Researchers explore non-coherent banding in site-specific recombination.
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Site-specific recombination on supercoiled circular DNA molecules can yield a variety of knots and catenanes. Twist knots are some of the most common conformations of these products and they can act as substrates for further rounds of site-specific recombination. They are also one of the simplest families of knots and …
We develop a topological model of site-specific recombination that applies to substrates which are the connected sum of two torus links of the form . Then we use our model to prove that all knots and links that can be produced by site-specific recombination on such substrates are contained in one of two…
We develop a model characterizing all possible knots and links arising from recombination starting with a twist knot substrate, extending previous work of Buck and Flapan. We show that all knot or link products fall into three well-understood families of knots and links, and prove that given a positive integer , the…
We develop a topological model of knots and links arising from a single (or multiple processive) round(s) of recombination starting with an unknot, unlink, or (2,m)-torus knot or link substrate. We show that all knotted or linked products fall into a single family, and prove that the size of this family grows linearly …
A site-specific Gordian distance between two spatial embeddings of an abstract graph is the minimal number of crossing changes from one to another where each crossing change is performed between two previously specified abstract edges of the graph. It is infinite in some cases. We determine the site-specific Gordian di…
Clinical AI models fail to transfer between sites due to site-specific practices.
Method improves robustness and generalizability of CATE estimation.
A new evolutionary algorithm improves k-means clustering by recombining the entire population.
A New Trinomial Recombination Tree Algorithm and Its Applications
Paper develops a high-order recombination algorithm for financial modeling.
The theme in this paper is the recombining binomial tree to price American put option when the underlying stock follows constant elasticity of variance(CEV) process. Recombining nodes of binomial tree are decided from finite difference scheme to emulate CEV process and the tree has a linear complexity. Also it is deriv…
In Divide & Recombine (D&R), big data are divided into subsets, each analytic method is applied to subsets, and the outputs are recombined. This enables deep analysis and practical computational performance. An innovate D\&R procedure is proposed to compute likelihood functions of data-model (DM) parameters for big dat…
We categorise coherent band (aka nullification) pathways between knots and 2-component links. Additionally, we characterise the minimal coherent band pathways (with intermediates) between any two knots or 2-component links with small crossing number. We demonstrate these band surgeries for knots and links with small cr…
New RL approach builds short ancestral recombination graphs.
Paper develops a new method for game options in local volatility models.
We extend the tangle model, originally developed by Ernst and Sumners, to include composite knots. We show that, for any prime tangle, there are no rational tangle attachments of distance greater than one that first yield a 4-plat and then a connected sum of 4-plats. This is done by building on results on exceptional D…
Market portfolio decomposed into body and tail legs
Deep learning improves evolutionary algorithms' adaptability.
Paper presents a new algorithm for predicting crop yield across fields.
Study decomposes market portfolio into body and tail legs, revealing systematic differences.
Study of Betti numbers in prodsimplicial complexes for directed graphs, focusing on DNA recombination.
The protein recombinase can change the knot type of circular DNA. The action of a recombinase converting one knot into another knot is normally mathematically modeled by band surgery. Band surgeries on a 2-bridge knot N((4mn-1)/(2m)) yielding a (2,2k)-torus link are characterized. We apply this and other rational tangl…
A new tree model, GRST, improves option pricing without log-normality assumptions.
A new data-level recombination strategy improves RGB-D salient object detection.
Parallelized Bayesian quadrature improves sample efficiency and inference.
Paper presents an efficient approach for integrating LSTM language models in LVCSR systems.
Improved kernel quadrature with convex weights using subsampling.
We give a short topological proof for Rubermans Theorem about mutation and volume, using the Maskit combination theorem and the homology of the linear group.
A general method to construct recombinant tree approximations for stochastic volatility models is developed and applied to the Heston model for stock price dynamics. In this application, the resulting approximation is a four tuple Markov process. The first two components are related to the stock and volatility processe…
The seemingly infinite diversity of the natural world arises from a relatively small set of coherent rules, such as the laws of physics or chemistry. We conjecture that these rules give rise to regularities that can be discovered through primarily unsupervised experiences and represented as abstract concepts. If such r…
Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial network (GAN) approach for predicting desirable 3D dose distributions that eschews th…
In plant and animal breeding studies a distinction is made between the genetic value (additive + epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this paper, we argue that t…
MCP learns reusable skills for complex tasks by combining simple ones.
Graph neural network predicts protonation energies of oxygen atoms in bio-oil molecules.
This paper gives new and elementary combinatorial topological proofs of the classification of unoriented and oriented rational knots and links. These proofs are based on the known classification of alternating knots through flyping, and the calculus of continued fractions. We characterize the class of strongly invertib…
We consider visual domains in which a class label specifies the content of an image, and class-irrelevant properties that differentiate instances constitute the style. We present a domain-independent method that permits the open-ended recombination of style of one image with the content of another. Open ended simply me…
New training method for ReLU networks achieves optimal weight size for memorization.
SwISS improves scalability of Bayesian inference for large datasets.
New model separates objects in scenes, enabling novel arrangements and depth.
In this paper a multi-factor generalization of Ho-Lee model is proposed. In sharp contrast to the classical Ho-Lee, this generalization allows for those movements other than parallel shifts, while it still is described by a recombining tree, and is stationary to be compatible with principal component analysis. Based on…
As the amount and complexity of genetic information increases it is necessary that we explore some efficient ways of handling these data. This study takes the "divide and conquer" approach for analyzing high dimensional genomic data. Our aims include reducing the dimensionality of the problem that has to be dealt one a…
New model uses less site-specific data for accurate hydrologic predictions.
Recombinant binomial trees are binary trees where each non-leaf node has two child nodes, but adjacent parents share a common child node. Such trees arise in finance when pricing an option. For example, valuation of a European option can be carried out by evaluating the expected value of asset payoffs with respect to r…
Generative model learns wireless channel distributions efficiently.
Wittgenstein's Rule Following evolves datasets by extrapolating structural descriptors.
Fusion of transformer networks using optimal transport for improved performance.
This paper is an introduction to rational tangles, rational knots and links and their applications to DNA. The paper can be read as an introduction to our more technical papers on rational tangles (math.GT/0311499) and on rational knots (math.GT/0212011). The present paper includes a self-contained account of the tangl…