A new deep learning method for tissue-cleared image registration.
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Motivation: Understanding functions of proteins in specific human tissues is essential for insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular function remains a critical challenge for biomedicine. Results: Here we present OhmNet, a hierarchy-aware unsupervised node feature le…
Gene expression levels in a population vary extensively across tissues. Such heterogeneity is caused by genetic variability and environmental factors, and is expected to be linked to disease development. The abundance of experimental data now enables the identification of features of gene expression profiles that are s…
Machine learning classifies colorectal tissue using photoacoustic microscopy.
PathologyGAN learns deep representations of cancer tissue images.
Model learns cancer tissue images onto a low-dimensional space revealing tissue characteristics.
Automatically classifying the tissues types of Region of Interest (ROI) in medical imaging has been an important application in Computer-Aided Diagnosis (CAD), such as classification of breast parenchymal tissue in the mammogram, classify lung disease patterns in High-Resolution Computed Tomography (HRCT) etc. Recently…
Cellina uses supervised disentanglement to predict cell behavior in tissues.
Achilles Tendon Rupture (ATR) is one of the typical soft tissue injuries. Rehabilitation after such a musculoskeletal injury remains a prolonged process with a very variable outcome. Accurately predicting rehabilitation outcome is crucial for treatment decision support. However, it is challenging to train an automatic …
Universal model for soft tissue mechanics under shock waves.
Study uses deep learning to quickly estimate tissue properties for personalized radio-frequency dosimetry.
Suppose one is faced with the challenge of tissue segmentation in MR images, without annotators at their center to provide labeled training data. One option is to go to another medical center for a trained classifier. Sadly, tissue classifiers do not generalize well across centers due to voxel intensity shifts caused b…
There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from challenges related to time, cost, and applicability to human physi…
Local semi-supervised method improves brain tissue classification in child MRI.
The paper presents the application of Variational Autoencoders (VAE) for data dimensionality reduction and explorative analysis of mass spectrometry imaging data (MSI). The results confirm that VAEs are capable of detecting the patterns associated with the different tissue sub-types with performance than standard appro…
Applying deep learning methods to mammography assessment has remained a challenging topic. Dense noise with sparse expressions, mega-pixel raw data resolution, lack of diverse examples have all been factors affecting performance. The lack of pixel-level ground truths have especially limited segmentation methods in push…
Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep Neural Networks (DNNs) that is capable of simultaneous inference of various properti…
Voxelwise classification approaches are popular and effective methods for tissue quantification in brain magnetic resonance imaging (MRI) scans. However, generalization of these approaches is hampered by large differences between sets of MRI scans such as differences in field strength, vendor or acquisition protocols. …
Many real-world vision problems suffer from inherent ambiguities. In clinical applications for example, it might not be clear from a CT scan alone which particular region is cancer tissue. Therefore a group of graders typically produces a set of diverse but plausible segmentations. We consider the task of learning a di…
New deep learning model generates accurate personalized human head models for electromagnetic dosimetry.
Novel method embeds generative model into Bayesian optimization for HD cardiac model parameter estimation.
Deep learning predicts tissue properties from cell-laden hydrogels.
An important part of Digital Pathology is the analysis of multiple digitised whole slide images from differently stained tissue sections. It is common practice to mount consecutive sections containing corresponding microscopic structures on glass slides, and to stain them differently to highlight specific tissue compon…
Deep network improves electrical tomography across multiple frequencies.
Paper proposes a neural network for estimating brain conductivity without segmentation.
The curvature of web curves is studied in 3D manifolds.
Physics-Informed Neural Networks (PINNs) benchmarked against clinical estimator and reveal parameter identifiability
Bayesian optimization on cardiac models using a graph convolutional VAE.
Surgeons normally need surgical scissors and tissue grippers to cut through a deformable surgical tissue. The cutting accuracy depends on the skills to manipulate these two tools. Such skills are part of basic surgical skills training as in the Fundamentals of Laparoscopic Surgery. The gripper is used to pinch a point …
EAGLE-Net enhances foundation models by integrating patch-level features for better tissue understanding.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that results in focal injury to the grey and white matter. The presence of white matter lesions biases morphometric analyses such as registration, individual longitudinal measurements and tissue segmentation for brain v…
Estimates target GGM using auxiliary studies with false discovery rate control.
Automatization of the diagnosis of any kind of disease is of great importance and it's gaining speed as more and more deep learning solutions are applied to different problems. One of such computer aided systems could be a decision support too able to accurately differentiate between different types of breast cancer hi…
Theory models nonlinear soft tissue elasticity and remodeling using extended Finsler geometry.
Over the last years, huge resources of biological and medical data have become available for research. This data offers great chances for machine learning applications in health care, e.g. for precision medicine, but is also challenging to analyze. Typical challenges include a large number of possibly correlated featur…
CNN improves frame selection for ultrasound elastography.
Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but suffers from several shortcomings related to tissue preparation, staining proto…
New biomarker predicts MRgFUS treatment outcome without contrast agents.
Purpose: Optical imaging is evolving as a key technique for advanced sensing in the operating room. Recent research has shown that machine learning algorithms can be used to address the inverse problem of converting pixel-wise multispectral reflectance measurements to underlying tissue parameters, such as oxygenation. …
AI enhances cancer diagnostics using spectroscopy.
We give a complete proof of the fact that the trace of the curvature of the connection associated to a planar d-web (d>3) is the sum of the Blaschke curvatures of its sub 3-webs.
Contrast enhanced ultrasound is a radiation-free imaging modality which uses encapsulated gas microbubbles for improved visualization of the vascular bed deep within the tissue. It has recently been used to enable imaging with unprecedented subwavelength spatial resolution by relying on super-resolution techniques. A t…
We propose a model for the credit and liquidity risks faced by clearing members of Central Counterparty Clearing houses (CCPs). This model aims to capture the features of: gap risk; feedback between clearing member default, market volatility and margining requirements; the different risks faced by various types of mark…
Tissue heterogeneity is a major confounding factor in studying individual populations that cannot be resolved directly by global profiling. Experimental solutions to mitigate tissue heterogeneity are expensive, time consuming, inapplicable to existing data, and may alter the original gene expression patterns. Here we a…
Unified model for network risks, including bilateral and central clearing, with practical applications.
Novel approach combines local and global brain changes for AD prediction.
Objective: In this work, we perform margin assessment of human breast tissue from optical coherence tomography (OCT) images using deep neural networks (DNNs). This work simulates an intraoperative setting for breast cancer lumpectomy. Methods: To train the DNNs, we use both the state-of-the-art methods (Weight Decay an…
Elasticity images map biomechanical properties of soft tissues to aid in the detection and diagnosis of pathological states. In particular, quasi-static ultrasonic (US) elastography techniques use force-displacement measurements acquired during an US scan to parameterize the spatio-temporal stress-strain behavior. Curr…