Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial network (GAN) approach for predicting desirable 3D dose distributions that eschews th…
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48 results for “treatment planning”
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
Framework improves health by planning actionable treatment processes.
problem Developing objective treatment processes in clinical settings.
method Surrogate Bayesian model combined with ML for personalized health improvement.
result Computed treatment processes are actionable and consistent with clinical knowledge.
The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this vision as they offer a means to monitor a patient's health status in real-time an…
A new algorithm learns optimal personalized treatment plans online with low regret.
problem Learning optimal dynamic treatment regimes in an online setting.
method Developed a novel algorithm balancing exploration and exploitation for rate-optimal regret.
result Guaranteed rate-optimal regret for linear transition and reward models.
Large Language Models-Enabled Digital Twins for Precision Medicine in Rare Gynecological Tumorscs.CL
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
EHR-MPC optimizes sepsis treatment using digital twins and inference-time control.
problem Optimal sepsis treatment policies are contested and difficult to adapt during inference.
method EHR-MPC decouples learning patient dynamics from treatment optimization, enabling inference-time control over learned digital twins.
result EHR-MPC achieves comparable off-policy performance and improved simulation performance compared to RL baselines.
In the modern healthcare system, rapidly expanding costs/complexity, the growing myriad of treatment options, and exploding information streams that often do not effectively reach the front lines hinder the ability to choose optimal treatment decisions over time. The goal in this paper is to develop a general purpose (…
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
We study the problem of estimating the continuous response over time to interventions using observational time series---a retrospective dataset where the policy by which the data are generated is unknown to the learner. We are motivated by applications where response varies by individuals and therefore, estimating resp…
Automates quality control for synthetic CTs generated from MR images.
problem Prevent downstream errors in RT treatment planning from synthetic CTs.
method Ensemble of sCT generators and uncertainty measure based on their disagreement.
result Uncertainty measure can detect input images outside expected MR distribution and sCT images with potential errors.
Estimates heterogeneous treatment effects by grouping conditional average treatment effects.
problem Non-randomized experiments suffer from selection bias.
method Doubly-robust estimator, machine learning for propensity score and conditional mean functions, linear projection model, Neyman-orthogonal moments.
result Lower absolute errors and smaller bias compared to benchmark estimator.
Pharmaceutical targeting is one of key inputs for making sales and marketing strategy planning. Targeting list is built on predicting physician's sales potential of certain type of patient. In this paper, we present a time-sensitive targeting framework leveraging time series model to predict patient's disease and treat…
Machine-assisted treatment recommendations hold a promise to reduce physician time and decision errors. We formulate the task as a sequence-to-sequence prediction model that takes the entire time-ordered medical history as input, and predicts a sequence of future clinical procedures and medications. It is built on the …
CausalLongPFN predicts counterfactual outcomes from time-series data.
problem Predicting future outcomes under varying treatments in time-series data with confounding and heterogeneity.
method Prior-fitted network pretrained on synthetic episodes of temporal structural causal models.
result CausalLongPFN outperforms domain-trained models on factual and counterfactual prediction tasks.
CNNs can be trained with clinically available segmentations for OARs in radiotherapy.
problem Lack of dedicated training volumes for CNNs in radiotherapy.
method Used clinically available segmentations from PACS, applied multi-label segmentation, empirically assessed training set size.
result Clinically available segmentations can be used to train an accurate OAR segmentation model.
This work aims to create a large-scale model for critical care time series data.
problem Lack of large-scale datasets and distribution shifts in critical care time series data.
method Harmonized dataset creation and transfer learning research.
result Established a foundation for large-scale multi-variate time series models in critical care.
A new method boosts survival analysis by stratifying patients and removing noise covariates.
problem Weak detection of treatment differences in randomized clinical trials due to patient heterogeneity.
method 5-Step Stratified Testing and Amalgamation Routine (5-STAR) using elastic net Cox regression and conditional inference trees.
result The 5-STAR routine significantly improves power in detecting treatment effects compared to traditional methods.
