Adherence can be defined as "the extent to which patients take their medications as prescribed by their healthcare providers"[Osterberg and Blaschke, 2005]. World Health Organization's reports point out that, in developed countries, only about 50% of patients with chronic diseases correctly follow their treatments. Thi…
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48 results for “therapy adherence”
latrend simplifies longitudinal clustering for numeric measurements.
problem Clustering of longitudinal data to identify common trends over time.
method Unified framework for applying various clustering methods.
result Facilitates comparison and rapid prototyping of new methods.
This study improves early prediction of CPAP therapy compliance.
problem Predicting early compliance with CPAP therapy to improve patient outcomes.
method Built classifiers for compliance at three CPAP therapy follow-up points.
result Month 3 classifier achieved highest f1-score of 87% in cross-validation and test.
The goal of personalized decision making is to map a unit's characteristics to an action tailored to maximize the expected outcome for that unit. Obtaining high-quality mappings of this type is the goal of the dynamic regime literature. In healthcare settings, optimizing policies with respect to a particular causal pat…
In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolut…
Simulation framework assesses ROI of chronic disease adherence and policy timing.
problem Uncertainty in ROI of adherence-enhancing interventions under heterogeneous patient behavior and socioeconomic variation.
method Simulation-based framework integrating disease progression, time-varying adherence, and policy timing.
result Early and adaptive interventions yield highest ROI, exceeding 20% under certain conditions.
Study finds non-adherence to schizophrenia meds leads to earlier adverse events.
problem Impact of medication non-adherence on adverse outcomes in schizophrenia patients.
method Survival analysis, causal inference methods (T-learner, S-learner, nearest neighbor matching), different amounts of longitudinal information.
result Non-adherence to schizophrenia meds advances adverse events by 1 to 4 months.
Smart bin monitors predict medication adherence with high accuracy.
problem Predicting chronic medication adherence to improve healthcare efficiency.
method Machine learning models trained on IoT device data.
result High predictive performance (ROC AUC 0.86).
Religious adherence reduces corporate greenwashing behavior.
problem Greenwashing behavior by corporations.
method Analysis of a large US firm sample (2005-2019), focusing on selective disclosure.
result Religious adherence correlates with lower greenwashing behavior.
Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial network (GAN) approach for predicting desirable 3D dose distributions that eschews th…
The paper tackles AI advice giving by considering adherence levels and defer options.
problem Inadequate consideration of human adherence to AI recommendations.
method Sequential decision-making model that considers adherence levels and incorporates a defer option.
result Specialized learning algorithms provide better convergence and empirical performance.
Paper derives policy rules from observational data for hepatitis C treatment.
problem Improving treatment guidelines for HIV/HCV co-infected patients.
method Weighted K-means algorithm for estimating CATEs, decision tree implementation.
result Identifies a subgroup with high spontaneous HCV clearance rate.
Proposes a framework for automated radiation therapy treatment planning with uncertainty quantification.
problem Quantifying uncertainties in dose-related quantities for automated treatment planning.
method Three-step pipeline: feature extraction, dose statistic prediction, and dose mimicking.
result Probabilistic treatment plans agree better with clinical counterparts than non-probabilistic ones.
A Machine Learning alternative to placebo-controlled clinical trials upon new diseases: A primerq-bio.QM
New disease drug trials use ML to predict best therapy.
problem Developing new drugs faster than usual clinical trials.
method Use Neural Network to predict drug effects from patient data.
result Neural Network outperforms traditional placebo-controlled trials.
HardCoRe-NAS finds fitting neural networks adhering to hard resource constraints.
problem Finding fitting neural networks that adhere to hard resource constraints.
method Accurate formulation of resource requirement and scalable search method.
result HardCoRe-NAS generates state-of-the-art architectures strictly satisfying hard resource constraints.
Study improves drug synergy prediction using ensemble learning.
problem Predicting drug synergy in complex diseases.
method Investigated different compound representations and proposed an ensemble model.
result Ensemble model outperforms baseline models.
OptiLIME improves LIME explanations by balancing stability and adherence.
problem LIME's instability and lack of reliability in explanations.
method OptiLIME uses a deterministic sampling approach and feature selection to maximize stability while retaining predefined adherence.
result OptiLIME provides more reliable and interpretable explanations.
