Develops methods for near-optimal personalized treatment recommendations.
problem Assigning optimal treatments to patients based on individual characteristics.
method Outcome weighted learning framework to estimate near-optimal alternative individualized treatment recommendations (A-ITR).
result Consistency of proposed methods and upper bound for risk between optimal and estimated recommendations.
Proposes DeepSDRF for continuous treatment recommendation from clinical survival data.
problem Continuous treatment recommendation in medical settings with survival data.
method Deep Survival Dose Response Function (DeepSDRF) for learning conditional average dose response (CADR) function.
result Similar performance of recommender algorithms based on random search and reinforcement learning.
The paper addresses treatment recommendation problems by optimizing distributional characteristics.
problem Optimizing treatment recommendations based on distributional targets.
method Characterizes the problem's difficulty and proposes near-optimal policies.
result Characterizes the difficulty of the problem and proposes near-regret optimal policies.
SAFER improves personalized treatment recommendations for dynamic clinical contexts.
problem Personalized treatment optimization in evolving clinical contexts with safety concerns.
method Integrates structured EHR and clinical notes, uses conformal prediction for safe recommendations.
result SAFER outperforms state-of-the-art baselines in recommendation metrics and mortality rates.
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
Proposes a framework for personalized treatment recommendations using observational data.
problem Estimating patient-level treatment effects from observational data.
method Integrates existing methods for learning patient-level causal models.
result Improves patient outcomes in heart failure patients with acute kidney injury.
BRACE addresses noncompliance in bandits, offering methods for recommendation and treatment policies.
problem Noncompliance in bandit problems complicates learning objectives and treatment effects.
method BRACE formalizes objective-choice, identifies direct-control regimes, and proposes a phase-doubling algorithm for IV inversion.
result BRACE delivers valid policy values and structural uncertainty, even under weak identification and homogeneity failure.
Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the linear Cox proportional hazards model require extensive feature engineering or pri…
It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the characteristics of multiple treatment stages, various symptoms, and multi-pathogenesis. More…
RL algorithms with medical integration improve personalized treatment recommendations.
problem Developing effective personalized treatment strategies for chronic diseases.
method Integrating medical knowledge into RL algorithms for DTR.
result Enhanced treatment recommendations with increased confidence.
Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking an action against the costs involved. In this work, we aim to automate this task…
When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions of electronic medical records (EMRs) that are only just recently being leveraged to i…
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Estimates citation impact to recommend best publication venue.
problem Choosing optimal publication venue for academic papers.
method Treatment effect estimation and bias correction method.
result Effective recommendation of publication venues based on citation potential.
The paper uses machine learning to find causal rules from business process logs.
problem Discovering causal relationships in business process logs.
method Action rule mining followed by causal machine learning (uplift trees).
result Identifies treatments with high causal effect on outcomes.
Researchers develop a method to measure treatment effects in settings with shared states.
problem Measuring treatment effects in settings with shared states like prices, recommendations, or social signals.
method Double machine learning (DML) theorem with conditions for efficient inference under shared-state interference.
result Efficient estimation of average direct effect (ADE) and global average treatment effect (GATE) in various models.
The paper examines A/B tests in recommendation systems to detect biased algorithm comparisons due to shared data.
problem Bias in comparing recommendation algorithms due to shared data.
method Formalized as a multi-armed bandit problem, analyzed the sign of difference-in-means estimator vs true GTE.
result Data sharing can lead to biased comparisons of recommendation algorithms, and a detection procedure is proposed.
Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking an action against the costs involved. In this work, we aim to automate this task…
Study optimizes experimental design for best treatment arm identification.
problem Identifying the best treatment arm given contextual information.
method Adaptive Sampling-Policy Learning (PLAS) strategy for minimax rate optimality.
result PLAS strategy achieves minimax rate optimality in expected simple regret.
Dynamic treatment recommendation systems based on large-scale electronic health records (EHRs) become a key to successfully improve practical clinical outcomes. Prior relevant studies recommend treatments either use supervised learning (e.g. matching the indicator signal which denotes doctor prescriptions), or reinforc…
The causal effect of a treatment can vary from person to person based on their individual characteristics and predispositions. Mining for patterns of individual-level effect differences, a problem known as heterogeneous treatment effect estimation, has many important applications, from precision medicine to recommender…
Machine-assisted treatment recommendations hold a promise to reduce physician time and decision errors. We formulate the task as a sequence-to-sequence prediction model that takes the entire time-ordered medical history as input, and predicts a sequence of future clinical procedures and medications. It is built on the …
Designs algorithms to assist humans without affecting their decisions.
problem Algorithms often fail to improve human decisions.
method Formalizes algorithm design using potential outcomes framework and monotonicity assumption.
result Derives minimax optimal recommendation algorithms for limited data.
Dr.S recommends cancer drugs based on genomic data.
problem Personalizing cancer treatments using genomic information.
method Machine learning to identify optimal drug-gene associations.
result Developed a Drug Recommendation System (Dr.S) for cancer cell lines.
CONE evaluates treatment assignment functions using networked observational data to mitigate hidden confounding bias.
problem Evaluate treatment assignment functions using networked observational data with hidden confounders.
method CONE framework that learns partial representations of latent confounders and combines them for counterfactual evaluation.
result Network information mitigates hidden confounding bias in counterfactual evaluation.
Framework assesses variable importance for heterogeneous treatment effects.
problem High-risk domains need reliable methods to assess treatment effect heterogeneity.
method Inferential framework based on Shapley values and semiparametric theory.
result Valid inference on variable importance for heterogeneous treatment effects.