Collectives can manipulate learning platforms by coordinated data submission, requiring strategic assessments and algorithms.
problem Collectives can influence learning platforms by altering data, posing risks and requiring strategic planning.
method Developed a theoretical and algorithmic framework to understand and mitigate collective manipulation of learning platforms.
result Demonstrated the need for strategic assessments and implementable coordination algorithms to prevent collective manipulation.
In this paper we study the problems of estimating heterogeneity in causal effects in experimental or observational studies and conducting inference about the magnitude of the differences in treatment effects across subsets of the population. In applications, our method provides a data-driven approach to determine which…
Learning causal effects from observational data greatly benefits a variety of domains such as health care, education and sociology. For instance, one could estimate the impact of a new drug on specific individuals to assist the clinic plan and improve the survival rate. In this paper, we focus on studying the problem o…
Estimating Heterogeneous Treatment Effects by Combining Weak Instruments and Observational Datastat.ME
Combines IV and observational data to estimate CATEs with low compliance and unobserved confounding.
problem Estimating CATEs in personalized medicine and analytics with observational data and weak IVs.
method Two-stage framework: first learns biased CATEs from observational data, then corrects using IV data.
result Effective in estimating CATEs with low compliance and unobserved confounding.
Surrogate-free machine learning-based organ dose reconstruction for pediatric abdominal radiotherapyphysics.med-ph
A ML-based method reconstructs 3D organ doses from 2D radiographs for pediatric abdominal radiotherapy.
problem Reconstructing detailed 3D dose distributions for childhood cancer survivors using limited 2D radiographs.
method Surrogate-free ML approach using 142 abdominal planning CTs, 300 artificial plans, and evolutionary algorithm.
result Accurate 3D dose reconstructions with MAEs ≤ 1.7 Gy for edge organs, validated on independent dataset.
The paper integrates AI and expert knowledge to optimize radiotherapy decisions.
problem Optimizing radiation dose planning considering patient-specific information.
method Integrating Gaussian process models with deep neural networks to quantify uncertainty.
result Improves AI model performance and guides clinical decision making.
Time inconsistency leads to intra-personal conflict and reconciliation strategies.
problem Time inconsistency in dynamic choice problems.
method Rigorous treatment of intra-personal equilibrium in continuous-time settings.
result A new approach to understanding and reconciling intra-personal conflicts.
EasiCS: the objective and fine-grained classification method of cervical spondylosis dysfunctioncs.LG
The precise diagnosis is of great significance in developing precise treatment plans to restore neck function and reduce the burden posed by the cervical spondylosis (CS). However, the current available neck function assessment method are subjective and coarse-grained. In this paper, based on the relationship among CS,…
This work provides safety guarantees for iterative GP predictions.
problem Analytical intractability of uncertainty tracking in iterative GP predictions.
method Deriving formal probability error bounds for iterative GP predictions.
result Formal bounds ensure that GP trajectories lie within specified regions with high probability.
Estimates sample size for subgroup analysis in randomized experiments.
problem Determining sample size for accurate subgroup analysis.
method Turns inference problem into simultaneous inference, calculates sample size based on confidence level and margin of error.
result Allows inversion of sample size to feasible number of treatment arms or partition complexity.
The paper assesses fairness in AI for financial services, using statistical methods.
problem Unintentional bias and insufficient model validation in AI applications.
method Statistical methods for imbalanced data treatment and bias mitigation.
result Fairness evaluation metrics applied to a credit card default payment example.
Bridges uplift modeling and sequential decision-making with online budget allocation.
problem Treatment allocation under budget constraints in digital advertising.
method Budget-Constrained Causal Bandits (BCCB) integrates learning, exploration, and budget pacing.
result Data-efficiency crossover: BCCB operates effectively from the first user, 3-5x lower performance variance.
Challenge aims to develop automated meningioma MRI segmentation models.
problem Lack of automated, objective tools for meningioma assessment.
method Develop and evaluate models on largest annotated dataset.
result Improved care of patients with meningioma through automated segmentation.
Accurate identification and localization of abnormalities from radiology images play an integral part in clinical diagnosis and treatment planning. Building a highly accurate prediction model for these tasks usually requires a large number of images manually annotated with labels and finding sites of abnormalities. In …
The Tech Decouplingq-fin.ST
Tech sector decouples from non-tech sectors post-2015, predicting economic growth.
problem Understanding the relationship between technology and economic growth.
method ARIMA modeling, stationarity tests, data wrangling, exploratory data analysis.
result The technology sector decouples from non-technology sectors post-2015 and predicts economic growth.