New method uses machine learning to estimate drug parameters in brain models.
problem Estimating unknown parameters in complex brain drug models.
method Physics-Informed Neural Networks (PINNs) for inverse problem solving.
result Accurate parameter estimation leads to precise drug concentration profiles.
Study uses machine learning to optimize antibiotic therapy for MRSA skin infections.
problem Optimizing antibiotic choice for MRSA skin infections due to reduced treatment options and side effects.
method Propensity score matching, machine learning models (SVM, RF, LASSO), counterfactual analysis.
result RF model shows stronger treatment heterogeneity and potential for therapy change.
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies. These models have differential performance across race and gender groups with inconsistent behavior a…
Study optimal and equitable encouragement policies for treatment adherence.
problem Optimal treatment adherence policies in the presence of human non-adherence.
method Covariate-conditional no-direct-effect model of encouragement; tractable policy characterizations under constraints.
result Induced treatment take-up is the fairness target, not recommendation rates.
We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy using a robustified nonlinear model, and (ii) adopting a randomized prescriptiv…
Algorithm minimizes regret while adhering to unknown safety constraints.
problem Online learning with unknown safety constraints.
method General meta-algorithm leveraging online regression and learning oracles.
result Concrete algorithm with regret for linear constraints.
Develops algorithm to find subgroups with different treatment effects in HIV patients.
problem Estimating treatment effects in EHR data with challenges like time-varying confounding.
method SDLD algorithm combining generalized interaction tree and longitudinal targeted maximum likelihood estimation.
result Identifies subgroups of HIV patients at higher risk of weight gain with dolutegravir-containing ARTs.
Digital Adherence Technologies (DATs) are an increasingly popular method for verifying patient adherence to many medications. We analyze data from one city served by 99DOTS, a phone-call-based DAT deployed for Tuberculosis (TB) treatment in India where nearly 3 million people are afflicted with the disease each year. T…
Determining whether hypotensive patients in intensive care units (ICUs) should receive fluid bolus therapy (FBT) has been an extremely challenging task for intensive care physicians as the corresponding increase in blood pressure has been hard to predict. Our study utilized regression models and attention-based recurre…
Paper uses imitation learning to create efficient insulin policies from MPC demonstrations.
problem Resource-constrained medical devices struggle with complex MPC optimizations and state estimation errors.
method Imitation learning of neural network policies from MPC-computed demonstrations, using Bayesian inference with Monte Carlo Dropout.
result Trained policies generalize well to different patient cohorts, outperforming traditional MPC with state estimation.
Large-scale ligand-based virtual screening for SARS-CoV-2 inhibitors using deep neural networksq-bio.BM
Deep neural network identifies potential SARS-CoV-2 inhibitors.
problem Finding novel therapies for SARS-CoV-2.
method Used ChemAI, a deep neural network trained on 220M data points, to screen and rank one billion molecules from the ZINC database.
result Identified 30,000 top-ranked compounds for further bioassays.
Spinal cord stimulation has enabled humans with motor complete spinal cord injury (SCI) to independently stand and recover some lost autonomic function. Quantifying the quality of bipedal standing under spinal stimulation is important for spinal rehabilitation therapies and for new strategies that seek to combine spina…
Enforcing safety is a key aspect of many problems pertaining to sequential decision making under uncertainty, which require the decisions made at every step to be both informative of the optimal decision and also safe. For example, we value both efficacy and comfort in medical therapy, and efficiency and safety in robo…
Develops a neural surrogate for proton dose calculation using Monte Carlo dropout uncertainty.
problem Computational demand in proton therapy workflows requiring repeated evaluations.
method Integrates Monte Carlo dropout into a neural network surrogate for fast, differentiable dose predictions and uncertainty quantification.
result Shows significant speedups over MC while retaining uncertainty information.
A new graphical model for discrete data without parametric restrictions.
problem Discrete data modeling with restrictions.
method Additive conditional independence and penalized estimation of precision operator.
result Consistency of the estimator in ultrahigh-dimensional settings.
New methods use RL and DA to improve dosing precision and reduce side effects.
problem Improving precision and safety of anticancer drug dosing.
method Bayesian data assimilation and reinforcement learning.
result Significantly reduces incidence of severe side effects.
