A locally-built, LLM-digested index of recent arXiv papers in quant finance, geometry/topology, and statistical ML — keyword search served straight from SQLite on this machine.
Proposes BGNN for tumor heterogeneity prediction using graph neural networks.
Determining the primary site of origin for metastatic tumors is one of the open problems in cancer care because the efficacy of treatment often depends on the cancer tissue of origin. Classification methods that can leverage tumor genomic data and predict the site of origin are therefore of great value. Because tumor D…
A method selects key genes from tumor transcriptomics data using kernel methods and improves classification performance.
Framework detects brain tumors robustly from MRI images.
New gene selection method improves tumor classification accuracy.
The paper demonstrates the use of the fully convolutional neural network for glioma segmentation on the BraTS 2019 dataset. Three-layers deep encoder-decoder architecture is used along with dense connection at encoder part to propagate the information from coarse layer to deep layers. This architecture is used to train…
Brain tumor segmentation from Magnetic Resonance Images (MRIs) is an important task to measure tumor responses to treatments. However, automatic segmentation is very challenging. This paper presents an automatic brain tumor segmentation method based on a Normalized Gaussian Bayesian classification and a new 3D Fluid Ve…
Sparse representation based classification (SRC) methods have achieved remarkable results. SRC, however, still suffer from requiring enough training samples, insufficient use of test samples and instability of representation. In this paper, a stable inverse projection representation based classification (IPRC) is prese…
Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only time-consuming but also requires medical expertise. On the other hand, images with…
Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are required to fully process the data. Deep learning offers an approach to learn featu…
Neural networks have recently been established as a viable classification method for imaging mass spectrometry data for tumor typing. For multi-laboratory scenarios however, certain confounding factors may strongly impede their performance. In this work, we introduce Deep Relevance Regularization, a method of restricti…
Unsupervised method selects genes for tumor subtype discovery.
Kidney tumor segmentation emerges as a new frontier of computer vision in medical imaging. This is partly due to its challenging manual annotation and great medical impact. Within the scope of the Kidney Tumor Segmentation Challenge 2019, that is aiming at combined kidney and tumor segmentation, this work proposes a no…
This study improves lung tumor segmentation in mice MRI scans with nnU-Net, reducing annotation needs.
Study uses image analysis to predict MSI status in tumors.
The analysis of cancer genomic data has long suffered "the curse of dimensionality". Sample sizes for most cancer genomic studies are a few hundreds at most while there are tens of thousands of genomic features studied. Various methods have been proposed to leverage prior biological knowledge, such as pathways, to more…
In this work we approach the brain tumor segmentation problem with a cascade of two CNNs inspired in the V-Net architecture \cite{VNet}, reformulating residual connections and making use of ROI masks to constrain the networks to train only on relevant voxels. This architecture allows dense training on problems with hig…
Glioma is one of the most common types of brain tumors; it arises in the glial cells in the human brain and in the spinal cord. In addition to having a high mortality rate, glioma treatment is also very expensive. Hence, automatic and accurate segmentation and measurement from the early stages are critical in order to …
Understanding the dynamics of brain tumor progression is essential for optimal treatment planning. Cast in a mathematical formulation, it is typically viewed as evaluation of a system of partial differential equations, wherein the physiological processes that govern the growth of the tumor are considered. To personaliz…
Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-p…
Automated brain tumor segmentation plays an important role in the diagnosis and prognosis of the patient. In addition, features from the tumorous brain help in predicting patients overall survival. The main focus of this paper is to segment tumor from BRATS 2018 benchmark dataset and use age, shape and volumetric featu…
The accurate automatic segmentation of gliomas and its intra-tumoral structures is important not only for treatment planning but also for follow-up evaluations. Several methods based on 2D and 3D Deep Neural Networks (DNN) have been developed to segment brain tumors and to classify different categories of tumors from d…
RCS-YOLO improves brain tumor detection speed and accuracy.
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
The majority of cancer treatments end in failure due to Intra-Tumor Heterogeneity (ITH). ITH in cancer is represented by clonal evolution where different sub-clones compete with each other for resources under conditions of Darwinian natural selection. Predicting the growth of these sub-clones within a tumour is among t…
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
The morphometry of a kidney tumor revealed by contrast-enhanced Computed Tomography (CT) imaging is an important factor in clinical decision making surrounding the lesion's diagnosis and treatment. Quantitative study of the relationship between kidney tumor morphology and clinical outcomes is difficult due to data scar…
EB-VAE combines tumor growth and dropout data for personalized treatment response modeling.
Segmentation of tumors in brain MRI images is a challenging task, where most recent methods demand large volumes of data with pixel-level annotations, which are generally costly to obtain. In contrast, image-level annotations, where only the presence of lesion is marked, are generally cheap, generated in far larger vol…
The recent state-of-the-art deep learning methods have significantly improved brain tumor segmentation. However, fully supervised training requires a large amount of manually labeled masks, which is highly time-consuming and needs domain expertise. Weakly supervised learning with scribbles provides a good trade-off bet…
Proposes ConRad model for lung cancer classification using radiomics and interpretable machine learning.
3D U-Net improves kidney and tumor segmentation from CT scans.
Brain cancer can be very fatal, but chances of survival increase through early detection and treatment. Doctors use Magnetic Resonance Imaging (MRI) to detect and locate tumors in the brain, and very carefully analyze scans to segment brain tumors. Manual segmentation is time consuming and tiring for doctors, and it ca…
Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, that can be applied to WGS data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant allele frequencies (VAFs) of point mutation…
A method for MRI brain tumor segmentation using feature vectors and kernel dictionary learning.
High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from…
Principal Component Analysis (PCA) has been used to study the pathogenesis of diseases. To enhance the interpretability of classical PCA, various improved PCA methods have been proposed to date. Among these, a typical method is the so-called sparse PCA, which focuses on seeking sparse loadings. However, the performance…
The emerging field of precision oncology relies on the accurate pinpointing of alterations in the molecular profile of a tumor to provide personalized targeted treatments. Current methodologies in the field commonly include the application of next generation sequencing technologies to a tumor sample, followed by the id…
Incorporating human domain knowledge for breast tumor diagnosis is challenging, since shape, boundary, curvature, intensity, or other common medical priors vary significantly across patients and cannot be employed. This work proposes a new approach for integrating visual saliency into a deep learning model for breast t…
The objectives of this "perspective" paper are to review some recent advances in sparse feature selection for regression and classification, as well as compressed sensing, and to discuss how these might be used to develop tools to advance personalized cancer therapy. As an illustration of the possibilities, a new algor…
Bayesian method transfers knowledge between brain tumor datasets.
Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes. It can be, however, strongly dependent on the area selection due to uneven mitotic figure distribution in the tumor section.We aimed to assess the question, how s…
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors. Here we describe the treeCRP, an extension of the Chinese restaurant process (CRP), a popular construction used in nonparametric mixture models, to infer the …
Deep learning improves brain tumor detection with few data.
This paper analyzes the use of 3D Convolutional Neural Networks for brain tumor segmentation in MR images. We address the problem using three different architectures that combine fine and coarse features to obtain the final segmentation. We compare three different networks that use multi-resolution features in terms of…
Challenge aims to develop automated meningioma MRI segmentation models.
New framework distinguishes lung cancer subtypes using MALDI mass spectrometry.
Noninvasive MR-guided focused ultrasound (MRgFUS) treatments are promising alternatives to the surgical removal of malignant tumors. A significant challenge is assessing the viability of treated tissue during and immediately after MRgFUS procedures. Current clinical assessment uses the nonperfused volume (NPV) biomarke…