Machine Learning (ML) is proving extremely beneficial in many healthcare applications. In pediatric oncology, retrospective studies that investigate the relationship between treatment and late adverse effects still rely on simple heuristics. To assess the effects of radiation therapy, treatment plans are typically simu…
MAGIC: Multi-task Gaussian process for joint imputation and classification in healthcare time seriesstat.ML
Unified framework for imputation and prediction in healthcare time series.
problem Time misalignment and data sparsity in healthcare time series.
method MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification) using hierarchical multi-task Gaussian process and functional logistic regression.
result Superior predictive accuracy compared to existing methods in two healthcare applications.
Improves RL planning by proposing sub-goals hierarchically.
problem Sequential planning assumption in RL.
method Divide-and-Conquer Monte Carlo Tree Search (DC-MCTS).
result Improves navigation and control tasks.
New method designs fairer transport plans with uncertainty.
problem Designing fair and balanced mass transport plans.
method Hierarchical fully probabilistic design (HFPD) for transport plans.
result Optimal hyperprior for transport plans with uncertain marginals.
We aim to reduce the burden of programming and deploying autonomous systems to work in concert with people in time-critical domains, such as military field operations and disaster response. Deployment plans for these operations are frequently negotiated on-the-fly by teams of human planners. A human operator then trans…
Study integrates reliability constraints into generation planning models.
problem Challenges in integrating reliability constraints with generation planning models.
method Leverages a weighted oblique decision tree (WODT) technique to embed reliability verification constraints.
result Demonstrates effectiveness in achieving reliable and optimal planning solutions.
New approach improves black-box planning efficiency by discovering focused macros.
problem Difficulty of deterministic planning increases exponentially with depth.
method Discovering macro-actions with focused effects to improve goal-count heuristics.
result Focused macros dramatically improve black-box planning efficiency.
Study motion planning for points avoiding obstacles in a plane.
problem Avoiding collisions for multiple points in a plane with unknown obstacles.
method Algebraic and topological tools for motion planning.
result New topological complexity for planar motion planning.
Selective planning with imperfect models reduces harmful effects of model inadequacy.
problem Harmful effects of using an imperfect model in reinforcement learning.
method Selective planning with heteroscedastic regression to estimate predictive uncertainty from model inadequacy.
result Effective selective planning requires considering both parameter uncertainty and model inadequacy.
CoMPNetX uses neural networks to efficiently solve constrained motion planning problems.
problem Finding collision-free paths on constraint manifolds efficiently.
method Neural generator and discriminator with neural gradients-based projection operator.
result CoMPNetX finds path solutions with high success rates and lower computation times.
This article asks how planning scholarship may effectively gain impact in planning practice through media exposure. In liberal democracies the public sphere is dominated by mass media. Therefore, working with such media is a prerequisite for effective public impact of planning research. Using the example of megaproject…
We introduce Dynamic Planning Networks (DPN), a novel architecture for deep reinforcement learning, that combines model-based and model-free aspects for online planning. Our architecture learns to dynamically construct plans using a learned state-transition model by selecting and traversing between simulated states and…
Antimicrobial resistance is an important public health concern that has implications in the practice of medicine worldwide. Accurately predicting resistance phenotypes from genome sequences shows great promise in promoting better use of antimicrobial agents, by determining which antibiotics are likely to be effective i…
New method combines heuristics and search techniques to speed up cooperative planning for autonomous vehicles.
problem Efficient cooperative planning for autonomous vehicles in complex traffic scenarios.
method Combining learned heuristics with Monte Carlo Tree Search (MCTS) to guide search towards promising actions.
result Better solutions at lower computational costs achieved through accelerated planning.
This paper presents a unifying framework for reinforcement learning and planning.
problem Sequential decision making in AI, formalized as MDP optimization.
method A unifying algorithmic framework (FRAP) for reinforcement learning and planning.
result Identifies common dimensions in MDP planning and learning algorithms.