Large Language Models-Enabled Digital Twins for Precision Medicine in Rare Gynecological Tumorscs.CL
Study uses LLMs to create personalized treatment plans for rare gynecological tumors.
problem Suboptimal management and poor prognosis due to low incidence and heterogeneity of rare gynecological tumors.
method Developed a digital twin system using LLMs to integrate clinical and biomarker data.
result LLM-enabled digital twins efficiently model individual patient trajectories and identify potential treatment options.
Deep learning predicts response to HER2-targeted breast cancer therapy.
problem Predicting response to HER2-targeted neoadjuvant chemotherapy.
method Developed and validated a deep learning approach using pre-treatment dynamic breast MRI.
result Deep learning model achieved strong performance in predicting pathological complete response.
Proposes a Gaussian process model for constrained dynamics learning.
problem Challenges in identifying constrained dynamics of mechanical systems.
method Combines analytical mechanics with Gaussian process regression.
result Improves data efficiency and constraint integrity in predictions.
Tree-based model averaging improves CATE estimation from diverse sites.
problem Limited sample size and privacy concerns prevent accurate personalized treatment effect estimation.
method Tree-based model averaging approach to estimate CATEs from multiple heterogeneous sites.
result Improved accuracy in estimating conditional average treatment effects (CATEs) across sites.
Limited Resource Allocation in a Non-Markovian World: The Case of Maternal and Child Healthcarecs.AI
New approach tackles non-Markovian behavior in maternal health programs.
problem Improving adherence and engagement in maternal and child healthcare programs.
method Extending RMABs to non-Markovian settings, using time-series forecasting and TARI policy.
result Significant increase in engagement and content listened compared to existing methods.
Causal machine learning for heterogeneous treatment effects in the presence of missing outcome datastat.ML
New methods for estimating treatment effects with missing data.
problem Missing outcome data complicates estimating treatment effects.
method Proposed two de-biased machine learning estimators (mDR-learner and mEP-learner) to address under-representation.
result Oracle efficiency of the proposed estimators under reasonable conditions.
Develops methods for finding counterfactual explanations in sequential decision making.
problem Finding counterfactual explanations for sequential decision making processes.
method Formal characterization of sequential actions and states using Markov decision processes and Gumbel-Max structural causal model. Introduces a polynomial time algorithm based on dynamic programming.
result Algorithm finds optimal counterfactual explanations for sequential decision making.
Paper tackles inventory management with deep learning, improving performance and adherence to constraints.
problem Managing inventory with limited resources and constraints.
method Proposes a novel method to sample from a distribution of possible constraint paths, extends exo-IDP formulation, introduces neural coordinator, and uses modified DirectBackprop algorithm.
result Deep reinforcement learning policies with a neural coordinator outperform classic baselines in terms of performance and adherence to constraints.
Synergistic Drug Combination Prediction by Integrating Multi-omics Data in Deep Learning Modelsq-bio.GN
Drug resistance is still a major challenge in cancer therapy. Drug combination is expected to overcome drug resistance. However, the number of possible drug combinations is enormous, and thus it is infeasible to experimentally screen all effective drug combinations considering the limited resources. Therefore, computat…
New algorithm speeds up causal inference for large data.
problem Efficiently estimating causal effects from large data.
method Causal Bag of Little Bootstraps (cBLOBS).
result Significantly improved computational efficiency with consistent estimates.
Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for cardiotoxicity before cardiotoxic treatments and providing preventive measures are potential solutions to improve cancer patients's quality of …
The paper tracks patient recovery using graphs of joint movement data.
problem Tracking individual patient recovery trajectories in physical therapy.
method Bayesian learning of Random Geometric Graphs from joint movement data.
result Optimal exercise routines can be recommended based on patient recovery data.
Characterizing a patient's progression through stages of sepsis is critical for enabling risk stratification and adaptive, personalized treatment. However, commonly used sepsis diagnostic criteria fail to account for significant underlying heterogeneity, both between patients as well as over time in a single patient. W…
Feature selection predicts immune state changes in RA mouse model.
problem Predicting the immune state change after RA immunotherapy.
method Feature selection algorithms applied to mouse CIA model data.
result Selected features predict both T cell markers and treatment efficacy.
Regulatory compliance is an organization's adherence to laws, regulations, guidelines and specifications relevant to its business. Compliance officers responsible for maintaining adherence constantly struggle to keep up with the large amount of changes in regulatory requirements. Keeping up with the changes entail two …