves gliomas segmentation on MRI scans.
problem Designing optimal deep learning architectures for brain tumor segmentation.
method Neural architecture search with probabilistic parameter learning for MRI brain tumor segmentation.
result Two optimal neural architectures for brain tumor segmentation were discovered.
Study generates synthetic MR images to improve glioma segmentation.
problem Scarce annotated medical image data for glioma patients.
method Used generative adversarial networks (GANs) to create synthetic MR images.
result Synthetic images improved U-Net segmentation performance.
This study improves lung tumor segmentation in mice MRI scans with nnU-Net, reducing annotation needs.
problem Accurate lung tumor segmentation in mice MRI scans for drug discovery.
method Optimized nnU-Net 3D model for lung tumor segmentation with minimal annotations.
result nnU-Net 3D models outperform 2D models in MRI mice scans, requiring fewer annotations.
In this work we approach the brain tumor segmentation problem with a cascade of two CNNs inspired in the V-Net architecture \cite{VNet}, reformulating residual connections and making use of ROI masks to constrain the networks to train only on relevant voxels. This architecture allows dense training on problems with hig…
A method selects key genes from tumor transcriptomics data using kernel methods and improves classification performance.
problem Feature selection for tumor classification using gene expression data.
method Multiple Kernel Learning with latent regularization and non-linear dimensionality reduction.
result Improved tumor classification performance on unseen test samples.
New method uses image-level and pixel-level annotations for brain tumor segmentation.
problem Challenges in obtaining pixel-level annotations for brain tumor segmentation.
method Proposes a learning-based framework that combines both pixel- and image-level annotations.
result Method's performance in segmentation quality is competitive with traditional fully-supervised approach.
Paper tackles brain tumor segmentation using weak labels and hierarchical training.
problem High manual labeling effort for fully supervised brain tumor segmentation.
method Uses scribbles and global labels for weak supervision, trains two networks in phases.
result Achieves competitive results on brain tumor segmentation and substructure segmentation.
Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-p…
Framework detects brain tumors robustly from MRI images.
problem Low clinical incidence of brain tumor cases makes diagnosis challenging.
method YOLOv8n for detection, DeiT for classification, PTP metric for evaluation.
result F1-score of 0.92 achieved with reduced computational resources.
Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of pathological processes underlying cancer, and in turn improve diagnosis and treatment opt…
Automated brain tumor segmentation plays an important role in the diagnosis and prognosis of the patient. In addition, features from the tumorous brain help in predicting patients overall survival. The main focus of this paper is to segment tumor from BRATS 2018 benchmark dataset and use age, shape and volumetric featu…
RCS-YOLO improves brain tumor detection speed and accuracy.
problem Efficiently detecting brain tumors with high accuracy and speed.
method Proposes RCS-YOLO, a fast and accurate brain tumor detector using YOLO with Reparameterized Convolution and channel Shuffle.
result RCS-YOLO outperforms other YOLO versions in speed and accuracy on brain tumor detection.
Enhanced deep learning model improves tumor segmentation in ultrasound images.
problem Challenges in integrating patient-specific medical priors into deep learning models.
method Integrates visual saliency into a U-Net architecture with attention blocks.
result Achieved a Dice similarity coefficient of 90.5 percent on a dataset of 510 images.
Study benchmarks contextual bandit algorithms for precision oncology using in vitro data.
problem Designing effective protocols for individual treatment assignment in precision oncology.
method Proposed a benchmark dataset of in vitro drug responses to evaluate contextual bandit algorithms.
result Bayesian bandit algorithms performed better than a rule-based baseline in minimizing regret.
3D U-Net improves kidney and tumor segmentation from CT scans.
problem Manual segmentation by clinicians is laborious and error-prone.
method Multi-scale supervised 3D U-Net with deep supervision and post-processing.
result MSS U-Net achieves high Dice coefficients (0.969 for kidney, 0.805 for tumor) on KiTS19 dataset.
Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, that can be applied to WGS data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant allele frequencies (VAFs) of point mutation…
Deep Relevance Regularization improves neural network performance in tumor typing.
problem Confounding factors hinder neural network performance in multi-laboratory imaging mass spectrometry data.
method Introduces Deep Relevance Regularization to restrict neural network focus.
result Deep Relevance Regularization robustifies neural networks and improves interpretability.
A method for MRI brain tumor segmentation using feature vectors and kernel dictionary learning.
problem Segmenting brain tumor regions in MRI images.
method Extracting feature vectors, training kernel dictionaries, and selecting informative feature vectors.
result The method outperforms other methods in segmentation accuracy and reduces training time.
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from…
Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only time-consuming but also requires medical expertise. On the other hand, images with…
Bayesian method transfers knowledge between brain tumor datasets.
problem Applying deep learning to small medical datasets.
method Generative Bayesian Prior network for knowledge transfer.
result Best results in Dice Similarity Coefficient for BRATS2018.