Confounding biases recommender systems, even when data seems fully observed.
problem Unmeasured features influencing both treatment and outcome in recommender systems.
method Illustrations and simulation studies showing how common practices introduce confounding.
result Standard recommender system practices can introduce confounding, reducing performance.
The goal of recommendation is to show users items that they will like. Though usually framed as a prediction, the spirit of recommendation is to answer an interventional question---for each user and movie, what would the rating be if we "forced" the user to watch the movie? To this end, we develop a causal approach to …
Fuses ITRs for primary and secondary outcomes to minimize harm.
problem Learn an ITR maximizing primary outcome while minimizing harm to secondary outcomes.
method Introduces fusion penalty to encourage similar recommendations for different outcomes. Two algorithms estimate the ITR using surrogate loss functions.
result Agreement rate between primary and secondary optimal ITRs converges faster than ignoring secondary outcomes.
This paper tackles selection bias in recommender systems by considering the neighborhood effect.
problem Selection bias in recommender systems due to filtering and user selection.
method Formalizes neighborhood effect as interference problem, introduces treatment representation, and proposes ideal loss.
result Proposed methods achieve unbiased learning when both selection bias and neighborhood effect are present.
Proposes methods for learning optimal dynamic treatment regimes robust to unconfoundedness violations.
problem Estimating optimal dynamic treatment regimes using historical observational data when unconfoundedness is violated.
method Utilizes proximal causal inference framework to propose three nonparametric identification methods, a (K+1)-robust method, and establish a semiparametric efficiency bound.
result Establishes the (K+1)-robust method for learning optimal dynamic treatment regimes, validating its efficiency and multiple robustness through numerical experiments.
Causal ML predicts treatment outcomes, aiding personalized medicine.
problem Predicting individualized treatment effects for personalized medicine.
method Flexible, data-driven methods using causal inference with clinical trial and real-world data.
result Causal ML allows for estimating individualized treatment effects.
Develops NFCF to reduce gender bias in social media recommendation systems.
problem Reduces gender bias in collaborative filtering systems on social media data.
method Pre-training and fine-tuning neural collaborative filtering with bias correction techniques.
result Achieves better performance and fairness in gender de-biased recommendations.
Proposes a generalized causal tree for handling multiple treatments in uplift modeling.
problem Handling multiple treatments in uplift modeling.
method Generalizes causal tree algorithm to handle multiple discrete and continuous-valued treatments.
result Demonstrates improved performance over existing methods in experiments and real data examples.
Proposes a fusion method for many treatment groups in ITRs.
problem Challenges in handling many treatment groups with data sparsity and covariate imbalance.
method Calibration-weighted treatment fusion procedure that balances covariates and fuses similar treatments.
result Ensures robust treatment group recovery and policy value compared to existing methods.
Study bridges welfare maximization and CATE estimation in policy learning.
problem Tackles the gap between empirical welfare maximization and conditional average treatment effect estimation in policy learning.
method Shows equivalence between EWM and least squares over reparameterized policy class, proposes regularization method.
result Both approaches are interchangeable under common conditions and share theoretical guarantees.
The paper learns personalized treatment rules from observational data.
problem Developing effective treatment policies for individual patients.
method Contextual bandit approach to minimize expected risk of treatment policies.
result The proposed method outperforms physicians and baseline approaches in IV and VP administration.
Two novel methods identify influential features in CMABs for better reward distribution.
problem Suboptimal features degrade rewards, interpretability, and efficiency in CMABs.
method Heterogeneous Incremental Effect (HIE) and Heterogeneous Distribution Divergence (HDD) methods.
result Consistent ability to identify influential HTE features, enhancing CMAB performance.
Framework integrates mental disorder measurements for personalized treatment.
problem Optimizing treatment for mental disorders with latent mental states and heterogeneity.
method Measurement theory and multi-layer neural network for complex treatment effects.
result Learned treatment policies outperform alternatives on heterogeneous treatment effects.
Expands statistical background for knee osteoarthritis treatment models.
problem Developing optimal exercise and weight loss treatments for knee osteoarthritis.
method Precision medicine models and jackknife cross-validation method.
result Jackknife estimator provides consistent value function estimation.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
A treatment regime is a function that maps individual patient information to a recommended treatment, hence explicitly incorporating the heterogeneity in need for treatment across individuals. Patient responses are dichotomous and can be predicted through an unknown relationship that depends on the patient information …
Study designs logging policies to minimize off-policy evaluation error.
problem Minimizing OPE error with logging policies for target policies.
method Characterizes reward-coverage tradeoff, proposes a unifying framework, derives optimal policies.
result Provides actionable guidance for firms choosing recommendation systems.
This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexit…
Dynamic treatment regimes are of growing interest across the clinical sciences as these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. A dynamic treatment regime is a sequence of decision rules, with a decision rule per stage of clinical intervention; each de…
Many scientific and engineering challenges -- ranging from personalized medicine to customized marketing recommendations -- require an understanding of treatment effect heterogeneity. In this paper, we develop a non-parametric causal forest for estimating heterogeneous treatment effects that extends Breiman's widely us…
Develops methods to learn optimal treatment regimes using causal tree methods.
problem Lack of methods for estimating treatment effects and handling complex patient data.
method Causal tree and causal forest methods for estimating heterogeneous treatment effects.
result Outperforms state-of-the-art baselines in cumulative regret and percentage of optimal decisions.
EMDE efficiently estimates manifold densities for diverse recommendation systems.
problem Efficiently estimating manifold densities for multi-modal recommendation systems.
method EMDE (Efficient Manifold Density Estimator) framework for arbitrary vector representations.
result Established new state-of-the-art results in top-k and session-based recommendation settings.